Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension.

abstract：:Two monoclonal antibodies directed against the native beta 2 subunit of Escherichia coli tryptophan synthase [L-serine hydro-lyase (adding indoleglycerol-phosphate), EC 4.2.1.20], one recognizing the C-terminal F1 domain and the other the N-terminal F2 domain, were used to detect immunoreactive intermediates in the fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blond S,Goldberg M

更新日期：1987-03-01 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:In the past 15 years, the adoption of subnational immigration policies in the United States, such as those established by individual states, has gone from nearly zero to over 300 per year. These include welcoming policies aimed at attracting and incorporating immigrants, as well as unwelcoming policies directed at den...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huo YJ,Dovidio JF,Jiménez TR,Schildkraut DJ

更新日期：2018-01-30 00:00:00

abstract：:Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a complex with elongin B an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwai K,Yamanaka K,Kamura T,Minato N,Conaway RC,Conaway JW,Klausner RD,Pause A

更新日期：1999-10-26 00:00:00

abstract：:Congenital malformations now represent the largest single cause of mortality in the infant of the diabetic mother. The mechanism by which diabetes exerts its teratogenic effects is not known. This study evaluated whether arachidonic acid might be involved, a possibility raised by the role of arachidonic acid in palata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldman AS,Baker L,Piddington R,Marx B,Herold R,Egler J

更新日期：1985-12-01 00:00:00

abstract：:The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and in certain cases, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rolfe M,Beer-Romero P,Glass S,Eckstein J,Berdo I,Theodoras A,Pagano M,Draetta G

更新日期：1995-04-11 00:00:00

abstract：:The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on major histocompatibility complex (MHC) class II molecules. To develop a tumor-specific superantigen for cancer therapy, we have made a recombinant fusion protein of SEA and the Fab region o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dohlsten M,Abrahmsén L,Björk P,Lando PA,Hedlund G,Forsberg G,Brodin T,Gascoigne NR,Förberg C,Lind P

更新日期：1994-09-13 00:00:00

abstract：:In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin AS,Coons AH

更新日期：1971-08-01 00:00:00

abstract：:A careful review of the literature in political science and neighboring social science disciplines shows that prevailing assumptions in the international development policy community about improved governance as a principal mechanism to reduce poverty in Africa rests more on faith than science. Conventional policy mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyden G

更新日期：2007-10-23 00:00:00

abstract：:From our current understanding of the genetic basis of development and pattern formation in Drosophila and vertebrates it is commonly thought that clusters of Hox genes sculpt the morphology of animals in specific body regions. Based on Hox gene conservation throughout the animal kingdom it is proposed that these gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kmita-Cunisse M,Loosli F,Bièrne J,Gehring WJ

更新日期：1998-03-17 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:Dynamic signals linking the actin cytoskeleton and cell adhesion receptors are essential for morphogenesis during development and normal tissue homeostasis. Abi1 is a central regulator of actin polymerization through interactions with multiple protein complexes. However, the in vivo role of Abi1 remains to be defined....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring C,Ginsberg MH,Haling J,Pendergast AM

更新日期：2011-01-04 00:00:00

abstract：:Duplication of genomic segments provides a primary resource for the origin of evolutionary novelties. However, most previous studies have focused on duplications of complete protein-coding genes, whereas little is known about the significance of duplication segments that are entirely internal to genes. Our examination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Lynch M

更新日期：2009-12-08 00:00:00

abstract：:Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Watatani K,Itoh Y,Okano H,Guillemot F,Nakajima K,Gotoh Y

更新日期：2009-08-04 00:00:00

abstract：:Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akamatsu Y,Dziadkowiec D,Ikeguchi M,Shinagawa H,Iwasaki H

更新日期：2003-12-23 00:00:00

abstract：:In the presence of the nucleotide analog adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]), effects of Ca2+ on stiffness and equatorial x-ray diffraction patterns of single skinned fibers of the rabbit psoas muscle were studied. It is shown that cross-bridges in the presence of ATP[gamma S] have properties of the w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraft T,Yu LC,Kuhn HJ,Brenner B

更新日期：1992-12-01 00:00:00

abstract：:In sexual populations, selection operates neither on the whole genome, which is repeatedly taken apart and reassembled by recombination, nor on individual alleles that are tightly linked to the chromosomal neighborhood. The resulting interference between linked alleles reduces the efficiency of selection and distorts ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neher RA,Kessinger TA,Shraiman BI

更新日期：2013-09-24 00:00:00

abstract：:The Wiskott-Aldrich syndrome protein (WASp) plays a major role in coupling T cell antigen receptor (TCR) stimulation to induction of actin cytoskeletal changes required for T cell activation. Here, we report that WASp inducibly binds the sorting nexin 9 (SNX9) in T cells and that WASp, SNX9, p85, and CD28 colocalize w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Badour K,McGavin MK,Zhang J,Freeman S,Vieira C,Filipp D,Julius M,Mills GB,Siminovitch KA

更新日期：2007-01-30 00:00:00

abstract：:There are large amounts of histone mRNA present in mouse eggs. These RNAs are rapidly degraded, as are other mRNAs, after fertilization and prior to the second cleavage. During cleavage, the histone mRNA accumulates as the embryo divides. The same sets of histone genes are expressed in eggs and embryos, although there...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves RA,Marzluff WF,Giebelhaus DH,Schultz GA

更新日期：1985-09-01 00:00:00

abstract：:The cheA locus of Escherichia coli, which is required for chemotactic behavior, encodes two polypeptide products designated p[cheA]L and p[cheA]S. The mode of synthesis of these two proteins was investigated by transferring various missense and nonsense mutations to a lambda transducing phage and observing the mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RA,Parkinson JS

更新日期：1980-09-01 00:00:00

abstract：:Signaling pathways regulating proliferation, differentiation, and apoptosis are commonly mediated through protein-protein interactions as well as reversible phosphorylation of proteins. To facilitate the study of regulated protein-protein interactions in cells and living animals, we optimized firefly luciferase protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luker KE,Smith MC,Luker GD,Gammon ST,Piwnica-Worms H,Piwnica-Worms D

更新日期：2004-08-17 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:The discovery of high-temperature superconductivity in iron pnictides raised the possibility of an unconventional superconducting mechanism in multiband materials. The observation of Fermi-surface (FS)-dependent nodeless superconducting gaps suggested that inter-FS interactions may play a crucial role in superconducti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terashima K,Sekiba Y,Bowen JH,Nakayama K,Kawahara T,Sato T,Richard P,Xu YM,Li LJ,Cao GH,Xu ZA,Ding H,Takahashi T

更新日期：2009-05-05 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:Here we show how a simple inorganic salt can spontaneously form autocatalytic sets of replicating inorganic molecules that work via molecular recognition based on the {PMo12} ≡ [PMo12O40]3- Keggin ion, and {Mo36} ≡ [H3Mo57M6(NO)6O183(H2O)18]22- cluster. These small clusters are able to catalyze their own formation via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miras HN,Mathis C,Xuan W,Long DL,Pow R,Cronin L

更新日期：2020-05-19 00:00:00

abstract：:Citizenship endows legal protections and is associated with economic and social gains for immigrants and their communities. In the United States, however, naturalization rates are relatively low. Yet we lack reliable knowledge as to what constrains immigrants from applying. Drawing on data from a public/private natura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hainmueller J,Lawrence D,Gest J,Hotard M,Koslowski R,Laitin DD

更新日期：2018-01-30 00:00:00

abstract：:Lithium is the most commonly used drug for the treatment of manic depressive illness. The precise mechanisms underlying its clinical efficacy remain unknown. We found that long-term exposure to lithium chloride dramatically protects cultured rat cerebellar, cerebral cortical, and hippocampal neurons against glutamate-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nonaka S,Hough CJ,Chuang DM

更新日期：1998-03-03 00:00:00

abstract：:A hallmark of the pathology of Alzheimer's disease is the accumulation of the microtubule-associated protein tau into fibrillar aggregates. Recent studies suggest that they accumulate because cytosolic chaperones fail to clear abnormally phosphorylated tau, preserving a pool of toxic tau intermediates within the neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickey CA,Koren J,Zhang YJ,Xu YF,Jinwal UK,Birnbaum MJ,Monks B,Sun M,Cheng JQ,Patterson C,Bailey RM,Dunmore J,Soresh S,Leon C,Morgan D,Petrucelli L

更新日期：2008-03-04 00:00:00

abstract：:Understanding the origin, nature, and functional significance of complex patterns of neural activity, as recorded by diverse electrophysiological and neuroimaging techniques, is a central challenge in neuroscience. Such patterns include collective oscillations emerging out of neural synchronization as well as highly h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： di Santo S,Villegas P,Burioni R,Muñoz MA

更新日期：2018-02-13 00:00:00