Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx.

abstract：:Residential location is thought to influence people's well-being, but different individuals may value residential areas differently. We examined how life satisfaction and personality traits are geographically distributed within the UK London metropolitan area, and how the strength of associations between personality t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jokela M,Bleidorn W,Lamb ME,Gosling SD,Rentfrow PJ

更新日期：2015-01-20 00:00:00

abstract：:Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonk FJ,Casewell NR,Henkel CV,Heimberg AM,Jansen HJ,McCleary RJ,Kerkkamp HM,Vos RA,Guerreiro I,Calvete JJ,Wüster W,Woods AE,Logan JM,Harrison RA,Castoe TA,de Koning AP,Pollock DD,Yandell M,Calderon D,Renjifo C,Cur

更新日期：2013-12-17 00:00:00

abstract：:Proteolipid protein (PLP) is the major myelin membrane protein of the central nervous system. We have isolated a copy of an alternatively spliced PLP gene transcript from a mouse brain cDNA library that was screened for PLP-related sequences. The encoded 241-amino acid protein differs from PLP by an internal deletion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nave KA,Lai C,Bloom FE,Milner RJ

更新日期：1987-08-01 00:00:00

abstract：:The effects of phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C, on Na+ influx were investigated in cultured human foreskin fibroblasts (HSWP cells). We report here that in serum-deprived HSWP cells the addition of PMA alone has no significant effect on Na+ influx. However, the addition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vicentini LM,Villereal ML

更新日期：1985-12-01 00:00:00

abstract：:Methylmalonyl-CoA mutase (2-methylmalonyl-CoA CoA-carbonylmutase, EC 5.4.99.2) is a mitochondrial enzyme whose deficiency in man leads to several biochemically and clinically heterogenous++ forms of methylmalonic acidemia. Intact fibroblasts from 21 patients with mutase apoenzyme deficiency have been pulse-labeled wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenton WA,Hack AM,Kraus JP,Rosenberg LE

更新日期：1987-03-01 00:00:00

abstract：:In the central nervous system, myelin proteolipid protein isoforms (PLP and DM20) play an essential structural role in myelination. It has been shown in several species that myelination is impaired by molecular defects resulting from single base mutations in the PLP gene. We have used DNA amplification by polymerase c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pham-Dinh D,Popot JL,Boespflug-Tanguy O,Landrieu P,Deleuze JF,Boué J,Jollès P,Dautigny A

更新日期：1991-09-01 00:00:00

abstract：:WIN antiviral compounds bind human rhinovirus, as well as enterovirus and parechovirus, in an internal cavity located within the viral protein capsid. Access to the buried pocket necessitates deviation from the average viral protein structure identified by crystallography. We investigated the dissociation of WIN 52084...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhou Z,Post CB

更新日期：2005-05-24 00:00:00

abstract：:We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have implicated these lincRNAs in diverse biological processes, including cell-cycle regulation, immune surveillance, and embryonic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalil AM,Guttman M,Huarte M,Garber M,Raj A,Rivea Morales D,Thomas K,Presser A,Bernstein BE,van Oudenaarden A,Regev A,Lander ES,Rinn JL

更新日期：2009-07-14 00:00:00

abstract：:The electrical transport through self-assembled monolayers of alkanedithiols was studied in large-area molecular junctions and described by the Simmons model [Simmons JG (1963) J Appl Phys 34:1793-1803 and 2581-2590] for tunneling through a practical barrier, i.e., a rectangular barrier with the image potential includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akkerman HB,Naber RC,Jongbloed B,van Hal PA,Blom PW,de Leeuw DM,de Boer B

更新日期：2007-07-03 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:The simultaneous addition of [D-Ala2, D-Leu5]-enkephalin and morphiceptin at concentrations at which 98% of enkephalin (delta) and morphine (mu) receptors are occupied only partially inhibits the binding of [3H]diprenorphine to rat brain membranes. These conditions, furthermore, do not affect the curves for displaceme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang KJ,Hazum E,Cuatrecasas P

更新日期：1981-07-01 00:00:00

abstract：:The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of administration other than injection. One clinically successful tactic to improve both protein circulation and delivery is to fuse the Fc domain of IgG to therapeutic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sockolosky JT,Tiffany MR,Szoka FC

更新日期：2012-10-02 00:00:00

abstract：:We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause a specific synaptic depression. To realize this situation experimentally, the Schaffer collateral projection to area CA1 in rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dudek SM,Bear MF

更新日期：1992-05-15 00:00:00

abstract：:Trigger factor (TF), the first chaperone in eubacteria to encounter the emerging nascent chain, binds to the large ribosomal subunit in the vicinity of the protein exit tunnel opening and forms a sheltered folding space. Here, we present the 3.5-A crystal structure of the physiological complex of the large ribosomal s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baram D,Pyetan E,Sittner A,Auerbach-Nevo T,Bashan A,Yonath A

更新日期：2005-08-23 00:00:00

abstract：:We have developed a procedure for purifying highly specific polyclonal antibodies against 5-methylcytosine. These antibodies were used to probe the distribution of 5-methylcytosine among fractionated nucleosomes of mouse cell chromatin. Our results demonstrate that at least 80% of the 5-methylcytosine is localized in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ball DJ,Gross DS,Garrard WT

更新日期：1983-09-01 00:00:00

abstract：:The process by which cells select one of several specific programs of genetic information in development was examined in homoeotic mutant Antennapedia of Rappaport in Drosophila melanogaster. The results show that the alteration of determination from antenna to leg induced by this homoeotic mutation occurs in a popula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Postlethwait JH,Schneiderman HA

更新日期：1969-09-01 00:00:00

abstract：:The ability of lysosomes to move within the cytoplasm is important for many cellular functions. This ability is particularly critical in neurons, which comprise vast, highly differentiated domains such as the axon and dendrites. The mechanisms that control lysosome movement in these domains, however, remain poorly und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farías GG,Guardia CM,De Pace R,Britt DJ,Bonifacino JS

更新日期：2017-04-04 00:00:00

abstract：:Among the tRNA population of the archaeal parasite Nanoarchaeum equitans are five species assembled from separate 5' and 3' tRNA halves and four species derived from tRNA precursors containing introns. In both groups an intervening sequence element must be removed during tRNA maturation. A bulge-helix-bulge (BHB) moti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randau L,Calvin K,Hall M,Yuan J,Podar M,Li H,Söll D

更新日期：2005-12-13 00:00:00

abstract：:We developed a "continual engagement" model to better integrate knowledge from policy makers, communities, and researchers with the goal of promoting more effective action to balance poverty alleviation and wildlife conservation in 4 pastoral ecosystems of East Africa. The model involved the creation of a core boundar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid RS,Nkedianye D,Said MY,Kaelo D,Neselle M,Makui O,Onetu L,Kiruswa S,Kamuaro NO,Kristjanson P,Ogutu J,BurnSilver SB,Goldman MJ,Boone RB,Galvin KA,Dickson NM,Clark WC

更新日期：2016-04-26 00:00:00

abstract：:Drugs with poor oral bioavailability usually are administered by hypodermic injection, which causes pain, poor patient compliance, the need for trained personnel, and risk of infectious disease transmission. Transdermal (TD) delivery provides an excellent alternative, but the barrier of skin's outer stratum corneum (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wermeling DP,Banks SL,Hudson DA,Gill HS,Gupta J,Prausnitz MR,Stinchcomb AL

更新日期：2008-02-12 00:00:00

abstract：:Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanotte O,Ronin Y,Agaba M,Nilsson P,Gelhaus A,Horstmann R,Sugimoto Y,Kemp S,Gibson J,Korol A,Soller M,Teale A

更新日期：2003-06-24 00:00:00

abstract：:Biological soil crusts (biocrusts)—communities of mosses, lichens, cyanobacteria, and heterotrophs living at the soil surface—are fundamental components of drylands worldwide, and destruction of biocrusts dramatically alters biogeochemical processes, hydrology, surface energy balance, and vegetation cover. Although th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrenberg S,Reed SC,Belnap J

更新日期：2015-09-29 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:Aquaporin-9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes. Because the physiological role/s of AQP9 remain undefined and the expression sites of AQP9 remain incomplete and conflicting, we generated AQP9 knockout mice. In the absence of physiologi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojek AM,Skowronski MT,Füchtbauer EM,Füchtbauer AC,Fenton RA,Agre P,Frøkiaer J,Nielsen S

更新日期：2007-02-27 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:CCAAT/enhancer binding protein (C/EBP) epsilon is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPepsilon gene is transcribed by two alternative promoters, Palpha and Pbeta. A combination of differential splicing and al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka R,Kim GD,Radomska HS,Lekstrom-Himes J,Smith LT,Antonson P,Tenen DG,Xanthopoulos KG

更新日期：1997-06-10 00:00:00

abstract：:A selenium-containing protein, selenoprotein A, is an essential component of the clostridial glycine reductase complex. This enzyme complex catalyzes the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP. Sequence information was obtained by au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sliwkowski MX,Stadtman TC

更新日期：1988-01-01 00:00:00

abstract：:When assembled into 13--19S particles, the reovirus nonstructural protein sigma-NS selectively binds single-stranded RNAs. Sedimentation analyses combined with binding to nitrocellulose membrane filters showed that 1--2 pmol of reovirus mRNAs from the large, medium, or small size classes saturated in vitro the binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamatos NM,Gomatos PJ

更新日期：1982-06-01 00:00:00

abstract：:The slow rolling motion of leukocytes along the walls of blood vessels mediated by specific receptor-ligand adhesion is important in inflammation and occurs in postcapillary venules over a wide range of wall shear stresses and vessel diameters. The ability of hydrodynamic collisions between cells to induce capture of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： King MR,Hammer DA

更新日期：2001-12-18 00:00:00

abstract：:The kainate receptor (KAR), a subtype of glutamate receptor, mediates excitatory synaptic responses at a subset of glutamatergic synapses. However, the molecular mechanisms underlying the trafficking of its different subunits are poorly understood. Here we use the CA1 hippocampal pyramidal cell, which lacks KAR-mediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng N,Shi YS,Nicoll RA

更新日期：2017-01-31 00:00:00