Training replicable predictors in multiple studies.

abstract：:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi K,Rivera J,Isersky C

更新日期：1985-03-01 00:00:00

abstract：:The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of the unphotolyzed E181Q mutant are nearly identical to spectra of the native pigment, supporting the view that Glu-181 is uncharged...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan EC,Kazmi MA,Ganim Z,Hou JM,Pan D,Chang BS,Sakmar TP,Mathies RA

更新日期：2003-08-05 00:00:00

abstract：:The serological properties of the gag gene products p15 and p12 of N- and B-tropic viruses of C57BL mice have been examined. Although these viruses were serologically identical by competition assays for proteins gp71 and p30, they were readily distinguishable in competition assays for proteins p15 and p12. Two isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benade LE,Ihle JN,Declève A

更新日期：1978-09-01 00:00:00

abstract：:BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bahn G,Park JS,Yun UJ,Lee YJ,Choi Y,Park JS,Baek SH,Choi BY,Cho YS,Kim HK,Han J,Sul JH,Baik SH,Lim J,Wakabayashi N,Bae SH,Han JW,Arumugam TV,Mattson MP,Jo DG

更新日期：2019-06-18 00:00:00

abstract：:The only known product of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 85,000-dalton protein, designated ST P85, that contains feline leukemia virus gag gene encoded proteins (p15, p12, and a fragment of p30) and a sarcoma virus-specific polypeptide. Antibodies directed against the latter immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbacid M,Beemon K,Devare SG

更新日期：1980-09-01 00:00:00

abstract：:Maternal microchimerism (MMc) has been associated with development of allospecific transplant tolerance, antitumor immunity, and cross-generational reproductive fitness, but its mode of action is unknown. We found in a murine model that MMc caused exposure to the noninherited maternal antigens in all offspring, but in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bracamonte-Baran W,Florentin J,Zhou Y,Jankowska-Gan E,Haynes WJ,Zhong W,Brennan TV,Dutta P,Claas FH,van Rood JJ,Burlingham WJ

更新日期：2017-01-31 00:00:00

abstract：:LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therape...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastan IH,Archer GE,McLendon RE,Friedman HS,Fuchs HE,Wang QC,Pai LH,Herndon J,Bigner DD

更新日期：1995-03-28 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:Phi chi174 DNA structures containing two different parental genomes were detected genetically and examined by electron microscopy. These structures consisted of two monomeric double-stranded DNA molecules linked in a figure 8 configuration. Such DNA structures were observed to be formed preferentially in host recA+ ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benbow RM,Zuccarelli AJ,Sinsheimer RL

更新日期：1975-01-01 00:00:00

abstract：:A 60,000-dalton polypeptide (p60) has been identified in the feline leukemia virus (FeLV) pseudotype of Moloney sarcoma virus [MSV(FeLV)]. This polypeptide is present in the purified virus complex in concentrations greater than either the murine p30 or the feline p27. Purified p60 crossreacts immunologically with muri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oskarsson MK,Robey WG,Harris CL,Fischinger PJ,Haapala DK,Vande Woude GF

更新日期：1975-06-01 00:00:00

abstract：:The assembly of clathrin-coated vesicles on Golgi membranes is initiated by the GTP-binding protein ADP ribosylation factor (ARF), which generates high-affinity membrane-binding sites for the heterotetrameric AP-1 adaptor complex. Once bound, the AP-1 recruits clathrin triskelia, which polymerize to form the coat. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Drake MT,Kornfeld S

更新日期：1999-04-27 00:00:00

abstract：:Barth, Larsen, and others showed that complex submanifolds of complex projective space, CP(N), of small codimension strongly resemble CP(N) both homotopically and cohomologically. These results are generalized to yield analogous results for complex subspaces of arbitrary homogeneous complex manifolds. One very special...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommese AJ

更新日期：1977-04-01 00:00:00

abstract：:The Max gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA binding site of Myc. Here we examine the expression of Max RNA in comparison to Myc RNA during cell growth and differentiation. Two species of RNA, a major 2.0- and a mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner AJ,Le Beau MM,Diaz MO,Hay N

更新日期：1992-04-01 00:00:00

abstract：:Rat carbonic anhydrase (CA) IV was purified by affinity chromatography and used to produce a specific antiserum in rabbits for immunolocalization studies in rat kidney. CA IV was localized in apical plasma membranes of the proximal convoluted tubule and the thick ascending limb of Henle. Both of these segments are inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown D,Zhu XL,Sly WS

更新日期：1990-10-01 00:00:00

abstract：:Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread. Actin tail formation by M. marinum is markedly reduced in macrophages deficient in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamm LM,Pak MA,Morisaki JH,Snapper SB,Rottner K,Lommel S,Brown EJ

更新日期：2005-10-11 00:00:00

abstract：:Hookworms are hematophagous nematodes that infect a wide range of mammalian hosts, including humans. There has been speculation for nearly a century as to the identity of the anticoagulant substances) used by these organisms to subvert host hemostasis. Using molecular cloning, we describe a family of potent small prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stassens P,Bergum PW,Gansemans Y,Jespers L,Laroche Y,Huang S,Maki S,Messens J,Lauwereys M,Cappello M,Hotez PJ,Lasters I,Vlasuk GP

更新日期：1996-03-05 00:00:00

abstract：:Vertebrates can modulate the sound levels entering their inner ears in the face of intense external sound or during their own vocalizations. Middle ear muscle contractions restrain the motion of the middle ear ossicles, attenuating the transmission of low-frequency sound and thereby protecting the hair cells in the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gridi-Papp M,Feng AS,Shen JX,Yu ZL,Rosowski JJ,Narins PM

更新日期：2008-08-05 00:00:00

abstract：:Sonic hedgehog (Shh) signaling plays diverse roles during animal development and adult tissue homeostasis through differential regulation of Gli family transcription factors. Dysregulated Shh signaling activities have been linked to birth defects and tumorigenesis. Here we report that Brg, an ATP-dependent chromatin r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhan X,Shi X,Zhang Z,Chen Y,Wu JI

更新日期：2011-08-02 00:00:00

abstract：:With the goal of developing techniques for DNA insertional mutagenesis in zebrafish, we established procedures for rapidly obtaining and injecting large numbers of fertilized eggs. Using either of two plasmid constructs, we injected uncut DNA into fertilized eggs at the one- or two-cell stage. Fish hatched from inject...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culp P,Nüsslein-Volhard C,Hopkins N

更新日期：1991-09-15 00:00:00

abstract：:Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integrate visual information. Here we used in vivo two-photon calcium imagi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochefort NL,Garaschuk O,Milos RI,Narushima M,Marandi N,Pichler B,Kovalchuk Y,Konnerth A

更新日期：2009-09-01 00:00:00

abstract：:The methyl-CpG dinucleotide containing a symmetrical 5-methylcytosine (mC) is involved in gene regulation and genome stability. We report here that methylation-mediated transcriptional repressor methylated DNA-binding domain 1 (MBD1) interacts with methylpurine-DNA glycosylase (MPG), which excises damaged bases from s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe S,Ichimura T,Fujita N,Tsuruzoe S,Ohki I,Shirakawa M,Kawasuji M,Nakao M

更新日期：2003-10-28 00:00:00

abstract：:A protein fraction from B. subtilis infected with phage SP01 (fraction LGG) stimulates the activity of RNA polymerase (EC 2.7.7.6; nucleosidetriphosphate:RNA nucleotidyltransferase) core from uninfected bacteria. Fraction LGG contains a protein (P-28, molecular weight 28,000) that is labeled after phage infection and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JJ,Petrusek RL,Geiduschek EP

更新日期：1975-06-01 00:00:00

abstract：:During the past several decades, numerous reports from disparate geographical areas have documented an increased frequency of "bleaching" in reef-forming corals. The phenomenon, triggered by increased sea surface temperatures, occurs when the cnidarian hosts digest and/or expel their intracellular, photosynthetic dino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernov D,Kvitt H,Haramaty L,Bibby TS,Gorbunov MY,Rosenfeld H,Falkowski PG

更新日期：2011-06-14 00:00:00

abstract：:Type VI protein secretion system (T6SS) is important for bacterial competition through contact-dependent killing of competitors. T6SS delivers effectors to neighboring cells and corresponding antagonistic proteins confer immunity against effectors that are delivered by sister cells. Although T6SS has been found in mor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong TG,Ho BT,Yoder-Himes DR,Mekalanos JJ

更新日期：2013-02-12 00:00:00

abstract：:Chromosomes are compacted hundreds of times to fit in the cell, packaged into dynamic folds whose structures are largely unknown. Here, we examine patterns in gene locations to infer large-scale features of bacterial chromosomes. Specifically, we analyzed >100 genomes and identified thousands of gene pairs that displa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright MA,Kharchenko P,Church GM,Segrè D

更新日期：2007-06-19 00:00:00

abstract：:Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisition and analysis for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz MM,Reisen F,Zgraggen S,Fischer S,Yuen D,Kang GJ,Chen L,Schneider G,Detmar M

更新日期：2012-10-02 00:00:00

abstract：:Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaurasiya S,Wu W,Strom AM,Warner M,Gustafsson JÅ

更新日期：2020-10-20 00:00:00

abstract：:The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webster GD,Sanderson MR,Skelly JV,Neidle S,Swann PF,Li BF,Tickle IJ

更新日期：1990-09-01 00:00:00

abstract：:We have found the two-dimensional electrophoretic technique of O'Farrell to be highly efficient in the detection of charge-change substitutions in a large number of proteins. We have applied this method to determine the level of heterozygosity of the most abundant proteins in Drosophila melanogaster adults from a natu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown AJ,Langley CH

更新日期：1979-05-01 00:00:00

abstract：:Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3-4(m), delNAS(m)) from the GNAS locus in humans causes autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib(delNASm)), a disorder of proximal tubular parathyroid hormone (PTH) resistance associated with loss of maternal G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández-Rebollo E,Maeda A,Reyes M,Turan S,Fröhlich LF,Plagge A,Kelsey G,Jüppner H,Bastepe M

更新日期：2012-04-24 00:00:00