Controllability in protein interaction networks.

abstract：:We have isolated lentivirus strains that are related to the human immunodeficiency virus (HIV) from African green monkeys (Cercopithecus aethiops; AGM). Although immunologically related, these SIVagm are clearly distinct from other simian immunodeficiency virus (SIV) isolates, including isolates from Macaca mulatta (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus G,Werner A,Baier M,Binniger D,Ferdinand FJ,Norley S,Kurth R

更新日期：1989-04-01 00:00:00

abstract：:Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadkarni S,Smith J,Sferruzzi-Perri AN,Ledwozyw A,Kishore M,Haas R,Mauro C,Williams DJ,Farsky SH,Marelli-Berg FM,Perretti M

更新日期：2016-12-27 00:00:00

abstract：:The int-1 and int-2 genes were first isolated as targets for transcriptional activation by proviral insertion mutations in mammary carcinomas induced by the mouse mammary tumor virus (MMTV). Since these proto-oncogenes are not expressed at detectable levels in previously tested normal tissues from adult mice, we sough...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakobovits A,Shackleford GM,Varmus HE,Martin GR

更新日期：1986-10-01 00:00:00

abstract：:The carboxy-terminal domain (CTD) code encrypted within the Y1S2P3T4S5P6S7 heptad repeats of RNA polymerase II (Pol2) is deeply rooted in eukaryal biology. Key steps to deciphering the code are identifying the events in gene expression that are governed by individual "letters" and then defining a vocabulary of multile...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez AM,Shuman S,Schwer B

更新日期：2018-11-06 00:00:00

abstract：:Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the prostate persists unabated under conditions of androgen deprivation and throughout the course of disease progression in a mouse prostate cancer model. To elucidate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMullin RP,Dobi A,Mutton LN,Orosz A,Maheshwari S,Shashikant CS,Bieberich CJ

更新日期：2010-01-05 00:00:00

abstract：:The strong consistency of least squares estimates in multiple regression models with independent errors is obtained under minimal assumptions on the design and weak moment conditions on the errors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai TL,Robbins H,Wei CZ

更新日期：1978-07-01 00:00:00

abstract：:Specific Ca2+ binding and Ca2+ activation of ATPase activity in scallop myosin require a regulatory light chain (RLC) from regulated (molluscan or vertebrate smooth) myosin; hybrids containing vertebrate skeletal RLCs do not bind Ca2+ and their ATPase activity is inhibited. Chimeras between scallop and chicken skeleta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jancso A,Szent-Györgyi AG

更新日期：1994-09-13 00:00:00

abstract：:Aggregation of the receptor for IgE on mast cells, basophils, and a tumor analog, rat basophilic leukemia (RBL) cells, induces a calcium-dependent degranulation of the cells. We have measured the membrane potential (delta psi) of RBL cells during this reaction by using the tetraphenylphosphonium ion (Ph4P+) equilibrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanner BI,Metzger H

更新日期：1983-09-01 00:00:00

abstract：:Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helbert W,Poulet L,Drouillard S,Mathieu S,Loiodice M,Couturier M,Lombard V,Terrapon N,Turchetto J,Vincentelli R,Henrissat B

更新日期：2019-03-26 00:00:00

abstract：:The biological function of Glu-181 in the photoactivation process of rhodopsin is explored through spectroscopic studies of site-specific mutants. Preresonance Raman vibrational spectra of the unphotolyzed E181Q mutant are nearly identical to spectra of the native pigment, supporting the view that Glu-181 is uncharged...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan EC,Kazmi MA,Ganim Z,Hou JM,Pan D,Chang BS,Sakmar TP,Mathies RA

更新日期：2003-08-05 00:00:00

abstract：:Outdoor ozone transported indoors initiates oxidative chemistry, forming volatile organic products. The influence of ozone chemistry on indoor air composition has not been directly quantified in normally occupied residences. Here, we explore indoor ozone chemistry in a house in California with two adult inhabitants. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Misztal PK,Arata C,Weschler CJ,Nazaroff WW,Goldstein AH

更新日期：2021-02-09 00:00:00

abstract：:Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline phosphatase (AP), forming conjugates that could bind to the surface of antigen-positive tumor cells. The conjugates were capable of converting a relatively noncytotoxic prodrug, etoposide phosphate (E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senter PD,Saulnier MG,Schreiber GJ,Hirschberg DL,Brown JP,Hellström I,Hellström KE

更新日期：1988-07-01 00:00:00

abstract：:Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amos-Landgraf JM,Irving AA,Hartman C,Hunter A,Laube B,Chen X,Clipson L,Newton MA,Dove WF

更新日期：2012-02-07 00:00:00

abstract：:Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure, but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane excitability and myocardial dysfunction remain uncertain. Failing human cardiomyocytes exhibit increased CaMKII and voltage-gated Ca(2+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koval OM,Guan X,Wu Y,Joiner ML,Gao Z,Chen B,Grumbach IM,Luczak ED,Colbran RJ,Song LS,Hund TJ,Mohler PJ,Anderson ME

更新日期：2010-03-16 00:00:00

abstract：:An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and in five families in Tradate, Italy. Structural study established that the major variant component was arginyl-albumin, in whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan SO,Arai K,Madison J,Laurell CB,Galliano M,Watkins S,Peach R,Myles T,George P,Putnam FW

更新日期：1990-05-01 00:00:00

abstract：:The AAA-ATPase thyroid hormone receptor interacting protein 13 (TRIP13), jointly with the Mad2-binding protein p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC). This checkpoint system ensures the accuracy of chromosome segregation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miniowitz-Shemtov S,Eytan E,Kaisari S,Sitry-Shevah D,Hershko A

更新日期：2015-09-15 00:00:00

abstract：:The flux of solvent water coupled to the transit of ions through protein pores is considerable. The effect of this electroosmotic solvent flow on the binding of a neutral molecule [beta-cyclodextrin (betaCD)] to sites within the staphylococcal alpha-hemolysin pore was investigated. Mutant alpha-hemolysin pores were us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu LQ,Cheley S,Bayley H

更新日期：2003-12-23 00:00:00

abstract：:The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalancette-Hebert M,Sharma A,Lyashchenko AK,Shneider NA

更新日期：2016-12-20 00:00:00

abstract：:Loss of a whole chromosome 5 or a deletion of its long arm (5q) is a recurring abnormality in malignant myeloid neoplasms. To determine the location of genes on 5q that may be involved in leukemogenesis, we examined the deleted chromosome 5 homologs in a series of 135 patients with malignant myeloid diseases. By compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Beau MM,Espinosa R 3rd,Neuman WL,Stock W,Roulston D,Larson RA,Keinanen M,Westbrook CA

更新日期：1993-06-15 00:00:00

abstract：:Apoptotic cells contain nuclear autoantigens that may initiate a systemic autoimmune response. To explore the mechanism of antibody binding to apoptotic cells, 3H9, a murine autoantibody with dual specificity for phospholipids and DNA, was used. H chain mutants of 3H9 were constructed, expressed as single-chain Fv (sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cocca BA,Seal SN,D'Agnillo P,Mueller YM,Katsikis PD,Rauch J,Weigert M,Radic MZ

更新日期：2001-11-20 00:00:00

abstract：:To explore protein space from a global perspective, we consider 9,710 SCOP (Structural Classification of Proteins) domains with up to 70% sequence identity and present all similarities among them as networks: In the "domain network," nodes represent domains, and edges connect domains that share "motifs," i.e., signifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepomnyachiy S,Ben-Tal N,Kolodny R

更新日期：2014-08-12 00:00:00

abstract：:The cellular localization of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 that appears to mediate certain actions of dopamine in the mammalian brain by acting as an inhibitor of protein phosphatase 1, was studied in the kidney of several species. DARPP-32 mRNA and DARPP-32-like immunoreactivity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meister B,Fryckstedt J,Schalling M,Cortés R,Hökfelt T,Aperia A,Hemmings HC Jr,Nairn AC,Ehrlich M,Greengard P

更新日期：1989-10-01 00:00:00

abstract：:Two precursors to Chinook salmon (Oncorhynchus tshawytscha) melanin-concentrating hormone, an important factor in teleosts involved in the control of skin pigmentation and stress responsiveness, have been identified from DNA sequence analysis. Both precursors encode proteins of 132 amino acids and they share 107/132 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minth CD,Qiu H,Akil H,Watson SJ,Dixon JE

更新日期：1989-06-01 00:00:00

abstract：:p90 ribosomal S6 kinase (RSK1) is an effector of both Ras/MEK/MAPK and PI3K/PDK1 pathways. We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility. RSK1 activation and p27pT198 both increase in early G(1). As for many kinase-substrate pairs, cellular RSK1 copreci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larrea MD,Hong F,Wander SA,da Silva TG,Helfman D,Lannigan D,Smith JA,Slingerland JM

更新日期：2009-06-09 00:00:00

abstract：:Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying cause of chronic toxoplasmosis. Consequently, mechanisms responsible for controlling development in the Toxoplasma intermediate life cycle have long been sought. Here, we identified 15 Toxoplasma mRNAs induced in early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radke JB,Lucas O,De Silva EK,Ma Y,Sullivan WJ Jr,Weiss LM,Llinas M,White MW

更新日期：2013-04-23 00:00:00

abstract：:A lost navigator must identify its current location and recover its facing direction to restore its bearings. We tested the idea that these two tasks--place recognition and heading retrieval--might be mediated by distinct cognitive systems in mice. Previous work has shown that numerous species, including young childre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Julian JB,Keinath AT,Muzzio IA,Epstein RA

更新日期：2015-05-19 00:00:00

abstract：:The molecular size and stability of the nerve growth factor (NGF) secreted in culture by L cells have been studied by sedimentation and gel filtration chromatography. Results indicate that L cell NGF has a molecular weight of 160,000. It contains as part of its structure a protein component that is biologically, immun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis NJ,Blanchard MH,Arnason BG,Young M

更新日期：1977-04-01 00:00:00

abstract：:The genomic sequences encoding the human lysosomal acid lipase/cholesteryl esterase (sterol esterase; EC 3.1.1.13) have been isolated and sequenced, and the information has been used to identify mutations in both alleles of the gene from a patient with Wolman disease, an autosomal recessive lysosomal lipid storage dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson RA,Byrum RS,Coates PM,Sando GN

更新日期：1994-03-29 00:00:00

abstract：:The folate-binding protein of rat liver mitochondria [Zamierowski, M. & Wagner, C. (1977) J. Biol. Chem. 252, 933-938] has been purified to homogeneity by a combination of gel filtration, DEAE-cellulose, and affinity chromatography. This protein was assayed by its ability to bind tetrahydro[3H]folic acid in vitro. the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wittwer AJ,Wagner C

更新日期：1980-08-01 00:00:00

abstract：:Effects of opiate receptor antagonists on centrally mediated cardiovascular responses to clonidine and beta-endorphin were studied in urethane-anesthetized spontaneously hypertensive Okamoto-Aoki rats (SHR), normotensive Sprague-Dawley rats, and Sprague-Dawley rats made hypertensive with deoxycorticosterone pivalate/s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosqueda-Garcia R,Kunos G

更新日期：1987-12-01 00:00:00