Abstract:
:The molecular size and stability of the nerve growth factor (NGF) secreted in culture by L cells have been studied by sedimentation and gel filtration chromatography. Results indicate that L cell NGF has a molecular weight of 160,000. It contains as part of its structure a protein component that is biologically, immunologically, and electrophoretically indistinguishable from the biologically active factor purified from mouse submandibular glands. However, unlike pure gland NGF, L cell NGF is highly stable in solution, and this finding indicates that L cell NGF is a form of the factor different from that previously described.
journal_name
Proc Natl Acad Sci U S Aauthors
Pantazis NJ,Blanchard MH,Arnason BG,Young Mdoi
10.1073/pnas.74.4.1492subject
Has Abstractpub_date
1977-04-01 00:00:00pages
1492-6issue
4eissn
0027-8424issn
1091-6490journal_volume
74pub_type
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