Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.

abstract：:Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific molecules, but because th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CL,DeBoever C,Jepsen K,Saenz CC,Carson DA,Frazer KA

更新日期：2015-06-09 00:00:00

abstract：:High-quality protein crystals meant for structural analysis by X-ray diffraction have been grown by various methods. The observation of dynamical diffraction in protein crystals is an interesting topic because dynamical diffraction generally occurs in perfect crystals such as Si crystals. However, to our knowledge, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki R,Koizumi H,Hirano K,Kumasaka T,Kojima K,Tachibana M

更新日期：2018-04-03 00:00:00

abstract：:Complex social behavior in Microtus voles and other mammals has been postulated to be under the direct genetic control of a single locus: the arginine vasopressin 1a receptor (avpr1a) gene. Using a phylogenetic approach, we show that a repetitive element in the promoter region of avpr1a, which reportedly causes social...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fink S,Excoffier L,Heckel G

更新日期：2006-07-18 00:00:00

abstract：:We report the cloning and expression of a cDNA encoding human sterol carrier protein 2 (SCP2). The 1.3-kilobase (kb) cDNA contains an open reading frame which encompasses a 143-amino acid sequence which is 89% identical to the rat SCP2 amino acid sequence. The deduced amino acid sequence of the polypeptide reveals a 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto R,Kallen CB,Babalola GO,Rennert H,Billheimer JT,Strauss JF 3rd

更新日期：1991-01-15 00:00:00

abstract：:Using a HeLa cell line stably transfected with the tat gene from human immunodeficiency virus type 1, we have found that the expression of the regulatory Tat protein suppresses the expression of cellular Mn-containing superoxide dismutase (Mn-SOD). This enzyme is one of the cell's primary defenses against oxygen-deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores SC,Marecki JC,Harper KP,Bose SK,Nelson SK,McCord JM

更新日期：1993-08-15 00:00:00

abstract：:A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression and activation domains of vnd/NK-2 homeodomain protein. A repression domain was identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stepchenko A,Nirenberg M

更新日期：2004-09-07 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:We have previously identified two species of the low-affinity human Fc receptor for IgE, Fc epsilon RIIa and Fc epsilon RIIb, which differ only in a short stretch of amino acids at the N-terminal cytoplasmic end. Their differential expressions on B cells and monocytes suggest that Fc epsilon RIIa and Fc epsilon RIIb a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokota A,Yukawa K,Yamamoto A,Sugiyama K,Suemura M,Tashiro Y,Kishimoto T,Kikutani H

更新日期：1992-06-01 00:00:00

abstract：:It is generally thought that an effective vaccine to prevent HIV-1 infection should elicit both strong neutralizing antibody and cytotoxic T lymphocyte responses. We recently demonstrated that potent, boostable, long-lived HIV-1 envelope (Env)-specific cytotoxic T lymphocyte responses can be elicited in rhesus monkeys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Letvin NL,Montefiori DC,Yasutomi Y,Perry HC,Davies ME,Lekutis C,Alroy M,Freed DC,Lord CI,Handt LK,Liu MA,Shiver JW

更新日期：1997-08-19 00:00:00

abstract：:A computational model is presented that can be used as a tool in the design of safer chemicals. This model predicts the rate of hydrogen-atom abstraction by cytochrome P450 enzymes. Excellent correlations between biotransformation rates and the calculated activation energies (delta Hact) of the cytochrome P450-mediate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yin H,Anders MW,Korzekwa KR,Higgins L,Thummel KE,Kharasch ED,Jones JP

更新日期：1995-11-21 00:00:00

abstract：:Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions blocking the activity of the inflammatory kinase IKKβ, a key regulator of neuroinflammatory pathways, is protective in several animal models of neurodegenerative di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochaba J,Fote G,Kachemov M,Thein S,Yeung SY,Lau AL,Hernandez S,Lim RG,Casale M,Neel MJ,Monuki ES,Reidling J,Housman DE,Thompson LM,Steffan JS

更新日期：2019-05-28 00:00:00

abstract：:Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul W

更新日期：2009-08-11 00:00:00

abstract：:Many studies have shown that individuals from invasive populations of many different plant species grow larger than individuals from native populations and that this difference has a genetic basis. This increased vigor in invasive populations is thought to be due to life history tradeoffs, in which selection favors th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feng YL,Lei YB,Wang RF,Callaway RM,Valiente-Banuet A,Inderjit,Li YP,Zheng YL

更新日期：2009-02-10 00:00:00

abstract：:Our laboratory has previously developed cell lines derived from mouse NIH 3T3 fibroblasts and C127 mammary tumor cells that stably express mouse mammary tumor virus (MMTV) long terminal repeat fusion genes in bovine papillomavirus-based episomes. Glucocorticoid hormone strongly activates transcription from episomes an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bresnick EH,John S,Berard DS,LeFebvre P,Hager GL

更新日期：1990-05-01 00:00:00

abstract：:The role of the Ca2+/phospholipid-dependent, diacylglycerol-activated enzyme protein kinase C (PKC) in rabbit eyelid conditioning was examined. PKC was partially purified from the CA1 region of hippocampal slices from naive, pseudoconditioned, and conditioned rabbits 24 hr after the rabbits were well conditioned. Crud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bank B,DeWeer A,Kuzirian AM,Rasmussen H,Alkon DL

更新日期：1988-03-01 00:00:00

abstract：:Bloom syndrome (BS) is a rare cancer-predisposing disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. BLM, the protein altered in BS, is a RecQ DNA helicase. This report shows that BLM is found in the nucleus of normal human cells in the nuclear domain 10 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yankiwski V,Marciniak RA,Guarente L,Neff NF

更新日期：2000-05-09 00:00:00

abstract：:Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaousis AD,Ollagnier de Choudens S,Gentekaki E,Long S,Gaston D,Stechmann A,Vinella D,Py B,Fontecave M,Barras F,Lukeš J,Roger AJ

更新日期：2012-06-26 00:00:00

abstract：:With the use of dynamic Monte Carlo simulations, the necessary conditions for the collapse from a random-coil denatured state to a structurally unique four-member beta-barrel native state of a model globular protein have been investigated. These systems are free to roam through all of configuration space--both native ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skolnick J,Kolinski A,Yaris R

更新日期：1988-07-01 00:00:00

abstract：:A mitochondrial ribosome with an approximate sedimentation coefficient of 60 S has been isolated from the ovary of the South African clawed toad, Xenopus laevis. This ribosome is active in a submitochondrial protein-synthesizing system. It contains two species of RNA, designated as "21S" and 13S RNA, which have sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson RF,Dawid IB

更新日期：1970-05-01 00:00:00

abstract：:Ecosystem restoration aims to restore biodiversity and valuable functions that have been degraded or lost. The Coral Triangle is a hotspot for marine biodiversity held in its coral reefs, seagrass meadows, and mangrove forests, all of which are in global decline. These coastal ecosystems support valuable fisheries and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams SL,Ambo-Rappe R,Sur C,Abbott JM,Limbong SR

更新日期：2017-11-07 00:00:00

abstract：:Bathorhodopsin-rhodopsin difference spectra of native 11-cis-rhodopsin and regenerated 9-cis-rhodopsin were measured at room temperature with a double-beam laser spectrophotometer after excitation at 532 nm. A detailed analysis of data obtained at 85 psec after excitation suggests that the bathorhodopsins generated fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spalink JD,Reynolds AH,Rentzepis PM,Sperling W,Applebury ML

更新日期：1983-04-01 00:00:00

abstract：:We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pennings S,Meersseman G,Bradbury EM

更新日期：1994-10-25 00:00:00

abstract：:The induction of hemoglobin synthesis by dimethylsulfoxide in cells infected with Friend leukemia virus has been shown to depend on the number of cell divisions after the addition of the inducing agent. In asynchronous cultures the cells have a generation time of 24 hr, and hemoglobin synthesis occurs after 48 hr in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClintock PR,Papaconstantinou J

更新日期：1974-11-01 00:00:00

abstract：:Outdoor ozone transported indoors initiates oxidative chemistry, forming volatile organic products. The influence of ozone chemistry on indoor air composition has not been directly quantified in normally occupied residences. Here, we explore indoor ozone chemistry in a house in California with two adult inhabitants. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Misztal PK,Arata C,Weschler CJ,Nazaroff WW,Goldstein AH

更新日期：2021-02-09 00:00:00

abstract：:The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beirowski B,Gustin J,Armour SM,Yamamoto H,Viader A,North BJ,Michán S,Baloh RH,Golden JP,Schmidt RE,Sinclair DA,Auwerx J,Milbrandt J

更新日期：2011-10-25 00:00:00

abstract：:Gene expression is controlled by sequence-specific transcription factors (TFs), which bind to regulatory sequences in DNA. TF binding occurs in nucleosome-depleted regions of DNA (NDRs), which generally encompass regions with lengths similar to those protected by nucleosomes. However, less is known about where within ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grossman SR,Engreitz J,Ray JP,Nguyen TH,Hacohen N,Lander ES

更新日期：2018-07-24 00:00:00

abstract：:Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial role in these behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saunderson EA,Spiers H,Mifsud KR,Gutierrez-Mecinas M,Trollope AF,Shaikh A,Mill J,Reul JM

更新日期：2016-04-26 00:00:00

abstract：:The hetR gene plays a very important role in cell differentiation of heterocystous cyanobacteria. To understand the mechanism of the hetR gene product in regulation of heterocyst differentiation, the recombinant HetR protein (rHetR) was overproduced in Escherichia coli. Purified rHetR was unstable and degraded easily ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou R,Wei X,Jiang N,Li H,Dong Y,Hsi KL,Zhao J

更新日期：1998-04-28 00:00:00

abstract：:To facilitate genetic analysis of the human pathogenic parvovirus B19, we constructed a hybrid B19 viral genome in which the defective B19 inverted terminal repeats were replaced with the full-length inverted terminal repeats from a nonpathogenic human parvovirus, the adeno-associated virus 2 (AAV). The hybrid AAV-B19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava CH,Samulski RJ,Lu L,Larsen SH,Srivastava A

更新日期：1989-10-01 00:00:00

abstract：:Recombinational repair of double-stranded DNA gaps was investigated in Ustilago maydis. The experimental system was designed for analysis of repair of an autonomously replicating plasmid containing a cloned gene disabled by an internal deletion. It was discovered that crossing over rarely accompanied gap repair. The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferguson DO,Holloman WK

更新日期：1996-05-28 00:00:00