Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.

abstract：:Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janeway KA,Kim SY,Lodish M,Nosé V,Rustin P,Gaal J,Dahia PL,Liegl B,Ball ER,Raygada M,Lai AH,Kelly L,Hornick JL,NIH Pediatric and Wild-Type GIST Clinic.,O'Sullivan M,de Krijger RR,Dinjens WN,Demetri GD,Antonescu CR,F

更新日期：2011-01-04 00:00:00

abstract：:Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geha RS,Milgrom H,Broff M,Alpert S,Martin S,Yunis EJ

更新日期：1979-08-01 00:00:00

abstract：:The sporulation of Saccharomyces cerevisiae in the presence of [2-13C]acetate was studied by 13C NMR spectroscopy. The fate of 13C label was analyzed in vivo and in cell extracts. During the first 4 hr of sporulation the major metabolite produced from [2-13C]acetate utilization was glutamate. From the labeling pattern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickinson JR,Dawes IW,Boyd AS,Baxter RL

更新日期：1983-10-01 00:00:00

abstract：:CD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and represent one of the main sources of virus replication. Gene therapy strategies are being developed that allow the transfer of exogenous genes into CD4(+) T lymphocytes whose expression might prevent viral infection or replication...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnierle BS,Stitz J,Bosch V,Nocken F,Merget-Millitzer H,Engelstädter M,Kurth R,Groner B,Cichutek K

更新日期：1997-08-05 00:00:00

abstract：:We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong W,Brovold M,Koeneman BA,Clark-Curtiss J,Curtiss R 3rd

更新日期：2012-11-20 00:00:00

abstract：:Multiple paleoclimate proxies are required for robust assessment of past hydroclimatic conditions. Currently, estimates of drought variability over the past several thousand years are based largely on tree-ring records. We produced a 1,500-y record of winter precipitation in the Pacific Northwest using a physical mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman BA,Abbott MB,Mann ME,Stansell ND,Finney BP

更新日期：2012-07-17 00:00:00

abstract：:The elevation of Ca2+ levels in the cytoplasm inactivates inward-rectifying K+ channels that play a central role in regulating the apertures of stomatal pores in higher plants. However, the mechanism for the Ca(2+)-mediated inhibition of K(+)-channel function is unknown. Using patch-clamp techniques, we show that cycl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan S,Li W,Rusnak F,Assmann SM,Schreiber SL

更新日期：1993-03-15 00:00:00

abstract：:Unlike normal cells, malignant rat and two simian virus 40-transformed human cell lines can neither grow nor survive in B12-and folate-supplemented media in which methionine is replaced by homocysteine. Yet three lines of evidence indicate that the malignant and transformed cells synthesize large amounts of methionine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman RM,Erbe RW

更新日期：1976-05-01 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:Cyclonic atmospheric vortices of varying intensity, collectively known as low-pressure systems (LPS), travel northwest across central India and produce more than half of the precipitation received by that fertile region and its ∼600 million inhabitants. Yet, future changes in LPS activity are poorly understood, due in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandeep S,Ajayamohan RS,Boos WR,Sabin TP,Praveen V

更新日期：2018-03-13 00:00:00

abstract：:Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholesterolemia (ARH), whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dvir H,Shah M,Girardi E,Guo L,Farquhar MG,Zajonc DM

更新日期：2012-05-01 00:00:00

abstract：:Extracts of insect cells infected with baculoviruses recombinant for the herpes simplex virus 1 (HSV-1)-encoded enzymes that are required for its replication can promote the rolling circle replication of circular plasmid templates. Replication is independent of a HSV-1 origin of replication (oris) or the HSV-1 origin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skaliter R,Lehman IR

更新日期：1994-10-25 00:00:00

abstract：:The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

更新日期：2021-01-12 00:00:00

abstract：:The only major glutamate receptor membrane-associated guanylate kinase scaffolds expressed in the young superficial superior colliculus (SC) are synapse-associated protein 102 (SAP102) and postsynaptic density protein 95 (PSD95). In this, as in all visual brain regions examined, synaptic PSD95 increases rapidly follow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao JP,Murata Y,Constantine-Paton M

更新日期：2013-01-08 00:00:00

abstract：:Poly(A)-containing HeLa cell mRNA prepared from cells labeled with [methyl-(3)H]methionine or [(32)P]phosphate was found to contain a variety of methylated, blocked 5'-terminal structures of two general types: m(7)GpppN(7)-Np and m(7)GpppN(m)-N(m)-Np. In addition, about one-third of the [(3)H]methyl label was present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi Y,Morgan M,Shatkin AJ,Jelinek W,Salditt-Georgieff M,Darnell JE

更新日期：1975-05-01 00:00:00

abstract：:Fumarase C was strongly induced by paraquat in a parental strain of Escherichia coli but was not induced in a strain lacking the soxRS response. Moreover, a strain that constitutively expresses the soxRS regulon contained more fumarase C than did the parental strain. The Mn-containing superoxide dismutase and glucose-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liochev SI,Fridovich I

更新日期：1992-07-01 00:00:00

abstract：:Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quirarte GL,Roozendaal B,McGaugh JL

更新日期：1997-12-09 00:00:00

abstract：:A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia cells taken directly from patients. Fetal thymus and liver are strongly reactive as are some normal, immature hemopoietic cells and activated lymphocytes. React...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutherland R,Delia D,Schneider C,Newman R,Kemshead J,Greaves M

更新日期：1981-07-01 00:00:00

abstract：:Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studies suggest that MyBP-C could...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luther PK,Winkler H,Taylor K,Zoghbi ME,Craig R,Padrón R,Squire JM,Liu J

更新日期：2011-07-12 00:00:00

abstract：:Conflict between groups of individuals is a prevalent feature in human societies. A common theoretical explanation for intergroup conflict is that it provides benefits to individuals within groups in the form of reproduction-enhancing resources, such as food, territory, or mates. However, it is not always the case tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques GJB,Simon B,Ispolatov Y,Doebeli M

更新日期：2019-07-09 00:00:00

abstract：:The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. beta ARK activity is markedly stimulated by the isoprenylated beta gamma subunit complex of heterotrimeric guanine nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inglese J,Luttrell LM,Iñiguez-Lluhi JA,Touhara K,Koch WJ,Lefkowitz RJ

更新日期：1994-04-26 00:00:00

abstract：:The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic home...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamitina T,Huang CG,Strange K

更新日期：2006-08-08 00:00:00

abstract：:Clostridium difficile has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease, with the transcontinental spread of various PCR ribotypes, including 001, 017, 027 and 078. However, the genetic basis for the emergence of C. difficile as a human pathogen is unclear. Whole genome sequencing was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He M,Sebaihia M,Lawley TD,Stabler RA,Dawson LF,Martin MJ,Holt KE,Seth-Smith HM,Quail MA,Rance R,Brooks K,Churcher C,Harris D,Bentley SD,Burrows C,Clark L,Corton C,Murray V,Rose G,Thurston S,van Tonder A,Walker D

更新日期：2010-04-20 00:00:00

abstract：:As a first step in assessing the efficacy of a gene transfer approach to the induction of transplantation tolerance in our miniature swine model, double-copy retroviral vectors engineered to express a drug-resistance marker (neomycin) and a swine class II DRB cDNA were constructed. Infectious particles containing thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafer GE,Emery DW,Gustafsson K,Germana S,Anderson WF,Sachs DH,LeGuern C

更新日期：1991-11-01 00:00:00

abstract：:The kinetics of the reduction of horseheart ferricytochrome c by sodium dithionite (phosphate buffer-sodium chloride; pH 6.5, mu = 1.0, 25 degrees ) features two reaction pathways; one with the rate constant k(3) = 1.17 x 10(4) M(-1) sec(-1), the other with the rate constant k(1)k(2)/k(-1) = 6.0 x 10(4) M(-1) sec(-1)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Creutz C,Sutin N

更新日期：1973-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) mediate apoptosis in many different cell types. We have previously shown that the antioxidant Mn(III) tetrakis(5,10,15,20-benzoic acid)porphyrin (MnTBAP) decreased intracellular ROS and prevented the apoptosis of activated T cells in vitro. To determine the mechanism(s) by which MnTBAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildeman DA,Mitchell T,Aronow B,Wojciechowski S,Kappler J,Marrack P

更新日期：2003-12-09 00:00:00

abstract：:Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PJ,Bellew TM,King MP,Freeman AE,Gilden RV,Huebner RJ

更新日期：1976-01-01 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino acids in culture (SILAC) coupled with nanospray tandem mass spectrometry, we identified CUB-domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Ong SE,Badu-Nkansah K,Schindler J,White FM,Hynes RO

更新日期：2011-01-25 00:00:00

abstract：:The cholesterol-dependent cytolysins (CDCs) constitute a large family of pore-forming toxins that function exclusively on cholesterol-containing membranes. A detailed analysis of the various stages in the cytolytic mechanism of three members of the CDC family revealed that significant depletion of cholesterol from the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giddings KS,Johnson AE,Tweten RK

更新日期：2003-09-30 00:00:00