Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.

abstract：:The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a role for ATM in thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vacchio MS,Olaru A,Livak F,Hodes RJ

更新日期：2007-04-10 00:00:00

abstract：:Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu BB,Park MH,Hagerman SR,Hammond PT

更新日期：2014-08-19 00:00:00

abstract：:Social decisions require evaluation of costs and benefits to oneself and others. Long associated with emotion and vigilance, the amygdala has recently been implicated in both decision-making and social behavior. The amygdala signals reward and punishment, as well as facial expressions and the gaze of others. Amygdala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Fagan NA,Toda K,Utevsky AV,Pearson JM,Platt ML

更新日期：2015-12-29 00:00:00

abstract：:Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma membrane. GFP-labeled versions of both proteins cluster at sites where secretory granules have docked. Single-particle tracking shows that minority populations of both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles MK,Barg S,Wan L,Midorikawa M,Chen X,Almers W

更新日期：2010-11-30 00:00:00

abstract：:Rat carbonic anhydrase (CA) IV was purified by affinity chromatography and used to produce a specific antiserum in rabbits for immunolocalization studies in rat kidney. CA IV was localized in apical plasma membranes of the proximal convoluted tubule and the thick ascending limb of Henle. Both of these segments are inv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown D,Zhu XL,Sly WS

更新日期：1990-10-01 00:00:00

abstract：:Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons JP,Al-Shawi R,Ellmerich S,Speck I,Aslam S,Hutchinson WL,Mangione PP,Disterer P,Gilbertson JA,Hunt T,Millar DJ,Minogue S,Bodin K,Pepys MB,Hawkins PN

更新日期：2013-10-01 00:00:00

abstract：:We have previously identified a self-reactive gamma delta T-cell clone (KN6) specific for the H-2T region gene product T22b. Now we have investigated by an in vitro mutagenesis analysis of the T22b gene the possibility that the interaction between the KN6 gamma delta T-cell receptor and T22b involves a peptide. The re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moriwaki S,Korn BS,Ichikawa Y,van Kaer L,Tonegawa S

更新日期：1993-12-01 00:00:00

abstract：:Periodical cicadas are well known for their prime-numbered life cycles (17 and 13 years) and their mass periodical emergences. The origination and persistence of prime-numbered cycles are explained by the hybridization hypothesis on the basis of their lower likelihood of hybridization with other cycles. Recently, we s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka Y,Yoshimura J,Simon C,Cooley JR,Tainaka K

更新日期：2009-06-02 00:00:00

abstract：:α-SNAP [soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein] and NSF proteins are conserved across eukaryotes and sustain cellular vesicle trafficking by mediating disassembly and reuse of SNARE protein complexes, which facilitate fusion of vesicles to target membranes. However, certain haplotypes of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bayless AM,Smith JM,Song J,McMinn PH,Teillet A,August BK,Bent AF

更新日期：2016-11-22 00:00:00

abstract：:Human liver alkaline phosphatase [ortho-phosphoric monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] was purified, and some of its physical and chemical properties were examined and compared to those of human placental alkaline phosphatase. The results indicated a different peptide structure for each, based u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Badger KS,Sussman HH

更新日期：1976-07-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele of HFE do not deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproule TJ,Jazwinska EC,Britton RS,Bacon BR,Fleming RE,Sly WS,Roopenian DC

更新日期：2001-04-24 00:00:00

abstract：:Integration sites for many retrotransposons and retroviruses are determined by interactions between retroelement-encoded integrases and specific DNA-bound proteins. The Saccharomyces retrotransposon Ty5 preferentially integrates into heterochromatin because of interactions between Ty5 integrase and the heterochromatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baller JA,Gao J,Voytas DF

更新日期：2011-12-20 00:00:00

abstract：:The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiswell BP,Zhang R,Murphy JW,Boggon TJ,Calderwood DA

更新日期：2008-12-30 00:00:00

abstract：:Tropical diversity has generally exceeded temperate diversity in the present and at points in the past, but whether measured differences have remained relatively constant through time has been unknown. Here we examine tropical vs. temperate diversities from the Neogene to Recent using the within-habitat diversity meas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buzas MA,Collins LS,Culver SJ

更新日期：2002-06-11 00:00:00

abstract：:A recently described organ culture system for human thymocytes is shown to support the generation of a diverse T-cell receptor repertoire in vitro: thymocytes of the alpha beta lineage, including representatives of the V beta families 5.2/5.3, 6.7, and 8, accounted for the majority of T-cell receptor-positive cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merkenschlager M,Fisher AG

更新日期：1992-05-15 00:00:00

abstract：:The basolateral membranes of Aplysia californica foregut absorptive cells contain both Cl(-)-stimulated ATPase and ATP-dependent Cl- transport activities, and each was inhibited by orthovanadate. Both of these orthovanadate-sensitive activities were reconstituted into proteoliposomes. The reaction sequence kinetics we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerencser GA,Zelezna B

更新日期：1993-09-01 00:00:00

abstract：:In many human cancers, tumor-specific chromosomal rearrangements are known to create chimeric products with the ability to transform cells. The EWS/WT1 protein is such a fusion product, resulting from a t(11;22) chromosomal translocation in desmoplastic small round cell tumors, where 265 aa from the EWS amino terminus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim J,Lee JM,Branton PE,Pelletier J

更新日期：1999-12-07 00:00:00

abstract：:An unbiased survey has been made of the stable, most abundant multi-protein complexes in Desulfovibrio vulgaris Hildenborough (DvH) that are larger than Mr approximately 400 k. The quaternary structures for 8 of the 16 complexes purified during this work were determined by single-particle reconstruction of negatively ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han BG,Dong M,Liu H,Camp L,Geller J,Singer M,Hazen TC,Choi M,Witkowska HE,Ball DA,Typke D,Downing KH,Shatsky M,Brenner SE,Chandonia JM,Biggin MD,Glaeser RM

更新日期：2009-09-29 00:00:00

abstract：:Most humans in the United States have been infected with BK virus (BKV), a human papovavirus. Because BKV has oncogenic properties, we have investigated whether it may be a cause of human cancer. Basic principles of tumor virology imply that BKV-induced tumors should contain BKV DNA sequences. Therefore, we assayed (b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wold WS,Mackey JK,Brackmann KH,Takemori N,Rigden P,Green M

更新日期：1978-01-01 00:00:00

abstract：:Costly interactions between species that arise as a by-product of ancestral similarities in communication signals are expected to persist only under specific evolutionary circumstances. Territorial aggression between species, for instance, is widely assumed to persist only when extrinsic barriers prevent niche diverge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drury JP,Cowen MC,Grether GF

更新日期：2020-06-09 00:00:00

abstract：:The endometrial epithelium of the uterus regenerates periodically. The cellular source of newly regenerated endometrial epithelia during a mouse estrous cycle or a human menstrual cycle is presently unknown. Here, I have used single-cell lineage tracing in the whole mouse uterus to demonstrate that epithelial stem cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin S

更新日期：2019-04-02 00:00:00

abstract：:We show that endemic (eBL), sporadic (sBL), and acquired immunodeficiency syndrome-associated (AIDS-BL) forms of Burkitt lymphoma (BL) carrying t(8;14) chromosomal translocations display different breakpoints within the immunoglobulin heavy-chain locus (IGH) on chromosome 14. In sBL (7 out of 11) and AIDS-BL (5 out of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neri A,Barriga F,Knowles DM,Magrath IT,Dalla-Favera R

更新日期：1988-04-01 00:00:00

abstract：:Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not understood. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Gehrke S,Imai Y,Huang Z,Ouyang Y,Wang JW,Yang L,Beal MF,Vogel H,Lu B

更新日期：2006-07-11 00:00:00

abstract：:Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuyama K,Ikawa T,Gentner B,Hozumi K,Harnprasopwat R,Lu J,Yamashita R,Ha D,Toyoshima T,Chanda B,Kawamata T,Yokoyama K,Wang S,Ando K,Lodish HF,Tojo A,Kawamoto H,Kotani A

更新日期：2013-08-13 00:00:00

abstract：:The molecular mechanism by which the homodimeric enzyme Cu/Zn superoxide dismutase (SOD) causes neural damage in amytrophic lateral sclerosis is yet poorly understood. A striking, as well as an unusual, feature of SOD is that it maintains intrasubunit disulfide bonds in the reducing environment of the cytosol. Here, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindberg MJ,Normark J,Holmgren A,Oliveberg M

更新日期：2004-11-09 00:00:00

abstract：:A series of spontaneous suppressors to the temperature-sensitive phenotype of the single-stranded DNA-binding protein mutation ssb-1 were isolated. A genomic library of EcoRI fragments from one of these suppressor strains was prepared by using pBR325 as the cloning vector. A 10.0-kilobase class of inserts was identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruben SM,VanDenBrink-Webb SE,Rein DC,Meyer RR

更新日期：1988-06-01 00:00:00

abstract：:Ocular dominance (OD) plasticity in mouse primary visual cortex (V1) declines during postnatal development and is absent beyond postnatal day 110 if mice are raised in standard cages (SCs). An enriched environment (EE) promotes OD plasticity in adult rats. Here, we explored cellular mechanisms of EE in mouse V1 and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greifzu F,Pielecka-Fortuna J,Kalogeraki E,Krempler K,Favaro PD,Schlüter OM,Löwel S

更新日期：2014-01-21 00:00:00

abstract：:This paper investigates quantitatively the characteristics of the local folding code. The overlapping four-residue fragments which make up the amino acid sequences of 114 proteins are divided into classes on the basis of the physical properties of their constituent amino acids. The distribution of structural types ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：1993-01-15 00:00:00

abstract：:Peripheral blood leukocytes, obtained from volunteers after vaccination or natural illness with influenza, were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a chromium-release assay. Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg SB,Six HR,Drake S,Couch RB

更新日期：1979-09-01 00:00:00

abstract：:Galectin-3 is a glycan-binding protein (GBP) that binds β-galactoside glycan structures to orchestrate a variety of important biological events, including the activation of hepatic stellate cells and regulation of immune responses. While the requisite glycan epitopes needed to bind galectin-3 have long been elucidated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joeh E,O'Leary T,Li W,Hawkins R,Hung JR,Parker CG,Huang ML

更新日期：2020-11-03 00:00:00