NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.

abstract：:In human adults, learning and memory under acute stress are characterized by an increased use of rigid habitual response strategies at the cost of flexible cognitive strategies. The immediate effects of stress on cognitive functioning early in life are not well understood. Here we show experimentally that acute stress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seehagen S,Schneider S,Rudolph J,Ernst S,Zmyj N

更新日期：2015-10-13 00:00:00

abstract：:Transforming growth factor beta (TGF-beta)-mediated G(1) arrest previously has been shown to specifically target inactivation of cyclin D:cyclin-dependent kinase (Cdk) 4/6 complexes. We report here that TGF-beta-treated human HepG2 hepatocellular carcinoma cells arrest in G(1), but retain continued cyclin D:Cdk4/6 act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagahara H,Ezhevsky SA,Vocero-Akbani AM,Kaldis P,Solomon MJ,Dowdy SF

更新日期：1999-12-21 00:00:00

abstract：:Iodine is an important nutrient and a significant sink of tropospheric ozone, a climate-forcing gas and air pollutant. Ozone interacts with seawater iodide, leading to volatile inorganic iodine release that likely represents the largest source of atmospheric iodine. Increasing ozone concentrations since the preindustr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legrand M,McConnell JR,Preunkert S,Arienzo M,Chellman N,Gleason K,Sherwen T,Evans MJ,Carpenter LJ

更新日期：2018-11-27 00:00:00

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaldivar D,Rauch A,Logothetis NK,Goense J

更新日期：2018-12-18 00:00:00

abstract：:Bacteria have evolved the ability to produce a wide range of structurally complex natural products historically called "secondary" metabolites. Although some of these compounds have been identified as bacterial communication cues, more frequently natural products are scrutinized for antibiotic activities that are rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleich R,Watrous JD,Dorrestein PC,Bowers AA,Shank EA

更新日期：2015-03-10 00:00:00

abstract：:Our conditional serum response factor (SRF) knockout, Srf (Cko), in the heart-forming region blocked the appearance of rhythmic beating myocytes, one of the earliest cardiac defects caused by the ablation of a cardiac-enriched transcription factor. The appearance of Hand1 and Smyd1, transcription and chromatin remodel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niu Z,Iyer D,Conway SJ,Martin JF,Ivey K,Srivastava D,Nordheim A,Schwartz RJ

更新日期：2008-11-18 00:00:00

abstract：:Full activation of T cells requires signaling through the T-cell antigen receptor (TCR) and additional surface molecules interacting with ligands on the antigen-presenting cell. TCR recognition of agonist ligands in the absence of accessory signals frequently results in the induction of a state of unresponsiveness ter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madrenas J,Schwartz RH,Germain RN

更新日期：1996-09-03 00:00:00

abstract：:Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a wide spectrum of human and animal diseases. The viral genome, packaged by the nucleoprotein (N), serves as a template for the polymerase complex, composed of the large protein (L) and the homo-tetrameric phosphoprotein (P). The ∼250-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdella R,Aggarwal M,Okura T,Lamb RA,He Y

更新日期：2020-03-03 00:00:00

abstract：:The mutagenic effect of low linear energy transfer ionizing radiation is reduced for a given dose as the dose rate (DR) is reduced to a low level, a phenomenon known as the direct DR effect. Our reanalysis of published data shows that for both somatic and germ-line mutations there is an opposite, inverse DR effect, wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vilenchik MM,Knudson AG Jr

更新日期：2000-05-09 00:00:00

abstract：:In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Chollier M,Watson LC,Cooper SB,Pufall MA,Liu JS,Borzym K,Vingron M,Yamamoto KR,Meijsing SH

更新日期：2013-10-29 00:00:00

abstract：:To determine possible differences in the cyclic AMP-dependent protein kinases of normal and psoriatic human fibroblasts, the levels of the regulatory subunits (RI and RII, respectively) of protein kinase I and protein kinase II were quantitated by photoaffinity labeling with 8-azido[32P]cAMP. The level of RII was sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brion DE,Raynaud F,Plet A,Laurent P,Leduc B,Anderson W

更新日期：1986-07-01 00:00:00

abstract：:Activation of the mitogen-activated protein kinase (MAP kinase) isoforms ERK1 and ERK2 was investigated in rat adipocytes. Kinase activities were measured by using myelin basic protein as substrate after the isoforms were resolved by Mono Q chromatography or by immunoprecipitation with specific antibodies. Insulin inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevetson BR,Kong X,Lawrence JC Jr

更新日期：1993-11-01 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:Lentiviruses, including HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite long compared with those of other retroviruses. However, mainly because of the lack of biochemical studies performed in cell types that are targets for HIV-1 infection, no clear consensus exists regardi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami T,Freed EO

更新日期：2000-01-04 00:00:00

abstract：:Bacterial outer membrane porins have a robust beta-barrel structure and therefore show potential for use as stochastic sensors based on single-molecule detection. The monomeric porin OmpG is especially attractive compared with multisubunit proteins because appropriate modifications of the pore can be easily achieved b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Khalid S,Sansom MS,Bayley H

更新日期：2008-04-29 00:00:00

abstract：:Archaeologists often argue whether Paleolithic works of art, cave paintings in particular, constitute reflections of the natural environment of humans at the time. They also debate the extent to which these paintings actually contain creative artistic expression, reflect the phenotypic variation of the surrounding env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pruvost M,Bellone R,Benecke N,Sandoval-Castellanos E,Cieslak M,Kuznetsova T,Morales-Muñiz A,O'Connor T,Reissmann M,Hofreiter M,Ludwig A

更新日期：2011-11-15 00:00:00

abstract：:Speciation involves the origin of trait differences that limit or prevent gene exchange and ultimately results in daughter populations that form monophyletic or exclusive genetic groups. However, for recently diverged populations or species between which reproductive isolation is often incomplete, gene genealogies wil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dopman EB,Pérez L,Bogdanowicz SM,Harrison RG

更新日期：2005-10-11 00:00:00

abstract：:The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful tool to facilitate the discovery of cancer genes that drive tumorigenesis in mouse models. In this study, we sought to identify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma (MB), a tumor of the cerebellu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Genovesi LA,Ng CG,Davis MJ,Remke M,Taylor MD,Adams DJ,Rust AG,Ward JM,Ban KH,Jenkins NA,Copeland NG,Wainwright BJ

更新日期：2013-11-12 00:00:00

abstract：:During mitochondrial ATP synthesis, F1-ATPase-the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites-undergoes a series of concerted conformational changes that couple proton translocation to the synthesis of the high levels of ATP required for cellular function. In the str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bianchet MA,Hullihen J,Pedersen PL,Amzel LM

更新日期：1998-09-15 00:00:00

abstract：:Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were inters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes DS,Bonner J

更新日期：1974-04-01 00:00:00

abstract：:Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions through the formation of interlocking hydrophobic seams between alpha-helical chains. Residues that form these seams occur at the first (a) and fourth (d) positions of a characteristic 7-aa repeat and are primarily aliphatic. The pote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yong W,Deng Y,Kallenbach NR,Lu M

更新日期：2004-11-16 00:00:00

abstract：:A gradual buildup of neuronal activity known as the "readiness potential" reliably precedes voluntary self-initiated movements, in the average time locked to movement onset. This buildup is presumed to reflect the final stages of planning and preparation for movement. Here we present a different interpretation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schurger A,Sitt JD,Dehaene S

更新日期：2012-10-16 00:00:00

abstract：:Mutational activation of the Ras oncogene products (H-Ras, K-Ras, and N-Ras) is frequently observed in human cancers, making them promising anticancer drug targets. Nonetheless, no effective strategy has been available for the development of Ras inhibitors, partly owing to the absence of well-defined surface pockets s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shima F,Yoshikawa Y,Ye M,Araki M,Matsumoto S,Liao J,Hu L,Sugimoto T,Ijiri Y,Takeda A,Nishiyama Y,Sato C,Muraoka S,Tamura A,Osoda T,Tsuda K,Miyakawa T,Fukunishi H,Shimada J,Kumasaka T,Yamamoto M,Kataoka T

更新日期：2013-05-14 00:00:00

abstract：:Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese. To discriminate against abundant competitors, the Nramp metal-binding site should favor softer transition metals, which interact either covalently or ionically w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bozzi AT,Bane LB,Weihofen WA,McCabe AL,Singharoy A,Chipot CJ,Schulten K,Gaudet R

更新日期：2016-09-13 00:00:00

abstract：:The inability to perceive and coordinate both internal and external signals that function to regulate cellular growth and proliferation is a hallmark of oncogenic transformation. To examine the effects of the v-mos oncogene on distinct signal transduction pathways, the 6m2 cell line was used, in which expression of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton BJ,DeFranco D

更新日期：1989-01-01 00:00:00

abstract：:Brief visual experience causes rapid physiological changes in the visual cortex during early postnatal development. A possible mediator of these effects is the immediate early genes whose protein products are involved in the rapid response of neurons to transsynaptic stimulation. Here we report evidence that the level...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen KM,McCormack MA,Villa-Komaroff L,Mower GD

更新日期：1992-06-15 00:00:00

abstract：:Ribbon synapses of photoreceptor cells and second-order bipolar neurons in the retina are specialized to transmit graded signals that encode light intensity. Neurotransmitter release at ribbon synapses exhibits two kinetically distinct components, which serve different sensory functions. The faster component is deplet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaithianathan T,Matthews G

更新日期：2014-06-10 00:00:00

abstract：:A rigorous numerical test of a hypothetical mechanism of a molecular motor should model explicitly the diffusive motion of the motor's degrees of freedom as well as the transition rates between the motor's chemical states. We present such a Brownian dynamics, mechanochemcial model of the coarse-grain structure of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craig EM,Linke H

更新日期：2009-10-27 00:00:00

abstract：:Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickinson LA,Gulizia RJ,Trauger JW,Baird EE,Mosier DE,Gottesfeld JM,Dervan PB

更新日期：1998-10-27 00:00:00