Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates.

abstract：:Let X = Omega/Gamma be a compact quotient of an irreducible bounded symmetric domain Omega of rank >/=2 by a discrete group omega of automorphisms without fixed points. It is well known that the Kähler-Einstein metric g on X carries seminegative curvature (in the sense of Griffiths). I show that any Hermitian metric h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mok N

更新日期：1986-04-01 00:00:00

abstract：:RNA molecules perform diverse regulatory functions in natural biological systems, and numerous synthetic RNA-based control devices that integrate sensing and gene-regulatory functions have been demonstrated, predominantly in bacteria and yeast. Despite potential advantages of RNA-based genetic control strategies in cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YY,Jensen MC,Smolke CD

更新日期：2010-05-11 00:00:00

abstract：:CD4 can physically associate with the CD3-T-cell receptor complex as visualized in cocapping experiments. This association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate with CD4. Similar as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojo JM,Saizawa K,Janeway CA Jr

更新日期：1989-05-01 00:00:00

abstract：:Optical waveguides simultaneously transport light at different colors, forming the basis of fiber-optic telecommunication networks that shuttle data in dozens of spectrally separated channels. Here, we reimagine this wavelength division multiplexing (WDM) paradigm in a novel context--the differentiated detection and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozcelik D,Parks JW,Wall TA,Stott MA,Cai H,Parks JW,Hawkins AR,Schmidt H

更新日期：2015-10-20 00:00:00

abstract：:The translational apparatus in cell-free extracts prepared from L cells infected with reovirus undergoes a time-dependent transition from cap dependence to cap independence. Extracts from uninfected L cells translate capped reovirus mRNA at high efficiency and synthesize the expected three size classes of reovirus pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skup D,Millward S

更新日期：1980-01-01 00:00:00

abstract：:In yeasts and mammals, PEX10 encodes an integral membrane protein with a C3HC4 RING finger motif in its C-terminal domain and is required for peroxisome biogenesis and matrix protein import. In humans, its dysfunction in peroxisome biogenesis leads to severe Zellweger Syndrome and infantile Refsum disease. Here we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schumann U,Wanner G,Veenhuis M,Schmid M,Gietl C

更新日期：2003-08-05 00:00:00

abstract：:Convergent evidence has revealed an association between insulin resistance and Alzheimer's disease (AD), and the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, an insulin sensitizer and mitochondrial activator, improves cognition in patients with early or mild-to-moderate AD. Apo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodbeck J,Balestra ME,Saunders AM,Roses AD,Mahley RW,Huang Y

更新日期：2008-01-29 00:00:00

abstract：:Specific [3H]retinoic acid (RA)-binding sites in nuclear and cytosolic extracts prepared from human myeloblastic leukemia HL-60 cells have been detected by sucrose density gradient sedimentation and size-exclusion high-performance liquid chromatography (HPLC) analyses. This RA-binding activity migrated as a single pea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nervi C,Grippo JF,Sherman MI,George MD,Jetten AM

更新日期：1989-08-01 00:00:00

abstract：:In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barducci A,Bonomi M,Prakash MK,Parrinello M

更新日期：2013-12-03 00:00:00

abstract：:Hox genes are conserved transcription factor-encoding genes that specify the identity of body regions in bilaterally symmetrical animals. In the cricket Gryllus bimaculatus, a member of the hemimetabolous insect group Orthoptera, the induction of a subset of mesodermal cells to form the primordial germ cells (PGCs) is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett AA,Nakamura T,Extavour CG

更新日期：2019-08-13 00:00:00

abstract：:All proteins of this world are constructed in compliance with the same rule. Accordingly, two totally unrelated proteins, on the average, share 30 identical tripeptides, two tetrapeptides, and one pentapeptide per 500 residues. With this in mind, the 221-residue-long influenza virus hemagglutinin II (IVHA-II), as a re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1991-04-15 00:00:00

abstract：:A major calmodulin-binding protein (CaM-BP) of Mr 240,000 was demonstrated in various rat tissues by using a 125I-labeled CaM gel overlay technique. This protein (designated p240) was detected in the particulate fraction and to a lesser extent in the cytosol of all tissues studied. Binding of CaM to p240 was completel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palfrey HC,Schiebler W,Greengard P

更新日期：1982-06-01 00:00:00

abstract：:The shape of the presynaptic action potential (AP) has a strong impact on neurotransmitter release. Because of the small size of most terminals in the central nervous system, little is known about the regulation of their AP shape during natural firing patterns in vivo. The calyx of Held is a giant axosomatic terminal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sierksma MC,Borst JGG

更新日期：2017-04-18 00:00:00

abstract：:Studies in vitro have established that free tryptophan induces tna operon expression by binding to the ribosome that has just completed synthesis of TnaC-tRNA(Pro), the peptidyl-tRNA precursor of the leader peptide of this operon. Tryptophan acts by inhibiting Release Factor 2-mediated cleavage of this peptidyl-tRNA a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cruz-Vera LR,Gong M,Yanofsky C

更新日期：2006-03-07 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG and KCNE1, but the precise mechanisms remain unclear. To clarify this situation we injected adenoviral vectors expressing wild-type or LQT mutants of HERG and KC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoppe UC,Marbán E,Johns DC

更新日期：2001-04-24 00:00:00

abstract：:T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient mouse to characterize its function in T cell activation and tolerance...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Chung Y,Bishop C,Daugherty B,Chute H,Holst P,Kurahara C,Lott F,Sun N,Welcher AA,Dong C

更新日期：2006-08-01 00:00:00

abstract：:Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA is caused by the inactivation of IF-3, an initiation factor required for the recycling of ribosomes and for their binding to messenger RNA. The evidence for this is that (i) the inhibition can be overcome by addition of exogenous If-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaempfer R,Kaufman J

更新日期：1973-04-01 00:00:00

abstract：:The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. Exon 1 (including the leader peptide sequence) and exon 2 were screened separately. Six ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bicknell DC,Rowan A,Bodmer WF

更新日期：1994-05-24 00:00:00

abstract：:The exo isomer of aflatoxin B1 (AFB1) 8,9-epoxide appears to be the only product of AFB1 involved in reaction with DNA and reacts with the N7 atom of guanine via an SN2 reaction from an intercalated state. Although the epoxide hydrolyzes rapidly in H2O (0.6 s-1 at 25 degrees C), very high yields of DNA adduct result. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson WW,Guengerich FP

更新日期：1997-06-10 00:00:00

abstract：:Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the starting population for reprogramming, which usually take weeks for expansion from a single biopsy. We show here that induced pluripotent stem (iPS) cells can be gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun N,Panetta NJ,Gupta DM,Wilson KD,Lee A,Jia F,Hu S,Cherry AM,Robbins RC,Longaker MT,Wu JC

更新日期：2009-09-15 00:00:00

abstract：:Autopsy studies suggest that most aging men will develop lesions that, if detected clinically, would be diagnosed as prostate cancer (PCa). Most of these cancers are indolent and remain localized; however, a subset of PCa is aggressive and accounts for more than 27,000 deaths in the United States annually. Identificat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Zheng SL,Isaacs SD,Wiley KE,Wiklund F,Sun J,Kader AK,Li G,Purcell LD,Kim ST,Hsu FC,Stattin P,Hugosson J,Adolfsson J,Walsh PC,Trent JM,Duggan D,Carpten J,Grönberg H,Isaacs WB

更新日期：2010-02-02 00:00:00

abstract：:The effects of the thymic polypeptide thymopoietin (Tpo) on the properties of the nicotinic acetylcholine receptor (AcChoR) were investigated by patch clamp techniques on mouse C2 myotubes and by biochemical assays on AcChoR-rich membrane fragments purified from the Torpedo marmorata electric organ. At high concentrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revah F,Mulle C,Pinset C,Audhya T,Goldstein G,Changeux JP

更新日期：1987-05-01 00:00:00

abstract：:Stem cells have been identified as essential for maintaining multiple organ systems, including the hematopoietic system. The distinct cell fates of self-renewal and differentiation of hematopoietic stem cells (HSCs) depend on cell division. Recently, several negative regulators of the cell cycle, such as the cyclin-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkley CR,Orkin SH

更新日期：2006-06-13 00:00:00

abstract：:How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin DM,Yang YH,Scolnick JA,Brunet LJ,Marsh H,Peng V,Okazaki Y,Hayashizaki Y,Speed TP,Ngai J

更新日期：2004-08-24 00:00:00

abstract：:Two types of progenitor cells of the human granulocytic and monocytic lineages (CFU-GM) can be distinguished by using mouse monoclonal antibodies against human hemopoietic cells. Type 1 CFU-GM contribute all of the peripheral blood CFU-GM as well as a small fraction of bone marrow CFU-GM and express surface antigens r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrero D,Broxmeyer HE,Pagliardi GL,Venuta S,Lange B,Pessano S,Rovera G

更新日期：1983-07-01 00:00:00

abstract：:The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of menstruation-associated toxic shock syndrome (TSS). In this work, we show that the human vaginal isolate Lactobacillus reuteri RC-14 produces small signaling mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Wang W,Xu SX,Magarvey NA,McCormick JK

更新日期：2011-02-22 00:00:00

abstract：:Efficient and controllable expression of a transgene usually requires the presence of intron sequences and much efforts have been made to produce retrovirus vectors that can transduce and integrate genes with introns. However, this has proven difficult because the viral RNA is spliced when it is synthesized in the nuc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li KJ,Garoff H

更新日期：1998-03-31 00:00:00

abstract：:We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautsch JW,Knowles AF,Jensen FC,Kaplan NO

更新日期：1980-04-01 00:00:00

abstract：:Supernumerary B chromosomes are optional additions to the basic set of A chromosomes, and occur in all eukaryotic groups. They differ from the basic complement in morphology, pairing behavior, and inheritance and are not required for normal growth and development. The current view is that B chromosomes are parasitic e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martis MM,Klemme S,Banaei-Moghaddam AM,Blattner FR,Macas J,Schmutzer T,Scholz U,Gundlach H,Wicker T,Šimková H,Novák P,Neumann P,Kubaláková M,Bauer E,Haseneyer G,Fuchs J,Doležel J,Stein N,Mayer KF,Houben A

更新日期：2012-08-14 00:00:00