Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis.

abstract：:The brain vesicular monoamine transporter (VMAT2) pumps monoamine neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP+) from neuronal cytoplasm into synaptic vesicles, from which amphetamines cause their release. Amphetamines and MPP+ each also act at nonvesi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Miner LL,Sora I,Ujike H,Revay RS,Kostic V,Jackson-Lewis V,Przedborski S,Uhl GR

更新日期：1997-09-02 00:00:00

abstract：:Studies in animals demonstrate a crucial role for the amygdala in emotional and social behavior, especially as related to fear and aggression. Whereas lesion and functional-imaging studies in humans indicate the amygdala's participation in assessing the significance of nonverbal as well as paralinguistic cues, direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isenberg N,Silbersweig D,Engelien A,Emmerich S,Malavade K,Beattie B,Leon AC,Stern E

更新日期：1999-08-31 00:00:00

abstract：:The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has been studied in considerable detail, but the importance of farnesylation for the B-type lamins, lamin B1 and lamin B2, has received little attention. Lamins B1 and B2 are expressed in nearly every cell type from the earliest s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung HJ,Nobumori C,Goulbourne CN,Tu Y,Lee JM,Tatar A,Wu D,Yoshinaga Y,de Jong PJ,Coffinier C,Fong LG,Young SG

更新日期：2013-05-21 00:00:00

abstract：:alpha-1-Antitrypsin is a serum protein that inhibits many proteolytic enzymes. Recently, it was suggested that the alpha-1-antitrypsin-trypsin complex is an acyl ester analogous to the acyl intermediate that forms between trypsin and its substrates. In previous work we showed that the alpha-1-antitrypsin-trypsin compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AB,Gruenke LD,Craig JC,Geczy D

更新日期：1977-10-01 00:00:00

abstract：:We construct a class of global exact solutions of the Einstein equations that extend the Oppeheimer-Snyder model to the case of nonzero pressure, inside the black hole, by incorporating a shock wave at the leading edge of the expansion of the galaxies, arbitrarily far beyond the Hubble length in the Friedmann-Robertso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoller J,Temple B

更新日期：2003-09-30 00:00:00

abstract：:The polymerization of deoxynucleoside triphosphates, catalyzed by terminal deoxynucleotidyl transferase from calf thymus gland, is strongly inhibited by various metal chelators. The reaction appears to be first order with respect to enzyme, deoxynucleoside triphosphate, and initiator, indicating that there is only one...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LM,Bollum FJ

更新日期：1970-04-01 00:00:00

abstract：:Methyl groups placed on varphiXsB1 replicative form DNA by the Escherichia coli B modification enzyme are located in the overlap between fragments Mbo II-3 and Alu I-2, a 61-base-pair DNA segment. Mutations that led to loss of susceptibility to restriction by E. coli B occurred within this segment at three positions s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lautenberger JA,Kan NC,Lackey D,Linn S,Edgell MH,Hutchison CA 3rd

更新日期：1978-05-01 00:00:00

abstract：:Avian homologues of mammalian gamma delta and alpha beta T-cell antigen receptors, TCR1 and TCR2, have been identified with monoclonal antibodies. These TCR isotypes are associated with the avian CD3 proteins on the T-cell surface. During chick development, T-cell subpopulations bearing CD3/TCR1 or CD3/TCR2 receptor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,Sowder JT,Lahti JM,Cihak J,Lösch U,Cooper MD

更新日期：1989-04-01 00:00:00

abstract：:The mechanism of the proline-catalyzed aldol reaction has stimulated considerable debate, and despite limited experimental data, at least five different mechanisms have been proposed. Complementary to recent theoretical studies we have initiated an experimental program with the goal of clarifying some of the basic mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： List B,Hoang L,Martin HJ

更新日期：2004-04-20 00:00:00

abstract：:As a first step in assessing the efficacy of a gene transfer approach to the induction of transplantation tolerance in our miniature swine model, double-copy retroviral vectors engineered to express a drug-resistance marker (neomycin) and a swine class II DRB cDNA were constructed. Infectious particles containing thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafer GE,Emery DW,Gustafsson K,Germana S,Anderson WF,Sachs DH,LeGuern C

更新日期：1991-11-01 00:00:00

abstract：:The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent observations have r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamar RI,Banigan EJ,Erbas A,Giuntoli RD,Olvera de la Cruz M,Johnson RC,Marko JF

更新日期：2017-04-18 00:00:00

abstract：:Human gene MAGE-1 encodes tumor-specific antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. This gene is expressed in a significant proportion of tumors of various histological types, but not in normal tissues except male germ-line cells. We reported previously that reporter genes dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet C,De Backer O,Faraoni I,Lurquin C,Brasseur F,Boon T

更新日期：1996-07-09 00:00:00

abstract：:A mutation partially suppressing the UV sensitivity caused by recF143 in a uvrA6 background was located at codon 37 of recA where GTG (valine) became ATG (methionine). This mutation, originally named srf-803, was renamed recA803. Little if any suppression of the recF143 defect in UV induction of a lexA regulon promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madiraju MV,Templin A,Clark AJ

更新日期：1988-09-01 00:00:00

abstract：:In a previous study we demonstrated that vesicular stomatitis virus (VSV) can be used as a vector to express a soluble protein in mammalian cells. Here we have generated VSV recombinants that express four different membrane proteins: the cellular CD4 protein, a CD4-G hybrid protein containing the ectodomain of CD4 and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnell MJ,Buonocore L,Kretzschmar E,Johnson E,Rose JK

更新日期：1996-10-15 00:00:00

abstract：:The mammary glands of prepubertal estrogen receptor (ER)beta-- mice are morphologically indistinguishable from those of WT littermates. It appears that, although ERbeta is expressed in the mouse mammary gland, it is not involved in ductal growth of the gland. In this study, we examined the possibility that ERbeta has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Förster C,Mäkela S,Wärri A,Kietz S,Becker D,Hultenby K,Warner M,Gustafsson JA

更新日期：2002-11-26 00:00:00

abstract：:Gene duplication is an important mechanism in the evolution of protein interaction networks. Duplications are followed by the gain and loss of interactions, rewiring the network at some unknown rate. Because rewiring is likely to change the distribution of network motifs within the duplicated interaction set, it shoul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presser A,Elowitz MB,Kellis M,Kishony R

更新日期：2008-01-22 00:00:00

abstract：:Hodgkin disease (HD) is characterized by a small number of malignant Hodgkin and Reed-Sternberg (H/RS) cells among a major population of nonmalignant cells. The analysis of H/RS cells has been hampered by their low frequency and fragility. Here, we describe the isolation of viable H/RS cells from HD affected tissues b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irsch J,Nitsch S,Hansmann ML,Rajewsky K,Tesch H,Diehl V,Jox A,Küppers R,Radbruch A

更新日期：1998-08-18 00:00:00

abstract：:Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates. Crucial for rapidly dividing cells, RNR is a target for cancer therapy. In eukaryotes, RNR comprises a heterooligomer of alpha(2) and beta(2) subunits. Rnr1, the alpha subunit, contains regulatory and ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu H,Faber C,Uchiki T,Racca J,Dealwis C

更新日期：2006-03-14 00:00:00

abstract：:Adaptive radiation is the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. Recent studies have identified general patterns in adaptive radiation and inferred that resource competition is a primary factor driving phenotypic divergence. The role and importance of other processes, su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosil P,Crespi BJ

更新日期：2006-06-13 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content expl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon K,Wang H,Lim J,Chun KS,Jang H,Yoo I,Wu D,Chen AJ,Gu CG,Lipschultz L,Kim JU,Kim J,Jeong H,Luan H,Park Y,Su CJ,Ishida Y,Madhvapathy SR,Ikoma A,Kwak JW,Yang DS,Banks A,Xu S,Huang Y,Chang JK,Rogers JA

更新日期：2021-02-02 00:00:00

abstract：:Sympathetic ganglia and some peripheral tissues of adult guinea pig and cat were analyzed by the indirect immunofluorescence technique with antisera to catecholamine-synthesizing enzymes and some peptides. In the guinea pig, noradrenergic neurons could be subdivided into three populations containing respectively (i) s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Hökfelt T,Anggård A,Terenius L,Elde R,Markey K,Goldstein M,Kimmel J

更新日期：1982-02-01 00:00:00

abstract：:Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended beta-sheet conformation. The nucleation of these beta-sheet aggregates is of particular interest, not only because it is the rate-determining step toward fiber ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petty SA,Decatur SM

更新日期：2005-10-04 00:00:00

abstract：:In the process of molecularly cloning unintegrated proviral DNA from NIH-3T3 mouse cells infected with Rauscher murine leukemia virus, we observed the occurrence of clones with inserts smaller than the expected Rauscher murine leukemia virus fragments. The insert of one of these clones, lambda.Xe-1, was characterized ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Hoorn FA,Onnekink C,van der Putten H,Zijlstra M,Bloemers HP

更新日期：1982-03-01 00:00:00

abstract：:Fluorescence in situ hybridization (FISH) is a powerful tool for physical mapping in human and other mammalian species. However, application of the FISH technique has been limited in plant species, especially for mapping single- or low-copy DNA sequences, due to inconsistent signal production in plant chromosome prepa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang J,Gill BS,Wang GL,Ronald PC,Ward DC

更新日期：1995-05-09 00:00:00

abstract：:Alterations in serotonin (5-hydroxytriptamine, 5-HT), norepinephrine, and gamma-aminobutyric acid have been linked to the pathophysiology of anxiety and depression, and medications that modulate these neurotransmitters are widely used to treat mood disorders. Recently, the neuropeptide substance P (SP) and its recepto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santarelli L,Gobbi G,Debs PC,Sibille ET,Blier P,Hen R,Heath MJ

更新日期：2001-02-13 00:00:00

abstract：:By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture. The mitochondria were found to be arranged along the cytoplasmic microtubules in ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Simon M,Singer SJ

更新日期：1978-08-01 00:00:00

abstract：:Six groups of Munich-Wistar rats underwent micropuncture study 2-10 weeks and morphologic studies 11-13 months after induction of streptozotocin diabetes or after sham treatment. Diabetic rats received diets containing 6% (group D6), 12% (D12), or 50% protein (D50) and were maintained under similar conditions of moder...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zatz R,Meyer TW,Rennke HG,Brenner BM

更新日期：1985-09-01 00:00:00

abstract：:Mice prefer to mate with individuals expressing different MHC genes from their own. Volatile components presenting MHC-dependent odor types are present in urine and can be detected by mice, as shown by extensive behavioral studies. Similar odor types are suspected to influence human behavior as well. Although a recent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montag S,Frank M,Ulmer H,Wernet D,Göpel W,Rammensee HG

更新日期：2001-07-31 00:00:00

abstract：:The Bacillus subtilis phage SP01, whose DNA contains 5-hydroxymethyluracil (hmUra) in place of thymine, codes for an abundant, small, basic protein called TF1. TF1 binds preferentially to hydroxymethyluracil-containing DNA and thereby selectively inhibits transcription of such DNA in vitro. The gene for TF1 has been s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene JR,Brennan SM,Andrew DJ,Thompson CC,Richards SH,Heinrikson RL,Geiduschek EP

更新日期：1984-11-01 00:00:00