A stationary-phase protein of Escherichia coli that affects the mode of association between the trp repressor protein and operator-bearing DNA.

abstract：:The binned distribution densities of magnitudes in both the complete and the declustered catalogs of earthquakes in the Southern California region have two significantly different branches with crossover magnitude near M = 4.8. In the case of declustered earthquakes, the b-values on the two branches differ significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knopoff L

更新日期：2000-10-24 00:00:00

abstract：:The I-J subregion of the mouse major histocompatibility complex has been reported to encode antigenic determinants expressed by suppressor T cells. Previously, cosmid clones were obtained from mouse sperm DNA that contain all of the sequences between the I-A and I-E subregions, where I-J has been mapped genetically. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronenberg M,Steinmetz M,Kobori J,Kraig E,Kapp JA,Pierce CW,Sorensen CM,Suzuki G,Tada T,Hood L

更新日期：1983-09-01 00:00:00

abstract：:The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beirowski B,Gustin J,Armour SM,Yamamoto H,Viader A,North BJ,Michán S,Baloh RH,Golden JP,Schmidt RE,Sinclair DA,Auwerx J,Milbrandt J

更新日期：2011-10-25 00:00:00

abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

更新日期：1994-03-15 00:00:00

abstract：:Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakata T,Ishiguro M,Aduma N,Izumi H,Kuroiwa A

更新日期：2013-02-26 00:00:00

abstract：:Somatic cell hybridization of mouse erythroleukemia (MEL) cells and HEL cells, a human erythroleukemia line that produces fetal (gamma) but fails to express adult (beta) globin, was used to test whether the expression of the two human globin genes is regulated cis or trans. An experimental approach using anti-human gl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papayannopoulou TH,Lindsley D,Kurachi S,Lewison K,Hemenway T,Melis M,Anagnou NP,Najfeld V

更新日期：1985-02-01 00:00:00

abstract：:A 2.5-fold stimulation of cyclic AMP cellular content is measured 60 sec after addition of 100 nM synthetic ovine corticotropin-releasing factor (C-RF; corticoliberin) to rat anterior pituitary cells in culture. A maximal response of cyclic AMP content at 400% above control is observed between 2 and 30 min after addit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giguère V,Labrie F,Côté J,Coy DH,Sueiras-Diaz J,Schally AV

更新日期：1982-06-01 00:00:00

abstract：:Social networks exhibit strikingly systematic patterns across a wide range of human contexts. Although genetic variation accounts for a significant portion of the variation in many complex social behaviors, the heritability of egocentric social network attributes is unknown. Here, we show that 3 of these attributes (i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH,Dawes CT,Christakis NA

更新日期：2009-02-10 00:00:00

abstract：:Phagocytes are a critical component of the innate immune response in humans and eliminate invading microorganisms through a process known as phagocytosis. Two distinct receptor-linked phagocytic pathways, one with Ab receptors (FcRs; FcR, Fc receptor) and the other complement receptors (CRs), mediate binding and inges...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi SD,Voyich JM,Buhl CL,Stahl RM,DeLeo FR

更新日期：2002-05-14 00:00:00

abstract：:The spatial organization of complex natural microbiomes is critical to understanding the interactions of the individual taxa that comprise a community. Although the revolution in DNA sequencing has provided an abundance of genomic-level information, the biogeography of microbiomes is almost entirely uncharted at the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mark Welch JL,Rossetti BJ,Rieken CW,Dewhirst FE,Borisy GG

更新日期：2016-02-09 00:00:00

abstract：:The influence of oxidation state on the pH dependence of the dissolution of the Fe(4)S(4) clusters of Chromatium vinosum ferredoxin and high-potential iron protein (HIPIP) has been studied. The first-order rate constants (k(obs)) for dissolution of both the Fe(4)S(4)(S-Cys)(4) (2-) and Fe(4)S(4)(S-Cys)(4) (3-) cluster...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maskiewicz R,Bruice TC

更新日期：1977-12-01 00:00:00

abstract：:In vitro DNA synthesis was studied in HeLa cell nuclei, with emphasis on the question of whether newly replicated DNA is associated with nucleosomes. The newly replicated DNA was twice as sensitive to digestion by micrococcal nuclease as mature chromatin DNA, reaching a limit digest at 20-25% acid-insoluble product. E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seale RL

更新日期：1978-06-01 00:00:00

abstract：:We show here that a cell-wall invertase encoded by the Incw1 gene is regulated at both the transcriptional and posttranscriptional levels by sugars in a heterotrophic cell suspension culture of maize. The Incw1 gene encoded two transcripts: Incw1-S (small) and Incw1-L (large); the size variation was attributable to di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng WH,Taliercio EW,Chourey PS

更新日期：1999-08-31 00:00:00

abstract：:Cell mechanics plays a role in stem cell reprogramming and differentiation. To understand this process better, we created a genetically encoded optical probe, named actin-cpstFRET-actin (AcpA), to report forces in actin in living cells in real time. We showed that stemness was associated with increased force in actin....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo J,Wang Y,Sachs F,Meng F

更新日期：2014-12-09 00:00:00

abstract：:Interdigital webbing has evolved repeatedly in tropical salamanders (bolitoglossines). This derived foot morphology is only one of many homoplastic traits in this diverse amphibian clade. Indeed, few if any morphological traits sort lineages within this clade. We investigate the processes underlying the homoplastic ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaekel M,Wake DB

更新日期：2007-12-18 00:00:00

abstract：:Small solutes affect protein and nucleic acid processes because of favorable or unfavorable chemical interactions of the solute with the biopolymer surface exposed or buried in the process. Large solutes also exclude volume and affect processes where biopolymer molecularity and/or shape changes. Here, we develop an an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles DB,LaCroix AS,Deines NF,Shkel I,Record MT Jr

更新日期：2011-08-02 00:00:00

abstract：:Signaling through the Toll receptor is required for dorsal/ventral polarity in Drosophila embryos, and also plays an evolutionarily conserved role in the immune response. Upon ligand binding, Toll appears to multimerize and activate the associated kinase, Pelle. However, the immediate downstream targets of Pelle have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen B,Liu H,Skolnik EY,Manley JL

更新日期：2001-07-17 00:00:00

abstract：:Although the F-specific ssRNA phage MS2 has long had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell. The phage initially binds to the F-pilus using its maturation protein (Mat), and then the Mat-bound gRNA is released from the viral capsid and somehow crosses the bacterial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harb L,Chamakura K,Khara P,Christie PJ,Young R,Zeng L

更新日期：2020-10-13 00:00:00

abstract：:Murine hematopoietic blast colony-forming cells (BL-CFCs) are able to generate up to 30,000 progeny blast cells within 10 d in agar cultures. Contained in these populations are large numbers of lineage-committed progenitor cells in the granulocytic and macrophage lineages. Sequential analyses of blast colonies reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D,Ng A,Mifsud S,Di Rago L

更新日期：2010-09-14 00:00:00

abstract：:A systematic comparison of crystal structures of nine different B-DNA dodecamers, in three different space groups, with and without A-tracts, shows that crystal packing or lattice forces are of secondary importance for helix axis bending, minor-groove width, and propeller twist. While other local helix parameters may ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickerson RE,Goodsell DS,Neidle S

更新日期：1994-04-26 00:00:00

abstract：:The dilute (d) coat color mutation on chromosome 9 is closely associated with an ecotropic murine leukemia virus (MuLV) genome [Jenkins, N.A., Copeland, N.G., Taylor, B.A. & Lee, B.K. (1981) Nature 293, 370-374]. DBA/2J mice homozygous for the reverse mutation to wild type at the dilute locus (d+2J) lack ecotropic vir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copeland NG,Jenkins NA,Lee BK

更新日期：1983-01-01 00:00:00

abstract：:Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaurasiya S,Wu W,Strom AM,Warner M,Gustafsson JÅ

更新日期：2020-10-20 00:00:00

abstract：:A derivative of Tn917 was constructed, referred to as Tn917-lac, which is capable of generating fusions that connect the transcripts of Bacillus subtilis chromosomal genes to the coding sequence of the lacZ gene of Escherichia coli. Two independent insertions of Tn917-lac into the gltA gene and one insertion into the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perkins JB,Youngman PJ

更新日期：1986-01-01 00:00:00

abstract：:Vertebrates, from zebra fish to humans, have an innate immune recognition of many bacterial flagellins. This involves a conserved eight-amino acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5). Several important human pathogens, such as Helicobacter pylori and Campylobacter jejuni, have escaped TL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kreutzberger MAB,Ewing C,Poly F,Wang F,Egelman EH

更新日期：2020-07-21 00:00:00

abstract：:The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dill O,Kievits F,Koch S,Ivanyi P,Hämmerling GJ

更新日期：1988-08-01 00:00:00

abstract：:Short interfering RNA (siRNA) is widely used for studying gene function and holds great promise as a tool for validating drug targets and treating disease. A critical assumption in these applications is that the effect of siRNA on cells is specific, i.e., limited to the specific knockdown of the target gene. In this a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Semizarov D,Frost L,Sarthy A,Kroeger P,Halbert DN,Fesik SW

更新日期：2003-05-27 00:00:00

abstract：:Metastasis of solid tumors is a key determinant of cancer patient survival. Targeting micrometastases using nanoparticles could offer a way to stop metastatic tumor growth before it causes excessive patient morbidity. However, nanoparticle delivery to micrometastases is difficult to investigate because micrometastases...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kingston BR,Syed AM,Ngai J,Sindhwani S,Chan WCW

更新日期：2019-07-23 00:00:00

abstract：:Spatial organization of the binding sites for the priming substrate, the template DNA, and the transcription inhibitor rifampicin (Rif) in Escherichia coli RNA polymerase (EC 2.7.7.6) was probed with chimeric compounds in which Rif is covalently attached to a ribonucleotide. The compounds bind to RNA polymerase in bif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mustaev A,Zaychikov E,Severinov K,Kashlev M,Polyakov A,Nikiforov V,Goldfarb A

更新日期：1994-12-06 00:00:00

abstract：:Given the known neuroreparative actions of IL-33 in experimental models of central nervous system (CNS) injury, we predicted that compounds which induce IL-33 are likely to promote remyelination. We found anacardic acid as a candidate molecule to serve as a therapeutic agent to promote remyelination. Addition of anaca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ljunggren-Rose Å,Natarajan C,Matta P,Pandey A,Upender I,Sriram S

更新日期：2020-09-01 00:00:00

abstract：:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray JM,Hill JJ,Bargmann CI

更新日期：2005-03-01 00:00:00