The long-range organization of a native photosynthetic membrane.

abstract：:A "supermarket revolution" has occurred in developing countries in the past 2 decades. We focus on three specific issues that reflect the impact of this revolution, particularly in Asia: continuity in transformation, innovation in transformation, and unique development strategies. First, the record shows that the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reardon T,Timmer CP,Minten B

更新日期：2012-07-31 00:00:00

abstract：:Hypophosphatasia is an inherited disorder characterized by defective bone mineralization and a deficiency of serum and tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) activity. Clinical severity is variable, ranging from death in utero (due to severe rickets) to pathologic fractures first presenting in adult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss MJ,Cole DE,Ray K,Whyte MP,Lafferty MA,Mulivor RA,Harris H

更新日期：1988-10-01 00:00:00

abstract：:Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castilla LH,Perrat P,Martinez NJ,Landrette SF,Keys R,Oikemus S,Flanegan J,Heilman S,Garrett L,Dutra A,Anderson S,Pihan GA,Wolff L,Liu PP

更新日期：2004-04-06 00:00:00

abstract：:Although Hsp90 displays general chaperone activity in vitro, few substrates of the chaperone have been identified in vivo, and the characteristics that render these substrates dependent on Hsp90 remain elusive. To investigate this issue, we exploited a paradoxical observation: several unrelated oncogenic viral tyrosin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Singer MA,Lindquist S

更新日期：1999-01-05 00:00:00

abstract：:Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann AC,Petras D,Quinn RA,Protsyuk I,Archer FI,Ransome E,Williams GJ,Bailey BA,Vermeij MJA,Alexandrov T,Dorrestein PC,Rohwer FL

更新日期：2017-10-31 00:00:00

abstract：:GPIbalpha binding to von Willebrand factor (VWF) exposed at a site of vascular injury is thought to be the first step in the formation of a hemostatic plug. However, our previous studies in VWF-deficient mice demonstrated delayed but not absent arterial thrombus formation, suggesting that, under these conditions, GPIb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bergmeier W,Piffath CL,Goerge T,Cifuni SM,Ruggeri ZM,Ware J,Wagner DD

更新日期：2006-11-07 00:00:00

abstract：:Two regioisomers with C3 or D3 symmetry of water-soluble carboxylic acid C60 derivatives, containing three malonic acid groups per molecule, were synthesized and found to be equipotent free radical scavengers in solution as assessed by EPR analysis. Both compounds also inhibited the excitotoxic death of cultured corti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dugan LL,Turetsky DM,Du C,Lobner D,Wheeler M,Almli CR,Shen CK,Luh TY,Choi DW,Lin TS

更新日期：1997-08-19 00:00:00

abstract：:We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a bifunctional enzyme catalyzed the modification and demodification of its substrate protein, with both...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura AC,Jiang P,Van Wassenhove L,Del Vecchio D,Merajver SD,Ninfa AJ

更新日期：2010-06-01 00:00:00

abstract：:Many studies have reported age-related changes in immune responses that could be due to alterations in lymphoid cell numbers or functions. Here we report the results of studies using immunofluorescent staining and in vitro assays of cellular function to compare the expression of cell surface antigens on lymphocytes fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidman CL,Luther EA,Marshall JD,Nguyen KA,Roopenian DC,Worthen SM

更新日期：1987-11-01 00:00:00

abstract：:The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SY,Asano M

更新日期：2008-08-26 00:00:00

abstract：:Insulin resistance drives the development of type 2 diabetes (T2D). In liver, diacylglycerol (DAG) is a key mediator of lipid-induced insulin resistance. DAG activates protein kinase C ε (PKCε), which phosphorylates and inhibits the insulin receptor. In rats, a 3-day high-fat diet produces hepatic insulin resistance t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gassaway BM,Petersen MC,Surovtseva YV,Barber KW,Sheetz JB,Aerni HR,Merkel JS,Samuel VT,Shulman GI,Rinehart J

更新日期：2018-09-18 00:00:00

abstract：:The convulsant agent methionine sulfoximine inhibits brain glutamine synthetase irreversibly and the inhibitor becomes bound to the active site of the enzyme as methionine sulfoximine phosphate. Only one of the four isomers of methionine sulfoximine, L-methionine-S-sulfoximine, inhibits glutamine synthetase. In the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe WB,Meister A

更新日期：1970-06-01 00:00:00

abstract：:The relationship between (187)Os/(186)Os and (143)Nd/(144)Nd in different manganese nodule fields is used to determine the (187)Os/(186)Os ratio of the continental terrains bounding the major ocean basins. The Atlantic Ocean drainages yield (187)Os/(186)Os of about 11; the Pacific Ocean, between 25 and 36; and the wes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turekian KK,Luck JM

更新日期：1984-12-01 00:00:00

abstract：:Neurons in the cochlear nuclei of duck embryos become responsive to tonal stimuli in an orderly spatial and temporal sequence. Cells responding to lower frequencies are recorded before those responding to higher frequencies. Auditory neurons are spatially arranged according to their characteristic frequencies, indicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konishi M

更新日期：1973-06-01 00:00:00

abstract：:Multiple cues, across multiple sensory modalities, are involved in mate choice in a wide range of animal taxa. This multiplicity leads to the prediction that, in adaptive radiations, sexual isolation results from divergence in multiple dimensions. However, difficulties in directly measuring preferences and detecting m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenlohe PA,Arnold SJ

更新日期：2010-09-21 00:00:00

abstract：:An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is exacerbated by the ability of the virus to evolve compensatory mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakowski DK,Barton JP,Peter L,Chandrashekar A,Bondzie E,Gao A,Barouch DH,Chakraborty AK

更新日期：2021-02-02 00:00:00

abstract：:We present the first experimental evidence to our knowledge that ingroup relations attenuate core disgust and that this helps explain the ability of groups to coact. In study 1, 45 student participants smelled a sweaty t-shirt bearing the logo of another university, with either their student identity (ingroup conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reicher SD,Templeton A,Neville F,Ferrari L,Drury J

更新日期：2016-03-08 00:00:00

abstract：:The assembly and composition of human excision nuclease were investigated by electrophoretic mobility shift assay and DNase I footprinting. Individual repair factors or any combination of up to four repair factors failed to form DNA-protein complexes of high specificity and stability. A stable complex of high specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakasugi M,Sancar A

更新日期：1998-06-09 00:00:00

abstract：:Retrosplenial cortex (RSC) is involved in visuospatial integration and spatial learning, and RSC neurons exhibit discrete, place cell-like sequential activity that resembles the population code of space in hippocampus. To investigate the origins and population dynamics of this activity, we combined longitudinal cellul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao D,Neumann AR,Sun J,Bonin V,Mohajerani MH,McNaughton BL

更新日期：2018-07-31 00:00:00

abstract：:Recent technical advances allow detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. Our group has previously estimated plasma glucose levels in healthy adults during a standard oral glucose tolerance test via exhaled VOC analysis....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novak BJ,Blake DR,Meinardi S,Rowland FS,Pontello A,Cooper DM,Galassetti PR

更新日期：2007-10-02 00:00:00

abstract：:During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM restores juvenile forms of plasticity, as for instance demonstrated by topographical reconnectivity in sensory pathways. However, to wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Happel MF,Niekisch H,Castiblanco Rivera LL,Ohl FW,Deliano M,Frischknecht R

更新日期：2014-02-18 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:Understanding the function of high-density lipoprotein (HDL) requires detailed knowledge of the structure of its primary protein, apolipoprotein A-I (APOA1). However, APOA1 flexibility and HDL heterogeneity have confounded decades of efforts to determine high-resolution structures and consistent models. Here, molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pourmousa M,Song HD,He Y,Heinecke JW,Segrest JP,Pastor RW

更新日期：2018-05-15 00:00:00

abstract：:On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved in top-down orienting of attention and a right-lateralized ventral attention system involved in reorienting attention in respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Corbetta M,Snyder AZ,Vincent JL,Raichle ME

更新日期：2006-06-27 00:00:00

abstract：:Genomic analyses of patients with congenital heart disease (CHD) have identified significant contribution from mutations affecting cilia genes and chromatin remodeling genes; however, the mechanism(s) connecting chromatin remodeling to CHD is unknown. Histone H2B monoubiquitination (H2Bub1) is catalyzed by the RNF20 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robson A,Makova SZ,Barish S,Zaidi S,Mehta S,Drozd J,Jin SC,Gelb BD,Seidman CE,Chung WK,Lifton RP,Khokha MK,Brueckner M

更新日期：2019-07-09 00:00:00

abstract：:The adaptations in the freshwater turtle that permit survival despite prolonged loss of mitochondrial ATP generation were investigated by comparing the bioenergetics of turtle brain slices with rat brain slices. Aerobic turtle brain shows no significant difference in basal levels of total ATP generation compared to ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robin ED,Lewiston N,Newman A,Simon LM,Theodore J

更新日期：1979-08-01 00:00:00

abstract：:Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Cimbro R,Lusso P,Berger EA

更新日期：2011-12-13 00:00:00

abstract：:The immunoglobulin light chain is thought to be organized into two structural domains, the constant and the variable regions, linked by a switch region of lesser tertiary organization. Light chains of homogeneous rabbit antibodies to pneumococcal polysaccharides labeled with (125)I were subjected to trypsin digestion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulsen K,Fraser KJ,Haber E

更新日期：1972-09-01 00:00:00

abstract：:Transposition of the genetically related insertion elements gamma delta and Tn3 is thought to involve two steps. In the case of transposition from one replicon to another, the first step is fusion of the parent and target replicons with the element appearing in direct orientation at the two junctions. In a subsequent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed RR

更新日期：1981-06-01 00:00:00

abstract：:Metazoan arrestins bind to seven-transmembrane (7TM) receptors to regulate function. Aspergillus nidulans PalF, a protein involved in the fungal ambient pH signaling pathway, contains arrestin N-terminal and C-terminal domains and binds strongly to two different regions within the C-terminal cytoplasmic tail of the 7T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herranz S,Rodríguez JM,Bussink HJ,Sánchez-Ferrero JC,Arst HN Jr,Peñalva MA,Vincent O

更新日期：2005-08-23 00:00:00