Abstract:
:Retrosplenial cortex (RSC) is involved in visuospatial integration and spatial learning, and RSC neurons exhibit discrete, place cell-like sequential activity that resembles the population code of space in hippocampus. To investigate the origins and population dynamics of this activity, we combined longitudinal cellular calcium imaging of dysgranular RSC neurons in mice with excitotoxic hippocampal lesions. We tracked the emergence and stability of RSC spatial activity over consecutive imaging sessions. Overall, spatial activity in RSC was experience-dependent, emerging gradually over time, but, as seen in the hippocampus, the spatial code changed dynamically across days. Bilateral but not unilateral hippocampal lesions impeded the development of spatial activity in RSC. Thus, the emergence of spatial activity in RSC, a major recipient of hippocampal information, depends critically on an intact hippocampus; the indirect connections between the dysgranular RSC and the hippocampus further indicate that hippocampus may exert such influences polysynaptically within neocortex.
journal_name
Proc Natl Acad Sci U S Aauthors
Mao D,Neumann AR,Sun J,Bonin V,Mohajerani MH,McNaughton BLdoi
10.1073/pnas.1803224115subject
Has Abstractpub_date
2018-07-31 00:00:00pages
8015-8018issue
31eissn
0027-8424issn
1091-6490pii
1803224115journal_volume
115pub_type
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