Abstract:
:Mycoplasmas require an external source of sterol for growth. For Mycoplasma capricolum this requirement is met not only by cholesterol but also by the methylcholestane derivatives lanosterol, cycloartenol, 4,4-dimethylcholesterol, and 4beta-methylcholestanol. Cholesteryl methyl ether and 3alpha-methylcholestanol serve equally well as sterol supplements. None of the growth-supporting sterol derivatives tested was metabolically modified. The unusual acceptance of diverse cholestane derivatives by a mycoplasma species contrasts with the structural attributes thought to be necessary for sterol function in eukaryotic membranes.
journal_name
Proc Natl Acad Sci U S Aauthors
Odriozola JM,Waitzkin E,Smith TL,Bloch Kdoi
10.1073/pnas.75.9.4107subject
Has Abstractpub_date
1978-09-01 00:00:00pages
4107-9issue
9eissn
0027-8424issn
1091-6490journal_volume
75pub_type
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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