Honey bees navigate according to a map-like spatial memory.

abstract：:Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss L,Slavin S,Reich S,Cohen P,Shuster S,Stern R,Kaganovsky E,Okon E,Rubinstein AM,Naor D

更新日期：2000-01-04 00:00:00

abstract：:Quantifying the uncertainty for the present climate and the predictions of climate change in the suite of imperfect Atmosphere Ocean Science (AOS) computer models is a central issue in climate change science. Here, a systematic approach to these issues with firm mathematical underpinning is developed through empirical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ,Gershgorin B

更新日期：2010-08-24 00:00:00

abstract：:The postdevelopmental basis of cellular identity and the unique cellular output of a particular neuron type are of particular interest in the nervous system because a detailed understanding of circuits responsible for complex processes in the brain is impeded by the often ambiguous classification of neurons in these c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz DJ,Goaillard JM,Marder EE

更新日期：2007-08-07 00:00:00

abstract：:Genetic selections that use proteinaceous transdominant inhibitors encoded by DNA libraries to cause mutant phenocopies may facilitate genetic analysis in traditionally nongenetic organisms. We performed a selection for random short peptides and larger protein fragments (collectively termed "perturbagens") that inhibi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caponigro G,Abedi MR,Hurlburt AP,Maxfield A,Judd W,Kamb A

更新日期：1998-06-23 00:00:00

abstract：:Exocytotic membrane fusion and secretion are promoted by the concerted action of GTP and Ca2+, although the precise site(s) of action in the process are not presently known. However, the calcium-dependent membrane fusion reaction driven by synexin (annexin VII) is an in vitro model for this process, which we have now ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caohuy H,Srivastava M,Pollard HB

更新日期：1996-10-01 00:00:00

abstract：:In recent years, advertisers and magazine editors have been widely criticized for taking digital photo retouching to an extreme. Impossibly thin, tall, and wrinkle- and blemish-free models are routinely splashed onto billboards, advertisements, and magazine covers. The ubiquity of these unrealistic and highly idealize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kee E,Farid H

更新日期：2011-12-13 00:00:00

abstract：:Particles composed of secondary organic material (SOM) are abundant in the lower troposphere. The viscosity of these particles is a fundamental property that is presently poorly quantified yet required for accurate modeling of their formation, growth, evaporation, and environmental impacts. Using two unique techniques...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renbaum-Wolff L,Grayson JW,Bateman AP,Kuwata M,Sellier M,Murray BJ,Shilling JE,Martin ST,Bertram AK

更新日期：2013-05-14 00:00:00

abstract：:Conjugated linoleic acids (CLAs) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. Several isomers of CLA exist, of which the (9Z, 11E) and (10E, 12Z) isomers have beneficial effects on human metabolism but are scarce in foods. Bacterial polyunsaturated fatty acid isomerases ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liavonchanka A,Hornung E,Feussner I,Rudolph MG

更新日期：2006-02-21 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) are endogenous neuropeptide ligands for the G protein-coupled receptors NPBWR1 and NPBWR2. Here we report that the majority of NPW neurons in the mesolimbic region possess tyrosine hydroxylase immunoreactivity, indicating that a small subset of dopaminergic neurons coexpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motoike T,Long JM,Tanaka H,Sinton CM,Skach A,Williams SC,Hammer RE,Sakurai T,Yanagisawa M

更新日期：2016-05-24 00:00:00

abstract：:Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheepers MRW,van IJzendoorn LJ,Prins MWJ

更新日期：2020-09-15 00:00:00

abstract：:A panel of 26 mouse-human somatic cell hybrids containing different human chromosome complements was analyzed with a cloned human pepsinogen cDNA probe to determine the chromosomal location and the number of genes encoding these proteins. A complex containing variable numbers of pepsinogen genes was localized to the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taggart RT,Mohandas TK,Shows TB,Bell GI

更新日期：1985-09-01 00:00:00

abstract：:Albatrosses (Diomedeidae) do not occur in the North Atlantic Ocean today except as vagrants, although five species were present in the early Pliocene. No fossil breeding sites of albatrosses were known previously. The timing of extinction of albatrosses in the North Atlantic was likewise unknown. Deposits that formed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olson SL,Hearty PJ

更新日期：2003-10-28 00:00:00

abstract：:NGC 7027 shows the richest spectrum of any known gaseous nebula. In the region of the spectrum surveyed we have measured lines of ions of H, He, C, N, O, F, Ne, Mg, Si, P, S, Cl, Ar, K, Ca, Mn, and Fe using the new Hamilton Echelle Spectrograph of Lick Observatory with a charge-coupled device (CCD) detector. Since a C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aller LH,Keyes CD

更新日期：1988-04-01 00:00:00

abstract：:The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during grow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Fujita M,Feng Q,Clardy J,Fink GR

更新日期：2004-04-06 00:00:00

abstract：:Natively unfolded proteins play key roles in normal and pathological biochemical processes. Despite their importance for function, this category of proteins remains beyond the reach of classical structural biology because of their inherent conformational heterogeneity. We present a description of the intrinsic conform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernadó P,Blanchard L,Timmins P,Marion D,Ruigrok RW,Blackledge M

更新日期：2005-11-22 00:00:00

abstract：:There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotnoir-White D,El Ezzy M,Boulay PL,Rozendaal M,Bouvier M,Gagnon E,Mader S

更新日期：2018-03-13 00:00:00

abstract：:We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency. This common disorder of cortisol biosynthesis is HLA-linked. The haplotype HLA-(A3);Bw47;DR7 is strongly associated with 21-OHase deficiency and always carries a null allele at the locus encodi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,New MI,Dupont B

更新日期：1984-12-01 00:00:00

abstract：:The major late transcriptional unit of adenovirus type 2 has served as a model for studying transcription in eukaryotes. We report that pausing and premature termination are intrinsic to the transcription of this transcriptional unit by RNA polymerase II. In vivo and in isolated nuclei, transcription pauses at discret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maderious A,Chen-Kiang S

更新日期：1984-10-01 00:00:00

abstract：:Circulating platelets have important functions in thrombosis and in modulating immune and inflammatory responses. However, the role of platelets in innate immunity to bacterial infection is largely unexplored. While human platelets rapidly kill Staphylococcus aureus, we found the neonatal pathogen group B Streptococcu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama S,Sun J,Fukahori K,Ando N,Wu M,Schwarz F,Siddiqui SS,Varki A,Marth JD,Nizet V

更新日期：2019-04-09 00:00:00

abstract：:Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu SR,Wierzbicki A,Orme CA,Cody AM,Hoyer JR,Nancollas GH,Zepeda S,De Yoreo JJ

更新日期：2004-02-17 00:00:00

abstract：:The commitment of differentiating cells to a specialized fate is fundamental to the correct assembly of tissues within a multicellular organism. Because commitment is often irreversible, entry into and progression through this phase of development must be tightly regulated. Under nitrogen-limiting conditions, the mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Videau P,Rivers OS,Hurd K,Ushijima B,Oshiro RT,Ende RJ,O'Hanlon SM,Cozy LM

更新日期：2016-11-08 00:00:00

abstract：:The Arabidopsis thaliana AtHKT1 protein, a Na(+)/K(+) transporter, is capable of mediating inward Na(+) currents in Xenopus laevis oocytes and K(+) uptake in Escherichia coli. HKT1 proteins are members of a superfamily of K(+) transporters. These proteins have been proposed to contain eight transmembrane segments and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato Y,Sakaguchi M,Mori Y,Saito K,Nakamura T,Bakker EP,Sato Y,Goshima S,Uozumi N

更新日期：2001-05-22 00:00:00

abstract：:Two types of progenitor cells of the human granulocytic and monocytic lineages (CFU-GM) can be distinguished by using mouse monoclonal antibodies against human hemopoietic cells. Type 1 CFU-GM contribute all of the peripheral blood CFU-GM as well as a small fraction of bone marrow CFU-GM and express surface antigens r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrero D,Broxmeyer HE,Pagliardi GL,Venuta S,Lange B,Pessano S,Rovera G

更新日期：1983-07-01 00:00:00

abstract：:The matrix of second derivatives of 21 apparent local energy minima of deca-L-alanine has been computed. The results show that all these conformations are true local energy minima and, therefore, potentially stable conformations for this peptide. Calculations of the relative statistical weights of these conformations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibson KD,Scheraga HA

更新日期：1969-06-01 00:00:00

abstract：:Granulocytes generate a "respiratory burst" of NADPH oxidase-dependent superoxide anion (O(2)(-*)) production that is required for efficient clearance of bacterial pathogens. Hv1 mediates a voltage-gated H(+) channel activity that is proposed to serve a charge-balancing role in granulocytic phagocytes such as neutroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey IS,Ruchti E,Kaczmarek JS,Clapham DE

更新日期：2009-05-05 00:00:00

abstract：:Neural crest stem cells arise within the central nervous system but then undergo an epithelial-to-mesenchymal transition to migrate away and contribute to the peripheral nervous system and craniofacial skeleton. Here we show that DNA methyltransferase 3B (DNMT3B) is responsible for the loss of competence of dorsal neu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu N,Strobl-Mazzulla PH,Simoes-Costa M,Sánchez-Vásquez E,Bronner ME

更新日期：2014-12-16 00:00:00

abstract：:We describe a technique for transferring electrophoretically separated bands of RNA from an agarose gel to paper strips. The RNA is coupled covalently to diazobenzyloxymethyl groups on the paper. After transfer and appropriate treatment of the paper to destroy remaining diazo groups, specific RNA bands can be detected...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alwine JC,Kemp DJ,Stark GR

更新日期：1977-12-01 00:00:00

abstract：:In response to hypoxia the hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of a network of genes encoding erythropoietin, vascular endothelial growth factor, and several glycolytic enzymes. HIF-1 consists of a heterodimer of two basic helix-loop-helix PAS (Per/Arnt/Sim) proteins, HIF-1alpha and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kallio PJ,Pongratz I,Gradin K,McGuire J,Poellinger L

更新日期：1997-05-27 00:00:00

abstract：:Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae. Genome expression profiling of cells treated with IAA identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusty R,Grisafi P,Fink GR

更新日期：2004-03-23 00:00:00

abstract：:Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the beta(1)-adrenergic receptor (beta(1)AR), a beta-blocker target, as candidate pharmacogenomic loci. Transfected cells, genotyped human nonfailing and failing ventricles, and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liggett SB,Mialet-Perez J,Thaneemit-Chen S,Weber SA,Greene SM,Hodne D,Nelson B,Morrison J,Domanski MJ,Wagoner LE,Abraham WT,Anderson JL,Carlquist JF,Krause-Steinrauf HJ,Lazzeroni LC,Port JD,Lavori PW,Bristow MR

更新日期：2006-07-25 00:00:00