Abstract:
:The human fungal pathogen Candida albicans shows a significant lag in growth when diluted into fresh minimal medium. This lag is abolished by the addition of conditioned medium from a high-density culture. The active component of conditioned medium is tyrosol, which is released into the medium continuously during growth. Under conditions permissive for germ-tube formation, tyrosol stimulates the formation of these filamentous protrusions. Because germ-tube formation is inhibited by farnesol, another quorum-sensing molecule, this process must be under complex positive and negative control by environmental conditions. The identification of tyrosol as an autoregulatory molecule has important implications on the dynamics of growth and morphogenesis in Candida.
journal_name
Proc Natl Acad Sci U S Aauthors
Chen H,Fujita M,Feng Q,Clardy J,Fink GRdoi
10.1073/pnas.0401416101keywords:
subject
Has Abstractpub_date
2004-04-06 00:00:00pages
5048-52issue
14eissn
0027-8424issn
1091-6490pii
0401416101journal_volume
101pub_type
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