Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections.

abstract：:Arsenic, a curative agent for acute promyelocytic leukemia, induces cell apoptosis and degradation of BCR-ABL in chronic myelogenous leukemia (CML). We demonstrated that ubiquitination and degradation of BCR-ABL was mediated by c-CBL, a RING-type E3 ligase that was also shown to be involved in ubiquitination for many ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao JH,Sun XY,Liu JX,Zhang QY,Liu P,Huang QH,Li KK,Chen Q,Chen Z,Chen SJ

更新日期：2010-12-14 00:00:00

abstract：:Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell-neuronal connections. We ascertained a family with autosomal recessive deafness...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz-Horta O,Abad C,Sennaroglu L,Foster J 2nd,DeSmidt A,Bademci G,Tokgoz-Yilmaz S,Duman D,Cengiz FB,Grati M,Fitoz S,Liu XZ,Farooq A,Imtiaz F,Currall BB,Morton CC,Nishita M,Minami Y,Lu Z,Walz K,Tekin M

更新日期：2016-05-24 00:00:00

abstract：:The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major portal for the release of factors responsible for the anabolic effects of mechanical loading on bone formation and remodeling. However, little is known about how the Cx43 molecule responds to mechanical stimulation leading to the openi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batra N,Burra S,Siller-Jackson AJ,Gu S,Xia X,Weber GF,DeSimone D,Bonewald LF,Lafer EM,Sprague E,Schwartz MA,Jiang JX

更新日期：2012-02-28 00:00:00

abstract：:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

更新日期：1991-04-15 00:00:00

abstract：:Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of olive oil have frequently been ascribed to its minor components, such as alpha-tocopherol, polyphenols, and other phenolic compounds that are not present in other oils. However, in this study we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terés S,Barceló-Coblijn G,Benet M,Alvarez R,Bressani R,Halver JE,Escribá PV

更新日期：2008-09-16 00:00:00

abstract：:A small proportion of the RNAs of mouse reticulocytes consists of beta major-globin mRNA sequences linked to sequences transcribed from the 5'-flanking region of the beta major-globin gene. These upstream RNAs are polyadenylylated and contain 700-800 nucleotides, and their 5' regions are heterogeneous. RNAs with simil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlson DP,Ross J

更新日期：1984-12-01 00:00:00

abstract：:Transcriptional activator proteins in bacteria often operate by interaction with the C-terminal domain of the alpha-subunit of RNA polymerase (RNAP). Here we report the discovery of an "anti-alpha" factor Spx in Bacillus subtilis that blocks transcriptional activation by binding to the alpha-C-terminal domain, thereby...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano S,Nakano MM,Zhang Y,Leelakriangsak M,Zuber P

更新日期：2003-04-01 00:00:00

abstract：:The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Mutations with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulawa CE,Connelly S,Devit M,Wang L,Weigel C,Fleming JA,Packman J,Powers ET,Wiseman RL,Foss TR,Wilson IA,Kelly JW,Labaudinière R

更新日期：2012-06-12 00:00:00

abstract：:In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopaminergic neurotransmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibb JA,Yan Z,Svenningsson P,Snyder GL,Pieribone VA,Horiuchi A,Nairn AC,Messer A,Greengard P

更新日期：2000-06-06 00:00:00

abstract：:Transgenic mice have been used to address the issue of the oncogenic potential of mutant guanine nucleotide stimulatory factor (Gs) alpha subunit in the thyroid gland. The expression of the mutant Arg-201-->His Gs alpha subunit transgene has been directed to murine thyroid epithelial cells by bovine thyroglobulin prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michiels FM,Caillou B,Talbot M,Dessarps-Freichey F,Maunoury MT,Schlumberger M,Mercken L,Monier R,Feunteun J

更新日期：1994-10-25 00:00:00

abstract：:Tomato flavor is dependent upon a complex mixture of volatiles including multiple acetate esters. Red-fruited species of the tomato clade accumulate a relatively low content of acetate esters in comparison with the green-fruited species. We show that the difference in volatile ester content between the red- and green-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goulet C,Mageroy MH,Lam NB,Floystad A,Tieman DM,Klee HJ

更新日期：2012-11-13 00:00:00

abstract：:To understand the evolution of a Theory of Mind, we need to understand the selective factors that might have jumpstarted its initial evolution. We argue that a subconscious, reflexive appreciation of others' intentions, emotions, and perspectives is at the roots of even the most complex forms of Theory of Mind and tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seyfarth RM,Cheney DL

更新日期：2013-06-18 00:00:00

abstract：:Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-associated actin structures obtain their functional specificity is unclear. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skau CT,Plotnikov SV,Doyle AD,Waterman CM

更新日期：2015-05-12 00:00:00

abstract：:ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases whose human mutations result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system phenotypes. Both proteins are nuclear-localized in keeping with their DDR functions, yet both are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng A,Zhao T,Tse KH,Chow HM,Cui Y,Jiang L,Du S,Loy MMT,Herrup K

更新日期：2018-01-09 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:Alzheimer's disease (AD) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (NFT) containing truncated and hyperphosphorylated Tau, extensive neuronal loss, and chronic neuroinflammation. However, the key molecular mechanism that dominates the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Liu X,Chen S,Ye K

更新日期：2018-12-26 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease in the tropics and subtropics with high morbidity and mortality. The facultative intracellular bacterium induces host cell fusion through its type VI secretion system 5 (T6SS5) as an important part of its pathogenesis in mammalian h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku JWK,Chen Y,Lim BJW,Gasser S,Crasta KC,Gan YH

更新日期：2020-07-07 00:00:00

abstract：:Kinesin-1 is a molecular motor protein that transports cargo along microtubules. Inside cells, the vast majority of kinesin-1 is regulated to conserve ATP and to ensure its proper intracellular distribution and coordination with other molecular motors. Regulated kinesin-1 folds in half at a hinge in its coiled-coil st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietrich KA,Sindelar CV,Brewer PD,Downing KH,Cremo CR,Rice SE

更新日期：2008-07-01 00:00:00

abstract：:The increasing threat of pathogen resistance to antibiotics requires the development of novel antimicrobial strategies. Here we present a proof of concept for a genetic strategy that aims to sensitize bacteria to antibiotics and selectively kill antibiotic-resistant bacteria. We use temperate phages to deliver a funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yosef I,Manor M,Kiro R,Qimron U

更新日期：2015-06-09 00:00:00

abstract：:The structure of HIV-1 Psi-RNA has been elucidated by a concerted approach combining structural probes with mass spectrometric detection (MS3D), which is not affected by the size and crystallization properties of target biomolecules. Distance constraints from bifunctional cross-linkers provided the information require...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu ET,Hawkins A,Eaton J,Fabris D

更新日期：2008-08-26 00:00:00

abstract：:ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-dependent mechanism through the formation of heterodimers with EGFR, Er...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Greenlee EB,Amick JR,Ligon GF,Lillquist JS,Natoli EJ Jr,Hadari Y,Alvarado D,Schlessinger J

更新日期：2015-10-27 00:00:00

abstract：:Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridriksson J,Yourganov G,Bonilha L,Basilakos A,Den Ouden DB,Rorden C

更新日期：2016-12-27 00:00:00

abstract：:DNA and protein determinants of nucleosome positioning have been examined after in vitro reconstitutions of native or modified histone octamers onto tandem repeats of 207- and 172-base-pair DNA sequences containing the Lytechinus variegatus 5S rRNA gene and onto monomeric sequences derived from these by digestion with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong F,Hansen JC,van Holde KE

更新日期：1990-08-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor, a subtype of excitatory amino acid receptor, mediates synaptic responses in many regions of the central nervous system. This receptor plays a critical role in the mechanisms of both synaptic plasticity and excitotoxicity. Although these receptors were generally thought to be a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monaghan DT,Olverman HJ,Nguyen L,Watkins JC,Cotman CW

更新日期：1988-12-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miorin L,Kehrer T,Sanchez-Aparicio MT,Zhang K,Cohen P,Patel RS,Cupic A,Makio T,Mei M,Moreno E,Danziger O,White KM,Rathnasinghe R,Uccellini M,Gao S,Aydillo T,Mena I,Yin X,Martin-Sancho L,Krogan NJ,Chanda SK,Schot

更新日期：2020-11-10 00:00:00

abstract：:Oncolytic viruses constitute a promising therapy against malignant gliomas (MGs). However, virus-induced type I IFN greatly limits its clinical application. The kinase mammalian target of rapamycin (mTOR) stimulates type I IFN production via phosphorylation of its effector proteins, 4E-BPs and S6Ks. Here we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alain T,Lun X,Martineau Y,Sean P,Pulendran B,Petroulakis E,Zemp FJ,Lemay CG,Roy D,Bell JC,Thomas G,Kozma SC,Forsyth PA,Costa-Mattioli M,Sonenberg N

更新日期：2010-01-26 00:00:00

abstract：:The 82-residue amino-terminal sequences of simian virus 40 large tumor antigen (TAg) and small tumor antigen (tAg) are identical. Genetic analysis of TAg lacking amino acids 1-82 revealed that it was transformation-defective, as revealed by the agar growth assay, except when introduced in the presence of tAg. Since th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montano X,Millikan R,Milhaven JM,Newsom DA,Ludlow JW,Arthur AK,Fanning E,Bikel I,Livingston DM

更新日期：1990-10-01 00:00:00

abstract：:Heymann nephritis is an experimental autoimmune disease model for human membranous nephropathy. We have recently identified a pathogenic epitope, clone 14 (C14), responsible for formation and deposition of glomerular immune complexes that is contained within the small subunit of the Heymann nephritis antigenic complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kerjaschki D,Ullrich R,Diem K,Pietromonaco S,Orlando RA,Farquhar MG

更新日期：1992-12-01 00:00:00

abstract：:Paramyxoviruses are enveloped, nonsegmented, negative-strand RNA viruses that cause a wide spectrum of human and animal diseases. The viral genome, packaged by the nucleoprotein (N), serves as a template for the polymerase complex, composed of the large protein (L) and the homo-tetrameric phosphoprotein (P). The ∼250-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdella R,Aggarwal M,Okura T,Lamb RA,He Y

更新日期：2020-03-03 00:00:00

abstract：:Indole-3-acetic acid is the major auxin in most plants. In Cruciferae, including Brassicaceae, indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile is formed from tryptophan via indole-3-acetaldoxime or indole glycosinolates as the intermediate. We cloned and sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobayashi M,Izui H,Nagasawa T,Yamada H

更新日期：1993-01-01 00:00:00