Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function.

abstract：:We describe a method for predicting the structure of alpha beta class proteins in the absence of information from homologous structures. The method is based on an associative memory model for short to intermediate range in sequence contacts and a contact potential for long range in sequence contacts. The coefficients ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hardin C,Eastwood MP,Prentiss MC,Luthey-Schulten Z,Wolynes PG

更新日期：2003-02-18 00:00:00

abstract：:The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the tick Ixodes scapularis How XIAP activates the IMD pathway in response to microbial infection remains ill defined. Here, we identified the XIAP enzymatic substrate p47 as a positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClure Carroll EE,Wang X,Shaw DK,O'Neal AJ,Oliva Chávez AS,Brown LJ,Boradia VM,Hammond HL,Pedra JHF

更新日期：2019-01-02 00:00:00

abstract：:Myosin V is an unconventional myosin proposed to be processive on actin filaments, analogous to kinesin on a microtubule [Mehta, A. D., et al. (1999) Nature (London) 400, 590-593]. To ascertain the unique properties of myosin V that permit processivity, we undertook a detailed kinetic analysis of the myosin V motor. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De La Cruz EM,Wells AL,Rosenfeld SS,Ostap EM,Sweeney HL

更新日期：1999-11-23 00:00:00

abstract：:Duplexes of 21-nt RNAs, known as short-interfering RNAs (siRNAs), efficiently inhibit gene expression by RNA interference (RNAi) when introduced into mammalian cells. We show that siRNAs can be synthesized by in vitro transcription with T7 RNA polymerase, providing an economical alternative to chemical synthesis of si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu JY,DeRuiter SL,Turner DL

更新日期：2002-04-30 00:00:00

abstract：:N6-Cyclohexyl[3H]adenosine ([3H]CHA) and 1,3-diethyl-8-[3H]phenylxanthine ([3H]DPX) to bind to adenosine receptors in brain membranes. The agonist [3H]CHA has high affinity in both bovine and guinea pig brain (Kd, 0.7 nM and 6 nM, respectively). [3H]CHA binding kinetics are slow (dissociation t1/2;60 min); binding is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruns RF,Daly JW,Snyder SH

更新日期：1980-09-01 00:00:00

abstract：:An expression for the equilibrium of the mean phenotypic value of a quantitative character is derived for a model in which the fitness of an individual depends on its own phenotype and the mean phenotypic value of a group of related individuals. When selection is weak the equilibrium mean is well predicted by Hamilton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ

更新日期：1980-12-01 00:00:00

abstract：:The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasenstaub A,Otte S,Callaway E,Sejnowski TJ

更新日期：2010-07-06 00:00:00

abstract：:We propose a motility mechanism that may result in the displacement of objects within the cell. The mechanism, which we call polymer-guided diffusion, involves a microscopic cycle of polymer association and dissociation from a lateral binding site. Reassociation occurs at the polymer subunit adjacent to that which has...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garel JR,Job D,Margolis RL

更新日期：1987-06-01 00:00:00

abstract：:This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Perdomo J,Bella A Jr,Nordberg J

更新日期：1971-08-01 00:00:00

abstract：:Population expansion in space, or range expansion, is widespread in nature and in clinical settings. Space competition among heterogeneous subpopulations during range expansion is essential to population ecology, and it may involve the interplay of multiple factors, primarily growth and motility of individuals. Struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuo W,Wu Y

更新日期：2020-03-03 00:00:00

abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

更新日期：1974-03-01 00:00:00

abstract：:The determination of macromolecular structures requires weighting of experimental evidence relative to prior physical information. Although it can critically affect the quality of the calculated structures, experimental data are routinely weighted on an empirical basis. At present, cross-validation is the most rigorou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Habeck M,Rieping W,Nilges M

更新日期：2006-02-07 00:00:00

abstract：:Herpesvirus saimiri (HVS) is the prototype member of a distinctive subset of lymphotropic herpesviruses (the gamma 2 subgroup) with A+T-rich coding sequences. In this paper, we show that cells productively infected with HVS contain high concentrations of a virus-specified thymidylate synthase (5,10-methylenetetrahydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honess RW,Bodemer W,Cameron KR,Niller HH,Fleckenstein B,Randall RE

更新日期：1986-06-01 00:00:00

abstract：:Recently, surface-sensitive spectroscopy data and molecular dynamics simulations have generated intense interest in the distribution of electrolyte ions between bulk water and the air/water interface. A partitioning model for cations and anions developed for biopolymer surface is extended here to interpret the effects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegram LM,Record MT Jr

更新日期：2006-09-26 00:00:00

abstract：:Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens. Mycobacterial IdeR is an iron-dependent repressor that shows 80% identity in the functional domains with its corynebacterial homologue, DtxR (diphtheria toxin repressor)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manabe YC,Saviola BJ,Sun L,Murphy JR,Bishai WR

更新日期：1999-10-26 00:00:00

abstract：:Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egger G,Jeong S,Escobar SG,Cortez CC,Li TW,Saito Y,Yoo CB,Jones PA,Liang G

更新日期：2006-09-19 00:00:00

abstract：:Migrations allow animals to track seasonal changes in resources, find mates, and avoid harsh climates, but these regular, long-distance movements also have implications for parasite dynamics and animal health. Migratory animals have been dubbed "superspreaders" of infection, but migration can also reduce parasite burd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peacock SJ,Krkošek M,Lewis MA,Molnár PK

更新日期：2020-05-19 00:00:00

abstract：:An artificial increase of cyclic diguanylate (c-di-GMP) levels in Sinorhizobium meliloti 8530, a bacterium that does not carry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes Congo red and calcofluor. Sugar composition and methylation analyses and NMR studies identified this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Mendoza D,Rodríguez-Carvajal MÁ,Romero-Jiménez L,Farias Gde A,Lloret J,Gallegos MT,Sanjuán J

更新日期：2015-02-17 00:00:00

abstract：:The biosynthesis of beta-nerve growth factor (betaNGF) was studied in mouse submaxillary glands incubated with L-[(35)S]cystine. betaNGF was isolated from tissue extracts by the addition of antiserum against betaNGF and the washed immunoprecipitates were analyzed by sodium dodecyl sulfate gel electrophoresis. With sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger EA,Shooter EM

更新日期：1977-09-01 00:00:00

abstract：:We created a high-throughput modality of photoactivated localization microscopy (PALM) that enables automated 3D PALM imaging of hundreds of synchronized bacteria during all stages of the cell cycle. We used high-throughput PALM to investigate the nanoscale organization of the bacterial cell division protein FtsZ in l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holden SJ,Pengo T,Meibom KL,Fernandez Fernandez C,Collier J,Manley S

更新日期：2014-03-25 00:00:00

abstract：:Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castilla LH,Perrat P,Martinez NJ,Landrette SF,Keys R,Oikemus S,Flanegan J,Heilman S,Garrett L,Dutra A,Anderson S,Pihan GA,Wolff L,Liu PP

更新日期：2004-04-06 00:00:00

abstract：:Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. The wild-type caspase recruitment domain of Apaf-1 was used as a dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mochizuki H,Hayakawa H,Migita M,Shibata M,Tanaka R,Suzuki A,Shimo-Nakanishi Y,Urabe T,Yamada M,Tamayose K,Shimada T,Miura M,Mizuno Y

更新日期：2001-09-11 00:00:00

abstract：:Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs harboring these alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

更新日期：2014-12-30 00:00:00

abstract：:RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit responsible for transcribing the general stress response genes when environmental stress is imposed on Bacillus subtilis. The C-terminal domain of RsbR and its paralogues is a substrate for the kinase function of another sigma(B) regulator, RsbT,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray JW,Delumeau O,Lewis RJ

更新日期：2005-11-29 00:00:00

abstract：:To test whether gravity is required for normal amphibian development, Xenopus laevis females were induced to ovulate aboard the orbiting Space Shuttle. Eggs were fertilized in vitro, and although early embryonic stages showed some abnormalities, the embryos were able to regulate and produce nearly normal larvae. These...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Souza KA,Black SD,Wassersug RJ

更新日期：1995-03-14 00:00:00

abstract：:Recent theoretical and experimental results point to the existence of small barriers to protein folding. These barriers can even be absent altogether, resulting in a continuous folding transition (i.e., downhill folding). With small barriers, the detailed properties of folding ensembles may become accessible to equili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muñoz V,Sanchez-Ruiz JM

更新日期：2004-12-21 00:00:00

abstract：:It is a well known fact that stirring keeps particles suspended in fluids. This is apparent, for instance, when shaking medicine flasks, when agitating tea deposits in a mug, or when heavy winds fill the air with dust particles. The commonplace nature of such observations makes it easy to accept that this feature will...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz J,Macías D,Peters F

更新日期：2004-12-21 00:00:00

abstract：:B-1 B cells have been proposed to be preferentially generated from fetal progenitors, but this view is challenged by studies concluding that B-1 production is sustained throughout adult life. To address this controversy, we compared the efficiency with which hematopoietic stem cells (HSCs) and common lymphoid progenit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber CL,Montecino-Rodriguez E,Dorshkind K

更新日期：2011-08-16 00:00:00

abstract：:The ability to grow the marine molluse Aplysia under laboratory conditions allows a detailed study of the formation of the nervous system and of the development of specific identified cells. I have found that the ganglia develop in a specific temporal order. Cerebral and pedal ganglia develop at hatching, the abdomina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriegstein AR

更新日期：1977-01-01 00:00:00

abstract：:Recent advances in electrodes for noninvasive recording of electroencephalograms expand opportunities collecting such data for diagnosis of neurological disorders and brain-computer interfaces. Existing technologies, however, cannot be used effectively in continuous, uninterrupted modes for more than a few days due to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norton JJ,Lee DS,Lee JW,Lee W,Kwon O,Won P,Jung SY,Cheng H,Jeong JW,Akce A,Umunna S,Na I,Kwon YH,Wang XQ,Liu Z,Paik U,Huang Y,Bretl T,Yeo WH,Rogers JA

更新日期：2015-03-31 00:00:00