Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels.

abstract：:The nanoscale distributions of electron density and electric fields in GaAs semiconductor devices are displayed with NMR experiments. The spectra are sensitive to the changes to the nuclear-spin Hamiltonian that are induced by perturbations delivered in synchrony with a line-narrowing pulse sequence. This POWER (pertu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempf JG,Miller MA,Weitekamp DP

更新日期：2008-12-23 00:00:00

abstract：:Osteogenin was recently purified and the amino acid sequences of tryptic peptides were determined. Osteogenin in conjunction with insoluble collagenous bone matrix induces cartilage and bone formation in vivo. To understand the mechanism of action of osteogenin, we examined its influence on periosteal cells, osteoblas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vukicevic S,Luyten FP,Reddi AH

更新日期：1989-11-01 00:00:00

abstract：:After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gais S,Albouy G,Boly M,Dang-Vu TT,Darsaud A,Desseilles M,Rauchs G,Schabus M,Sterpenich V,Vandewalle G,Maquet P,Peigneux P

更新日期：2007-11-20 00:00:00

abstract：:Four overlapping cosmid clones were constructed that contain the complete genome of the attenuated Oka strain of VZV. Transfection of human melanoma cells with the four cosmids resulted in production of infectious VZV. A double-stranded oligonucleotide, encoding a stop codon in all three open reading frames, was inser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen JI,Seidel KE

更新日期：1993-08-01 00:00:00

abstract：:3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is markedly elevated under several pathological conditions, including Huntington disease and human immunodeficiency virus infection. Here we demonstrate that micromolar concentrations (1-100 microM) of 3-HK cause cell death in primary neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuda S,Nishiyama N,Saito H,Katsuki H

更新日期：1996-10-29 00:00:00

abstract：:Ten eleven translocation (TET) enzymes (TET1/TET2/TET3) and thymine DNA glycosylase (TDG) play crucial roles in early embryonic and germ cell development by mediating DNA demethylation. However, the molecular mechanisms that regulate TETs/TDG expression and their role in cellular differentiation, including that of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu X,Jin L,Wang X,Luo A,Hu J,Zheng X,Tsark WM,Riggs AD,Ku HT,Huang W

更新日期：2013-10-29 00:00:00

abstract：:The genes coding for apolipoproteins (apo) AI, CIII, and AIV, designated APOA1, APOC3, and APOA4, respectively, are closely linked and tandemly organized in the long arm of the human chromosome 11. A DNA rearrangement involving the genes encoding apoAI and apoCIII in certain patients with premature atherosclerosis has...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karathanasis SK,Ferris E,Haddad IA

更新日期：1987-10-01 00:00:00

abstract：:The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main barriers of tumori...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hydbring P,Bahram F,Su Y,Tronnersjö S,Högstrand K,von der Lehr N,Sharifi HR,Lilischkis R,Hein N,Wu S,Vervoorts J,Henriksson M,Grandien A,Lüscher B,Larsson LG

更新日期：2010-01-05 00:00:00

abstract：:Regulation of ion transport in plants is essential for cell function. Abiotic stress unbalances cell ion homeostasis, and plants tend to readjust it, regulating membrane transporters and channels. The plant hormone abscisic acid (ABA) and the second messenger Ca(2+) are central in such processes, as they are involved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diaz M,Sanchez-Barrena MJ,Gonzalez-Rubio JM,Rodriguez L,Fernandez D,Antoni R,Yunta C,Belda-Palazon B,Gonzalez-Guzman M,Peirats-Llobet M,Menendez M,Boskovic J,Marquez JA,Rodriguez PL,Albert A

更新日期：2016-01-19 00:00:00

abstract：:We show that epidermal growth factor (EGF) receptor can be transferred in a biologically active orientation from donor hepatic membranes to recipient receptorless fibroblast cells. The recipient cells (NR-6) normally lack EGF receptors and are biologically unresponsive to EGF. The transfer of receptors from donor plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishayee S,Feinman J,Pittenger M,Michael H,Das M

更新日期：1982-03-01 00:00:00

abstract：:Aotus monkeys, which are generally killed when infected with the human malaria parasite Plasmodium falciparum, have been identified and grouped by karyotype. These animals were immunized with parasite material obtained from P. falciparum cultivated in vitro which had been maintained in culture for over a year. When su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reese RT,Trager W,Jensen JB,Miller DA,Tantravahi R

更新日期：1978-11-01 00:00:00

abstract：:To explore the lethal, ataxic phenotype of complex I deficiency in Ndufs4 knockout (KO) mice, we inactivated Ndufs4 selectively in neurons and glia (NesKO mice). NesKO mice manifested the same symptoms as KO mice including retarded growth, loss of motor ability, breathing abnormalities, and death by approximately 7 wk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quintana A,Kruse SE,Kapur RP,Sanz E,Palmiter RD

更新日期：2010-06-15 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:The complete coding region of maize transposable element Ac and truncated but active derivatives of it were placed under the control of promoters of different strength and tested for the ability to excise transposable element Ds from a beta-glucuronidase reporter gene in a cotransfection assay in Petunia protoplasts. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker D,Lütticke R,Li M,Starlinger P

更新日期：1992-06-15 00:00:00

abstract：:Precise regulation of the evolutionarily conserved hypoxia-inducible transcription factor (HIF) ensures proper adaptation to variations in oxygen availability throughout development and into adulthood. Oxygen-dependent regulation of HIF stability and activity are mediated by hydroxylation of conserved proline and aspa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dann CE 3rd,Bruick RK,Deisenhofer J

更新日期：2002-11-26 00:00:00

abstract：:The roles of superoxide and H2O2 in the cytotoxicity of paraquat were assessed in Chinese hamster ovary cells. Neither catalase nor superoxide dismutase inhibited the loss of ability to form colonies when added to the medium. When introduced into the cells, superoxide dismutase but not catalase inhibited the toxicity ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bagley AC,Krall J,Lynch RE

更新日期：1986-05-01 00:00:00

abstract：:Estrogen receptor beta (ER-beta) regulates diverse physiological functions in the human body. Current studies are confined to ER-beta1, and the functional roles of isoforms 2, 4, and 5 remain unclear. Full-length ER-beta4 and -beta5 isoforms were obtained from a prostate cell line, and they exhibit differential expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung YK,Mak P,Hassan S,Ho SM

更新日期：2006-08-29 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:Ras has achieved notoriety as an oncogene aberrantly activated in multiple human tumors. Approximately 30% of all human tumors express an oncogenic form of this GTPase that is locked in an active conformation as a result of being insensitive to Ras GTPase-activating proteins (GAPs), proteins that normally regulate the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin H,Wang X,Ying J,Wong AH,Cui Y,Srivastava G,Shen ZY,Li EM,Zhang Q,Jin J,Kupzig S,Chan AT,Cullen PJ,Tao Q

更新日期：2007-07-24 00:00:00

abstract：:We have shown that the silk fibroin gene from Bombyx mori is faithfully transcribed in an in vitro transcription system of the HeLa cell extract prepared by the method of Manley et al. [Manley, J. L., Fire, A., Cano, A., Sharp, P. A. & Gefter, M. L. (1980) Proc. Natl. Acad. Sci. USA 77, 3855-3859]. Using this system a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsujimoto Y,Hirose S,Tsuda M,Suzuki Y

更新日期：1981-08-01 00:00:00

abstract：:Many fatal neurodegenerative diseases such as Alzheimer's, Parkinson, the prion-related diseases, and non-neurodegenerative disorders such as type II diabetes are characterized by abnormal amyloid fiber aggregates, suggesting a common mechanism of pathogenesis. We have discovered that a class of systematically designe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hauser CA,Deng R,Mishra A,Loo Y,Khoe U,Zhuang F,Cheong DW,Accardo A,Sullivan MB,Riekel C,Ying JY,Hauser UA

更新日期：2011-01-25 00:00:00

abstract：:The circadian clock modulates expression of a large fraction of the Arabidopsis genome and affects many aspects of plant growth and development. We have discovered one way in which the circadian system regulates hormone signaling, identifying a node that links the clock and auxin networks. Auxin plays key roles in dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawat R,Schwartz J,Jones MA,Sairanen I,Cheng Y,Andersson CR,Zhao Y,Ljung K,Harmer SL

更新日期：2009-09-29 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:It is well-established morphologically that bipolar cells, the second-order neurons in the vertebrate retina, make reciprocal synapses with amacrine cells in the inner plexiform layer. However, neither the property nor the physiological function of the feedback synapse is understood. Autoradiographic and immunohistoch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachibana M,Kaneko A

更新日期：1987-05-01 00:00:00

abstract：:Liver fibrosis interferes with normal liver function and facilitates hepatocellular carcinoma (HCC) development, representing a major threat to human health. Here, we present a comprehensive perspective of microRNA (miRNA) function on targeting the fibrotic microenvironment. Starting from a murine HCC model, we identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkler I,Bitter C,Winkler S,Weichenhan D,Thavamani A,Hengstler JG,Borkham-Kamphorst E,Kohlbacher O,Plass C,Geffers R,Weiskirchen R,Nordheim A

更新日期：2020-01-07 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:Cyanobacterial clock proteins KaiA and KaiC are proposed as positive and negative regulators in the autoregulatory circadian kaiBC expression, respectively. Here, we show that activation of kaiBC expression by kaiA requires KaiC, suggesting a positive feedback control in the cyanobacterial clockwork. We found that rob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwasaki H,Nishiwaki T,Kitayama Y,Nakajima M,Kondo T

更新日期：2002-11-26 00:00:00

abstract：:Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization of G-protein-coupled receptors. Herein we describe the generation of monoclonal antibodies (mAbs) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oppermann M,Diversé-Pierluissi M,Drazner MH,Dyer SL,Freedman NJ,Peppel KC,Lefkowitz RJ

更新日期：1996-07-23 00:00:00

abstract：:Voltage gating of hyperpolarization-activated cation (HCN) channels is potentiated by direct binding of cAMP to a cytoplasmic cAMP-sensing domain (CSD). When unliganded, the CSD inhibits hyperpolarization-dependent opening of the HCN channel gate; cAMP binding relieves this autoinhibition so that opening becomes more ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicks NL,Wong T,Sun J,Madden Z,Young EC

更新日期：2011-01-11 00:00:00

abstract：:Myocardial ischemic disease is the major cause of death worldwide. After myocardial infarction, reperfusion of infracted heart has been an important objective of strategies to improve outcomes. However, cardiac ischemia/reperfusion (I/R) is characterized by inflammation, arrhythmias, cardiomyocyte damage, and, at the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fauconnier J,Meli AC,Thireau J,Roberge S,Shan J,Sassi Y,Reiken SR,Rauzier JM,Marchand A,Chauvier D,Cassan C,Crozier C,Bideaux P,Lompré AM,Jacotot E,Marks AR,Lacampagne A

更新日期：2011-08-09 00:00:00