Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria.

abstract：:We have isolated rat brain cDNA clones encoding AE2, a homologue of the erythrocyte anion exchanger, band 3 (AE1). Immunocytochemistry and in situ hybridization reveal that, in brain, AE2 expression is restricted to the basolateral membrane of the choroid plexus epithelium. Expression of a full-length mouse AE2 cDNA i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindsey AE,Schneider K,Simmons DM,Baron R,Lee BS,Kopito RR

更新日期：1990-07-01 00:00:00

abstract：:Preadipocytes can give rise to either white adipocytes or beige adipocytes. Owing to their distinct abilities in nutrient storage and energy expenditure, strategies that specifically promote "beiging" of adipocytes hold great promise for counterbalancing obesity and metabolic diseases. Yet, factors dictating the diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu K,Lin L,Li Q,Xue Y,Zheng F,Wang G,Zheng C,Du L,Hu M,Huang Y,Shao C,Kong X,Melino G,Shi Y,Wang Y

更新日期：2020-02-04 00:00:00

abstract：:Plants adapt to alterations in light conditions by controlling their gene expression profiles. Expression of light-inducible genes is transcriptionally induced by transcription factors such as HY5. However, few detailed analyses have been carried out on the control of transcription start sites (TSSs). Of the various w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurihara Y,Makita Y,Kawashima M,Fujita T,Iwasaki S,Matsui M

更新日期：2018-07-24 00:00:00

abstract：:During Drosophila development, nuclear and cell divisions are coordinated in response to developmental signals. In yeast and mammalian cells, signals that control cell division regulate the activity of cyclin-dependent kinases (Cdks) through proteins such as cyclins that interact with the Cdks. Here we describe two Dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finley RL Jr,Thomas BJ,Zipursky SL,Brent R

更新日期：1996-04-02 00:00:00

abstract：:Biotin plays an essential role in growth of mycobacteria. Synthesis of the cofactor is essential for Mycobacterium tuberculosis to establish and maintain chronic infections in a murine model of tuberculosis. Although the late steps of mycobacterial biotin synthesis, assembly of the heterocyclic rings, are thought to f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cronan JE

更新日期：2020-09-22 00:00:00

abstract：:Lost myelin can be replaced after injury or during demyelinating diseases in a regenerative process called remyelination. In the central nervous system (CNS), the myelin sheaths, which protect axons and allow the fast propagation of electrical impulses, are produced by oligodendrocytes. The abundance and widespread di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bielecki B,Mattern C,Ghoumari AM,Javaid S,Smietanka K,Abi Ghanem C,Mhaouty-Kodja S,Ghandour MS,Baulieu EE,Franklin RJ,Schumacher M,Traiffort E

更新日期：2016-12-20 00:00:00

abstract：:Jasmonoyl-isoleucine (JA-Ile), the active form of the plant hormone jasmonate (JA), is sensed by the F-box protein CORONATINE INSENSITIVE 1 (COI1), a component of a functional Skp-Cullin-F-box E3 ubiquitin ligase complex. Sensing of JA-Ile by COI1 rapidly triggers genome-wide transcriptional changes that are largely r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An C,Li L,Zhai Q,You Y,Deng L,Wu F,Chen R,Jiang H,Wang H,Chen Q,Li C

更新日期：2017-10-17 00:00:00

abstract：:Archaeochemistry as the application of the most recent analytical techniques to ancient samples now provides an unprecedented understanding of human culture throughout history. In this paper, we report on a multiplatform analytical investigation of 170-y-old champagne bottles found in a shipwreck at the bottom of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeandet P,Heinzmann SS,Roullier-Gall C,Cilindre C,Aron A,Deville MA,Moritz F,Karbowiak T,Demarville D,Brun C,Moreau F,Michalke B,Liger-Belair G,Witting M,Lucio M,Steyer D,Gougeon RD,Schmitt-Kopplin P

更新日期：2015-05-12 00:00:00

abstract：:Decisions always involve both facts and values, whereas most science communication focuses only on facts. If science communication is intended to inform decisions, it must be competent with regard to both facts and values. Public participation inevitably involves both facts and values. Research on public participation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietz T

更新日期：2013-08-20 00:00:00

abstract：:As global climate continues to warm, melting of glaciers releases a large quantity of mercury (Hg) originally locked in ice into the atmosphere and downstream ecosystems. Here, we show an opposite process that captures atmospheric Hg through glacier-to-vegetation succession. Our study using stable isotope techniques a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Luo J,Yuan W,Lin CJ,Wang F,Liu C,Wang G,Feng X

更新日期：2020-01-28 00:00:00

abstract：:The mechanism by which cells recognize and complete replicated regions at their precise doubling point must be remarkably efficient, occurring thousands of times per cell division along the chromosomes of humans. However, this process remains poorly understood. Here we show that, in Escherichia coli, the completion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wendel BM,Courcelle CT,Courcelle J

更新日期：2014-11-18 00:00:00

abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Sl,Bottoli I,Goller M,Vogt PK

更新日期：1999-05-11 00:00:00

abstract：:Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes. In this study, we demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathew G,Hannan A,Hertzler-Schaefer K,Wang F,Feng GS,Zhong J,Zhao JJ,Downward J,Zhang X

更新日期：2016-11-15 00:00:00

abstract：:Aggregation chimeras were formed between C57BL/6 mice heterozygous for the Apc(min) (Min) mutation and wild-type SWR mice, that differ in their Pla2g2a status, a modifier of Apc(min), and also in their resistance to intestinal polyp formation. Variation in the dolichos biflorus agglutinin-staining patterns of the inte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novelli MR,Wasan H,Rosewell I,Bee J,Tomlinson IP,Wright NA,Bodmer WF

更新日期：1999-10-26 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The underlying mechanism requires an intact 80-aa stretch ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prasad KV,Ao Z,Yoon Y,Wu MX,Rizk M,Jacquot S,Schlossman SF

更新日期：1997-06-10 00:00:00

abstract：:Transmural stimulation of the isolated adrenal gland of the rat and guinea pig results in secretion of catecholamine. The secretion is due to activation of cholinergic receptors of the adrenal medulla by acetylcholine released from splanchnic nerve terminals after transmural stimulation. Our aim was to see whether the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakade AR,Wakade TD

更新日期：1982-05-01 00:00:00

abstract：:The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the riboz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCall MJ,Hendry P,Jennings PA

更新日期：1992-07-01 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, self-recognition and the thereby promoted aggregation of thousands of cells into protective flocs is mediated by a family of cell-surface adhesins, the flocculins (Flo). Based on this social behavior FLO genes fulfill the definition of "greenbeard" genes, which direct coo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veelders M,Brückner S,Ott D,Unverzagt C,Mösch HU,Essen LO

更新日期：2010-12-28 00:00:00

abstract：:The tumorigenic properties of Rous sarcoma virus are attributable to a 60,000-dalton protein, pp60v--src, encoded by a single viral gene, v-src. A homologous gene, c-src, that contains the information for a 60,000-dalton protein, pp60c--src, has been identified in all tested vertebrate cells. By screening a recombinan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker RC,Varmus HE,Bishop JM

更新日期：1981-09-01 00:00:00

abstract：:Rabbit corneas denuded of their endothelium were coated with bovine corneal endothelial cells (from steers) previously maintained in tissue culture for short (20 generations) or prolonged (200 generations) periods. When grafted back into female rabbits, the corneal buttons remained clear and showed no edema. In contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gospodarowicz D,Greenburg G,Alvarado J

更新日期：1979-01-01 00:00:00

abstract：:The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su SS,Modrich P

更新日期：1986-07-01 00:00:00

abstract：:ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturational degradation of intracellular organelles and in the biosynthesis of antiinflammatory and proresolving eicosanoids. Here we hypothesized that lower mammals (mice, rats, pigs) express 12-lipoxygenating ALOX15 orthologs. In contrast, 15-lipoxygenat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adel S,Karst F,González-Lafont À,Pekárová M,Saura P,Masgrau L,Lluch JM,Stehling S,Horn T,Kuhn H,Heydeck D

更新日期：2016-07-26 00:00:00

abstract：:Signaling through the Toll receptor is required for dorsal/ventral polarity in Drosophila embryos, and also plays an evolutionarily conserved role in the immune response. Upon ligand binding, Toll appears to multimerize and activate the associated kinase, Pelle. However, the immediate downstream targets of Pelle have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen B,Liu H,Skolnik EY,Manley JL

更新日期：2001-07-17 00:00:00

abstract：:Leaflets of Samanea saman open and close rhythmically, driven by an endogenous circadian clock. Light has a rapid, direct effect on the movements and also rephases the rhythm. We investigated whether light signals might be mediated by increased inositolphospholipid turnover, a mechanism for signal transduction that is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse MJ,Crain RC,Satter RL

更新日期：1987-10-01 00:00:00

abstract：:We study the dynamic network of e-mail traffic and find that it develops self-organized coherent structures similar to those appearing in many nonlinear dynamic systems. Such structures are uncovered by a general information theoretic approach to dynamic networks based on the analysis of synchronization among trios of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckmann JP,Moses E,Sergi D

更新日期：2004-10-05 00:00:00

abstract：:The nucleotide sequence of intracellular 26S mRNA of Sindbis virus has been determined by direct sequence analysis of the cDNA made to this RNA with reverse transcriptase. From this, the amino acid sequences of the encoded virus structural proteins, which include a basic capsid protein and two integral membrane glycop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice CM,Strauss JH

更新日期：1981-04-01 00:00:00

abstract：:Seed germination is a complex trait of key ecological and agronomic significance. Few genetic factors regulating germination have been identified, and the means by which their concerted action controls this developmental process remains largely unknown. Using publicly available gene expression data from Arabidopsis th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassel GW,Lan H,Glaab E,Gibbs DJ,Gerjets T,Krasnogor N,Bonner AJ,Holdsworth MJ,Provart NJ

更新日期：2011-06-07 00:00:00

abstract：:S-nitrosation is a posttranslational, oxidative addition of NO to cysteine residues of proteins that has been proposed as a cGMP-independent signaling pathway [Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Nat Rev Mol Cell Biol 6:150-166]. A paradox of S-nitrosation is that only a small set of reactive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell DA,Morton SU,Fernhoff NB,Marletta MA

更新日期：2007-07-10 00:00:00

abstract：:Higher plants process two distinct, nuclear gene-encoded glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins, a Calvin-cycle enzyme active within chloroplasts and a glycolytic enzyme active within the cytosol. The gene for the chloroplast enzyme was previously suggested to be of endosymbiotic origin. Since the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin W,Brinkmann H,Savonna C,Cerff R

更新日期：1993-09-15 00:00:00