Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.

abstract：:Ascorbic acid, at nontoxic concentrations, causes a substantial reduction in the ability of avian tumor viruses to replicate in both primary avian tendon cells and chicken embryo fibroblasts. The virus-infected cultures appear to be less transformed in the presence of ascorbic acid by the criteria of morphology, reduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bissell MJ,Hatie C,Farson DA,Schwarz RI,Soo WJ

更新日期：1980-05-01 00:00:00

abstract：:P transposable elements in Drosophila are mobilized via a cut-and-paste mechanism. The broken DNA ends generated during transposition can be repaired via the homology-directed synthesis-dependent strand annealing or by nonhomologous end joining (NHEJ). Genetic studies have demonstrated an interaction between the gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Min B,Weinert BT,Rio DC

更新日期：2004-06-15 00:00:00

abstract：:In both Escherichia coli and Salmonella typhimurium there is approximately balanced synthesis of the six catalytic and six regulatory polypeptide chains of the regulatory enzyme aspartate transcarbamoylase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2). This control is achieved by the contiguous pyr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauza CD,Karels MJ,Navre M,Schachman HK

更新日期：1982-07-01 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:The thin layer of airway surface liquid (ASL) contains antimicrobial substances that kill the small numbers of bacteria that are constantly being deposited in the lungs. An increase in ASL salt concentration inhibits the activity of airway antimicrobial factors and may partially explain the pathogenesis of cystic fibr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabner J,Seiler MP,Launspach JL,Karp PH,Kearney WR,Look DC,Smith JJ,Welsh MJ

更新日期：2000-10-10 00:00:00

abstract：:Opportunistic infections are often polymicrobial. Two of the most important bacterial opportunistic pathogens of humans, Pseudomonas aeruginosa and Staphylococcus aureus, frequently are coisolated from infections of catheters, endotracheal tubes, skin, eyes, and the respiratory tract, including the airways of people w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman LR,Déziel E,D'Argenio DA,Lépine F,Emerson J,McNamara S,Gibson RL,Ramsey BW,Miller SI

更新日期：2006-12-26 00:00:00

abstract：:We report the direct measurement of thermodynamic properties of colloidal hard spheres by optical microscopy. By using confocal microscopy, we obtain three-dimensional snapshots of a colloidal hard-sphere suspension over a wide range of densities. From these snapshots, the available volume to insert an additional sphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dullens RP,Aarts DG,Kegel WK

更新日期：2006-01-17 00:00:00

abstract：:The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of circumstances, the covalent complex is converted to a long-lived or dead-end product that can result in chromosome breakage and cell death. We have discovered and par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SW,Burgin AB Jr,Huizenga BN,Robertson CA,Yao KC,Nash HA

更新日期：1996-10-15 00:00:00

abstract：:The bacterial actin homolog, MreB, forms helical cables within the cell that are required for maintenance of a rod shape. These helical structures are thought to be involved in the spatial organization of cell wall (peptidoglycan) synthesizing complexes of penicillin-binding proteins (PBPs). Here, we examined the role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Divakaruni AV,Loo RR,Xie Y,Loo JA,Gober JW

更新日期：2005-12-20 00:00:00

abstract：:A randomized double-blind controlled trial was conducted to determine the efficacy of passive immunotherapy in the treatment of symptomatic human immunodeficiency virus (HIV) infection. This trial included 86 symptomatic patients randomized to receive plasma rich in anti-HIV-1 antibody or standard seronegative plasma....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vittecoq D,Chevret S,Morand-Joubert L,Heshmati F,Audat F,Bary M,Dusautoir T,Bismuth A,Viard JP,Barré-Sinoussi F

更新日期：1995-02-14 00:00:00

abstract：:Concentrations and isotopic compositions of ethane and propane in cold, deeply buried sediments from the southeastern Pacific are best explained by microbial production of these gases in situ. Reduction of acetate to ethane provides one feasible mechanism. Propane is enriched in (13)C relative to ethane. The amount is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinrichs KU,Hayes JM,Bach W,Spivack AJ,Hmelo LR,Holm NG,Johnson CG,Sylva SP

更新日期：2006-10-03 00:00:00

abstract：:Parathyroid hormone (PTH) is central to calcium homeostasis and bone maintenance in vertebrates, and as such it has been used for treating osteoporosis. It acts primarily by binding to its receptor, PTH1R, a member of the class B G protein-coupled receptor (GPCR) family that also includes receptors for glucagon, calci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pioszak AA,Xu HE

更新日期：2008-04-01 00:00:00

abstract：:Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonk FJ,Casewell NR,Henkel CV,Heimberg AM,Jansen HJ,McCleary RJ,Kerkkamp HM,Vos RA,Guerreiro I,Calvete JJ,Wüster W,Woods AE,Logan JM,Harrison RA,Castoe TA,de Koning AP,Pollock DD,Yandell M,Calderon D,Renjifo C,Cur

更新日期：2013-12-17 00:00:00

abstract：:An implicit assumption of speciation biology is that population differentiation is an important stage of evolutionary diversification, but its significance as a rate-limiting control on phylogenetic speciation dynamics remains largely untested. If population differentiation within a species is related to its speciatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvey MG,Seeholzer GF,Smith BT,Rabosky DL,Cuervo AM,Brumfield RT

更新日期：2017-06-13 00:00:00

abstract：:The relationship between performance and ability is a central concern in the social sciences: Are the most successful much more able than others, and are failures unskilled? Prior research has shown that noise and self-reinforcing dynamics make performance unpredictable and lead to a weak association between ability a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denrell J,Liu C

更新日期：2012-06-12 00:00:00

abstract：:A discussion of the range of applicability of Forster long-range energy transfer in the determination of macromolecular dimensions and conformational dynamics is given. Emphasis is laid on the effect of restrictions in the orientational freedom of donor and acceptor and on the importance of the orientational averaging...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dale RE,Eisinger J

更新日期：1976-02-01 00:00:00

abstract：:Aotus monkeys, which are generally killed when infected with the human malaria parasite Plasmodium falciparum, have been identified and grouped by karyotype. These animals were immunized with parasite material obtained from P. falciparum cultivated in vitro which had been maintained in culture for over a year. When su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reese RT,Trager W,Jensen JB,Miller DA,Tantravahi R

更新日期：1978-11-01 00:00:00

abstract：:The effects of urea and of guanidinium chloride on binding constants in water for 6-(4-tert-butylanilino)-naphthalene-2-sulfonate and of bis(p-tert-butylphenyl) phosphate binding to beta-cyclodextrin and to N,N'-bis(6-beta-cyclo-dextrinyl)imidazolium ion have been determined. Their effects on the water solubility of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breslow R,Halfon S

更新日期：1992-08-01 00:00:00

abstract：:Total heterogeneous nuclear RNA from HeLa cells infected with adenovirus for 18-20 hr stimulates amino acid incorporation into protein in a cell-free system from Ehrlich ascites tumors. This stimulation of protein synthesis by the nuclear RNA requires intact nuclei. The role of nuclei in this system is unknown, but ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee NK,Weissbach H

更新日期：1974-08-01 00:00:00

abstract：:The kidney has an extraordinary ability to maintain stable fractional solute and fluid reabsorption over a wide range of glomerular filtration rates (GFRs). Internalization of filtered low molecular weight proteins, vitamins, hormones, and other small molecules is mediated by the proximal tubule (PT) multiligand recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raghavan V,Rbaibi Y,Pastor-Soler NM,Carattino MD,Weisz OA

更新日期：2014-06-10 00:00:00

abstract：:A rice Dwarf 1 gene was identified by using a map-based cloning strategy. Its recessive mutant allele confers a dwarf phenotype. Linkage analysis revealed that a cDNA encoding the alpha-subunit of GTP-binding protein cosegregated with d1 in 3,185 d1 segregants. Southern hybridization analysis with this cDNA as a probe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashikari M,Wu J,Yano M,Sasaki T,Yoshimura A

更新日期：1999-08-31 00:00:00

abstract：:The circadian clock in eukaryotes controls transcriptional and posttranscriptional events, including regulation of the levels and phosphorylation state of translation factors. However, the mechanisms underlying clock control of translation initiation, and the impact of this potential regulation on rhythmic protein syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karki S,Castillo K,Ding Z,Kerr O,Lamb TM,Wu C,Sachs MS,Bell-Pedersen D

更新日期：2020-05-19 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:The adenoviral E1A oncogene sensitizes mammalian cells to tumor necrosis factor-alpha (TNF-alpha), in part by repressing the nuclear factor-kappa B (NF-kappa B)-dependent defense against this cytokine. Other E1A activities involve binding to either p300/cyclic AMP response element-binding protein (CBP) or retinoblasto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JL,Walker TA,Worthen GS,Radke JR

更新日期：2002-07-23 00:00:00

abstract：:Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Laat SW,van der Saag PT,Shinitzky M

更新日期：1977-10-01 00:00:00

abstract：:Stabilization of neuronal activity by homeostatic control systems is fundamental for proper functioning of neural circuits. Failure in neuronal homeostasis has been hypothesized to underlie common pathophysiological mechanisms in a variety of brain disorders. However, the key molecules regulating homeostasis in centra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vertkin I,Styr B,Slomowitz E,Ofir N,Shapira I,Berner D,Fedorova T,Laviv T,Barak-Broner N,Greitzer-Antes D,Gassmann M,Bettler B,Lotan I,Slutsky I

更新日期：2015-06-23 00:00:00

abstract：:Seed dormancy is a trait of considerable adaptive significance because it maximizes seedling survival by preventing premature germination under unfavorable conditions. Understanding how seeds break dormancy and initiate growth is also of great agricultural and biotechnological interest. Abscisic acid (ABA) plays prima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez-Molina L,Mongrand S,Chua NH

更新日期：2001-04-10 00:00:00

abstract：:Secretion of inflammatory mediators by rat mast cells (line RBL-2H3) was earlier shown to be inhibited upon clustering a membrane glycoprotein by monoclonal antibody G63. This glycoprotein, named mast cell function-associated antigen (MAFA), was also shown to interfere with the coupling cascade of the type 1 Fc epsilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guthmann MD,Tal M,Pecht I

更新日期：1995-09-26 00:00:00

abstract：:Vascular flow through tissues is regulated via a number of homeostatic mechanisms. Localized control of tissue blood flow, or autoregulation, is a key factor in regulating tissue perfusion and oxygenation. We show here that the net balance between two hypoxia-inducible factor (HIF) transcription factor isoforms, HIF-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowburn AS,Takeda N,Boutin AT,Kim JW,Sterling JC,Nakasaki M,Southwood M,Goldrath AW,Jamora C,Nizet V,Chilvers ER,Johnson RS

更新日期：2013-10-22 00:00:00

abstract：:Previous studies have established that incubation of low density lipoprotein (LDL) with cultured endothelial cells (EC) converts it to a new form (EC-modified LDL) that is now recognized by a specific receptor on macrophages (the acetyl LDL receptor) and is taken up and degraded 3-10 times more rapidly than native LDL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parthasarathy S,Steinbrecher UP,Barnett J,Witztum JL,Steinberg D

更新日期：1985-05-01 00:00:00