Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase.

abstract：:The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arinaminpathy N,Kapadia S,May RM

更新日期：2012-11-06 00:00:00

abstract：:Non-protein-coding RNA genes play an important role in various biological processes. How new RNA genes originated and whether this process is controlled by similar evolutionary mechanisms for the origin of protein-coding genes remains unclear. A young chimeric RNA gene that we term sphinx (spx) provides the first insi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Brunet FG,Nevo E,Long M

更新日期：2002-04-02 00:00:00

abstract：:Protein kinases are important mediators of much of the signal transduction that occurs in eukaryotic cells. Unfortunately, the identification of protein kinase substrates has proven to be a difficult task, and we generally know few, if any, of the physiologically relevant targets of any particular kinase. Here, we des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budovskaya YV,Stephan JS,Deminoff SJ,Herman PK

更新日期：2005-09-27 00:00:00

abstract：:Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with beta-sandwich architecture. Herein, we propose by stretching two model sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimov DK,Thirumalai D

更新日期：2000-06-20 00:00:00

abstract：:Many complex systems are organized in the form of a network embedded in space. Important examples include the physical Internet infrastructure, road networks, flight connections, brain functional networks, and social networks. The effect of space on network topology has recently come under the spotlight because of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Expert P,Evans TS,Blondel VD,Lambiotte R

更新日期：2011-05-10 00:00:00

abstract：:HIV buds from lipid rafts and requires cholesterol for its egress from and entry into cells. Viral accessory protein Nef plays a major role in this process. In this study, it not only increased the biosynthesis of lipid rafts and viral particles with newly synthesized cholesterol, but also enriched them. Furthermore, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng YH,Plemenitas A,Fielding CJ,Peterlin BM

更新日期：2003-07-08 00:00:00

abstract：:DNA sequence complementary to Trypanosoma brucei mRNAs coding for the synthesis of the variant-specific antigens AnTat 1.1 and AnTat 1.8 have been cloned and characterized. These sequences have been used as probes to analyze the corresponding genes in the nuclear DNA. The two genes seem to be represented in several (t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pays E,Van Meirvenne N,Le Ray D,Steinert M

更新日期：1981-05-01 00:00:00

abstract：:A cell line has been developed from the imaginal wing discs of the lepidopteran insect Trichoplusia ni (Hübner). The cells grow in suspension as fluid-filled, multicellular vesicles. The cell line has been designated IAL-TND1. Two-dimensional electrophoresis (isoelectric focusing and sodium dodecyl sulfate/polyacrylam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynn DE,Miller SG,Oberlander H

更新日期：1982-04-01 00:00:00

abstract：:Life history events, such as traumatic stress, illness, or starvation, can influence us through molecular changes that are recorded in a pattern of characteristic chromatin modifications. These modifications are often associated with adaptive adjustments in gene expression that can persist throughout the lifetime of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demoinet E,Li S,Roy R

更新日期：2017-03-28 00:00:00

abstract：:Wnt signaling regulates many aspects of development by increasing the signaling activity of beta-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for the formation of the beta-catenin degradation complex. Genetic studies with Drosophila suggest that Axin promotes cytoplasmic lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cong F,Varmus H

更新日期：2004-03-02 00:00:00

abstract：:The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosphorylation of the necroptotic effector pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) by the upstream protein kinase RIPK3 is a hallmark of pathway activation, the precise checkpoints ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie EJ,Birkinshaw RW,Koide A,Denbaum E,Hildebrand JM,Garnish SE,Davies KA,Sandow JJ,Samson AL,Gavin X,Fitzgibbon C,Young SN,Hennessy PJ,Smith PPC,Webb AI,Czabotar PE,Koide S,Murphy JM

更新日期：2020-04-14 00:00:00

abstract：:Polymorphism may play an important role in speciation because new species could originate from the distinctive morphs observed in polymorphic populations. However, much remains to be understood about the process by which morphs found new species. To detail the steps of this mode of speciation, we studied the geographi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corl A,Davis AR,Kuchta SR,Sinervo B

更新日期：2010-03-02 00:00:00

abstract：:The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300. The KIX domain binds regulatory proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang K,Stanfield RL,Martinez-Yamout MA,Dyson HJ,Wilson IA,Wright PE

更新日期：2018-10-02 00:00:00

abstract：:Epidermal growth factor (EGF) stimulates membrane protein phosphorylation in a human cell line, A-431. The known hepatic mitogenic action of EGF and the reduction in EGF receptor number that occurs during liver regeneration led us to study whether EGF-dependent protein kinase activity was present in rat liver and whet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin RA,O'Keefe EJ,Earp HS

更新日期：1982-02-01 00:00:00

abstract：:Imprinted gene expression associated with Prader-Willi syndrome (PWS) and Angelman syndrome (AS) is controlled by two imprinting centers (ICs), the PWS-IC and the AS-IC. The PWS-IC operates in cis to activate transcription of genes that are expressed exclusively from the paternal allele. We have created a conditional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DuBose AJ,Smith EY,Johnstone KA,Resnick JL

更新日期：2012-02-28 00:00:00

abstract：:Chromosome region 11p15.5 harbors unidentified genes involved in neoplasms and in the genetic disease Beckwith-Wiedemann syndrome. The genetic analysis of a 170-kb region at 11p15.5 between loci D11S601 and D11S679 resulted in the identification of six transcriptional units. Three genes, hNAP2, CDKN1C, and KVLQT1, are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwienbacher C,Sabbioni S,Campi M,Veronese A,Bernardi G,Menegatti A,Hatada I,Mukai T,Ohashi H,Barbanti-Brodano G,Croce CM,Negrini M

更新日期：1998-03-31 00:00:00

abstract：:Global warming is expected to lead to a large increase in atmospheric water vapor content and to changes in the hydrological cycle, which include an intensification of precipitation extremes. The intensity of precipitation extremes is widely held to increase proportionately to the increase in atmospheric water vapor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Gorman PA,Schneider T

更新日期：2009-09-01 00:00:00

abstract：:Type IV pili are thin filaments that extend from the poles of a diverse group of bacteria, enabling them to move at speeds of a few tenths of a micrometer per second. They are required for twitching motility, e.g., in Pseudomonas aeruginosa and Neisseria gonorrhoeae, and for social gliding motility in Myxococcus xanth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skerker JM,Berg HC

更新日期：2001-06-05 00:00:00

abstract：:High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takano-Yamamoto T,Rodan GA

更新日期：1990-03-01 00:00:00

abstract：:The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG and KCNE1, but the precise mechanisms remain unclear. To clarify this situation we injected adenoviral vectors expressing wild-type or LQT mutants of HERG and KC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoppe UC,Marbán E,Johns DC

更新日期：2001-04-24 00:00:00

abstract：:One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') or (5')CpNpGGpNpC(5')). Although there is wide s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selker EU,Freitag M,Kothe GO,Margolin BS,Rountree MR,Allis CD,Tamaru H

更新日期：2002-12-10 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:The localization of endothelin 1 mRNA and endothelin-like immunoreactivity was investigated in samples of neurologically normal nervous system tissue from 10 adults by using in situ hybridization and immunocytochemistry. Tissue sections of spinal cord and dorsal root ganglia were hybridized with an 35S-radiolabeled en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giaid A,Gibson SJ,Ibrahim BN,Legon S,Bloom SR,Yanagisawa M,Masaki T,Varndell IM,Polak JM

更新日期：1989-10-01 00:00:00

abstract：:Inhibin, a gonadal hormone capable of preferential suppression of pituitary follicle-stimulating hormone (FSH) secretion, has recently been purified. The major form of this protein is an alpha beta heterodimer encoded by two separate genes. In contrast to the FSH-suppressing action of the alpha beta heterodimer, the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsueh AJ,Dahl KD,Vaughan J,Tucker E,Rivier J,Bardin CW,Vale W

更新日期：1987-07-01 00:00:00

abstract：:F(o)F(1)-ATP synthase manufactures the energy "currency," ATP, of living cells. The soluble F(1) portion, called F(1)-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the gamma-subunit. A coarse-grained plastic network model is used to show at a residue level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pu J,Karplus M

更新日期：2008-01-29 00:00:00

abstract：:Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over prolif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhandari D,Lopez-Sanchez I,To A,Lo IC,Aznar N,Leyme A,Gupta V,Niesman I,Maddox AL,Garcia-Marcos M,Farquhar MG,Ghosh P

更新日期：2015-09-01 00:00:00

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:Idiopathic interstitial pneumonias (IIPs) have a progressive and often fatal course, and their enigmatic etiology has complicated approaches to effective therapies. Idiopathic pulmonary fibrosis (IPF) is the most common of IIPs and shares with IIPs an increased incidence with age and unexplained scarring in the lung. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alder JK,Chen JJ,Lancaster L,Danoff S,Su SC,Cogan JD,Vulto I,Xie M,Qi X,Tuder RM,Phillips JA 3rd,Lansdorp PM,Loyd JE,Armanios MY

更新日期：2008-09-02 00:00:00

abstract：:Phospholipase Cε (PLCε) has been characterized as a direct effector of Ras in vitro and in cellular systems; however, the role of PLCε in tumorigenesis and its link to Ras in this context remain unclear. To assess the role of PLCε in Ras-driven cancers, we generated two new mouse strains: one carrying a targeted delet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martins M,McCarthy A,Baxendale R,Guichard S,Magno L,Kessaris N,El-Bahrawy M,Yu P,Katan M

更新日期：2014-03-18 00:00:00

abstract：:Serial passage of simian virus 40 (SV40) at high multiplicity of infection leads to the emergence of variants with deleted, substituted, and/or duplicated DNA. Individual variants have been cloned by selective complementation with temperature sensitive SV40 mutants, or nonselectively by coinfection of cells with wild-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brockman WW,Nathans D

更新日期：1974-03-01 00:00:00