Global warming accelerates uptake of atmospheric mercury in regions experiencing glacier retreat.

abstract：:A sequence-specific single-stranded DNA-binding protein from the trypanosomatid protozoan Crithidia fasciculata binds to a sequence of 12 nucleotides located at the origin of replication of kinetoplast DNA minicircles. This sequence, termed the universal minicircle sequence (UMS), is conserved in the kinetoplast DNA m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzfati Y,Abeliovich H,Kapeller I,Shlomai J

更新日期：1992-08-01 00:00:00

abstract：:Phosphorylation is a major mechanism regulating the activity of ion channels that remains poorly understood with respect to T-type calcium channels (Cav3). These channels are low voltage-activated calcium channels that play a key role in cellular excitability and various physiological functions. Their dysfunction has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blesneac I,Chemin J,Bidaud I,Huc-Brandt S,Vandermoere F,Lory P

更新日期：2015-11-03 00:00:00

abstract：:A mixture of two recombinant plasmids was microinjected into mouse thymidine kinase-negative fibroblasts (L cells). One plasmid contained the thymidine kinase gene of herpes simplex virus type I and the other contained the human beta globin gene. Seven fibroblast colonies arising from injected cells incubated in hypox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WF,Killos L,Sanders-Haigh L,Kretschmer PJ,Diacumakos EG

更新日期：1980-09-01 00:00:00

abstract：:Radioimmunoassays specific for the N and C termini of human prothymosin alpha and the N terminus of human parathymosin alpha were employed for the measurement of the levels of alpha-thymosins in human thymus, spleen, and liver during normal growth and intestine and breast in malignant growth. A differential expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsitsiloni OE,Stiakakis J,Koutselinis A,Gogas J,Markopoulos C,Yialouris P,Bekris S,Panoussopoulos D,Kiortsis V,Voelter W

更新日期：1993-10-15 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a transcriptional coactivator that controls expression of metabolic/energetic genes, programming cellular responses to nutrient and environmental adaptations such as fasting, cold, or exercise. Unlike other coactivators, PGC-1α contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tavares CDJ,Aigner S,Sharabi K,Sathe S,Mutlu B,Yeo GW,Puigserver P

更新日期：2020-09-08 00:00:00

abstract：:Development of the nervous system in the amphibian embryo is initiated during gastrulation by an inductive interaction between chordamesoderm and dorsal ectoderm. The induced ectoderm forms the neural plate while uninduced ectoderm generates epidermis. We screened for genes activated during gastrulation and expressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter K,Grunz H,Dawid IB

更新日期：1988-11-01 00:00:00

abstract：:We have measured the fidelity of bidirectional, semiconservative DNA synthesis by a human DNA replication complex in vitro. Replication was performed by extracts of HeLa cells in the presence of simian virus 40 (SV40) large tumor antigen by using a double-stranded phage M13mp2 DNA template containing the SV40 origin o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts JD,Kunkel TA

更新日期：1988-10-01 00:00:00

abstract：:Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations-differences that may be essential to long-term survival. Here, we introduce a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayer A,Mora T,Rivoire O,Walczak AM

更新日期：2016-08-02 00:00:00

abstract：:Environmental and anthropogenic factors often drive population declines in top predators, but how their influences may combine remains unclear. Albatrosses are particularly threatened. They breed in fast-changing environments, and their extensive foraging ranges expose them to incidental mortality (bycatch) in multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo D,Forcada J,Wood AG,Tuck GN,Ireland L,Pradel R,Croxall JP,Phillips RA

更新日期：2017-12-12 00:00:00

abstract：:The past decade of scientific ocean drilling has revealed seemingly ubiquitous, slow-growing microbial life within a range of deep biosphere habitats. Integrated Ocean Drilling Program Expedition 337 expanded these studies by successfully coring Miocene-aged coal beds 2 km below the seafloor hypothesized to be "hot sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trembath-Reichert E,Morono Y,Ijiri A,Hoshino T,Dawson KS,Inagaki F,Orphan VJ

更新日期：2017-10-31 00:00:00

abstract：:2'-Deoxyadenosine 5'-O-(1-thiotriphosphate) (dATP[alpha S]) was introduced into the 3' ends of DNA restriction fragments with Escherichia coli DNA polymerase I to give phosphorothioate internucleotide linkages. Such "capped" 3' ends were found to be resistant to exonuclease III digestion. Moreover, the resistance to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putney SD,Benkovic SJ,Schimmel PR

更新日期：1981-12-01 00:00:00

abstract：:Humans assess the credibility of information gained from others on a daily basis; this ongoing assessment is especially crucial for avoiding exploitation by others. We used a repeated, two-person bargaining game and a cognitive hierarchy model to test how subjects judge the information sent asymmetrically from one pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatt MA,Lohrenz T,Camerer CF,Montague PR

更新日期：2012-05-29 00:00:00

abstract：:Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked mu, delta, and kappa opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon receptor activation. However, little is known about which of the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KS,Lee KW,Lee KW,Im JY,Yoo JY,Kim SW,Lee JK,Nestler EJ,Han PL

更新日期：2006-03-07 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00

abstract：:Chromosome 14 allelic loss is common in nasopharyngeal carcinoma (NPC) and may reflect essential tumor suppressor gene loss in tumorigenesis. An intact chromosome 14 was transferred to an NPC cell line using a microcell-mediated chromosome transfer approach. Microcell hybrids (MCHs) containing intact exogenously trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Lung HL,Ko JM,Cheng Y,Stanbridge EJ,Zabarovsky ER,Nicholls JM,Chua D,Tsao SW,Guan XY,Lung ML

更新日期：2009-08-25 00:00:00

abstract：:Several authors have considered Markov processes defined by the motion of a particle on a fixed line with a random velocity(1, 6, 8, 10) or a random diffusivity.(5, 12) A "random evolution" is a natural but apparently new generalization of this notion. In this note we hope to show that this concept leads to simple and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griego RJ,Hersh R

更新日期：1969-02-01 00:00:00

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00

abstract：:The antitumor drug Taxol stabilizes microtubules and reduces their dynamicity, promoting mitotic arrest and cell death. Upon assembly of the alpha/beta-tubulin heterodimer, GTP bound to beta-tubulin is hydrolyzed to GDP reaching a steady-state equilibrium between free tubulin dimers and microtubules. The binding of Ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao H,Verdier-Pinard P,Fernandez-Fuentes N,Burd B,Angeletti R,Fiser A,Horwitz SB,Orr GA

更新日期：2006-07-05 00:00:00

abstract：:To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral cytopathicity or by immune-mediated lysis. We show that uncultured peripheral blood mononuclear cells of many patients contain cytot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klenerman P,Phillips RE,Rinaldo CR,Wahl LM,Ogg G,May RM,McMichael AJ,Nowak MA

更新日期：1996-12-24 00:00:00

abstract：:The P23T mutant of human gammaD-crystallin (HGD) is associated with cataract. We have previously investigated the solution properties of this mutant, as well as those of the closely related P23V and P23S mutants, and shown that although mutations at site 23 of HGD do not produce a significant structural change in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McManus JJ,Lomakin A,Ogun O,Pande A,Basan M,Pande J,Benedek GB

更新日期：2007-10-23 00:00:00

abstract：:Vibrio cholerae O1 exists as two major serotypes, Inaba and Ogawa, which are associated with the O antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The 20-kilobase rfb regions encoding O-antigen biosynthesis in strains 569B (Inaba) and O17 (Ogawa) have been cloned in Escherichia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stroeher UH,Karageorgos LE,Morona R,Manning PA

更新日期：1992-04-01 00:00:00

abstract：:Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their role in the transmission of infectious agents is less established. Recent studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ

更新日期：2013-08-06 00:00:00

abstract：:Somatic crossing over in flies heterozygous for a dominant Minute mutant may result in two cells, homozygous for wild type and Minute, respectively. If both cells took part in development, a twin spot of two genotypes, different from the rest of the body, would result. Two-hundred wild type spots were found, none of w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern C,Tokunaga C

更新日期：1971-02-01 00:00:00

abstract：:Presynaptic and postsynaptic differentiation occurs at axodendritic contacts between CNS neurons. Synaptic adhesion mediated by synaptic cell adhesion molecule (SynCAM) and beta-neurexins/neuroligins triggers presynaptic differentiation. The signals that trigger postsynaptic differentiation are, however, unknown. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam CI,Chen L

更新日期：2005-04-26 00:00:00

abstract：:Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise a sophisticated network of transcription factors. Receptor activator of NF-kappaB ligand (RANKL) stimulates the differentiation of bone-resorbing osteoclasts through the induction o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishikawa K,Nakashima T,Hayashi M,Fukunaga T,Kato S,Kodama T,Takahashi S,Calame K,Takayanagi H

更新日期：2010-02-16 00:00:00

abstract：:Song syntax, defined as orderly temporal arrangements of acoustic units within a bird song, is a conspicuous feature of the songs of many species of passerine birds. While syntactical features play a role in interspecific song recognition by males of many bird species, syntax variation within species and female respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balaban E

更新日期：1988-05-01 00:00:00

abstract：:We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA-protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding sites are identified by most methods, DiSEL uncovered nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhimsaria D,Rodríguez-Martínez JA,Pan J,Roston D,Korkmaz EN,Cui Q,Ramanathan P,Ansari AZ

更新日期：2018-11-06 00:00:00

abstract：:The three-dimensional structure of O,O',N-trimethyl-d-tubocurarine, a neuromuscular blocking agent, has been determined by x-ray crystallography. This may help to provide insight into its pharmacologic action. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobell HM,Sakore TD,Tavale SS,Canepa FG,Pauling P,Petcher TJ

更新日期：1972-08-01 00:00:00

abstract：:We investigate the problem of learning to play the game of rock-paper-scissors. Each player attempts to improve her/his average score by adjusting the frequency of the three possible responses, using reinforcement learning. For the zero sum game the learning process displays Hamiltonian chaos. Thus, the learning traje...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato Y,Akiyama E,Farmer JD

更新日期：2002-04-02 00:00:00

abstract：:Online education is rapidly expanding in response to rising demand for higher and continuing education, but many online students struggle to achieve their educational goals. Several behavioral science interventions have shown promise in raising student persistence and completion rates in a handful of courses, but evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kizilcec RF,Reich J,Yeomans M,Dann C,Brunskill E,Lopez G,Turkay S,Williams JJ,Tingley D

更新日期：2020-06-30 00:00:00