Additive effects of climate and fisheries drive ongoing declines in multiple albatross species.

abstract：:Mutations in the human glucocerebrosidase gene cause Gaucher disease. A cDNA clone containing the entire human glucocerebrosidase coding region from normal cells has been isolated using lambda gt11 expression libraries. The complete nucleotide sequence, a restriction map, and a hydropathy profile are presented. Hybrid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorge J,West C,Westwood B,Beutler E

更新日期：1985-11-01 00:00:00

abstract：:Electron collisions with atoms, ions, molecules, and surfaces are critically important to the understanding and modeling of low-temperature plasmas (LTPs), and so in the development of technologies based on LTPs. Recent progress in obtaining experimental benchmark data and the development of highly sophisticated compu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartschat K,Kushner MJ

更新日期：2016-06-28 00:00:00

abstract：:Influenza is a lipid-enveloped, pleomorphic virus. We combine electron cryotomography and analysis of images of frozen-hydrated virions to determine the structural organization of filamentous influenza A virus. Influenza A/Udorn/72 virions are capsule-shaped or filamentous particles of highly uniform diameter. We show...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calder LJ,Wasilewski S,Berriman JA,Rosenthal PB

更新日期：2010-06-08 00:00:00

abstract：:After more than two decades of study, many fundamental questions remain unanswered about the dynamics of glass-forming materials confined to thin films. Experiments and simulations indicate that free interfaces enhance dynamics over length scales larger than molecular sizes, and this effect strengthens at lower temper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivancic RJS,Riggleman RA

更新日期：2020-10-13 00:00:00

abstract：:We used a modified subtractive suppression hybridization to identify cellular genes that show altered expression in Burkitt lymphomas (BLs) in the presence of Epstein-Barr virus (EBV). Comparison of the gene expression patterns of an EBV-negative clone of the originally EBV-positive BL line Akata, with its Neo(R)-EBV ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiss C,Nishikawa J,Takada K,Trivedi P,Klein G,Szekely L

更新日期：2003-04-15 00:00:00

abstract：:Spatial working memory or short-term place memory is impaired in schizophrenia. The efficiency of antipsychotic drugs, particularly of typical antipsychotics, on cognitive deficit in schizophrenia remains disputable. Inhibition of serotonin (5-HT) 2A/2C receptors is important for cognitive improvement in schizophrenic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bubenikova-Valesova V,Stuchlik A,Svoboda J,Bures J,Vales K

更新日期：2008-01-22 00:00:00

abstract：:Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox CD,Rinehart KL Jr,Moore ML,Cook JC Jr

更新日期：1981-07-01 00:00:00

abstract：:Adhesive P pili of uropathogenic Escherichia coli were not assembled by a strain that lacks the periplasmic disulfide isomerase DsbA. This defect was mostly attributed to the immunoglobulin-like pilus chaperone PapD, which possesses an unusual intrasheet disulfide bond between the last two beta-strands of its CD4-like...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacob-Dubuisson F,Pinkner J,Xu Z,Striker R,Padmanhaban A,Hultgren SJ

更新日期：1994-11-22 00:00:00

abstract：:Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the concentration of an inhibitor such as Colcemid. Fibroblasts of high population do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bell E,Ivarsson B,Merrill C

更新日期：1979-03-01 00:00:00

abstract：:In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geck P,Maffini MV,Szelei J,Sonnenschein C,Soto AM

更新日期：2000-08-29 00:00:00

abstract：:Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1974-05-01 00:00:00

abstract：:The molecular size and stability of the nerve growth factor (NGF) secreted in culture by L cells have been studied by sedimentation and gel filtration chromatography. Results indicate that L cell NGF has a molecular weight of 160,000. It contains as part of its structure a protein component that is biologically, immun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis NJ,Blanchard MH,Arnason BG,Young M

更新日期：1977-04-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal, genetic, neurological disorder resulting from a trinucleotide repeat expansion in the gene that encodes for the protein huntingtin. These excessive repeats confer a toxic gain of function on huntingtin, which leads to the degeneration of striatal and cortical neurons and a devasta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McBride JL,Ramaswamy S,Gasmi M,Bartus RT,Herzog CD,Brandon EP,Zhou L,Pitzer MR,Berry-Kravis EM,Kordower JH

更新日期：2006-06-13 00:00:00

abstract：:Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results or even tamper with data in order to achieve desired outcom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adda J,Decker C,Ottaviani M

更新日期：2020-06-16 00:00:00

abstract：:The effect of alpha-latrotoxin from black widow spider venom upon guinea pig cerebral cortical synaptosomes is described. Plasma membrane potential (delta psi p), in situ mitochondrial membrane potential (delta psi m), Ca2+ transport, gamma-amino[3H]butyrate release, [3H]noradrenaline release, and synaptosomal ATP wer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicholls DG,Rugolo M,Scott IG,Meldolesi J

更新日期：1982-12-01 00:00:00

abstract：:Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune synd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell JH,Rush B,Weaver C,Wang R

更新日期：1993-05-15 00:00:00

abstract：:Fungi of the recently defined order Sebacinales (Basidiomycota) are involved in a wide spectrum of mutualistic symbioses (including mycorrhizae) with various plants, thereby exhibiting a unique potential for biocontrol strategies. The axenically cultivable root endophyte Piriformospora indica is a model organism of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh S,Hückelhoven R,Schäfer P,Imani J,Sharma M,Weiss M,Waller F,Kogel KH

更新日期：2006-12-05 00:00:00

abstract：:In monocots, many genes demonstrate a significant negative GC gradient, meaning that the GC content declines along the orientation of transcription. Such a gradient is not observed in the genes of the dicot plant Arabidopsis. In addition, a lack of homology is often observed when comparing the 5' end of the coding reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang N,Ferguson AA,Slotkin RK,Lisch D

更新日期：2011-01-25 00:00:00

abstract：:Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. The results of molecular dynamics simulations of the substrate in solution and in the active site of chorismate mutase are reported. Two nonreactive conformers of chorismate ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo H,Cui Q,Lipscomb WN,Karplus M

更新日期：2001-07-31 00:00:00

abstract：:Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermosura MC,Nayakanti H,Dorovkov MV,Calderon FR,Ryazanov AG,Haymer DS,Garruto RM

更新日期：2005-08-09 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

更新日期：2021-02-09 00:00:00

abstract：:Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman BG,Class Freeman AM

更新日期：2014-03-25 00:00:00

abstract：:Here the first reproductive sterility system for the tephritid fruit fly pest, Anastrepha suspensa, is presented, based on lethality primarily limited to embryos heterozygous for a conditional lethal transgene combination. This tetracycline (Tet)-suppressible system uses a driver construct having the promoter from the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schetelig MF,Handler AM

更新日期：2012-06-12 00:00:00

abstract：:Aggregation chimeras were formed between C57BL/6 mice heterozygous for the Apc(min) (Min) mutation and wild-type SWR mice, that differ in their Pla2g2a status, a modifier of Apc(min), and also in their resistance to intestinal polyp formation. Variation in the dolichos biflorus agglutinin-staining patterns of the inte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novelli MR,Wasan H,Rosewell I,Bee J,Tomlinson IP,Wright NA,Bodmer WF

更新日期：1999-10-26 00:00:00

abstract：:Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse. Heterozygotes carry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge C,Stanley P

更新日期：2008-02-05 00:00:00

abstract：:Modern practice for training classification deepnets involves a terminal phase of training (TPT), which begins at the epoch where training error first vanishes. During TPT, the training error stays effectively zero, while training loss is pushed toward zero. Direct measurements of TPT, for three prototypical deepnet a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papyan V,Han XY,Donoho DL

更新日期：2020-10-06 00:00:00

abstract：:A 320-base-pair repeated sequence was observed when DNA samples from the filarial parasites Brugia malayi and Brugia pahangi were digested with the restriction endonuclease Hha I. A 640-base-pair dimer of the repeated sequence from B. malayi was inserted into the plasmid pBR322. When dot hybridization was used, the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McReynolds LA,DeSimone SM,Williams SA

更新日期：1986-02-01 00:00:00

abstract：:Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89-93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can have electronic influ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickey M,Goeddel D,Crane Z,Shi Y

更新日期：2004-04-20 00:00:00

abstract：:An mRNA fraction coding for hexon polypeptide, the major virion structural protein, was purified by gel electrophoresis from extracts of adenovirus 2-infected cells late in the lytic cycle. The mRNA sequences in this fraction were mapped between 51.7 and 61.3 units on the genome by visualizing RNA-DNA hybrids in the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berget SM,Moore C,Sharp PA

更新日期：1977-08-01 00:00:00

abstract：:Let T(k) (epsilon)(lambda; t(1),..., t(k)) = rho(X(t) (1))q(epsilon)(X(t) (2) - X(t) (1))... q(epsilon)(X(t(k) ) - X(t(k) )-1), where X(t) is a Brownian motion in R(2), lambda(dx) = rho(x)dx, and q(epsilon) converges to Dirac's delta function as epsilon downward arrow 0. The self-intersection local times of order k ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dynkin EB

更新日期：1986-06-01 00:00:00