SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.

abstract：:The opposite slopes of "Evolution Canyon" in Israel have served as a natural model system of adaptation to a microclimate contrast. Long-term studies of Drosophila melanogaster populations inhabiting the canyon have exhibited significant interslope divergence in thermal and drought stress resistance, candidate genes, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hübner S,Rashkovetsky E,Kim YB,Oh JH,Michalak K,Weiner D,Korol AB,Nevo E,Michalak P

更新日期：2013-12-24 00:00:00

abstract：:Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed "CLIK" (Cutoff Linked to Interaction Knowledge) that overlays biologi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dittmar JC,Pierce S,Rothstein R,Reid RJ

更新日期：2013-04-30 00:00:00

abstract：:Little is known about the catalytic mechanism of the recently discovered ThyX family of flavin-dependent thymidylate synthases that are required for thymidylate (deoxythymidine 5'-monophosphate) synthesis in a large number of microbial species. Using a combination of site-directed mutagenesis and biochemical measureme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leduc D,Graziani S,Lipowski G,Marchand C,Le Maréchal P,Liebl U,Myllykallio H

更新日期：2004-05-11 00:00:00

abstract：:T-cell migration into tissue depends on a cascade of rapid and selective adhesive interactions with endothelium. "Triggering" is a step in that cascade required to activate T-cell integrins. Hepatocyte growth factor (HGF) may be a physiologically relevant trigger, since we demonstrate that HGF can induce both adhesion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DH,Harvath L,Bottaro DP,Interrante R,Catalano G,Tanaka Y,Strain A,Hubscher SG,Shaw S

更新日期：1994-07-19 00:00:00

abstract：:By commandeering cellular translation initiation factors, or destroying those dispensable for viral mRNA translation, viruses often suppress host protein synthesis. In contrast, cellular protein synthesis proceeds in human cytomegalovirus (HCMV)-infected cells, forcing viral and cellular mRNAs to compete for limiting ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKinney C,Perez C,Mohr I

更新日期：2012-04-10 00:00:00

abstract：:A human lambdaV (Mcg) and a human lambdaII (Vil) myeloma protein have identical sequences in their first hypervariable segments although they differ at 21 positions throughout the variable region. If a different structural gene is responsible for each subgroup, the findings favor insertion of information for the hyper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA,Bilofsky H

更新日期：1975-12-01 00:00:00

abstract：:Treatment of human fibroblast cells with human fibroblast (beta)interferon for up to 8 hr resulted in the accumulation of at least four mRNAs. The mRNAs were isolated from cellular polysomes and characterized by stimulation of translation in a wheat germ cell-free protein synthesis system. The mRNAs appear as early as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colonno RJ

更新日期：1981-08-01 00:00:00

abstract：:Despite the success statistical physics has enjoyed at predicting the properties of materials for given parameters, the inverse problem, identifying which material parameters produce given, desired properties, is only beginning to be addressed. Recently, several methods have emerged across disciplines that draw upon o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miskin MZ,Khaira G,de Pablo JJ,Jaeger HM

更新日期：2016-01-05 00:00:00

abstract：:By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior. Evidence supporting this notion is based on several findings: (i) a high...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van der Ploeg LH,Martin WJ,Howard AD,Nargund RP,Austin CP,Guan X,Drisko J,Cashen D,Sebhat I,Patchett AA,Figueroa DJ,DiLella AG,Connolly BM,Weinberg DH,Tan CP,Palyha OC,Pong SS,MacNeil T,Rosenblum C,Vongs A,Tang R

更新日期：2002-08-20 00:00:00

abstract：:A 6.2-kb full-length clone encoding a distinct protein-tyrosine phosphatase (PTP; EC 3.1.3.48), PTPD1, was isolated from a human skeletal muscle cDNA library. The cDNA encodes a protein of 1174 amino acids with N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family, which also includes the tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Møller NP,Møller KB,Lammers R,Kharitonenkov A,Sures I,Ullrich A

更新日期：1994-08-02 00:00:00

abstract：:A heterogeneous RNA fraction with properties resembling those of messenger RNA was identified in mammalian mitochondria. Synthesis of contaminating RNA of nuclear origin was suppressed by treatment with camptothecin. Labeling of the messenger-like RNA is completely inhibited by ethidium bromide, a specific inhibitor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perlman S,Abelson HT,Penman S

更新日期：1973-02-01 00:00:00

abstract：:Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation of resistance suggested that new quinolones could be found that would require cells to obtain two topoisomerase mutations to display resistanc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao X,Xu C,Domagala J,Drlica K

更新日期：1997-12-09 00:00:00

abstract：:Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV) genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, Bhattacharjee B, Jensen JD, Gibson L, Kowalik TF (2011) PLoS Pathog 7:e1001344]. Here, we deep sequence HCMV genomes recovered from single and longitud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cudini J,Roy S,Houldcroft CJ,Bryant JM,Depledge DP,Tutill H,Veys P,Williams R,Worth AJJ,Tamuri AU,Goldstein RA,Breuer J

更新日期：2019-03-19 00:00:00

abstract：:Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875-85]. High-pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerch MT,Horwitz J,McCoy J,Hubbell WL

更新日期：2013-12-03 00:00:00

abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

更新日期：2007-04-03 00:00:00

abstract：:cDNAs encoding a delayed-rectifier-type K+ channel were cloned from both neonatal rat heart and ovariectomized, diethylstilbestrol-primed rat uterus by using the polymerase chain reaction. Both clones have nucleotide sequences identical to that encoding the rat kidney IsK channel [Takumi, T., Ohkubo, H. & Nakanishi, S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Folander K,Smith JS,Antanavage J,Bennett C,Stein RB,Swanson R

更新日期：1990-04-01 00:00:00

abstract：:At the onset of apoptosis, the peroxidation of cardiolipin at the inner mitochondrial membrane by cytochrome c requires an open coordination site on the heme. We report a 1.45-Å resolution structure of yeast iso-1-cytochrome c with the Met80 heme ligand swung out of the heme crevice and replaced by a water molecule. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClelland LJ,Mou TC,Jeakins-Cooley ME,Sprang SR,Bowler BE

更新日期：2014-05-06 00:00:00

abstract：:Flagellar microtubules from Chlamydomonas and sea urchin sperm were used as in vitro assembly sites for chick brain tubulin. Brain microtubules assembled onto the A-tubules, central tubules, and, to a limited extent, onto the distal ends of the axonemes at low tubulin concentrations and onto distal and proximal ends a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Binder LI,Dentler WL,Rosenbaum JL

更新日期：1975-03-01 00:00:00

abstract：:The mode of binding of the competitive inhibitor 2-benzyl-3-formylpropanoic acid to the active site of carboxypeptidase A has been studied by x-ray diffraction methods to a resolution of 1.7 A. The actual species bound to the enzyme was determined to be the gem-diol resulting from covalent hydration at the aldehyde ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christianson DW,Lipscomb WN

更新日期：1985-10-01 00:00:00

abstract：:The assembly of clathrin-coated vesicles on Golgi membranes is initiated by the GTP-binding protein ADP ribosylation factor (ARF), which generates high-affinity membrane-binding sites for the heterotetrameric AP-1 adaptor complex. Once bound, the AP-1 recruits clathrin triskelia, which polymerize to form the coat. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Y,Drake MT,Kornfeld S

更新日期：1999-04-27 00:00:00

abstract：:Viral membrane fusion proteins of class I are trimers in which the protomeric unit is a complex of a surface subunit (SU) and a fusion active transmembrane subunit (TM). Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sjöberg M,Löving R,Lindqvist B,Garoff H

更新日期：2017-03-07 00:00:00

abstract：:Legionella pneumophila causes a potentially fatal form of pneumonia by replicating within macrophages in the Legionella-containing vacuole (LCV). Bacterial survival and proliferation within the LCV rely on hundreds of secreted effector proteins comprising high functional redundancy. The vacuolar membrane-localized Mav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christenson ET,Isaac DT,Yoshida K,Lipo E,Kim JS,Ghirlando R,Isberg RR,Banerjee A

更新日期：2019-09-03 00:00:00

abstract：:The functions of individual basal transcription factors during the formation of an initiation complex by RNA polymerase II remain largely unknown. Transcription factor IIE (TFIIE) has recently been shown to bind to multiple targets in the initiation complex. To assess the role of zinc binding in basal transcription, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maxon ME,Tjian R

更新日期：1994-09-27 00:00:00

abstract：:Opitz syndrome (OS) is a genetically heterogeneous disorder characterized by defects of the ventral midline, including hypertelorism, cleft lip and palate, heart defects, and mental retardation. We recently identified the gene responsible for X-linked OS. The ubiquitously expressed gene product, MID1, is a member of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweiger S,Foerster J,Lehmann T,Suckow V,Muller YA,Walter G,Davies T,Porter H,van Bokhoven H,Lunt PW,Traub P,Ropers HH

更新日期：1999-03-16 00:00:00

abstract：:Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kocatürk B,Van den Berg YW,Tieken C,Mieog JS,de Kruijf EM,Engels CC,van der Ent MA,Kuppen PJ,Van de Velde CJ,Ruf W,Reitsma PH,Osanto S,Liefers GJ,Bogdanov VY,Versteeg HH

更新日期：2013-07-09 00:00:00

abstract：:A study has been made of Cauchy's problem for a class of abstract parabolic differential equations. Our study is based upon a transformation that maps solutions of second-order abstract Cauchy problems into solutions of first-order. This is a preliminary report on some of the results obtained. These results include (1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson JA

更新日期：1971-09-01 00:00:00

abstract：:c-Jun transcriptional activity is augmented by expression of oncogenic Ras and Raf proteins. This study demonstrates a direct correlation between Ras transforming activity and c-Jun activation, supporting an important role for c-Jun in transformation by Ras. Since we observed that Ras activated c-Jun transcriptional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westwick JK,Cox AD,Der CJ,Cobb MH,Hibi M,Karin M,Brenner DA

更新日期：1994-06-21 00:00:00

abstract：:In the absence of lasers approaching trapped ion clock transitions in sharpness we propose to replace the 12.49 m laser field exciting the D3/2-D5/2 transition of the single Ba+ ion A in D3/2 with the near-field of a close by identical ion B in the excited D5/2 state. We tune the frequency of the near-field by the dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H,Zhao X,Yu N,Nagourney W

更新日期：1996-07-09 00:00:00

abstract：:Phylogenetic analysis of Plasmodium parasites has indicated that their modern-day distribution is a result of a series of human-mediated dispersals involving transport between Africa, Europe, America, and Asia. A major outstanding question is the phylogenetic affinity of the malaria causing parasites Plasmodium vivax ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelabert P,Sandoval-Velasco M,Olalde I,Fregel R,Rieux A,Escosa R,Aranda C,Paaijmans K,Mueller I,Gilbert MT,Lalueza-Fox C

更新日期：2016-10-11 00:00:00

abstract：:In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fransson P,Skiöld B,Horsch S,Nordell A,Blennow M,Lagercrantz H,Aden U

更新日期：2007-09-25 00:00:00