Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage.

abstract：:Control of transcription and enzyme activities are two interwoven regulatory systems essential for the function of a metabolic node. Saccharomyces cerevisiae strains differing in enzyme activities at the chorismate branch point of aromatic amino acid biosynthesis were constructed by recombinant DNA technology. Express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krappmann S,Lipscomb WN,Braus GH

更新日期：2000-12-05 00:00:00

abstract：:Sponges (Porifera), the simplest and earliest multicellular organisms, are thought to have evolved from their unicellular ancestors about 1 billion years ago by developing cell-recognition and adhesion mechanisms to discriminate against "non-self." Consequently, they are used as models for investigating recognition ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haseley SR,Vermeer HJ,Kamerling JP,Vliegenthart JF

更新日期：2001-07-31 00:00:00

abstract：:Mechanisms leading to down-regulation of activated microglia and astrocytes are poorly understood, in spite of the potentially detrimental role of activated glia in neurodegeneration. Prostaglandins, produced both by neurons and glia, may serve as mediators of glial and neuronal functions. We examined the influence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrova TV,Akama KT,Van Eldik LJ

更新日期：1999-04-13 00:00:00

abstract：:We demonstrate the application of molecular rotational spectroscopy to measure the conformation isomerization rate of vibrationally excited pent-1-en-4-yne (pentenyne). The rotational spectra of single quantum states of pentenyne are acquired by using a combination of IR-Fourier transform microwave double-resonance sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dian BC,Brown GG,Douglass KO,Rees FS,Johns JE,Nair P,Suenram RD,Pate BH

更新日期：2008-09-02 00:00:00

abstract：:We have determined the nucleotide sequences of the Klebsiella pneumoniae nifL (regulation of N2 fixation genes) and the Escherichia coli glnA (glutamine synthetase) promoters. We compared these sequences with the published sequences of three other promoters that, like the nifL and glnA promoters, are activated by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ow DW,Sundaresan V,Rothstein DM,Brown SE,Ausubel FM

更新日期：1983-05-01 00:00:00

abstract：:DNA microarrays comprising approximately 95% of the Bacillus subtilis annotated protein coding ORFs were deployed to generate a series of snapshots of genomewide transcriptional changes that occur when cells are grown under various conditions that are expected to increase or decrease transcription of the trp operon se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berka RM,Cui X,Yanofsky C

更新日期：2003-05-13 00:00:00

abstract：:Meningococcal meningitis remains a substantial cause of mortality and morbidity worldwide. Until recently, countries in the African meningitis belt were susceptible to devastating outbreaks, largely attributed to serogroup A Neisseria meningitidis (MenA). Vaccination with glycoconjugates of MenA capsular polysaccharid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques P,Dello Iacono L,Gimeno A,Biolchi A,Romano MR,Arda A,Bernardes GJL,Jimenez-Barbero J,Berti F,Rappuoli R,Adamo R

更新日期：2020-11-24 00:00:00

abstract：:Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutations are single-step changes, but infrequent large jumps in repeat number also occur. We used computer simulations to determin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Rienzo A,Peterson AC,Garza JC,Valdes AM,Slatkin M,Freimer NB

更新日期：1994-04-12 00:00:00

abstract：:The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain containing a GTPase module and a three-helix bundle followed by two transmembrane (TM) segments and a C-terminal tail (CT). Fusion depends on a GTP hydrolysis-induced conformatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu TY,Bian X,Sun S,Hu X,Klemm RW,Prinz WA,Rapoport TA,Hu J

更新日期：2012-08-07 00:00:00

abstract：:In the penis, nitric oxide (NO) can be formed by both neuronal NO synthase and endothelial NOS (eNOS). eNOS is activated by viscous drag/shear stress in blood vessels to produce NO continuously, a process mediated by the phosphatidylinositol 3-kinase (PI3kinase)/Akt pathway. Here we show that PI3-kinase/Akt physiologi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurt KJ,Musicki B,Palese MA,Crone JK,Becker RE,Moriarity JL,Snyder SH,Burnett AL

更新日期：2002-03-19 00:00:00

abstract：:A new common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses was demonstrated by the use of rabbit antiserum against feline leukemia virus and the indirect membrane immunofluorescence test. Common cell-surface antigen was found in all leukemias of all strains of mice tested, in norma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiki T,Mellors RC,Hardy WD Jr

更新日期：1973-06-01 00:00:00

abstract：:The dnaZX gene of Escherichia coli directs the synthesis of two proteins, DnaZ and DnaX. These products are confirmed as the gamma and tau subunits of DNA polymerase III because antibody to a synthetic peptide present in both the DnaZ and DnaX proteins reacts also with the gamma and tau subunits of holoenzyme. To char...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SH,Walker JR

更新日期：1987-05-01 00:00:00

abstract：:Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub-100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malý P,Gruber JM,Cogdell RJ,Mančal T,van Grondelle R

更新日期：2016-03-15 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:Sparse sensor placement is a central challenge in the efficient characterization of complex systems when the cost of acquiring and processing data is high. Leading sparse sensing methods typically exploit either spatial or temporal correlations, but rarely both. This work introduces a sparse sensor optimization that i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohren TL,Daniel TL,Brunton SL,Brunton BW

更新日期：2018-10-16 00:00:00

abstract：:Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of sarcomeres, and reactivation of fetal genes, often culminating in heart failure and sudden death. Given the emerging roles of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Rooij E,Sutherland LB,Liu N,Williams AH,McAnally J,Gerard RD,Richardson JA,Olson EN

更新日期：2006-11-28 00:00:00

abstract：:Apis mellifera originated in Africa and extended its range into Eurasia in two or more ancient expansions. In 1956, honey bees of African origin were introduced into South America, their descendents admixing with previously introduced European bees, giving rise to the highly invasive and economically devastating "Afri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zayed A,Whitfield CW

更新日期：2008-03-04 00:00:00

abstract：:Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to extracellular glucose and how glucose controls nutrient homeostasis remain unknown. Here, we show that a putative Droso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohyama-Koganeya A,Kim YJ,Miura M,Hirabayashi Y

更新日期：2008-10-07 00:00:00

abstract：:Many chemoattractants cause chemotaxis of leukocytes by stimulating a structurally distinct class of G protein-coupled receptors. To identify receptor functions required for chemotaxis, we studied chemotaxis in HEK293 cells transfected with receptors for nonchemokine ligands or for interleukin 8 (IL-8), a classical ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neptune ER,Bourne HR

更新日期：1997-12-23 00:00:00

abstract：:A Jurassic salamander, Beiyanerpeton jianpingensis (gen. et sp. nov.), from a recently found site in western Liaoning Province, China is the earliest known record of Salamandroidea. As a Late Jurassic record of the group, it extends the range of the clade by ~40 Ma. The Late Jurassic taxon is neotenic and represented ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao KQ,Shubin NH

更新日期：2012-04-10 00:00:00

abstract：:Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the mechanism through which epigenetic regulation modulates intestinal epithelial integrity remains largely undefined. Here we show that EZH2, the catalytic subunit of polycomb repressive complex (PRC2), is indispensable for m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Peng J,Sun T,Li N,Zhang L,Ren J,Yuan H,Kan S,Pan Q,Li X,Ding Y,Jiang M,Cong X,Tan M,Ma Y,Fu D,Cai S,Xiao Y,Wang X,Qin J

更新日期：2017-05-09 00:00:00

abstract：:KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

更新日期：2021-02-09 00:00:00

abstract：:Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12. Analysis by two-dimensional gel electrophoresis showed that two DR beta genes were expressed in each cell line studied. One of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee BS,Rust NA,McMichael AJ,McDevitt HO

更新日期：1987-07-01 00:00:00

abstract：:Ho endonuclease of Saccharomyces cerevisiae is a homing endonuclease that makes a site-specific double-strand break in the MAT gene in late G(1). Here we show that Ho is rapidly degraded via the ubiquitin-26S proteasome system through two ubiquitin-conjugating enzymes UBC2(Rad6) and UBC3(Cdc34). UBC2(Rad6) is complexe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplun L,Ivantsiv Y,Kornitzer D,Raveh D

更新日期：2000-08-29 00:00:00

abstract：:The biotic recovery from Earth's most severe extinction event at the Permian-Triassic boundary largely reestablished the preextinction structure of marine trophic networks, with marine reptiles assuming the predator roles. However, the highest trophic level of today's marine ecosystems, i.e., macropredatory tetrapods ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fröbisch NB,Fröbisch J,Sander PM,Schmitz L,Rieppel O

更新日期：2013-01-22 00:00:00

abstract：:The development of anther and pollen is important for male reproduction, and this process is coordinately regulated by many external and internal cues. In this study, we systematically examined the male reproductive phenotypes of a series of brassinosteroid biosynthetic and signaling mutants and found that, besides th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye Q,Zhu W,Li L,Zhang S,Yin Y,Ma H,Wang X

更新日期：2010-03-30 00:00:00

abstract：:There is currently no consensus on the importance of climate change in Mesoamerican prehistory. Some invoke drought as a causal factor in major cultural transitions, including the abandonment of many sites at 900 CE, while others conclude that cultural factors were more important. This lack of agreement reflects the f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhattacharya T,Byrne R,Böhnel H,Wogau K,Kienel U,Ingram BL,Zimmerman S

更新日期：2015-02-10 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Regulated proteolysis is required to execute many cellular programs. In Caulobacter crescentus, timely degradation of the master regulator CtrA by ClpXP protease is essential for cell-cycle progression and requires the colocalization of CtrA and RcdA. Here, we establish a biochemical framework to understand regulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chien P,Perchuk BS,Laub MT,Sauer RT,Baker TA

更新日期：2007-04-17 00:00:00

abstract：:Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization to stress granules u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boncella AE,Shattuck JE,Cascarina SM,Paul KR,Baer MH,Fomicheva A,Lamb AK,Ross ED

更新日期：2020-03-17 00:00:00