Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2.

abstract：:Binding and uptake of alpha-fetoprotein (AFP) by mouse T-lymphoma YAC-1 cells exhibited the characteristics of receptor-mediated endocytosis. The binding saturation curve obtained by incubating YAC-1 cells at 4 degrees C with 125I-labeled AFP at different concentrations (50 ng/ml to 2.5 mg/ml) showed three saturation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naval J,Villacampa MJ,Goguel AF,Uriel J

更新日期：1985-05-01 00:00:00

abstract：:The carbon budget and dynamics of the Earth's interior, including the core, are currently very poorly understood. Diamond-bearing, mantle-derived rocks show a very well defined peak at δ(13)C ≈ -5 ± 3‰ with a very broad distribution to lower values (∼-40‰). The processes that have produced the wide δ(13)C distribution...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horita J,Polyakov VB

更新日期：2015-01-06 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:Guanylin and uroguanylin are intestinal peptides that stimulate chloride secretion by activating a common set of receptor-guanylate cyclase signaling molecules located on the mucosal surface of enterocytes. High mucosal acidity, similar to the pH occurring within the fluid microclimate domain at the mucosal surface of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamra FK,Eber SL,Chin DT,Currie MG,Forte LR

更新日期：1997-03-18 00:00:00

abstract：:The perceptual quality of odors usually is robust to variability in concentration. However, maps of neural activation across the olfactory bulb glomerular layer are not stable in this respect; rather, glomerular odor representations both broaden and intensify as odorant concentrations are increased. The relative level...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleland TA,Johnson BA,Leon M,Linster C

更新日期：2007-02-06 00:00:00

abstract：:The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghendler Y,Teng MK,Liu JH,Witte T,Liu J,Kim KS,Kern P,Chang HC,Wang JH,Reinherz EL

更新日期：1998-08-18 00:00:00

abstract：:The clinical efficacy of local anesthetic and antiarrhythmic drugs is due to their voltage- and frequency-dependent block of Na+ channels. Quaternary local anesthetic analogs such as QX-314, which are permanently charged and membrane-impermeant, effectively block cardiac Na+ channels when applied from either side of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qu Y,Rogers J,Tanada T,Scheuer T,Catterall WA

更新日期：1995-12-05 00:00:00

abstract：:Malignant spreading of cancer cells requires cell surface proteases that cleave the crosslinked collagenous matrix of connective tissues. From correlating the morphologically defined invasiveness of tumor cells with the presence of specific membrane-associated proteases, we have identified a malignant human melanoma c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aoyama A,Chen WT

更新日期：1990-11-01 00:00:00

abstract：:A procedure using ion exchange chromatography has been developed to detect alterations in a polysaccharide produced by Neurospora crassa. The polysaccharide, isolated from medium that has supported the growth of a culture, is highly responsive to the 3-methyl-2-benzothiazolinone hydrazone assay, indicating a high hexo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Springer WD,Srb AM

更新日期：1978-03-01 00:00:00

abstract：:Molecular dynamics (MD) simulations provide essential information about the thermodynamics and dynamics of proteins. To construct the free-energy surface from equilibrium trajectories, it is necessary to group the individual snapshots in a meaningful way. The inherent structures (IS) are shown to provide an appropriat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao F,Karplus M

更新日期：2010-05-18 00:00:00

abstract：:Ocean acidification represents a key threat to coral reefs by reducing the calcification rate of framework builders. In addition, acidification is likely to affect the relationship between corals and their symbiotic dinoflagellates and the productivity of this association. However, little is known about how acidificat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony KR,Kline DI,Diaz-Pulido G,Dove S,Hoegh-Guldberg O

更新日期：2008-11-11 00:00:00

abstract：:Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janeway KA,Kim SY,Lodish M,Nosé V,Rustin P,Gaal J,Dahia PL,Liegl B,Ball ER,Raygada M,Lai AH,Kelly L,Hornick JL,NIH Pediatric and Wild-Type GIST Clinic.,O'Sullivan M,de Krijger RR,Dinjens WN,Demetri GD,Antonescu CR,F

更新日期：2011-01-04 00:00:00

abstract：:The nucleic acid sequence of the 3' region of human T-cell leukemia virus type II (HTLV-II) proviral DNA was determined using a HTLV-II proviral clone that could be recovered as infectious, transforming virus. The sequence data indicate a region of unknown function of approximately equal to 1.6 kilobase pairs in the 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimotohno K,Wachsman W,Takahashi Y,Golde DW,Miwa M,Sugimura T,Chen IS

更新日期：1984-11-01 00:00:00

abstract：:We have isolated a gene from Escherichia coli homologous to the gene encoding the Mr 83,000 Drosophila heat shock protein (hsp83). In E. coli the protein homologous to hsp83 is a heat shock protein called C62.5. The predicted amino acid sequence of C62.5 is 41% and 42% identical to the Drosophila and human hsp83 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bardwell JC,Craig EA

更新日期：1987-08-01 00:00:00

abstract：:Activation of the CB2 receptor is apparently an endogenous protective mechanism. Thus, it restrains inflammation and protects the skeleton against age-related bone loss. However, the endogenous cannabinoids, as well as Δ(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid recept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoum R,Baraghithy S,Chourasia M,Breuer A,Mussai N,Attar-Namdar M,Kogan NM,Raphael B,Bolognini D,Cascio MG,Marini P,Pertwee RG,Shurki A,Mechoulam R,Bab I

更新日期：2015-07-14 00:00:00

abstract：:NFATc (a member of the family of nuclear factors of activated T cells) is a transcriptional factor responsible for the Ca(2+)-inducible activation of cytokine genes during the immune response. In resting T cells, NFATc is retained in the cytoplasm by a mechanism that depends on multiple phosphorylations in an N-termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Uesugi M,Verdine GL

更新日期：2000-06-20 00:00:00

abstract：:Earlier we have shown that oscillations with a long period ("supercycles") may arise in two-locus systems experiencing cyclical selection with a short period. However, this mode of complex limiting behavior appeared to be possible for narrow ranges of parameters. Here we demonstrate that a multilocus system subjected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirzhner VM,Korol AB,Nevo E

更新日期：1996-06-25 00:00:00

abstract：:The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanekiyo T,Ban T,Aritake K,Huang ZL,Qu WM,Okazaki I,Mohri I,Murayama S,Ozono K,Taniike M,Goto Y,Urade Y

更新日期：2007-04-10 00:00:00

abstract：:To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H](+)-PN200-110 and [3H]azidopine. Regions of alpha 1 photolabeled by these ligands were then identified by antibody mapping of proteolytic fragments. Approximately 50% of the specific labeling b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Striessnig J,Murphy BJ,Catterall WA

更新日期：1991-12-01 00:00:00

abstract：:Xenogeneic monoclonal antibodies were prepared to the murine interleukin 2 (IL-2)-dependent HT2 cell line. One rat IgM monoclonal antibody (7D4) was identified that inhibited proliferation of the HT2 cells and of IL-2-dependent CTLL cells in the presence of crude rat IL-2 as well as of purified human IL-2. The level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malek TR,Robb RJ,Shevach EM

更新日期：1983-09-01 00:00:00

abstract：:Living organisms detect changes in temperature using thermosensory molecules. However, these molecules and/or their mechanisms for sensing temperature differ among organisms. To identify thermosensory molecules in plants, we investigated chloroplast positioning in response to temperature changes and identified a blue-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujii Y,Tanaka H,Konno N,Ogasawara Y,Hamashima N,Tamura S,Hasegawa S,Hayasaki Y,Okajima K,Kodama Y

更新日期：2017-08-22 00:00:00

abstract：:The intracellular pathogen Salmonella enterica serovar Typhimurium requires the mgtC gene to cause disease. The mgtC transcript includes a long leader region that harbors a short proline codon-rich ORF--termed mgtP--the translation of which is predicted to favor formation of one of two alternative stem-loop structures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EJ,Choi J,Groisman EA

更新日期：2014-02-25 00:00:00

abstract：:Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelshtein D,Werman A,Novick D,Barak S,Rubinstein M

更新日期：2013-04-30 00:00:00

abstract：:The Eemian (last interglacial, 130-115 ka) was likely the warmest of all interglacials of the last 800 ka, with summer Arctic temperatures 3-5 °C above present. Here, we present improved Eemian climate records from central Greenland, reconstructed from the base of the Greenland Ice Sheet Project 2 (GISP2) ice core. Ou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau AM,Bender ML,Robinson A,Brook EJ

更新日期：2016-08-30 00:00:00

abstract：:In monocots, many genes demonstrate a significant negative GC gradient, meaning that the GC content declines along the orientation of transcription. Such a gradient is not observed in the genes of the dicot plant Arabidopsis. In addition, a lack of homology is often observed when comparing the 5' end of the coding reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang N,Ferguson AA,Slotkin RK,Lisch D

更新日期：2011-01-25 00:00:00

abstract：:The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SY,Asano M

更新日期：2008-08-26 00:00:00

abstract：:Insights into the pathogenesis of migraine with aura may be gained from a study of human Ca(V)2.1 channels containing mutations linked to familial hemiplegic migraine (FHM). Here, we extend the previous single-channel analysis to human Ca(V)2.1 channels containing mutation V1457L. This mutation increased the channel o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tottene A,Fellin T,Pagnutti S,Luvisetto S,Striessnig J,Fletcher C,Pietrobon D

更新日期：2002-10-01 00:00:00

abstract：:A system is described for assembling infectious bacteriophage phi 6 nucleocapsids in vitro. Procapsids encoded by cDNA copies of genomic segment L in Escherichia coli were used to package and replicate viral RNA segments. The resulting filled particles were shown to be capable of infecting host cell spheroplasts after...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olkkonen VM,Gottlieb P,Strassman J,Qiao XY,Bamford DH,Mindich L

更新日期：1990-12-01 00:00:00

abstract：:The membrane proteins of peripheral light-harvesting complexes (LHCs) bind chlorophylls and carotenoids and transfer energy to the reaction centers for photosynthesis. LHCs of chlorophytes, chromophytes, dinophytes, and rhodophytes are similar in that they have three transmembrane regions and several highly conserved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grabowski B,Cunningham FX Jr,Gantt E

更新日期：2001-02-27 00:00:00

abstract：:Sarcoplasmic reticulum vesicles were exposed to various thiol-directed spin labels, and the position of the label on the inner or outer vesicle surface was investigated as a function of the ATPase (adenosinetriphosphatase; ATP phosphohydrolase, EC 3.6.1.3) chemical state. Previous measurements of label accessibility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Champeil P,Rigaud JL,Gary-Bobo CM

更新日期：1980-05-01 00:00:00