Protein dynamics investigated by inherent structure analysis.

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:Phosphoinositides are essential lipid regulators of trafficking and signaling pathways of all eukaryotic cells. Phosphatidylinositol 4-phosphate (PtdIns4P) is an intermediate in the synthesis of several important phosphoinositide species but also serves as a regulatory molecule in its own right. Phosphatidylinositol 4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szentpetery Z,Várnai P,Balla T

更新日期：2010-05-04 00:00:00

abstract：:Two types of benzodiazepine receptors have been demonstrated in mammalian tissues, one which is localized on neuronal elements in brain and the other, on glial cells and in peripheral tissues such as kidney. In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline car...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starosta-Rubinstein S,Ciliax BJ,Penney JB,McKeever P,Young AB

更新日期：1987-02-01 00:00:00

abstract：:Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carfí A,Smith CA,Smolak PJ,McGrew J,Wiley DC

更新日期：1999-10-26 00:00:00

abstract：:We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a bifunctional enzyme catalyzed the modification and demodification of its substrate protein, with both...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura AC,Jiang P,Van Wassenhove L,Del Vecchio D,Merajver SD,Ninfa AJ

更新日期：2010-06-01 00:00:00

abstract：:Newly translated tubulin molecules undergo a series of complex interactions with nascent chain-binding chaperones, including prefoldin (PFD) and chaperonin-containing TCP-1 (CCT). By screening for oryzalin hypersensitivity, we identified several mutants of Arabidopsis that have lesions in PFD subunits. The pfd6-1 muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Y,Deng Z,Paredez AR,DeBolt S,Wang ZY,Somerville C

更新日期：2008-11-18 00:00:00

abstract：:Cystic fibrosis (CF) is an autosomal recessive disorder, the most common lethal genetic disease in Caucasians. Respiratory disease is the major cause of morbidity and mortality. Indeed, 95% of CF patients die of respiratory failure. Pseudomonas aeruginosa, an opportunistic pathogen, chronically infects the lungs of ov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JD,Feng W,Gallup M,Kim JH,Gum J,Kim Y,Basbaum C

更新日期：1998-05-12 00:00:00

abstract：:In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maughan SC,Pasternak M,Cairns N,Kiddle G,Brach T,Jarvis R,Haas F,Nieuwland J,Lim B,Müller C,Salcedo-Sora E,Kruse C,Orsel M,Hell R,Miller AJ,Bray P,Foyer CH,Murray JA,Meyer AJ,Cobbett CS

更新日期：2010-02-02 00:00:00

abstract：:Cancer patients and tumor-bearing mice possess serum antibodies that recognize antigens expressed by cancer cells at the time of diagnosis. After diagnosis, cancers progress to more aggressive stages, most often by acquiring new genetic changes that can give rise to new proteins, some of which are antigenic. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spiotto MT,Reth MA,Schreiber H

更新日期：2003-04-29 00:00:00

abstract：:Recommended Daily Allowances (US RDA) of the Food and Drug Administration for ascorbic acid are higher than Recommended Dietary Allowances (set by the Food and Nutrition Board) for adults. There is a 6-fold margin between the requirement to prevent scurvy and the US RDA. The high requirement reported for the rhesus mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jukes TH

更新日期：1975-10-01 00:00:00

abstract：:Coat components localize to specific membrane domains, where they sort selected transmembrane proteins. To study how clathrin coats are stabilized on such domains and to identify the protein networks involved, we combined proteomic screens and in vitro liposome-based assays that recapitulate the fidelity of protein so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baust T,Czupalla C,Krause E,Bourel-Bonnet L,Hoflack B

更新日期：2006-02-28 00:00:00

abstract：:Brn-4 is a member of the POU transcription factor family and is expressed in the central nervous system. In this study, we addressed whether Brn-4 regulates expression of the D1A dopamine receptor gene. We found a functional Brn-4 responsive element in the intron of this gene by means of cotransfection chloramphenical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazawa H,Imafuku I,Minowa MT,Kanazawa I,Hamada H,Mouradian MM

更新日期：1996-10-15 00:00:00

abstract：:We propose a phylogeny for the evolution of tRNA that is based on the ubiquity and conservation of tRNA-like structures in the replication of contemporary genomes. This phylogeny is unique in suggesting that the function of tRNA in replication dates back to the very beginnings of life on earth, before the advent of te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maizels N,Weiner AM

更新日期：1994-07-19 00:00:00

abstract：:Most evidence supports the view that ER alpha is responsible for estrogen (ovarian estradiol, E(2))-induced proliferation in the epithelial cells of the mammary gland, but despite this, proliferating epithelial cells do not express ER alpha. We have examined this apparent paradox by studying the role of ER alpha and E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng G,Weihua Z,Warner M,Gustafsson JA

更新日期：2004-03-16 00:00:00

abstract：:Regulated proteolysis is required to execute many cellular programs. In Caulobacter crescentus, timely degradation of the master regulator CtrA by ClpXP protease is essential for cell-cycle progression and requires the colocalization of CtrA and RcdA. Here, we establish a biochemical framework to understand regulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chien P,Perchuk BS,Laub MT,Sauer RT,Baker TA

更新日期：2007-04-17 00:00:00

abstract：:The phenotype and antigenic specificity of cells secreting interleukin (IL) 4, IL-6, and interferon gamma was studied in mice during primary and secondary immune responses. T lymphocytes were the major source of interferon gamma, whereas non-B/non-T cells were the dominant source of IL-4 and IL-6 in the spleens of imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aoki I,Kinzer C,Shirai A,Paul WE,Klinman DM

更新日期：1995-03-28 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) genes encode transcription factors belonging to the orphan subfamily of the steroid/thyroid hormone receptor superfamily. Two COUP-TF counterparts have been cloned from mouse. In an attempt to study the function of these genes in the developing central...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu Y,Cooney AJ,Kuratani S,DeMayo FJ,Tsai SY,Tsai MJ

更新日期：1994-05-10 00:00:00

abstract：:Defects in clearing apoptotic debris disrupt tissue and immunological homeostasis, leading to autoimmune and inflammatory diseases. Herein, we report that macrophages from lupus-prone MRL/lpr mice have impaired lysosomal maturation, resulting in heightened ROS production and attenuated lysosomal acidification. Impaire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monteith AJ,Kang S,Scott E,Hillman K,Rajfur Z,Jacobson K,Costello MJ,Vilen BJ

更新日期：2016-04-12 00:00:00

abstract：:Chloroplast retrograde signaling networks are vital for chloroplast biogenesis, operation, and signaling, including excess light and drought stress signaling. To date, retrograde signaling has been considered in the context of land plant adaptation, but not regarding the origin and evolution of signaling cascades link...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Wang Y,Chan KX,Marchant DB,Franks PJ,Randall D,Tee EE,Chen G,Ramesh S,Phua SY,Zhang B,Hills A,Dai F,Xue D,Gilliham M,Tyerman S,Nevo E,Wu F,Zhang G,Wong GK,Leebens-Mack JH,Melkonian M,Blatt MR,Soltis P

更新日期：2019-03-12 00:00:00

abstract：:Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PCa. AR transcriptional reactivation is central to resistance, as evidenced by the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyquist MD,Li Y,Hwang TH,Manlove LS,Vessella RL,Silverstein KA,Voytas DF,Dehm SM

更新日期：2013-10-22 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:The first step in the formation of the protease resistant form (PrPSc) of prion proteins involves a conformational transition of the monomeric cellular form of PrPC to a more stable aggregation prone state PrPC*. A search of PDBselect and Escherichia coli and yeast genomes shows that the exact pattern of charges in he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dima RI,Thirumalai D

更新日期：2004-10-26 00:00:00

abstract：:A monomorphic anti-HLA-G monoclonal antibody (mAb) was obtained by immunization of HLA-B27/human beta 2-microglobulin double-transgenic mice with transfected murine L cells expressing both HLA-G and human beta 2-microglobulin. This mAb, designated BFL.1, specifically recognizes, by flow cytometry analysis, the immuniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bensussan A,Mansur IG,Mallet V,Rodriguez AM,Girr M,Weiss EH,Brem G,Boumsell L,Gluckman E,Dausset J

更新日期：1995-10-24 00:00:00

abstract：:Muscular dystrophy is a general term encompassing muscle disorders that cause weakness and wasting, typically leading to premature death. Membrane instability, as a result of a genetic disruption within the dystrophin-glycoprotein complex (DGC), is thought to induce myofiber degeneration, although the downstream mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millay DP,Goonasekera SA,Sargent MA,Maillet M,Aronow BJ,Molkentin JD

更新日期：2009-11-10 00:00:00

abstract：:The quantum mechanical problem of the hydrogen atom is treated by use of a finite difference equation in place of Schrödinger's differential equation. The exact solution leads to a wave vector energy expression that is readily converted to the Bohr-Rydberg formula. (The calculations here reported are limited to spheri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall FT

更新日期：1986-08-01 00:00:00

abstract：:The evolutionary process that occurs when a species colonizes a new environment provides an opportunity to explore the mechanisms underlying genetic adaptation, which is essential knowledge for understanding evolution and the maintenance of biodiversity. Atlantic herring has an estimated total breeding stock of about ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill J,Enbody ED,Pettersson ME,Sprehn CG,Bekkevold D,Folkvord A,Laikre L,Kleinau G,Scheerer P,Andersson L

更新日期：2019-09-10 00:00:00

abstract：:Activation of an anticancer innate immune response is highly desirable because of its inherent ability to generate an adaptive antitumor T-cell response. However, insufficient safety of innate immune modulators limits clinical use to topical applications. Toll-like receptor 5 (TLR5) agonists are favorably positioned a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brackett CM,Kojouharov B,Veith J,Greene KF,Burdelya LG,Gollnick SO,Abrams SI,Gudkov AV

更新日期：2016-02-16 00:00:00

abstract：:The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesis. However, our understanding of the underlying mechanisms remains ill-defined. We have developed a mouse paternal low-protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watkins AJ,Dias I,Tsuro H,Allen D,Emes RD,Moreton J,Wilson R,Ingram RJM,Sinclair KD

更新日期：2018-10-02 00:00:00

abstract：:Proteins, nucleic acids, and fluorescein-conjugated antibody are shown to be identifidable in situ via the fluorescence excited by the focused electron beam of a canning electron microscope. A molecular species is identified by its characteristic fluorescence spectrum and by a characteristic alteration of the spectrum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hough PV,McKinney WR,Ledbeter MC,Pollack RE,Moos HW

更新日期：1976-02-01 00:00:00

abstract：:Murine embryonal carcinoma (EC) cells are refractory to infection by retroviruses because retroviral long terminal repeat (LTR) enhancers have little activity in EC cells. A previous report described the isolation of clonal EC cell lines that express the integrated neomycin-resistance gene (neo) linked to the Moloney ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taketo M,Tanaka M

更新日期：1987-06-01 00:00:00