Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells.

abstract：:The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5', C-1', and C-4' positions of deoxyribose on each strand. In a dodecamer oligodeoxyribonucleotide containing the sequence AGC.GCT, a bistranded lesion staggered two nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kappen LS,Goldberg IH

更新日期：1992-08-01 00:00:00

abstract：:Homologous recombination is an important biological process that occurs in all organisms and facilitates genome rearrangements and repair of DNA double-strand breaks. Eukaryotic Rad51 proteins (Rad51sp or Rhp51 in fission yeast) are functional and structural homologs of bacterial RecA protein, an evolutionarily conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akamatsu Y,Dziadkowiec D,Ikeguchi M,Shinagawa H,Iwasaki H

更新日期：2003-12-23 00:00:00

abstract：:The peptide composition of purified Histocompatibility-2 (H-2) reactive glycoprotein fragments from two murine strains allelic at the H-2 locus (H-2(b) and H-2(d)) were compared by a cellulose thin-layer peptide mapping micro technique. Approximately 70 per cent of the theoretical maximum number of peptides produced b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimada A,Yamane K,Nathenson SG

更新日期：1970-03-01 00:00:00

abstract：:A somatic hybrid of ASL-1 leukemia cells [H-2a, thymus leukemia (TL)1,2,3, Thy-1b] and LM(TK)-cells [H-2-k, TL(-), Thy-1 (-), thymidine kinase deficient] was formed with the aid of inactivated Sendai virus. The selection of hybrid cell clones was facilitated by the inability of ASL-1 cells to grow in vitro and of LM(T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang W,Cohen EP

更新日期：1975-05-01 00:00:00

abstract：:Mutations in the DAX-1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome; NR0B1] gene cause X-linked AHC associated with hypogonadotropic hypogonadism. DAX-1 encodes an unusual orphan member of the nuclear hormone receptor superfamily, acting as a transcriptional rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann SG,Lalli E,Sassone-Corsi P

更新日期：2002-06-11 00:00:00

abstract：:The discipline-wide effort to database the fossil record at the occurrence level has made it possible to estimate marine invertebrate extinction and origination rates with much greater accuracy. The new data show that two biotic mechanisms have hastened recoveries from mass extinctions and confined diversity to a rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alroy J

更新日期：2008-08-12 00:00:00

abstract：:Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2), subsequently processed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kracker S,Imai K,Gardès P,Ochs HD,Fischer A,Durandy AH

更新日期：2010-12-21 00:00:00

abstract：:Taking advantage of a fluorescent Ca(2+) indicator selectively targeted to the trans-Golgi lumen, we here demonstrate that its Ca(2+) homeostatic mechanisms are distinct from those of the other Golgi subcompartments: (i) Ca(2+) uptake depends exclusively on the activity of the secretory pathway Ca(2+) ATPase1 (SPCA1),...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lissandron V,Podini P,Pizzo P,Pozzan T

更新日期：2010-05-18 00:00:00

abstract：:Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wabl M,Steinberg C

更新日期：1982-11-01 00:00:00

abstract：:The Black Death, originating in Asia, arrived in the Mediterranean harbors of Europe in 1347 CE, via the land and sea trade routes of the ancient Silk Road system. This epidemic marked the start of the second plague pandemic, which lasted in Europe until the early 19th century. This pandemic is generally understood as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmid BV,Büntgen U,Easterday WR,Ginzler C,Walløe L,Bramanti B,Stenseth NC

更新日期：2015-03-10 00:00:00

abstract：:The plant hormone abscisic acid (ABA) is produced in response to abiotic stresses and mediates stomatal closure in response to drought via recently identified ABA receptors (pyrabactin resistance/regulatory component of ABA receptor; PYR/RCAR). SLAC1 encodes a central guard cell S-type anion channel that mediates ABA-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt B,Brodsky DE,Xue S,Negi J,Iba K,Kangasjärvi J,Ghassemian M,Stephan AB,Hu H,Schroeder JI

更新日期：2012-06-26 00:00:00

abstract：:A recombinant plasmid containing a DNA segment complementary to rat liver albumin mRNA has been constructed, cloned, and used to examine the organization of albumin gene. The 18S fraction of total liver poly(A)-containing RNA was copied into a double-stranded cDNA by avian myeloblastosis virus reverse transcriptase an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kioussis D,Hamilton R,Hanson RW,Tilghman SM,Taylor JM

更新日期：1979-09-01 00:00:00

abstract：:Zea mays L. ssp. mays, or corn, one of the most important crops and a model for plant genetics, has a genome approximately 80% the size of the human genome. To gain global insight into the organization of its genome, we have sequenced the ends of large insert clones, yielding a cumulative length of one-eighth of the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Messing J,Bharti AK,Karlowski WM,Gundlach H,Kim HR,Yu Y,Wei F,Fuks G,Soderlund CA,Mayer KF,Wing RA

更新日期：2004-10-05 00:00:00

abstract：:The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by posttranslational cleavage. A highly specific, virally encoded protease is required for this essential proteolytic processing. In this study, the HIV protease gene prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debouck C,Gorniak JG,Strickler JE,Meek TD,Metcalf BW,Rosenberg M

更新日期：1987-12-01 00:00:00

abstract：:Active coping underlies a healthy stress response, but neural processes supporting such resilient coping are not well-known. Using a brief, sustained exposure paradigm contrasting highly stressful, threatening, and violent stimuli versus nonaversive neutral visual stimuli in a functional magnetic resonance imaging (fM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinha R,Lacadie CM,Constable RT,Seo D

更新日期：2016-08-02 00:00:00

abstract：:Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumová A,Trávnícková Z,Peters R,Schwartz WJ,Illnerová H

更新日期：1995-08-15 00:00:00

abstract：:By Southern blotting and hybridization analysis using 32P-labeled poly(dT-dG) . poly(dC-dA) as a probe, we have found, in eukaryotic genomes, a huge number of stretches of dT-dG alternating sequence, a sequence that has been shown to adopt the Z-DNA conformation under some conditions. This sequence was found in all eu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamada H,Petrino MG,Kakunaga T

更新日期：1982-11-01 00:00:00

abstract：:Vascular endothelial growth factor receptor-3 (VEGFR-3) is a major mediator of lymphangiogenesis. Recently, VEGFR-3 ligands, VEGF-C, and VEGF-D were reported to promote tumor lymphangiogenesis and lymphatic metastasis, and these processes were inhibited by blocking of the VEGFR-3-signaling pathway. Here, we have adapt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kubo H,Cao R,Brakenhielm E,Mäkinen T,Cao Y,Alitalo K

更新日期：2002-06-25 00:00:00

abstract：:The rapid induction of type I IFN is a central event of the innate defense against viral infections and is tightly regulated by a number of cellular molecules. Viral components induce strong type I IFN responses through the activation of toll-like receptors (TLRs) and intracellular cytoplasmic receptors such as an RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arimoto K,Funami K,Saeki Y,Tanaka K,Okawa K,Takeuchi O,Akira S,Murakami Y,Shimotohno K

更新日期：2010-09-07 00:00:00

abstract：:Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in close proximity to target proteins. This interaction is thought to depend on binding of the type II regulatory (RII) sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton KA,Johnson BD,Hausken ZE,Westenbroek RE,Idzerda RL,Scheuer T,Scott JD,Catterall WA,McKnight GS

更新日期：1997-09-30 00:00:00

abstract：:Activation energies for the individual steps of secretory and viral fusion are reported to be large [Oberhauser, A. F., Monck, J. R. & Fernandez, J. M. (1992) Biophys. J. 61, 800-809; Clague, M. J., Schoch, C., Zech, L. & Blumenthal, R. (1990) Biochemistry 29, 1303-1308]. Understanding the cause for these large activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee J,Lentz BR

更新日期：1998-08-04 00:00:00

abstract：:The annual migration of ∼1.2 million wildebeest (Connochaetes taurinus) through the Serengeti Mara Ecosystem is the largest remaining overland migration in the world. One of the most iconic portions of their migration is crossing of the Mara River, during which thousands drown annually. These mass drownings have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subalusky AL,Dutton CL,Rosi EJ,Post DM

更新日期：2017-07-18 00:00:00

abstract：:Maximum likelihood estimators and other direct optimization-based estimators dominated statistical estimation and prediction for decades. Yet, the principled foundations supporting their dominance do not apply to the discrete high-dimensional inference problems of the 21st century. As it is well known, statistical dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvalho LE,Lawrence CE

更新日期：2008-03-04 00:00:00

abstract：:Painful peripheral neuropathies are precipitated by nerve injury from disease or trauma. All such injuries will be accompanied by an inflammatory reaction, a neuritis, that will mobilize the immune system. The role of the inflammation itself is difficult to determine in the presence of structural damage to the nerve. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett GJ

更新日期：1999-07-06 00:00:00

abstract：:In most organisms, light plays a key role in the synchronization of the circadian timing system with the environmental day-night cycle. Light pulses that phase-shift the circadian clock also induce the expression of period (per) genes in vertebrates. Here, we report the cloning of a zebrafish per gene, zfper4, which i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vallone D,Gondi SB,Whitmore D,Foulkes NS

更新日期：2004-03-23 00:00:00

abstract：:Small molecules of biological origin continue to yield the most promising leads for drug design, but systematic approaches for exploring nature's cache of structural diversity are lacking. Here, we demonstrate the use of 2D NMR spectroscopy to screen a library of biorationally selected insect metabolite samples for pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deyrup ST,Eckman LE,McCarthy PH,Smedley SR,Meinwald J,Schroeder FC

更新日期：2011-06-14 00:00:00

abstract：:This study details the immune response to cartilage proteoglycan in experimental chronic IgG-induced immune synovitis. Antibodies reactive with purified rabbit proteoglycan monomer were observed in nine of nine rabbits with immune synovitis. IgG-immunized but nonsynovitic control animals with no pathology showed no an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoo JU,Kresina TF,Malemud CJ,Goldberg VM

更新日期：1987-02-01 00:00:00

abstract：:The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to determine the rates. Method I obtained the spontaneous mutation rate from the increase in the mutation frequency of a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren ST,Schultz RA,Chang CC,Wade MH,Trosko JE

更新日期：1981-05-01 00:00:00

abstract：:Mutant Escherichia coli strains in which export of the LamB protein (coded for by the lamB gene) to the outer membrane of the cell is prevented have been described previously. One of these mutant strains contains a small (12-base pair) deletion mutation within the region of the lamB gene that codes for the NH2-termina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emr SD,Silhavy TJ

更新日期：1983-08-01 00:00:00

abstract：:Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death. The majority of affected individuals harbor a loss-of-function mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards KL,Milligan CJ,Richardson RJ,Jancovski N,Grunnet M,Jacobson LH,Undheim EAB,Mobli M,Chow CY,Herzig V,Csoti A,Panyi G,Reid CA,King GF,Petrou S

更新日期：2018-08-21 00:00:00