Comparison of the peptide composition of two histocompatibility-2 alloantigens.

abstract：:The impact of ligand binding on nuclear receptor (NR) structure and the ability of target cells to distinguish between different receptor-ligand complexes are key determinants of the pharmacological activity of NR ligands. However, until relatively recently, these mechanistic insights have not been used in a prospecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph JD,Wittmann BM,Dwyer MA,Cui H,Dye DA,McDonnell DP,Norris JD

更新日期：2009-07-21 00:00:00

abstract：:Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked mu, delta, and kappa opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon receptor activation. However, little is known about which of the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KS,Lee KW,Lee KW,Im JY,Yoo JY,Kim SW,Lee JK,Nestler EJ,Han PL

更新日期：2006-03-07 00:00:00

abstract：:To achieve accurate aminoacylation of tRNAs with their cognate amino acids, errors in aminoacylation are corrected by the "editing" mechanism in several aminoacyl-tRNA synthetases. Phenylalanyl-tRNA synthetase (PheRS) hydrolyzes, or edits, misformed tyrosyl-tRNA with its editing domain in the beta subunit. We report t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasaki HM,Sekine S,Sengoku T,Fukunaga R,Hattori M,Utsunomiya Y,Kuroishi C,Kuramitsu S,Shirouzu M,Yokoyama S

更新日期：2006-10-03 00:00:00

abstract：:A rigorous numerical test of a hypothetical mechanism of a molecular motor should model explicitly the diffusive motion of the motor's degrees of freedom as well as the transition rates between the motor's chemical states. We present such a Brownian dynamics, mechanochemcial model of the coarse-grain structure of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craig EM,Linke H

更新日期：2009-10-27 00:00:00

abstract：:CD45, a protein tyrosine phosphatase that regulates Src family kinases, is important for regulating T cell and B cell receptor signaling; however, little is known about how CD45 regulates immunoreceptor tyrosine-based activation motif (ITAM)-dependent natural killer (NK) cell receptor signaling and the resulting effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hesslein DG,Takaki R,Hermiston ML,Weiss A,Lanier LL

更新日期：2006-05-02 00:00:00

abstract：:Spo11 and the Rad50-Mre11 complex have been indirectly implicated in processes associated with DNA replication. These proteins also have been shown to have early meiotic roles essential for the formation of a programmed DNA double-strand break known in Saccharomyces cerevisiae to initiate meiotic recombination. In bot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merino ST,Cummings WJ,Acharya SN,Zolan ME

更新日期：2000-09-12 00:00:00

abstract：:Therapeutic mAbs must not only bind to their target but must also be free from "developability issues" such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski's rule of five to guide the selection of molecules with appropriate biophysical properties, there is cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raybould MIJ,Marks C,Krawczyk K,Taddese B,Nowak J,Lewis AP,Bujotzek A,Shi J,Deane CM

更新日期：2019-03-05 00:00:00

abstract：:Nanos (Nos) is an evolutionarily conserved protein essential for the survival of primordial germ cells. In Drosophila, maternal Nos partitions into pole cells and suppresses apoptosis to permit proper germ-line development. However, how this critical event is regulated by Nos has remained elusive. Here, we report that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato K,Hayashi Y,Ninomiya Y,Shigenobu S,Arita K,Mukai M,Kobayashi S

更新日期：2007-05-01 00:00:00

abstract：:A critique is presented of the Lumsden-Wilson theory [Lumsden, C. J. & Wilson, E. O. (1980) Proc. Natl. Acad. Sci. USA 77, 4382-4386] of the transmission of cultural traits. An analysis of the underlying assumptions and the mathematical nature of the theory clarifies its essentially reductionist and determinist qualit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alper JS,Lange RV

更新日期：1981-06-01 00:00:00

abstract：:Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish NF,Gao F,Li H,Giorgi EE,Barbian HJ,Parrish EH,Zajic L,Iyer SS,Decker JM,Kumar A,Hora B,Berg A,Cai F,Hopper J,Denny TN,Ding H,Ochsenbauer C,Kappes JC,Galimidi RP,West AP Jr,Bjorkman PJ,Wilen CB,Doms RW

更新日期：2013-04-23 00:00:00

abstract：:Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machius M,Chuang JL,Wynn RM,Tomchick DR,Chuang DT

更新日期：2001-09-25 00:00:00

abstract：:Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muhich ML,Iida CT,Horikoshi M,Roeder RG,Parker CS

更新日期：1990-12-01 00:00:00

abstract：:Brief incubation of partially purified preparations of hormone-sensitive lipase from rat epididymal fat pads with ATP, Mg(++), cyclic adenosine 3':5'-monophosphate and rabbit muscle protein kinase (phosphorylase b kinase kinase) resulted in enhancement of lipolytic activity (44-93%). Little or no activation was observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttunen JK,Steinberg D,Mayer SE

更新日期：1970-09-01 00:00:00

abstract：:Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veesler D,Spinelli S,Mahony J,Lichière J,Blangy S,Bricogne G,Legrand P,Ortiz-Lombardia M,Campanacci V,van Sinderen D,Cambillau C

更新日期：2012-06-05 00:00:00

abstract：:Gastrin-releasing peptide (GRP) is a 27-amino acid neuroendocrine hormone that may play a role in the pathophysiology of small cell lung carcinoma. GRP and bombesin, a structurally related peptide, stimulate the growth of some cultured cell types. C-terminal GRP peptide analogs were developed that inhibited 6 nM bombe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leban JJ,Kull FC Jr,Landavazo A,Stockstill B,McDermed JD

更新日期：1993-03-01 00:00:00

abstract：:In systemic lupus erythematosus (SLE), T helper cells exhibit increased and prolonged expression of cell-surface CD40 ligand (CD154), spontaneously overproduce interleukin-10 (IL-10), but underproduce interferon-gamma (IFN-gamma). We tested the hypothesis that the imbalance of these gene products reflects skewed expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra N,Brown DR,Olorenshaw IM,Kammer GM

更新日期：2001-02-27 00:00:00

abstract：:We report here the crystal structure of the RuvB motor protein from Thermus thermophilus HB8, which drives branch migration of the Holliday junction during homologous recombination. RuvB has a crescent-like architecture consisting of three consecutive domains, the first two of which are involved in ATP binding and hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamada K,Kunishima N,Mayanagi K,Ohnishi T,Nishino T,Iwasaki H,Shinagawa H,Morikawa K

更新日期：2001-02-13 00:00:00

abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

更新日期：2015-12-08 00:00:00

abstract：:The growth or decay of population of a single species interacting with a large number of other species (or environment) according to the Volterra-Lotka model is investigated. When the environment is initially very close to its equilibrium level, the growth of a single species follows a generalized Verhulst law, contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R

更新日期：1973-11-01 00:00:00

abstract：:The involvement of chemical exchange in 2D IR heterodyne echo spectroscopy is characterized through the hydrogen-bond exchange between CH3OH and the CN of CH3CN. The exchange dynamics on the hydrogen-bond potential surfaces associated with different quantum states of the high-frequency CN stretching mode contributes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Hochstrasser RM

更新日期：2005-08-09 00:00:00

abstract：:Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catoire M,Alex S,Paraskevopulos N,Mattijssen F,Evers-van Gogh I,Schaart G,Jeppesen J,Kneppers A,Mensink M,Voshol PJ,Olivecrona G,Tan NS,Hesselink MK,Berbée JF,Rensen PC,Kalkhoven E,Schrauwen P,Kersten S

更新日期：2014-03-18 00:00:00

abstract：:Following proteolytic conversion of fibrinogen to fibrin, clot assembly commences with formation of double-stranded fibrils that subsequently branch extensively in forming a three-dimensional network. Plasmin digests of fibrin clots that had first been covalently crosslinked by plasma transglutaminase (factor XIIIa) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosesson MW,Siebenlist KR,Amrani DL,DiOrio JP

更新日期：1989-02-01 00:00:00

abstract：:Antibodies were raised against two synthetic peptides whose sequences correspond respectively to the COOH-terminal end (residues 501-516) of the protein encoded by the gene for the delta chain and to a proposed cytoplasmic region (residues 350-358) of the beta chain of the acetylcholine receptor from Torpedo californi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young EF,Ralston E,Blake J,Ramachandran J,Hall ZW,Stroud RM

更新日期：1985-01-01 00:00:00

abstract：:Murine embryonal carcinoma (EC) cells are refractory to infection by retroviruses because retroviral long terminal repeat (LTR) enhancers have little activity in EC cells. A previous report described the isolation of clonal EC cell lines that express the integrated neomycin-resistance gene (neo) linked to the Moloney ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taketo M,Tanaka M

更新日期：1987-06-01 00:00:00

abstract：:Understanding the origin, nature, and functional significance of complex patterns of neural activity, as recorded by diverse electrophysiological and neuroimaging techniques, is a central challenge in neuroscience. Such patterns include collective oscillations emerging out of neural synchronization as well as highly h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： di Santo S,Villegas P,Burioni R,Muñoz MA

更新日期：2018-02-13 00:00:00

abstract：:Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread. Actin tail formation by M. marinum is markedly reduced in macrophages deficient in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamm LM,Pak MA,Morisaki JH,Snapper SB,Rottner K,Lommel S,Brown EJ

更新日期：2005-10-11 00:00:00

abstract：:Atomic level characterization of proteins and other macromolecules in the living cell is challenging. Recent advances in NMR instrumentation and methods, however, have enabled in-cell studies with prospects for multidimensional spectral characterization of individual macromolecular components. We present NMR data on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustus AM,Reardon PN,Spicer LD

更新日期：2009-03-31 00:00:00

abstract：:Maximum likelihood estimators and other direct optimization-based estimators dominated statistical estimation and prediction for decades. Yet, the principled foundations supporting their dominance do not apply to the discrete high-dimensional inference problems of the 21st century. As it is well known, statistical dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvalho LE,Lawrence CE

更新日期：2008-03-04 00:00:00

abstract：:Almost all democratic societies evolved socially and politically out of authoritarian and nondemocratic regimes. These changes not only altered the allocation of economic resources in society but also the structure of political power. In this paper, we develop a framework for studying the dynamics of political and soc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acemoglu D,Egorov G,Sonin K

更新日期：2011-12-27 00:00:00

abstract：:We demonstrate theoretically and experimentally the spontaneous clustering of solitons in partially coherent wavefronts during the final stages of pattern formation initiated by modulation instability and noise. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sears SM,Martin H,Christodoulides DN,Segev M

更新日期：2002-04-16 00:00:00