A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

abstract：:O-GlcNAc glycosylation (or O-GlcNAcylation) is a dynamic, inducible posttranslational modification found on proteins associated with neurodegenerative diseases such as α-synuclein, amyloid precursor protein, and tau. Deletion of the O-GlcNAc transferase (ogt) gene responsible for the modification causes early postnata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang AC,Jensen EH,Rexach JE,Vinters HV,Hsieh-Wilson LC

更新日期：2016-12-27 00:00:00

abstract：:Exchange proteins directly activated by cAMP (Epac1 and Epac2) have been recently recognized as key players in β-adrenergic-dependent cardiac arrhythmias. Whereas Epac1 overexpression can lead to cardiac hypertrophy and Epac2 activation can be arrhythmogenic, it is unknown whether distinct subcellular distribution of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira L,Rehmann H,Lao DH,Erickson JR,Bossuyt J,Chen J,Bers DM

更新日期：2015-03-31 00:00:00

abstract：:Given the slow unfolding of what may become catastrophic changes to Earth's climate, many are understandably distraught by failures of public policy to rise to the magnitude of the challenge. Few in the science community would think to question the scientific response to the unfolding changes. However, is the science ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmer T,Stevens B

更新日期：2019-12-03 00:00:00

abstract：:Triton X-100-solubilized high-density microsomes from insulin-treated rat adipocytes exhibit a marked increase in serine/threonine and tyrosine kinase activities toward exogenous histone when compared to controls. The insulin-dependent activation of microsomal histone kinase activities occurs within the physiological ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu KT,Khalaf N,Czech MP

更新日期：1987-06-01 00:00:00

abstract：:Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans. Studies over the last 30 years conclude that the protein is a dimer, bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee Y,Willers C,Kunji ER,Crichton PG

更新日期：2015-06-02 00:00:00

abstract：:Genes carried by EcoRI endonuclease-generated fragments of Staphylococcus plasmid DNA have been covalently joined to the E. coli antibiotic-resistance plasmid pSC101, and the resulting hybrid molecules have been introduced into E. coli by transformation. The newly constructed plasmids replicate as biologically functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang AC,Cohen SN

更新日期：1974-04-01 00:00:00

abstract：:The role of rising atmospheric CO2 in modulating estuarine carbonate system dynamics remains poorly characterized, likely due to myriad processes driving the complex chemistry in these habitats. We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pacella SR,Brown CA,Waldbusser GG,Labiosa RG,Hales B

更新日期：2018-04-10 00:00:00

abstract：:Insufficient and disrupted sleep is linked with cardiovascular and metabolic dysregulation and morbidity. The current study examines the degree to which differences in sleep between black/African American (AA) and white/European American (EA) adults explain racial differences in cardiometabolic (CMB) disease risk. Tot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtis DS,Fuller-Rowell TE,El-Sheikh M,Carnethon MR,Ryff CD

更新日期：2017-08-15 00:00:00

abstract：:In the last decade, a number of quantitative epidemiological studies of specific diseases have been done in developing countries that for the first time allow estimation of the total burden of disease (mortality and morbidity) attributable to use of solid fuels in adult women and young children, who jointly receive th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith KR

更新日期：2000-11-21 00:00:00

abstract：:Egg activation is the process in which mature oocytes are released from developmental arrest and gain competency for embryonic development. In Drosophila and other arthropods, eggs are activated by mechanical pressure in the female reproductive tract, whereas in most other species, eggs are activated by fertilization....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Wolfner MF

更新日期：2019-09-17 00:00:00

abstract：:Chinese hamster-human somatic cell hybrids were analyzed for the expression of human galactose-1-phosphate uridyltransferase (GALT; UDPglucose:alpha-D-galactose-1-phosphate uridyltransferase, EC 2.7.7.12) by electrophoresis and for the presence of human chromosomes cytogenetically with the aid of Q-banding. Three of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohandas T,Sparkes RS,Sparkes MC,Shulkin JD

更新日期：1977-12-01 00:00:00

abstract：:Forkhead box P3 (FOXP3)-positive Treg cells are crucial for maintaining immune homeostasis. FOXP3 cooperates with its binding partners to elicit Treg cells' signature and function, but the molecular mechanisms underlying the modulation of the FOXP3 complex remain unclear. Here we report that Deleted in breast cancer 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao Y,Tang J,Chen W,Li Q,Nie J,Lin F,Wu Q,Chen Z,Gao Z,Fan H,Tsun A,Shen J,Chen G,Liu Z,Lou Z,Olsen NJ,Zheng SG,Li B

更新日期：2015-06-23 00:00:00

abstract：:This is a multinanosecond molecular dynamics study of a bio-nano complex formed by a carbon nanoparticle, a buckyball C(60), and a biological molecule, an antibody, with high binding affinity and specificity. In the simulation, the ball is completely desolvated by the binding site of the antibody by means of a nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noon WH,Kong Y,Ma J

更新日期：2002-04-30 00:00:00

abstract：:The mechanisms underlying analgesia related to social touch are not clear. While recent research highlights the role of the empathy of the observer to pain relief in the target, the contribution of social interaction to analgesia is unknown. The current study examines brain-to-brain coupling during pain with interpers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein P,Weissman-Fogel I,Dumas G,Shamay-Tsoory SG

更新日期：2018-03-13 00:00:00

abstract：:We have carried out partial amino acid sequence analysis of a putative nuclear pore complex protein (nucleoporin) of rat that reacts with wheat germ agglutinin and with the polyspecific monoclonal antibody 414. Surprisingly, these partial amino acid sequence data revealed a high degree of similarity with the human CAN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraemer D,Wozniak RW,Blobel G,Radu A

更新日期：1994-02-15 00:00:00

abstract：:Individual organisms are complex in a special way. The organization and function of their parts seem directed toward a purpose: the survival and reproduction of that individual. Groups of organisms are different. They may also be complex, but that is usually because their parts, the individual organisms, are working a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strassmann JE,Queller DC

更新日期：2007-05-15 00:00:00

abstract：:Molecular modeling and two-dimensional NMR techniques enable us to identify structural features in the third variable region (V3) loop of the human immunodeficiency virus (HIV) surface glycoprotein gp120, in particular the principal neutralizing determinant (PND), that remain conserved despite the sequence variation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontenot JD,Gatewood JM,Mariappan SV,Pau CP,Parekh BS,George JR,Gupta G

更新日期：1995-01-03 00:00:00

abstract：:Evidence for hydrogen bonding between 5'-ribonucleotides in water has been obtained from a 220-MHz proton magnetic resonance study of nitrogenous protons. The amino groups of GMP, AMP, and CMP exhibit proton resonance lines which are somewhat broadened by proton exchange with the solvent at 0 degrees ; their downfield...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raszka M,Kaplan NO

更新日期：1972-08-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis, including hypothalamic corticotropin-releasing hormone (CRH) and pituitary corticotropin, is one of the first endocrine systems to develop during fetal life, probably because glucocorticoid secretion is necessary for the maturation of many essential fetal organs. Consiste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venihaki M,Carrigan A,Dikkes P,Majzoub JA

更新日期：2000-06-20 00:00:00

abstract：:Leukocyte adherence to endothelium is in part mediated by the transient expression of endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial surfaces stimulated by tumor necrosis factor alpha (TNF), interleukin (IL) 1, or bacterial lipopolysaccharide (LPS). The intracellular factors controlling induction of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery KF,Osborn L,Hession C,Tizard R,Goff D,Vassallo C,Tarr PI,Bomsztyk K,Lobb R,Harlan JM

更新日期：1991-08-01 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:The nanoscale distributions of electron density and electric fields in GaAs semiconductor devices are displayed with NMR experiments. The spectra are sensitive to the changes to the nuclear-spin Hamiltonian that are induced by perturbations delivered in synchrony with a line-narrowing pulse sequence. This POWER (pertu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempf JG,Miller MA,Weitekamp DP

更新日期：2008-12-23 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00

abstract：:Growth factor-induced signals govern the expression of three D-type cyclins, which, in turn, function as regulatory subunits of cyclin-dependent kinases (cdks) to control cell cycle transitions during the late G1 interval. 32D myeloid cells, which self-renew as uncommitted precursors in interleukin 3 (IL-3), express c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato JY,Sherr CJ

更新日期：1993-12-15 00:00:00

abstract：:The freezing tolerance of protoplasts isolated from nonacclimated rye leaves (Secale cereale L. cv Puma) was significantly altered by using a pH-induced protoplastliposome fusion technique to modify the lipid composition of the plasma membrane. The increase in freezing tolerance was elicited by fusion with liposomes c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steponkus PL,Uemura M,Balsamo RA,Arvinte T,Lynch DV

更新日期：1988-12-01 00:00:00

abstract：:The rate constants for CO binding to the five-coordinate ferrous iron complexes of 5,10,15,20-[pyromellitoyl(tetrakis-o-oxyoxyphenyl)]porphyrin and 5,10,15,20-[pyromellitoyl(tetrakis-o-oxypropoxyphenyl)]porphyrin have been measured and compared with the corresponding rate constants for other hemes and hemoproteins. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rose EJ,Venkatasubramanian PN,Swartz JC,Jones RD,Basolo F,Hoffman BM

更新日期：1982-09-01 00:00:00

abstract：:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ,Hartzell HC,Yoshikami D

更新日期：1975-08-01 00:00:00

abstract：:The efficacy of boron neutron capture therapy (BNCT) for the treatment of intracerebrally implanted rat gliosarcomas was tested. Preferential accumulation of 10B in tumors was achieved by continuous infusion of the sulfhydryl borane dimer, Na4(10)B24H22S2, at a rate of 45-50 micrograms of 10B per g of body weight per ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joel DD,Fairchild RG,Laissue JA,Saraf SK,Kalef-Ezra JA,Slatkin DN

更新日期：1990-12-01 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:Gene-environment interactions are important determinants of cancer risk. Traditionally, gene-environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we demonstrate that a disti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JD,Davis BJ,Cai SL,Barrett JC,Conti CJ,Walker CL

更新日期：2005-06-14 00:00:00