Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.

abstract：:For more than a century we have understood that our brain's left hemisphere is the primary site for processing language, yet why this is so has remained more elusive. Using positron emission tomography, we report cerebral blood flow activity in profoundly deaf signers processing specific aspects of sign language in ke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petitto LA,Zatorre RJ,Gauna K,Nikelski EJ,Dostie D,Evans AC

更新日期：2000-12-05 00:00:00

abstract：:CCAAT enhancer-binding protein-alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of adipocyte genes during adipogenesis. Nuclear factor C/EBP undifferentiated protein (CUP), an isoform of activator protein-2alpha (AP-2alpha), binds to repressive elements in the C/EBPalpha gene promoter, silencing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang MS,Lane MD

更新日期：2000-11-07 00:00:00

abstract：:Topographic sensory maps are a prominent feature of the adult primate brain. Here, we asked whether topographic representations of the body are present at birth. Using functional MRI (fMRI), we find that the newborn somatomotor system, spanning frontoparietal cortex and subcortex, comprises multiple topographic repres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arcaro MJ,Schade PF,Livingstone MS

更新日期：2019-12-03 00:00:00

abstract：:Chromatin boundaries or insulators modulate enhancer-promoter interactions in complex genetic loci. However, the mechanism underlying insulator activity is not known. Previous studies showed that the activity of the Drosophila suHw insulator is abolished by the tandem arrangement (pairing) of the insulator elements, s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder P,Cai HN

更新日期：2003-04-29 00:00:00

abstract：:The temporal distribution of the major extinctions over the past 250 million years has been investigated statistically using various forms of time series analysis. The analyzed record is based on variation in extinction intensity for fossil families of marine vertebrates, invertebrates, and protozoans and contains 12 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raup DM,Sepkoski JJ Jr

更新日期：1984-02-01 00:00:00

abstract：:Oxidation of genomic DNA forms the guanine lesion 7,8-dihydro-8-oxoguanine (8-oxoG). When in the template base position during DNA synthesis the 8-oxoG lesion has dual coding potential by virtue of its anti- and syn-conformations, base pairing with cytosine and adenine, respectively. This impacts mutagenesis, because ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batra VK,Shock DD,Beard WA,McKenna CE,Wilson SH

更新日期：2012-01-03 00:00:00

abstract：:Multiple epiphyseal dysplasia (MED) is a degenerative cartilage condition shown in some cases to be caused by mutations in genes encoding cartilage oligomeric matrix protein or type IX collagen. We studied a family with autosomal dominant MED affecting predominantly the knee joints and a mild proximal myopathy. Geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bönnemann CG,Cox GF,Shapiro F,Wu JJ,Feener CA,Thompson TG,Anthony DC,Eyre DR,Darras BT,Kunkel LM

更新日期：2000-02-01 00:00:00

abstract：:In FRTL5 rat thyroid cells, norepinephrine, by interacting with alpha 1-adrenergic receptors, stimulates inositol phosphate formation, through activation of phospholipase C, and arachidonic acid release. Recent studies have shown that GTP-binding proteins couple several types of receptors to phospholipase C activation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burch RM,Luini A,Axelrod J

更新日期：1986-10-01 00:00:00

abstract：:The phosphorylation state of the Na,K-ATPase alpha subunit has been examined in 32P-labeled sciatic nerves of control and streptozotocin-treated diabetic rats. Intact nerves were challenged with protein kinase (PK) modulators and alpha-subunit 32P labeling was analyzed after immunoprecipitation. In control nerves, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borghini I,Geering K,Gjinovci A,Wollheim CB,Pralong WF

更新日期：1994-06-21 00:00:00

abstract：:Transposition is a multistep process in which a transposable element DNA sequence moves from its original genetic location to a new site. Early steps in this process include the formation of a transposition complex in which the end sequences of the transposable element are brought together in a structurally precise fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IYu,Kil YV,Reznikoff WS

更新日期：1994-11-08 00:00:00

abstract：:Introduction of a sequence encoding 147 amino acids from human immunodeficiency virus type I (HIV-1) strain MN glycoprotein gp120 into the RNA genome of the stably attenuated Mengo virus strain vM16 yielded an infectious recombinant virus, vMLN450, which expressed the heterologous HIV-1 sequence along with the normal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altmeyer R,Escriou N,Girard M,Palmenberg A,van der Werf S

更新日期：1994-10-11 00:00:00

abstract：:The error frequency of in vitro DNA synthesis using a natural DNA template has been measured with a biological assay for nucleotide substitutions. phiX174 DNA containing an amber mutation was copied in vitro by Escherichia coli DNA polymerase I, and the reversion frequency of the progeny DNA was determined by transfec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weymouth LA,Loeb LA

更新日期：1978-04-01 00:00:00

abstract：:High-quality protein crystals meant for structural analysis by X-ray diffraction have been grown by various methods. The observation of dynamical diffraction in protein crystals is an interesting topic because dynamical diffraction generally occurs in perfect crystals such as Si crystals. However, to our knowledge, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki R,Koizumi H,Hirano K,Kumasaka T,Kojima K,Tachibana M

更新日期：2018-04-03 00:00:00

abstract：:Hypophosphatasia is a heritable form of rickets/osteomalacia with extremely variable clinical expression. Severe forms are inherited in an autosomal recessive fashion; the mode of transmission of mild forms is uncertain. The biochemical hallmark of hypophosphatasia is deficient activity of the tissue-nonspecific isozy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henthorn PS,Raducha M,Fedde KN,Lafferty MA,Whyte MP

更新日期：1992-10-15 00:00:00

abstract：:The Ca2+/calmodulin (CaM)-dependent protein phosphatase calcineurin is rapidly phosphorylated (0.8 mol of 32PO4 per mol of 60-kDa subunit of calcineurin) by brain Ca2+/CaM-dependent protein kinase II (CaM-kinase II). This reaction requires the autophosphorylated, Ca2+-independent form of CaM-kinase II since Ca2+/CaM b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto Y,King MM,Soderling TR

更新日期：1988-09-01 00:00:00

abstract：:Repetitive sequences are hotspots of evolution at multiple levels. However, due to difficulties involved in their assembly and analysis, the role of repeats in tumor evolution is poorly understood. We developed a rigorous motif-based methodology to quantify variations in the repeat content, beyond microsatellites, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Persi E,Prandi D,Wolf YI,Pozniak Y,Barnabas GD,Levanon K,Barshack I,Barbieri C,Gasperini P,Beltran H,Faltas BM,Rubin MA,Geiger T,Koonin EV,Demichelis F,Horn D

更新日期：2019-08-20 00:00:00

abstract：:The substrate specificity of thermophilic xylose isomerase from Clostridium thermosulfurogenes was examined by using predictions from the known crystal structure of the Arthrobacter enzyme and site-directed mutagenesis of the thermophile xylA gene. The orientation of glucose as a substrate in the active site of the th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng M,Lee C,Bagdasarian M,Zeikus JG

更新日期：1991-05-01 00:00:00

abstract：:Genetic and biochemical studies on enzymes known to be involved in regulating DNA supercoiling yield a complex spectrum of effects on the Escherichia coli SOS system. Previous studies indicated that only inhibition of DNA gyrase by antibiotics that act on the DNA gyrase A subunit results in turning on the E. coli SOS ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith CL

更新日期：1983-05-01 00:00:00

abstract：:Random graphs are useful models of social and technological networks. To date, most of the research in this area has concerned geometric properties of the graphs. Here we focus on processes taking place on the network. In particular we are interested in how their behavior on networks differs from that in homogeneously...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durrett R

更新日期：2010-03-09 00:00:00

abstract：:Plants constantly undergo external mechanical loads such as wind or touch and respond to these stimuli by acclimating their growth processes. A fascinating feature of this mechanical-induced growth response is that it can occur rapidly and at long distance from the initial site of stimulation, suggesting the existence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louf JF,Guéna G,Badel E,Forterre Y

更新日期：2017-10-17 00:00:00

abstract：:Both stem cells and mast cells express c-kit and proliferate after exposure to c-kit ligand. Mutations in c-kit may enhance or interfere with the ability of c-kit receptor to initiate the intracellular pathways resulting in cell proliferation. These observations suggested to us that mastocytosis might in some patients...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagata H,Worobec AS,Oh CK,Chowdhury BA,Tannenbaum S,Suzuki Y,Metcalfe DD

更新日期：1995-11-07 00:00:00

abstract：:Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular mechanisms contributing to the functions of these structures are poorly understood. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tekinay AB,Nong Y,Miwa JM,Lieberam I,Ibanez-Tallon I,Greengard P,Heintz N

更新日期：2009-03-17 00:00:00

abstract：:A comparison of five constant region sequences of human and mouse k and lambda immunoglobulin chains has been undertaken in order to reveal sequence homologies and evolutionary relationships. Simultaneously, a comparison with the three-dimensional structure of one mouse k-chain (McPC 603) has suggested structural reas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kabat EA,Padlan EA,Davies DR

更新日期：1975-07-01 00:00:00

abstract：:After fertilization of the sea urchin, Strongyl-ocentrotus purpuratus, a crosslinked fertilization membrane is formed; the crosslinks (dityrosine residues) are synthesized in a reaction catalyzed by an ovoperoxidase that is released from the cortical granules during fertilization. The substrate for ovoperoxidase activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foerder CA,Klebanoff SJ,Shapiro BM

更新日期：1978-07-01 00:00:00

abstract：:Solution at 2.5-A resolution of the three-dimensional structure of H-2Ld with a single nine-residue peptide provides a structural basis for understanding its unique interaction with beta-2 microglobulin (beta2m) and peptide. Consistent with the biological data that show an unusually weak association of Ld with beta2m,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balendiran GK,Solheim JC,Young AC,Hansen TH,Nathenson SG,Sacchettini JC

更新日期：1997-06-24 00:00:00

abstract：:Here, we identified and characterized a Ly49 family member, designated as Ly49Q. The Ly49q gene encodes a 273-aa protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) at the N terminus of its cytoplasmic domain. We show that the ITIM of Ly49Q can recruit SHP-2 and SHP-1 in a tyrosine phosphorylation-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyama-Sorimachi N,Tsujimura Y,Maruya M,Onoda A,Kubota T,Koyasu S,Inaba K,Karasuyama H

更新日期：2004-01-27 00:00:00

abstract：:This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang ACY,Chang ACH,Kirillova A,Sasagawa K,Su W,Weber G,Lin J,Termglinchan V,Karakikes I,Seeger T,Dainis AM,Hinson JT,Seidman J,Seidman CE,Day JW,Ashley E,Wu JC,Blau HM

更新日期：2018-09-11 00:00:00

abstract：:Most higher eukaryotic tubulins are separated into alpha- and beta-tubulin when electrophoresed in NaDodSO4- denaturing gels, while many lower eukaryotic tubulins are poorly resolved under these conditions, which include a stacking gel (pH 6.80) and a separating gel (pH 8.80). By lowering the pH of the separating gel ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suprenant KA,Hays E,LeCluyse E,Dentler WL

更新日期：1985-10-01 00:00:00

abstract：:Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpotential D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh BH,Zhu MY,Lee JK,Kelly IM,Bahiraei F

更新日期：1997-11-11 00:00:00

abstract：:Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamase A,Muraguchi T,Naka K,Tanaka S,Kinoshita M,Hoshii T,Ohmura M,Shugo H,Ooshio T,Nakada M,Sawamoto K,Onodera M,Matsumoto K,Oshima M,Asano M,Saya H,Okano H,Suda T,Hamada J,Hirao A

更新日期：2009-10-06 00:00:00