Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues.

abstract：:Previously metal-ion sites have been used as structural and functional probes in seven transmembrane receptors (7TM), but as yet all the engineered sites have been inactivating. Based on presumed agonist interaction points in transmembrane III (TM-III) and -VII of the beta(2)-adrenergic receptor, in this paper we cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elling CE,Thirstrup K,Holst B,Schwartz TW

更新日期：1999-10-26 00:00:00

abstract：:It is well known that two regular tetrahedra can be combined with a single regular octahedron to tile (complete fill) three-dimensional Euclidean space . This structure was called the "octet truss" by Buckminster Fuller. It was believed that such a tiling, which is the Delaunay tessellation of the face-centered cubic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway JH,Jiao Y,Torquato S

更新日期：2011-07-05 00:00:00

abstract：:Activated thiol-Sepharose [agarose-(glutathione-2-pyridyl disulfide) conjugate] has been used to immobilize proteins with a single or a few thiol groups via disulfide bridges. The immobilized proteins were subsequently proteolytically degraded. After washing, the thiol-containing peptides were eluted with a reducing a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egorov TA,Svenson A,Rydén L,Carlsson J

更新日期：1975-08-01 00:00:00

abstract：:The molecular mechanism by which the homodimeric enzyme Cu/Zn superoxide dismutase (SOD) causes neural damage in amytrophic lateral sclerosis is yet poorly understood. A striking, as well as an unusual, feature of SOD is that it maintains intrasubunit disulfide bonds in the reducing environment of the cytosol. Here, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindberg MJ,Normark J,Holmgren A,Oliveberg M

更新日期：2004-11-09 00:00:00

abstract：:Downstream placement of a strong transcriptional termination signal has made possible the cloning of bacteriophage T5 promoters known to exhibit high signal strength. The cloning system constructed contains two easily assayable indicator functions whose expression is controlled by the integration of promoters and term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gentz R,Langner A,Chang AC,Cohen SN,Bujard H

更新日期：1981-08-01 00:00:00

abstract：:The strikingly high incidence of obstructed labor due to the disproportion of fetal size and the mother's pelvic dimensions has puzzled evolutionary scientists for decades. Here we propose that these high rates are a direct consequence of the distinct characteristics of human obstetric selection. Neonatal size relativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitteroecker P,Huttegger SM,Fischer B,Pavlicev M

更新日期：2016-12-20 00:00:00

abstract：:A plasmid that consists of an 812-base-pair segment containing the replication origin of plasmid ColE1 and of a 1240-base-pair segment containing a beta-lactamase gene has been constructed. The plasmid DNA has three principal sites where transcription is initiated in vitro. One is located in the ColE1 segment 555 nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Itoh T,Tomizawa J

更新日期：1980-05-01 00:00:00

abstract：:Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa-Pereira AP,Tininini S,Strobl B,Alonzi T,Schlaak JF,Is'harc H,Gesualdo I,Newman SJ,Kerr IM,Poli V

更新日期：2002-06-11 00:00:00

abstract：:31P nuclear magnetic relaxation rates for phosphocreatine in intact frog gastrocnemius were compared with those observed in model solutions at 4 degrees, a temperature at which muscle maintains its physiological state for at least 5 hr. Both nuclear Overhauser effect and spin-lattice relaxation rate (1/T1) experiments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Burt CT

更新日期：1977-10-01 00:00:00

abstract：:Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy⋅s-1). Compared with conventional dose-rate (CONV; 0.07-0.1 Gy⋅s-1) modalities, we showed that FLASH did not cause radiation-induced deficits in learning and memory in mice. Moreover, 6 months a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montay-Gruel P,Acharya MM,Petersson K,Alikhani L,Yakkala C,Allen BD,Ollivier J,Petit B,Jorge PG,Syage AR,Nguyen TA,Baddour AAD,Lu C,Singh P,Moeckli R,Bochud F,Germond JF,Froidevaux P,Bailat C,Bourhis J,Vozenin MC

更新日期：2019-05-28 00:00:00

abstract：:Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine ES,Crozier RA,Black IB,Plummer MR

更新日期：1998-08-18 00:00:00

abstract：:In this contribution, we study situations in which nanoparticles in a fluid are strongly heated, generating high heat fluxes. This situation is relevant to experiments in which a fluid is locally heated by using selective absorption of radiation by solid particles. We first study this situation for different types of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merabia S,Shenogin S,Joly L,Keblinski P,Barrat JL

更新日期：2009-09-08 00:00:00

abstract：:Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowtell D,Fu P,Simon M,Senior P

更新日期：1992-07-15 00:00:00

abstract：:Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirotsou M,Zhang Z,Deb A,Zhang L,Gnecchi M,Noiseux N,Mu H,Pachori A,Dzau V

更新日期：2007-01-30 00:00:00

abstract：:Knowledge of the relative contributions of different water sources to intracellular fluids and body water is important for many fields of study, ranging from animal physiology to paleoclimate. The intracellular fluid environment of cells is challenging to study due to the difficulties of accessing and sampling the con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Yu C,Wang F,Chang SJ,Yao J,Blake RE

更新日期：2016-05-24 00:00:00

abstract：:IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by IFN-alpha/beta are the ubiquitin-like ISG15 protein and its E1- (Ube1L) and E2- (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins. It is likely that ISG15 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Denison C,Huibregtse JM,Gygi S,Krug RM

更新日期：2005-07-19 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) trans-activator protein, Tat, specifically stimulates transcription from the viral long terminal repeat. Tat binds to an RNA stem-loop structure encoded by the trans-activation response region (TAR). To test whether TAR is functional when displaced downstream of the star...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Churcher MJ,Lowe AD,Gait MJ,Karn J

更新日期：1995-03-14 00:00:00

abstract：:Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas EA,Dean B,Pavey G,Sutcliffe JG

更新日期：2001-03-27 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:The neotropical Heliconius butterflies are famous examples of Müllerian mimicry, due to the diverse array of shared, brightly colored wing patterns that advertise the butterflies' unpalatability. The parallel geographical variation in these patterns within several widespread species has been invoked to support the con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower AV

更新日期：1994-07-05 00:00:00

abstract：:Why do members of the public share some scientific findings and not others? What can scientists do to increase the chances that their findings will be shared widely among nonscientists? To address these questions, we integrate past research on the psychological drivers of interpersonal communication with a study exami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milkman KL,Berger J

更新日期：2014-09-16 00:00:00

abstract：:Serological expression cloning of antigens eliciting a humoral immune response to a syngeneic mouse sarcoma identified pem (mouse placenta and embryonic expression gene) as a new member of the cancer/testis family. To identify the human homologue of pem, mouse pem sequences and pem-related expressed sequence tags from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono T,Kurashige T,Harada N,Noguchi Y,Saika T,Niikawa N,Aoe M,Nakamura S,Higashi T,Hiraki A,Wada H,Kumon H,Old LJ,Nakayama E

更新日期：2001-03-13 00:00:00

abstract：:Increased clouds and precipitation normally decrease the diurnal temperature range (DTR) and thus have commonly been offered as explanation for the trend of reduced DTR observed for many land areas over the last several decades. Observations show, however, that the DTR was reduced most in dry regions and especially in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou L,Dickinson RE,Tian Y,Vose RS,Dai Y

更新日期：2007-11-13 00:00:00

abstract：:Metallic nanoscale structures are capable of supporting surface plasmon polaritons (SPPs), propagating collective electron oscillations with tight spatial confinement at the metal surface. SPPs represent one of the most promising structures to beat the diffraction limit imposed by conventional dielectric optics. Ag na...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Pausauskie P,Huang J,Yang P

更新日期：2009-12-15 00:00:00

abstract：:We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH latera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olulade OA,Seydell-Greenwald A,Chambers CE,Turkeltaub PE,Dromerick AW,Berl MM,Gaillard WD,Newport EL

更新日期：2020-09-22 00:00:00

abstract：:In recent years, a large body of research has demonstrated that judgments and behaviors can propagate from person to person. Phenomena as diverse as political mobilization, health practices, altruism, and emotional states exhibit similar dynamics of social contagion. The precise mechanisms of judgment propagation are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moussaïd M,Herzog SM,Kämmer JE,Hertwig R

更新日期：2017-04-18 00:00:00

abstract：:We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishikawa J,Yamashita A,Mikami Y,Hoshino Y,Kurita H,Hotta K,Shiba T,Hattori M

更新日期：2004-10-12 00:00:00

abstract：:In virtually every real-life situation humans are confronted with complex and cluttered visual environments that contain a multitude of objects. Because of the limited capacity of the visual system, objects compete for neural representation and cognitive processing resources. Previous work has shown that such attentio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser D,Stein T,Peelen MV

更新日期：2014-07-29 00:00:00

abstract：:Lambdoid phages form clear plaques and show reduced ability to establish immunity in strains of Escherichia coli that lack adenylate cyclase or catabolite activator protein. The absence of the activator protein or cyclic AMP reduces the frequency of lysogenization, but does not prevent steady-state repressor synthesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grodzicker T,Arditti RR,Eisen H

更新日期：1972-02-01 00:00:00

abstract：:Bright, photostable, and nontoxic fluorescent contrast agents are critical for biological imaging. "Self-healing" dyes, in which triplet states are intramolecularly quenched, enable fluorescence imaging by increasing fluorophore brightness and longevity, while simultaneously reducing the generation of reactive oxygen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pati AK,El Bakouri O,Jockusch S,Zhou Z,Altman RB,Fitzgerald GA,Asher WB,Terry DS,Borgia A,Holsey MD,Batchelder JE,Abeywickrama C,Huddle B,Rufa D,Javitch JA,Ottosson H,Blanchard SC

更新日期：2020-09-29 00:00:00