The complete genomic sequence of Nocardia farcinica IFM 10152.

abstract：:Viral membrane fusion proteins of class I are trimers in which the protomeric unit is a complex of a surface subunit (SU) and a fusion active transmembrane subunit (TM). Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sjöberg M,Löving R,Lindqvist B,Garoff H

更新日期：2017-03-07 00:00:00

abstract：:The numbers and proportion of neurons in areas and regions of cortex were determined for a single cortical hemisphere from two prosimian galagos, one New World owl monkey, one Old World macaque monkey, and one baboon. The results suggest that there is a common plan of cortical organization across the species examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins CE,Airey DC,Young NA,Leitch DB,Kaas JH

更新日期：2010-09-07 00:00:00

abstract：:Hierarchical cellular structures are ubiquitous in nature because of their low-density, high-specific properties, and multifunctionality. Inspired by these systems, we created lightweight ceramic architectures composed of closed-cell porous struts patterned in the form of hexagonal and triangular honeycombs by direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muth JT,Dixon PG,Woish L,Gibson LJ,Lewis JA

更新日期：2017-02-21 00:00:00

abstract：:Paleoclimate studies suggest that increased global warmth during the Eocene epoch was greatly amplified at high latitudes, a state that climate models cannot fully reproduce. However, proxy estimates of Eocene near-Antarctic sea surface temperatures (SSTs) have produced widely divergent results at similar latitudes, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglas PM,Affek HP,Ivany LC,Houben AJ,Sijp WP,Sluijs A,Schouten S,Pagani M

更新日期：2014-05-06 00:00:00

abstract：:Histone methylation has an important role in transcriptional regulation. However, unlike H3K4 and H3K9 methylation, the role of H4K20 monomethylation (H4K20me-1) in transcriptional regulation remains unclear. Here, we show that Wnt3a specifically stimulates H4K20 monomethylation at the T cell factor (TCF)-binding elem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Nie F,Wang S,Li L

更新日期：2011-02-22 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:Members of the order Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence (TRS) was identified. Nine TRSs were previously reported for the arterivirus Simian hemorrhagic fever virus (SHFV). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di H,Madden JC Jr,Morantz EK,Tang HY,Graham RL,Baric RS,Brinton MA

更新日期：2017-10-17 00:00:00

abstract：:In vitro translation of cellular poly(A)+ RNA coupled with immunoprecipitation was developed as a technique for characterizing 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptors and assessing receptor mRNA activity. Cell-free translation of poly(A)+ RNA isolated from chicken intestine revealed two immunoprecipitable fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangelsdorf DJ,Pike JW,Haussler MR

更新日期：1987-01-01 00:00:00

abstract：:Copper homeostasis is essential for bacterial pathogen fitness and infection, and has been the focus of a number of recent studies. In Salmonella, envelope protection against copper overload and macrophage survival depends on CueP, a major copper-binding protein in the periplasm. This protein is also required to deliv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pezza A,Pontel LB,López C,Soncini FC

更新日期：2016-10-11 00:00:00

abstract：:The biological function of the soluble form of the amyloid beta-protein (ABP) was examined by assaying its interaction with neuronal receptors expressed in Xenopus oocytes. ABP weakly activated tachykinin receptors, but in the presence of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4- propionate-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura H,Schubert D

更新日期：1993-08-15 00:00:00

abstract：:Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO. EPO has been shown to protect primary cultured neurons from N-methyl-D-aspartate (NMDA) receptor-mediated glutamate toxicity. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakanaka M,Wen TC,Matsuda S,Masuda S,Morishita E,Nagao M,Sasaki R

更新日期：1998-04-14 00:00:00

abstract：:Over the past five decades, ultra high vacuum (uhv) techniques applied to well-defined single-crystal samples (the "surface science paradigm") have transformed our understanding of fundamental surface chemistry. To translate this success to the world of realistic heterogeneous catalysis, however, requires one seriousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyngaran P,Madden DC,Jenkins SJ,King DA

更新日期：2011-01-18 00:00:00

abstract：:The protein defective in hereditary hemochromatosis, called HFE, is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Its association with beta2M was previously shown to be necessary for its stability, normal intracellular processing, and cell surface expression in transfected COS ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Waheed A,Grubb JH,Zhou XY,Tomatsu S,Fleming RE,Costaldi ME,Britton RS,Bacon BR,Sly WS

更新日期：2002-03-05 00:00:00

abstract：:Despite extensive studies, the structural basis for the mechanochemical coupling in the rotary molecular motor F1-ATPase (F1) is still incomplete. We performed single-molecule FRET measurements to monitor conformational changes in the stator ring-α3β3, while simultaneously monitoring rotations of the central shaft-γ. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawa M,Okazaki K,Kobayashi M,Matsui T,Hummer G,Masaike T,Nishizaka T

更新日期：2016-05-24 00:00:00

abstract：:We present a physical and molecular genetic characterization of Drosophila melanogaster TFIIE (dTFIIE), a component of the basal RNA polymerase II transcription apparatus. We have purified dTFIIE to near homogeneity from nuclear extracts of Drosophila embryos and found that it is composed of two subunits with apparent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Hansen SK,Ratts R,Zhou S,Snook AJ,Zehring W

更新日期：1997-01-21 00:00:00

abstract：:Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor NE,Van Dort CJ,Kenny JD,Pei J,Guidera JA,Vlasov KY,Lee JT,Boyden ES,Brown EN,Solt K

更新日期：2016-11-08 00:00:00

abstract：:Agrobacterium is a unique model system as well as a major biotechnological tool for genetic manipulation of plant cells. It is still unknown, however, whether host cellular factors exist that are limiting for infection, and whether their overexpression in plant cells can increase the efficiency of the infection. Here,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzfira T,Vaidya M,Citovsky V

更新日期：2002-08-06 00:00:00

abstract：:Experiments were performed to ascertain the degree to which the amount of amino acids might be one of the regulatory factors that control the activity of the nucleolar RNA polymerase. Assays of the enzymatic activity were done with isolated nuclei from cells incubated with low and high concentrations of amino acids. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franze-Fernández MT,Pogo AO

更新日期：1971-12-01 00:00:00

abstract：:Estimates of relative rates of molecular evolution from a DNA-hybridization phylogeny for 26 hummingbird species provide evidence for a negative association between elevation and rate of single-copy genome evolution. This effect of elevation on rate remains significant even after taking into account a significant nega...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bleiweiss R

更新日期：1998-01-20 00:00:00

abstract：:We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response. This response is anti-idiotypic in nature because lymphocytes so primed display accelerated memory responses only when restimulated by autologous lymphoblasts that have been a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suciu-Foca N,Reed E,Rohowsky C,Kung P,King DW

更新日期：1983-02-01 00:00:00

abstract：:The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spirochetes must migrate through complex, polymeric environments such as the basement membrane of the tick...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harman MW,Dunham-Ems SM,Caimano MJ,Belperron AA,Bockenstedt LK,Fu HC,Radolf JD,Wolgemuth CW

更新日期：2012-02-21 00:00:00

abstract：:Global climate change is expected to have broad ecological consequences for species and communities. Attempts to forecast these consequences usually assume that changes in air or water temperature will translate into equivalent changes in a species' organismal body temperature. This simple change is unlikely because a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilman SE,Wethey DS,Helmuth B

更新日期：2006-06-20 00:00:00

abstract：:The acetylcholine receptor is a protein that contains certain critical disulfide bonds. Experiments were designed to determine the role such bonds might play in the physiological activity of the receptor. Modification of the receptor with sodium bisulfite and diamide produced an increase in the time constants of the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinacker A,Zuazaga DC

更新日期：1981-12-01 00:00:00

abstract：:In t(15;17) acute promyelocytic leukemia, all-trans retinoic acid (RA) induces leukemic cell maturation in vitro and remission in acute promyelocytic leukemia patients, but in vivo treatments invariably lead to relapse with resistance to RA. NB4, a maturation-inducible cell line, and NB4-RAr sublines (R1 and R2) displ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruchaud S,Duprez E,Gendron MC,Houge G,Genieser HG,Jastorff B,Doskeland SO,Lanotte M

更新日期：1994-08-30 00:00:00

abstract：:Heavy electronic states originating from the f atomic orbitals underlie a rich variety of quantum phases of matter. We use atomic scale imaging and spectroscopy with the scanning tunneling microscope to examine the novel electronic states that emerge from the uranium f states in URu(2)Si(2). We find that, as the tempe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aynajian P,da Silva Neto EH,Parker CV,Huang Y,Pasupathy A,Mydosh J,Yazdani A

更新日期：2010-06-08 00:00:00

abstract：:Synthesis of mouse metallothionein (MT)-I and MT-II is transcriptionally induced by the synthetic glucocorticoid, dexamethasone (DEX) or both in vivo as well as in numerous cell lines. However, the location(s) of a glucocorticoid response element (GRE) has not been described. The observation that a marked MT-I gene, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly EJ,Sandgren EP,Brinster RL,Palmiter RD

更新日期：1997-09-16 00:00:00

abstract：:Cryptococcus neoformans (CN), an encapsulated, ubiquitous environmental yeast, is pathogenic for humans, primarily those with compromised immune function. CN is believed to be a facultative intracellular pathogen. Time-lapsed video microscopy revealed that yeast began to replicate and divide 2 hours after ingestion by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tucker SC,Casadevall A

更新日期：2002-03-05 00:00:00

abstract：:Gyrate atrophy (GA), a recessive eye disease involving progressive loss of vision due to chorioretinal degeneration, is associated with a deficiency of the mitochondrial enzyme ornithine aminotransferase (OATase; ornithine-oxo-acid aminotransferase; L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13) with consequent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramesh V,McClatchey AI,Ramesh N,Benoit LA,Berson EL,Shih VE,Gusella JF

更新日期：1988-06-01 00:00:00

abstract：:The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux in macrophages, promotes bile acid synthesis in liver, and inhibits intestinal cholesterol absorption, actions that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joseph SB,McKilligin E,Pei L,Watson MA,Collins AR,Laffitte BA,Chen M,Noh G,Goodman J,Hagger GN,Tran J,Tippin TK,Wang X,Lusis AJ,Hsueh WA,Law RE,Collins JL,Willson TM,Tontonoz P

更新日期：2002-05-28 00:00:00

abstract：:The rRNA intervening sequence of Tetrahymena is a catalytic RNA molecule, or "ribozyme." A tertiary-structure model of the active site of this ribozyme has been constructed based on comparative sequence analysis of related group I intervening sequences, data on the accessibility of each nucleotide to chemical and enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Cech TR

更新日期：1987-12-01 00:00:00