Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

abstract：:The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collin L,Usiello A,Erbs E,Mathis C,Borrelli E

更新日期：2004-01-06 00:00:00

abstract：:Valproic acid (VPA) is an anticonvulsant drug that is also used to treat migraines and bipolar disorder. Its proposed biological targets include human voltage-gated sodium channels, among other membrane proteins. We used the prokaryotic NavMs sodium channel, which has been shown to be a good exemplar for drug binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zanatta G,Sula A,Miles AJ,Ng LCT,Torella R,Pryde DC,DeCaen PG,Wallace BA

更新日期：2019-12-10 00:00:00

abstract：:Mutant alleles at the dilute unconventional myosin heavy chain locus cause diluted coat color, opisthotonic seizures, and death. The dilute coat color phenotype is caused by irregular clumping of pigment in the hair, but amounts of melanin are unchanged from wild-type controls. The melanocyte phenotype has been descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provance DW Jr,Wei M,Ipe V,Mercer JA

更新日期：1996-12-10 00:00:00

abstract：:Activity-dependent means of altering calcium (Ca(2)(+)) influx are assumed to be of great physiological consequence, although definitive tests of this assumption have only begun to emerge. Facilitation and inactivation offer two opposing, activity-dependent means of altering Ca(2+) influx via cardiac Ca(v)1.2 calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaich A,Welling A,Fischer S,Wegener JW,Köstner K,Hofmann F,Moosmang S

更新日期：2010-06-01 00:00:00

abstract：:Translocations involving chromosome band 11q23, found in acute lymphoid and myeloid leukemias, disrupt the MLL gene. This gene encodes a putative transcription factor with homology to the zinc fingers and other domains of the Drosophila trithorax gene product and to the "AT-hook" motif of high mobility group proteins....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeleznik-Le NJ,Harden AM,Rowley JD

更新日期：1994-10-25 00:00:00

abstract：:There is a hypothesis that dangerous diseases such as bovine spongiform encephalopathy, Creutzfeldt-Jakob, Alzheimer's, fatal familial insomnia, and several others are induced by propagation of wrong or misfolded conformations of some vital proteins. If for some reason the misfolded conformations were acquired by many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Małolepsza E,Boniecki M,Kolinski A,Piela L

更新日期：2005-05-31 00:00:00

abstract：:In this paper is presented the theory of a class of locally convex lattices (L-lattices) of real functions which generalize the classical Lebesgue spaces. The monotone and dominated convergence theorems for convergence almost everywhere and sequential and order completeness of such lattices are established. These resu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogdanowicz WM

更新日期：1970-06-01 00:00:00

abstract：:By using a simplified model of small open liquid-like clusters with surface effects, in the gas phase, it is shown how the statistical thermodynamics of small systems can be extended to include metastable supersaturated gaseous states not too far from the gas-liquid equilibrium transition point. To accomplish this, on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL,Chamberlin RV

更新日期：1998-10-27 00:00:00

abstract：:Protein-DNA interactions were studied in vivo at the region containing a human DNA replication origin, located at the 3' end of the lamin B2 gene and partially overlapping the promoter of another gene, located downstream. DNase I treatment of nuclei isolated from both exponentially growing and nonproliferating HL-60 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimitrova DS,Giacca M,Demarchi F,Biamonti G,Riva S,Falaschi A

更新日期：1996-02-20 00:00:00

abstract：:The estrogen receptor (E2R) from rabbit uterus has an enhanced affinity for BrdUrd-substituted DNA compared to unsubstituted DNA. Increasing levels of BrdUrd substitution (from 0 to 100%) in a DNA sample are associated with increasingly tighter binding of E2R to that DNA as measured by equilibrium competition experime...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kallos J,Fasy TM,Hollander VP,Bick MD

更新日期：1978-10-01 00:00:00

abstract：:Genomes exhibit diverse patterns of species-specific GC content, GC and AT skews, codon bias, and mutation bias. Despite intensive investigations and the rapid accumulation of sequence data, the causes of these a priori different genome biases have not been agreed on and seem multifactorial and idiosyncratic. We show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vetsigian K,Goldenfeld N

更新日期：2009-01-06 00:00:00

abstract：:A mutant (ML 308-22) was isolated from Escherichia coli ML 308, which had lost the normal capacity to accumulate lactose analogs despite an increase in the membrane carrier activity. The exit of thiomethylgalactoside was much faster than normal, accounting for the inability of the cell to maintain high intracellular c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong PT,Kashket ER,Wilson TH

更新日期：1970-01-01 00:00:00

abstract：:The five alpha genes of herpes simplex virus 1 are the first set of genes to be expressed after infection. Previous studies have shown that alpha genes resident in eukaryotic cells are induced by infection with herpes simplex virus 1 or 2 but not by other herpesviruses and indicate that the alpha trans-inducing factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellett PE,McKnight JL,Jenkins FJ,Roizman B

更新日期：1985-09-01 00:00:00

abstract：:Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback-controlled confinement of single cells w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cattin CJ,Düggelin M,Martinez-Martin D,Gerber C,Müller DJ,Stewart MP

更新日期：2015-09-08 00:00:00

abstract：:TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease. Here, we show that inhibition of TAK1 in mice by a cardiac-specific dominant-negative mutation evokes electrophysiological and biochemical properties reminiscent of hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie M,Zhang D,Dyck JR,Li Y,Zhang H,Morishima M,Mann DL,Taffet GE,Baldini A,Khoury DS,Schneider MD

更新日期：2006-11-14 00:00:00

abstract：:Bathorhodopsin-rhodopsin difference spectra of native 11-cis-rhodopsin and regenerated 9-cis-rhodopsin were measured at room temperature with a double-beam laser spectrophotometer after excitation at 532 nm. A detailed analysis of data obtained at 85 psec after excitation suggests that the bathorhodopsins generated fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spalink JD,Reynolds AH,Rentzepis PM,Sperling W,Applebury ML

更新日期：1983-04-01 00:00:00

abstract：:The 1,3-1,4-beta-glucanase from Bacillus macerans (wtGLU) and the 1, 4-beta-xylanase from Bacillus subtilis (wtXYN) are both single-domain jellyroll proteins catalyzing similar enzymatic reactions. In the fusion protein GluXyn-1, the two proteins are joined by insertion of the entire XYN domain into a surface loop of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aÿ J,Götz F,Borriss R,Heinemann U

更新日期：1998-06-09 00:00:00

abstract：:The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahmann JD,Wecking DA,Putter V,Lowenhaupt K,Kim YG,Schmieder P,Oschkinat H,Rich A,Schade M

更新日期：2004-03-02 00:00:00

abstract：:A 16-amino acid residue peptide derived from a consensus motif of natural ferredoxins incorporates a tetranuclear iron sulfur cluster under physiological conditions. Successful assembly of the [4Fe-4S]2+/1+ cluster within a monomeric peptide was demonstrated using size exclusion chromatography, UV-visible, visible CD,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibney BR,Mulholland SE,Rabanal F,Dutton PL

更新日期：1996-12-24 00:00:00

abstract：:Deleting an important active-site residue of diphtheria toxin, glutamic acid-148, reduces the toxin's ADP-ribosyltransferase activity by a factor of greater than 10(4). We considered using this mutation to construct a recombinant toxoid for expression by live attenuated vaccines and explored second-site mutations that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Killeen KP,Escuyer V,Mekalanos JJ,Collier RJ

更新日期：1992-07-01 00:00:00

abstract：:OLE (ornate, large, extremophilic) RNAs comprise a class of structured noncoding RNAs (ncRNAs) found in many extremophilic bacteria species. OLE RNAs constitute one of the longest and most widespread bacterial ncRNA classes whose major biochemical function remains unknown. In the Gram-positive alkaliphile Bacillus hal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris KA,Zhou Z,Peters ML,Wilkins SG,Breaker RR

更新日期：2018-07-03 00:00:00

abstract：:Phage phi 29 terminal protein, p3, essentially pure, was isolated in a denatured form from viral particles, and anti-p3 antiserum was obtained. A radioimmunoassay to detect and quantitate protein p3 was developed. By using this assay, native protein p3 was highly purified from Escherichia coli cells harboring a gene 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prieto I,Lázaro JM,García JA,Hermoso JM,Salas M

更新日期：1984-03-01 00:00:00

abstract：:Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with myopathy (NLSDM) characterized by a systemic TG accumulation. Mice with a genetic deletion of ATGL (AKO) also accumulate TG in many tissues. However, neither NLS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber R,Hofer P,Taschler U,Voshol PJ,Rechberger GN,Kotzbeck P,Jaeger D,Preiss-Landl K,Lord CC,Brown JM,Haemmerle G,Zimmermann R,Vidal-Puig A,Zechner R

更新日期：2015-11-10 00:00:00

abstract：:The recent discovery of superconductivity with relatively high transition temperature (Tc) in the layered iron-based quaternary oxypnictides La[O(1-x)F(x)] FeAs by Kamihara et al. [Kamihara Y, Watanabe T, Hirano M, Hosono H (2008) Iron-based layered superconductor La[O1-xFx] FeAs (x = 0.05-0.12) with Tc = 26 K. J Am C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu FC,Luo JY,Yeh KW,Chen TK,Huang TW,Wu PM,Lee YC,Huang YL,Chu YY,Yan DC,Wu MK

更新日期：2008-09-23 00:00:00

abstract：:The regulation of major histocompatibility complex class II gene expression is directly involved in the control of normal and abnormal immune responses. In humans, HLA-DR, -DQ, and -DP class II heterodimers are encoded by a family of alpha- and beta-chain genes clustered in the major histocompatibility complex. Their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reith W,Barras E,Satola S,Kobr M,Reinhart D,Sanchez CH,Mach B

更新日期：1989-06-01 00:00:00

abstract：:The Mpemba effect occurs when a hot system cools faster than an initially colder one, when both are refrigerated in the same thermal reservoir. Using the custom-built supercomputer Janus II, we study the Mpemba effect in spin glasses and show that it is a nonequilibrium process, governed by the coherence length ξ of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baity-Jesi M,Calore E,Cruz A,Fernandez LA,Gil-Narvión JM,Gordillo-Guerrero A,Iñiguez D,Lasanta A,Maiorano A,Marinari E,Martin-Mayor V,Moreno-Gordo J,Muñoz Sudupe A,Navarro D,Parisi G,Perez-Gaviro S,Ricci-Tersenghi F,Rui

更新日期：2019-07-30 00:00:00

abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joos F,Spahni R

更新日期：2008-02-05 00:00:00

abstract：:Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the yeast Saccharomyces cerevisiae, are excellent models of asymmetric cell division, this phenotype occ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorpe PH,Bruno J,Rothstein R

更新日期：2009-04-21 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are potent mitogens for various cancers, including carcinoma of the prostate. In several experimental cancers, treatment with antagonists of growth hormone-releasing hormone (GH-RH) produces a reduction in IGF-I and -II, concomitant to inhibition of tumor growth. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamharzi N,Schally AV,Koppán M,Groot K

更新日期：1998-07-21 00:00:00

abstract：:In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maita N,Okada K,Hatakeyama K,Hakoshima T

更新日期：2002-02-05 00:00:00