11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

abstract：:Phosphorylation plays a critical role in controlling the function of cytoskeletal assemblies but no direct method yet exists to measure the phosphorylation state of proteins at the level of individual molecules and assemblies. Herein, we apply scanning transmission electron microscopy in combination with electron ener...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leapman RD,Gallant PE,Reese TS,Andrews SB

更新日期：1997-07-22 00:00:00

abstract：:Phosphatidylionsitol 4,5-bisphosphate (PIP(2)), a substrate of phospholipase C, has recently been recognized to regulate membrane-associated proteins and act as a signal molecule in phospholipase C-linked Gq-coupled receptor (GqPCR) pathways. However, it is not known whether PIP(2) depletion induced by GqPCRs can act ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho H,Lee D,Lee SH,Ho WK

更新日期：2005-03-22 00:00:00

abstract：:Insertion mutations previously constructed within the proximal region of the yeast invertase signal sequence did not interfere with secretion or glycosylation of the enzyme. We now describe deletion mutations within the same signal sequence. Large deletions truncating the hydrophobic core of the signal peptide prevent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perlman D,Raney P,Halvorson HO

更新日期：1986-07-01 00:00:00

abstract：:Prostate carcinoma is the second leading cause of death from malignancy in men in the United States. Prostate cancer cells express type I insulin-like growth factor receptor (IGF-IR) and prostate cancer selectively metastazises to bone, which is an environment rich in insulin-like growth factors (IGFs), thereby suppor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burfeind P,Chernicky CL,Rininsland F,Ilan J,Ilan J

更新日期：1996-07-09 00:00:00

abstract：:Low-frequency thalamocortical oscillations that underlie drowsiness and slow-wave sleep depend on rhythmic inhibition of relay cells by neurons in the reticular nucleus (RTN) under the influence of corticothalamic fibers that branch to innervate RTN neurons and relay neurons. To generate oscillations, input to RTN pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golshani P,Liu XB,Jones EG

更新日期：2001-03-27 00:00:00

abstract：:Phototropin is a blue light photoreceptor for tropic responses, relocation of chloroplasts, and stomata opening in plants. Phototropin has two chromophoric domains named light-oxygen-voltage-sensing (LOV) 1 and 2 in the N-terminal half, and a serine/threonine (Ser/Thr) protein kinase motif in the C-terminal half. Conc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuoka D,Tokutomi S

更新日期：2005-09-13 00:00:00

abstract：:Cancer cells are characterized by genetic mutations that deregulate cell proliferation and suppress cell death. To arrest the uncontrolled replication of malignant cells, conventional chemotherapies systemically disrupt cell division, causing diverse and often severe side effects as a result of collateral damage to no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venkataraman S,Dirks RM,Ueda CT,Pierce NA

更新日期：2010-09-28 00:00:00

abstract：:Insufficient and disrupted sleep is linked with cardiovascular and metabolic dysregulation and morbidity. The current study examines the degree to which differences in sleep between black/African American (AA) and white/European American (EA) adults explain racial differences in cardiometabolic (CMB) disease risk. Tot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtis DS,Fuller-Rowell TE,El-Sheikh M,Carnethon MR,Ryff CD

更新日期：2017-08-15 00:00:00

abstract：:Transport of sodium, chloride, and taurocholate was studied in primary cultures of adult rat hepatocytes incubated in a balanced electrolyte solution containing 150 mM NaCl, various concentrations of taurocholate, and (22)Na, (36)Cl, [(3)H]taurocholate, and 3-O-[(3)H]methyl-D-glucose. Lithium chloride, choline chlorid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharschmidt BF,Stephens JE

更新日期：1981-02-01 00:00:00

abstract：:Under anesthesia with sodium pentobarbital, the sciatic nerves of rats were transected bilaterally, and a catheter was inserted into the central end of the left renal artery. After an initial flush, an Alzet pump was attached to the catheter, containing various concentrations of glycyl-L-glutamine (Gly-Gln), methylpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koelle GB,Han MS

更新日期：1990-12-01 00:00:00

abstract：:Energy transfer is enhanced by translational diffusion of the donor and acceptor [Steinberg, I. Z. & Katchalski, E. (1968) J. Chem. Phys. 48, 2404-2410]. The effect of diffusion on energy transfer depends on Dtau(0)/s(2), in which D is the sum of the diffusion coefficients of the donor and acceptor, tau(0) is the life...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas DD,Carlsen WF,Stryer L

更新日期：1978-12-01 00:00:00

abstract：:The light-harvesting phycobilisome in cyanobacteria and red algae requires the lyase-catalyzed chromophorylation of phycobiliproteins. There are three functionally distinct lyase families known. The heterodimeric E/F type is specific for attaching bilins covalently to α-subunits of phycocyanins and phycoerythrins. Unl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Höppner A,Xu QZ,Gärtner W,Scheer H,Zhou M,Zhao KH

更新日期：2017-12-12 00:00:00

abstract：:The traditional disciplines of science are grounded in the observation and measurement of object properties. Recent advances in digital computer technology have spawned numerous computer-based imaging systems that extend the range of observation and measurement into realms that would otherwise be inaccessible. More im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck RN

更新日期：1993-11-01 00:00:00

abstract：:From the types of ring chromosomes induced in x-irradiated Chinese hamster ovary (CHO) cells, we deduce the existence of switches in the polarity of chromosomal DNA; if there is a continuous DNA double helix along the full length of the chromosome then the polarity switches imply 3'-3' and 5'-5' phosphodiester linkage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff S,Lindsley DL,Peacock WJ

更新日期：1976-03-01 00:00:00

abstract：:A nitrogenase-inspired biomimetic chalcogel system comprising double-cubane [Mo2Fe6S8(SPh)3] and single-cubane (Fe4S4) biomimetic clusters demonstrates photocatalytic N2 fixation and conversion to NH3 in ambient temperature and pressure conditions. Replacing the Fe4S4 clusters in this system with other inert ions such...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Kelley MS,Wu W,Banerjee A,Douvalis AP,Wu J,Zhang Y,Schatz GC,Kanatzidis MG

更新日期：2016-05-17 00:00:00

abstract：:E12 and E47 are two non-tissue-specific helix-loop-helix (HLH) transcription factors encoded by the E2A gene. Previous studies suggested that they are involved in regulation of differentiation in many tissue types including muscle, blood, and nerve through direct heterodimer interactions with tissue-specific HLH prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang Y,Kim CG,Bartelmez S,Cheng P,Groudine M,Weintraub H

更新日期：1992-12-15 00:00:00

abstract：:Chromosome rearrangements, such as large deletions, inversions, or translocations, mediate migration of large DNA segments within or between chromosomes, which can have major effects on cellular genetic control. A method for chromosome manipulation would be very useful for studying the consequences of large-scale DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Deursen J,Fornerod M,Van Rees B,Grosveld G

更新日期：1995-08-01 00:00:00

abstract：:The rise of inorganic-biological hybrid organisms for solar-to-chemical production has spurred mechanistic investigations into the dynamics of the biotic-abiotic interface to drive the development of next-generation systems. The model system, Moorella thermoacetica-cadmium sulfide (CdS), combines an inorganic semicond...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kornienko N,Sakimoto KK,Herlihy DM,Nguyen SC,Alivisatos AP,Harris CB,Schwartzberg A,Yang P

更新日期：2016-10-18 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:We have previously extracted a protein from inflammatory mouse granuloma that fully protects normal mice against lethal Listeria monocytogenes infection. We now report that polyclonal antibodies directed against this protein react with a human urinary fraction that also provides full protection of normal mice against ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontan E,Saklani-Jusforgues H,Fauve RM

更新日期：1992-05-15 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:The molecular basis of bacterial cell morphogenesis remains largely an open question. Here we discover a morphogenic protein, RodZ, which is widely conserved across the bacterial kingdom. In Caulobacter crescentus, RodZ is essential for viability and is involved in all aspects of this organism's complex morphology. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alyahya SA,Alexander R,Costa T,Henriques AO,Emonet T,Jacobs-Wagner C

更新日期：2009-01-27 00:00:00

abstract：:Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has been implicated in the repair of topoisomerase I (Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3'-end DNA alterations including 3'-phosphoglycolate and 3'-abasic sites, and ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das BB,Dexheimer TS,Maddali K,Pommier Y

更新日期：2010-11-16 00:00:00

abstract：:The torI gene has been identified by using a genetic multicopy approach as a negative regulator of the torCAD operon that encodes the trimethylamine N-oxide reductase respiratory system in Escherichia coli. The negative effect was due to a previously unidentified small ORF (66 aa) of phage origin that we called torI f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ansaldi M,Théraulaz L,Méjean V

更新日期：2004-06-22 00:00:00

abstract：:We have studied the effects of food restriction (FR) and substitution of fish oil (FO; omega 3) for corn oil (CO; omega 6) on breast tumor incidence and survival in mouse mammary tumor virus/v-Ha-ras transgenic (Onco) mice. The diets were as follows: group 1, 5% (wt/wt) CO fed ad libitum (AL); group 2, 5% CO, restrict...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandes G,Chandrasekar B,Troyer DA,Venkatraman JT,Good RA

更新日期：1995-07-03 00:00:00

abstract：:Nerve growth factor (NGF) serum levels were measured in 49 patients with asthma and/or rhinoconjunctivitis and/or urticaria-angioedema. Clinical and biochemical parameters, such as bronchial reactivity, total and specific serum IgE levels, and circulating eosinophil cationic protein levels, were evaluated in relation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonini S,Lambiase A,Bonini S,Angelucci F,Magrini L,Manni L,Aloe L

更新日期：1996-10-01 00:00:00

abstract：:The results of previous preclinical and clinical studies have identified angiogenin (ANG) as a potentially important target for anticancer therapy. Here we report the design and implementation of a high-throughput screening assay to identify small molecules that bind to the ribonucleolytic active site of ANG, which is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kao RY,Jenkins JL,Olson KA,Key ME,Fett JW,Shapiro R

更新日期：2002-07-23 00:00:00

abstract：:Cholera and enterotoxigenic Escherichia coli (ETEC) are among the most common causes of acute infantile gastroenteritis globally. We previously developed a rice-based vaccine that expressed cholera toxin B subunit (MucoRice-CTB) and had the advantages of being cold chain-free and providing protection against cholera t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhara D,Yuki Y,Nochi T,Kodama T,Mejima M,Kurokawa S,Takahashi Y,Nanno M,Nakanishi U,Takaiwa F,Honda T,Kiyono H

更新日期：2010-05-11 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:We are interested in tracking changes in large-scale data by periodically creating an agglomerative clustering and examining the evolution of clusters (communities) over time. We examine a large real-world data set: the NEC CiteSeer database, a linked network of >250,000 papers. Tracking changes over time requires a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopcroft J,Khan O,Kulis B,Selman B

更新日期：2004-04-06 00:00:00