Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine.

abstract：:High ambient ozone (O3) concentrations are a widespread and persistent problem globally. Although studies have documented the role of forests in removing O3 and one of its precursors, nitrogen dioxide (NO2), the cost effectiveness of using peri-urban reforestation for O3 abatement purposes has not been examined. We de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger T,Escobedo FJ,Hernandez JL,Varela S,Delphin S,Fisher JR,Waldron J

更新日期：2014-10-07 00:00:00

abstract：:Many cell surface receptors are multimeric proteins, composed of several structural domains, some involved in ligand recognition, whereas others are responsible for signal transduction. In most cases, the mechanism of how ligand interaction in the extracellular domains leads to the activation of effector domains remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Cao J,Jiang M,Labesse G,Liu J,Pin JP,Rondard P

更新日期：2011-09-13 00:00:00

abstract：:The vaccinia virus early transcription factor (VETF), a heterodimeric protein composed of 82- and 70-kDa subunits, interacts with viral early promoters at both a sequence-specific core region upstream and a sequence-independent region downstream of the RNA start site. To determine the VETF subunit-promoter interaction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cassetti MA,Moss B

更新日期：1996-07-23 00:00:00

abstract：:Salt and water secretion from intestinal epithelia requires enhancement of anion permeability across the apical membrane of Cl- secreting cells lining the crypt, the secretory gland of the intestine. Paneth cells located at the base of the small intestinal crypt release enteric defensins (cryptdins) apically into the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lencer WI,Cheung G,Strohmeier GR,Currie MG,Ouellette AJ,Selsted ME,Madara JL

更新日期：1997-08-05 00:00:00

abstract：:Single-copy transgenes in Caenorhabditis elegans can be subjected to a potent, irreversible silencing process termed small RNA-induced epigenetic silencing (RNAe). RNAe is promoted by the Piwi Argonaute protein PRG-1 and associated Piwi-interacting RNAs (piRNAs), as well as by proteins that promote and respond to seco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leopold LE,Heestand BN,Seong S,Shtessel L,Ahmed S

更新日期：2015-05-19 00:00:00

abstract：:By analogy with receptor-mediated endocytosis, clathrin-coated membrane segments at locations other than at the plasma membrane have been implicated in intracellular membrane transport/sorting. The crucial role of the Golgi apparatus in these processes prompted us to study the distribution at this level of clathrin-im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orci L,Ravazzola M,Amherdt M,Louvard D,Perrelet A

更新日期：1985-08-01 00:00:00

abstract：:High levels of D-serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N-methyl-D-aspartate receptors. In glial cultures of rat cerebral cortex, D-serine is enriched in type II astrocytes and is released upon stimulation with agonists of non-N-methyl-D-aspartate glutamate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolosker H,Sheth KN,Takahashi M,Mothet JP,Brady RO Jr,Ferris CD,Snyder SH

更新日期：1999-01-19 00:00:00

abstract：:A series of recombinant plasmids was generated in Escherichia coli in which the TEM beta-lactamase translocon (TnA) was inserted into the small plasmid RSF1010. RSF1010 is a 5.5 X 10(6) dalton nonconjugative plasmid which confers resistance to streptomycin and sulfonamide. The recombinant plasmids can be classified in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffron F,Rubens C,Falkow S

更新日期：1975-09-01 00:00:00

abstract：:The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SY,Asano M

更新日期：2008-08-26 00:00:00

abstract：:Environmental cues are transmitted to the interior of the cell via a complex network of signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins are two such major signaling hubs in eukaryotes. Conventionally, canonical signal transduction via trimeric G proteins is thought to be triggered exclusively ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Midde KK,Aznar N,Laederich MB,Ma GS,Kunkel MT,Newton AC,Ghosh P

更新日期：2015-03-03 00:00:00

abstract：:Solvent additives (cosolvents, osmolytes) modulate biochemical reactions if, during the course of the reaction, there is a change in preferential interactions of solvent components with the reacting system. Preferential interactions can be expressed in terms of preferential binding of the cosolvent or its preferential...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Timasheff SN

更新日期：2002-07-23 00:00:00

abstract：:We have previously shown that mammary epithelial specific expression of the activated erbB2 allele under the control of the endogenous promoter in mice resulted in the formation of mammary adenocarcinomas. To assess whether mammary tumorigenesis in this model is influenced by the developmental window of expression, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrechek ER,Hardy WR,Laing MA,Muller WJ

更新日期：2004-04-06 00:00:00

abstract：:The conformation of L-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) has been derived from electron-density maps calculated at 2.8-A resolution with phases obtained from two heavy-atom derivatives and the bound coenzyme, NAD. Like other dehydrogenases, 3-hydroxyacyl-CoA dehydrogenase is a double-domain structure, but t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birktoft JJ,Holden HM,Hamlin R,Xuong NH,Banaszak LJ

更新日期：1987-12-01 00:00:00

abstract：:Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4(+) T cell depletion, which might partially be explained by higher virulence of SI variants compared with NSI variants. Because NSI and SI variants use different coreceptors for entry of target cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaak H,van't Wout AB,Brouwer M,Hooibrink B,Hovenkamp E,Schuitemaker H

更新日期：2000-02-01 00:00:00

abstract：:Gap junctions are specialized membrane regions that seem to mediate intercellular communication. They appear to contain closely packed arrays of equally sized particles all of which, upon freeze-cleaving, remain attached to one membrane leaflet and not to the other. One gap junction cleavage face, therefore, always ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staehelin LA

更新日期：1972-05-01 00:00:00

abstract：:The covalent linkage of supramolecular monomers provides a powerful strategy for constructing dynamic polymeric materials whose properties can be readily tuned either by the selection of monomers or the choice of functional linkers. In this strategy, the stabilities of the supramolecular monomers and the reactions use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Li S,Yan X,Zhou Z,Saha ML,Wang YC,Stang PJ

更新日期：2016-10-04 00:00:00

abstract：:p19ARF has been implicated as a key regulator of p53 stability and activation. While numerous stresses activate the p53 growth arrest pathway, those requiring p19ARF remain to be elucidated. We used p19ARF knockout mouse embryo fibroblasts to show that DNA damage and microtubule disruption require p19ARF to induce p53...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan SH,Moritsugu J,Wahl GM

更新日期：2000-03-28 00:00:00

abstract：:O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects of most O-GlcNAcylation events remain uncharacterized. One prevalent hypothesis is that O-GlcNAc m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toleman CA,Schumacher MA,Yu SH,Zeng W,Cox NJ,Smith TJ,Soderblom EJ,Wands AM,Kohler JJ,Boyce M

更新日期：2018-06-05 00:00:00

abstract：:Land plants have distinct developmental programs in haploid (gametophyte) and diploid (sporophyte) generations. Although usually the two programs strictly alternate at fertilization and meiosis, one program can be induced during the other program. In a process called apogamy, cells of the gametophyte other than the eg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okano Y,Aono N,Hiwatashi Y,Murata T,Nishiyama T,Ishikawa T,Kubo M,Hasebe M

更新日期：2009-09-22 00:00:00

abstract：:Filipin, digitonin, and saponin react with membrane cholesterol to produce unique membrane alterations (sterol-specific complexes) that are easily discernible in freeze-fracture replicas. We have treated both noninnervated and innervated Xenopus embryonic muscle cells in culture with these agents. Freeze-fracture of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridgman PC,Nakajima Y

更新日期：1981-02-01 00:00:00

abstract：:C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30% decrease in the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallorga P,Tallman JF,Henneberry RC,Hirata F,Strittmatter WT,Axelrod J

更新日期：1980-03-01 00:00:00

abstract：:Evidence is assembled from the literature to support the argument that myocardial infarction and death results from narrowing of coronary arteries-a process that may result from various causes, as discussed in this paper. Angiotensin and hypertension are suggested as among the chief components of such processes. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Page IH

更新日期：1972-07-01 00:00:00

abstract：:Two prominent timekeeping systems, the cell cycle, which controls cell division, and the circadian system, which controls 24-h rhythms of physiology and behavior, are found in nearly all living organisms. A distinct feature of circadian rhythms is that they are temperature-compensated such that the period of the rhyth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeom M,Pendergast JS,Ohmiya Y,Yamazaki S

更新日期：2010-05-25 00:00:00

abstract：:Annealed metals are surprisingly difficult to cut, involving high forces and an unusually thick "chip." This anomaly has long been explained, based on ex situ observations, using a model of smooth plastic flow with uniform shear to describe material removal by chip formation. Here we show that this phenomenon is actua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeung H,Viswanathan K,Compton WD,Chandrasekar S

更新日期：2015-08-11 00:00:00

abstract：:The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao SW,Kobayashi K,Johansen FE,Sollid LM,Andersen JT,Milford E,Roopenian DC,Lencer WI,Blumberg RS

更新日期：2008-07-08 00:00:00

abstract：:Synaptobrevin/vesicle-associated membrane protein (VAMP) and syntaxin are potential vesicle donor and target membrane receptors of a docking complex that requires N-ethylmaleimide-sensitive factor (NSF) and soluble NSF-attachment proteins as soluble factors for vesicle fusion with target membranes. Members of this doc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamasaki S,Hu Y,Binz T,Kalkuhl A,Kurazono H,Tamura T,Jahn R,Kandel E,Niemann H

更新日期：1994-05-24 00:00:00

abstract：:VIP21/caveolin is localized to both caveolae and apical transport vesicles and presumably cycles between the cell surface and the Golgi complex. We have studied the lipid interactions of this protein by reconstituting Escherichia coli-expressed VIP21/caveolin into liposomes. Surprisingly, the protein reconstituted onl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murata M,Peränen J,Schreiner R,Wieland F,Kurzchalia TV,Simons K

更新日期：1995-10-24 00:00:00

abstract：:Evidence is presented for two natural transcription initiators positioned internally in the histidine operon of Salmonella typhimurium. They were detected using highly polar S. typhimurium his mutants as recipients for F' Escherichia coli his episomes. These intergeneric complementation tests provide a sensitive metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atkins JF,Loper JC

更新日期：1970-04-01 00:00:00

abstract：:Monoamines, including dopamine (DA), have been linked to aggression in various species. However, the precise role or roles served by the amine in aggression have been difficult to define because dopaminergic systems influence many behaviors, and all can be altered by changing the function of dopaminergic neurons. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alekseyenko OV,Chan YB,Li R,Kravitz EA

更新日期：2013-04-09 00:00:00

abstract：:Dyskeratosis congenita is a premature aging syndrome characterized by muco-cutaneous features and a range of other abnormalities, including early greying, dental loss, osteoporosis, and malignancy. Dyskeratosis congenita cells age prematurely and have very short telomeres. Patients have mutations in genes that encode ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vulliamy T,Beswick R,Kirwan M,Marrone A,Digweed M,Walne A,Dokal I

更新日期：2008-06-10 00:00:00