Spectroscopic elucidation of energy transfer in hybrid inorganic-biological organisms for solar-to-chemical production.

abstract：:The mechanisms underlying analgesia related to social touch are not clear. While recent research highlights the role of the empathy of the observer to pain relief in the target, the contribution of social interaction to analgesia is unknown. The current study examines brain-to-brain coupling during pain with interpers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein P,Weissman-Fogel I,Dumas G,Shamay-Tsoory SG

更新日期：2018-03-13 00:00:00

abstract：:The plant kingdom contains vastly untapped natural product chemistry, which has been traditionally explored through the activity-guided approach. Here, we describe a gene-guided approach to discover and engineer a class of plant ribosomal peptides, the branched cyclic lyciumins. Initially isolated from the Chinese wol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kersten RD,Weng JK

更新日期：2018-11-13 00:00:00

abstract：:Studies of tumors from human familial adenomatous polyposis, sporadic colon cancer, and mouse and rat models of intestinal cancer indicate that the majority of early adenomas develop through loss of normal function of the Adenomatous polyposis coli (APC) gene. In murine models of familial adenomatous polyposis, specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amos-Landgraf JM,Irving AA,Hartman C,Hunter A,Laube B,Chen X,Clipson L,Newton MA,Dove WF

更新日期：2012-02-07 00:00:00

abstract：:Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR). Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhargava A,Clifton MS,Mhaske P,Liao M,Pothoulakis C,Leeman SE,Grady EF

更新日期：2013-01-08 00:00:00

abstract：:The early steps in the biosynthesis of Taxol involve the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene followed by cytochrome P450-mediated hydroxylation at C5, acetylation of this intermediate, and a second cytochrome P450-dependent hydroxylation at C10 to yield taxadien-5 alpha-acetoxy-10 beta-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoendorf A,Rithner CD,Williams RM,Croteau RB

更新日期：2001-02-13 00:00:00

abstract：:PTP1C, a protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48) containing two src homology 2 domains, is poorly active when assayed with various protein substrates in vitro. Its activity is stimulated > 1000-fold by anionic phospholipids when myelin basic protein or mitogen-activated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Z,Shen SH,Fischer EH

更新日期：1993-05-01 00:00:00

abstract：:The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit ferrochelatase, has been isolated and purified. The pigment has been resolved into one major, one minor, and two trace components, all of which appear to be isomeric porphyrins. The major fract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz de Montellano PR,Beilan HS,Kunze KL

更新日期：1981-03-01 00:00:00

abstract：:This investigation was undertaken to determine the possible role of growth hormone (GH) in the hormonal regulation of hepatic low density lipoprotein (LDL) receptor expression. Treatment of normal rats with estrogen (ethynylestradiol, 5 mg/kg per day) increased the number of hepatic LDL receptors, and the LDL receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudling M,Norstedt G,Olivecrona H,Reihnér E,Gustafsson JA,Angelin B

更新日期：1992-08-01 00:00:00

abstract：:The monoclonal antibodies (mAb) DA6.147, DA6.164, and HIG.48 against human Ia antigens, but not the W6/32 mAb against human class I major histocompatibility complex antigens or the anti-monocyte OKM1 and 63D3 mAb, stimulated monocytes to secrete interleukin 1 (IL-1). IL-1 was measured by its property of promoting the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palacios R

更新日期：1985-10-01 00:00:00

abstract：:Filipin, digitonin, and saponin react with membrane cholesterol to produce unique membrane alterations (sterol-specific complexes) that are easily discernible in freeze-fracture replicas. We have treated both noninnervated and innervated Xenopus embryonic muscle cells in culture with these agents. Freeze-fracture of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridgman PC,Nakajima Y

更新日期：1981-02-01 00:00:00

abstract：:We have isolated a gene from Escherichia coli homologous to the gene encoding the Mr 83,000 Drosophila heat shock protein (hsp83). In E. coli the protein homologous to hsp83 is a heat shock protein called C62.5. The predicted amino acid sequence of C62.5 is 41% and 42% identical to the Drosophila and human hsp83 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bardwell JC,Craig EA

更新日期：1987-08-01 00:00:00

abstract：:Membranes were purified from rat muscle by a differential centrifugation method that avoids the use of salt extraction or incubations at elevated temperature. Three populations of membrane-limited vesicles were defined having average densities of 1.112 (fraction I), 1.141 (fraction II), and 1.158 (fraction III) g/ml i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barchi RL,Bonilla E,Wong M

更新日期：1977-01-01 00:00:00

abstract：:Rat beta-lipotropin was isolated from 40 anterior pituitaries using high efficiency chromatography columns and sensitive fluorometric methods. The beta-lipotropin was characterized as to molecular weight, amino acid composition, and generation of opioid activity by trypsinization. Other opioid peptides, as well as a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubinstein M,Stein S,Gerber LD,Udenfriend S

更新日期：1977-07-01 00:00:00

abstract：:We have produced a soluble form of a mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region of an immunoglobulin kappa light chain. These chimeric molecules composed of V alpha C alpha C kappa and V beta C beta C kappa chains were efficiently secreted (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grégoire C,Rebaï N,Schweisguth F,Necker A,Mazza G,Auphan N,Millward A,Schmitt-Verhulst AM,Malissen B

更新日期：1991-09-15 00:00:00

abstract：:The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver-Feldhaus J,Gruis NA,Neuhausen S,Le Paslier D,Stockert E,Skolnick MH,Kamb A

更新日期：1994-08-02 00:00:00

abstract：:Lipid interactions with the integral membrane protein Na,K-ATPase (ATP phosphohydrolase, EC 3.6.1.3) purified from the electric organ of Electrophorus electricus were studied by spin labeling. A protein-associated component (boundary layer) in equilibrium with the fluid bilayer is clearly evident in the electron spin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brotherus JR,Jost PC,Griffith OH,Keana JF,Hokin LE

更新日期：1980-01-01 00:00:00

abstract：:Measles virus (MeV) is the poster child for acute infection followed by lifelong immunity. However, recent work shows the presence of MeV RNA in multiple sites for up to 3 mo after infection in a proportion of infected children. Here, we use experimental infection of rhesus macaques to show that prolonged RNA presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Kouyos RD,Adams RJ,Grenfell BT,Griffin DE

更新日期：2012-09-11 00:00:00

abstract：:A common genetic mutation found in clear cell renal cell carcinoma (CC-RCC) is the loss of the von Hippel-Lindau (VHL) gene, which results in stabilization of hypoxia-inducible factors (HIFs), and contributes to cancer progression and metastasis. CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razorenova OV,Finger EC,Colavitti R,Chernikova SB,Boiko AD,Chan CK,Krieg A,Bedogni B,LaGory E,Weissman IL,Broome-Powell M,Giaccia AJ

更新日期：2011-02-01 00:00:00

abstract：:Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT protomers form close contacts throughout the entire structure of ligand-bound receptor dimers, and that the dimeric receptors adopt multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opatowsky Y,Lax I,Tomé F,Bleichert F,Unger VM,Schlessinger J

更新日期：2014-02-04 00:00:00

abstract：:Voltage-gated channels maintain cellular resting potentials and generate neuronal action potentials by regulating ion flux. Here, we show that Ether-à-go-go (EAG) K+ channels also regulate intracellular signaling pathways by a mechanism that is independent of ion flux and depends on the position of the voltage sensor....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegle AP,Marble DD,Wilson GF

更新日期：2006-02-21 00:00:00

abstract：:It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et(2)Zn, and (S)-1,1'-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation of the alkynylzinc ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao G,Xie RG,Pu L

更新日期：2004-04-13 00:00:00

abstract：:The conditional lifetime expectancy function (LEF) is the expected lifetime of a subject given survival past a certain time point and the values of a set of explanatory variables. This function is attractive to researchers because it summarizes the entire residual life distribution and has an easy interpretation compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong J,Klein BE,Klein R,Wahba G

更新日期：2015-09-29 00:00:00

abstract：:Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports transcellular transfer of tau misfolding (seeding) as the mechanism of spread within an affected brain, a process reminiscent of viral infection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McEwan WA,Falcon B,Vaysburd M,Clift D,Oblak AL,Ghetti B,Goedert M,James LC

更新日期：2017-01-17 00:00:00

abstract：:Young male baboons born in captivity were immunized with an attenuated, cryopreserved schistosomular vaccine derived from gamma-irradiated (50 krad) cercariae of the Puerto Rican strain of Schistosoma mansoni. Protection against a heterologous Kenyan strain of S. mansoni, after percutaneous infection, was assessed. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damian RT,Roberts ML,Powell MR,Clark JD,Lewis FA,Stirewalt MA

更新日期：1984-06-01 00:00:00

abstract：:The search for technosignatures from hypothetical galactic civilizations is going through a new phase of intense activity. For the first time, a significant fraction of the vast search space is expected to be sampled in the foreseeable future, potentially bringing informative data about the abundance of detectable ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grimaldi C,Marcy GW

更新日期：2018-10-16 00:00:00

abstract：:Rat hepatoma cells infected with mouse mammary tumor virus contain multiple forms of unintegrated viral DNA when grown in the presence of glucocorticoids. Using the DNA transfer procedure of Southern, we have prepared restriction endonuclease fragment maps of these forms of viral DNA. The maps indicate that: (i) the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shank PR,Cohen JC,Varmus HE,Yamamoto KR,Ringold GM

更新日期：1978-05-01 00:00:00

abstract：:Mutations in the human glucocerebrosidase gene cause Gaucher disease. A cDNA clone containing the entire human glucocerebrosidase coding region from normal cells has been isolated using lambda gt11 expression libraries. The complete nucleotide sequence, a restriction map, and a hydropathy profile are presented. Hybrid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorge J,West C,Westwood B,Beutler E

更新日期：1985-11-01 00:00:00

abstract：:Scientific cinematography using ultrafast optical imaging is a common tool to study motion. In opaque organisms or structures, X-ray radiography captures sequences of 2D projections to visualize morphological dynamics, but for many applications full four-dimensional (4D) spatiotemporal information is highly desirable....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： dos Santos Rolo T,Ershov A,van de Kamp T,Baumbach T

更新日期：2014-03-18 00:00:00

abstract：:Antibodies were raised against two synthetic peptides whose sequences correspond respectively to the COOH-terminal end (residues 501-516) of the protein encoded by the gene for the delta chain and to a proposed cytoplasmic region (residues 350-358) of the beta chain of the acetylcholine receptor from Torpedo californi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young EF,Ralston E,Blake J,Ramachandran J,Hall ZW,Stroud RM

更新日期：1985-01-01 00:00:00

abstract：:The environmental backdrop to the evolution and spread of early Homo sapiens in East Africa is known mainly from isolated outcrops and distant marine sediment cores. Here we present results from new scientific drill cores from Lake Malawi, the first long and continuous, high-fidelity records of tropical climate change...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scholz CA,Johnson TC,Cohen AS,King JW,Peck JA,Overpeck JT,Talbot MR,Brown ET,Kalindekafe L,Amoako PY,Lyons RP,Shanahan TM,Castañeda IS,Heil CW,Forman SL,McHargue LR,Beuning KR,Gomez J,Pierson J

更新日期：2007-10-16 00:00:00