Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli.

abstract：:We use age distributions of sea otters (Enhydra lutris) found dead on beaches of western Prince William Sound, Alaska, between 1976 and 1998 in conjunction with time-varying demographic models to test for lingering effects from the 1989 Exxon Valdez oil spill. Our results show that sea otters in this area had decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monson DH,Doak DF,Ballachey BE,Johnson A,Bodkin JL

更新日期：2000-06-06 00:00:00

abstract：:Little is known about the molecular mechanisms by which the embryo proper and suspensor of plant embryos activate specific gene sets shortly after fertilization. We analyzed the upstream region of the scarlet runner bean (Phaseolus coccineus) G564 gene to understand how genes are activated specifically within the susp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawashima T,Wang X,Henry KF,Bi Y,Weterings K,Goldberg RB

更新日期：2009-03-03 00:00:00

abstract：:The torI gene has been identified by using a genetic multicopy approach as a negative regulator of the torCAD operon that encodes the trimethylamine N-oxide reductase respiratory system in Escherichia coli. The negative effect was due to a previously unidentified small ORF (66 aa) of phage origin that we called torI f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ansaldi M,Théraulaz L,Méjean V

更新日期：2004-06-22 00:00:00

abstract：:One of the critical issues regarding proteins with a four-helix bundle motif is which interactions play the major role in stabilizing this type of folded structure: the interaction among the four alpha-helices or the interaction between the loop and helix segments. To answer this question, an energetic analysis has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou KC,Maggiora GM,Scheraga HA

更新日期：1992-08-15 00:00:00

abstract：:Golgi-associated cytoplasmic proteins, such as the coatomer protein complex, are required for vesicle budding and trafficking. We have previously described a cytoplasmic phosphoprotein, p200, which binds dynamically and specifically to Golgi membranes. The p200 protein is dissociated from Golgi membranes in the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narula N,Stow JL

更新日期：1995-03-28 00:00:00

abstract：:To enable discovery of serum antibodies indicative of disease and simultaneously develop reagents suitable for diagnosis, in vitro directed evolution was applied to identify consensus peptides recognized by patients' serum antibodies. Bacterial cell-displayed peptide libraries were quantitatively screened for binders ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballew JT,Murray JA,Collin P,Mäki M,Kagnoff MF,Kaukinen K,Daugherty PS

更新日期：2013-11-26 00:00:00

abstract：:Three distinct endosomal fractions were isolated in high purity from livers of estradiol-treated rats. Each fraction had characteristic physical and ultrastructural properties, but the lipid composition and major proteins of their membranes were similar and differed from those derived from the Golgi apparatus. Injecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcher JD,Hamilton RL,Brady SE,Hornick CA,Jaeckle S,Schneider WJ,Havel RJ

更新日期：1987-10-01 00:00:00

abstract：:Loquacious-PD (Loqs-PD) is required for biogenesis of many endogenous siRNAs in Drosophila In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of substrates normally refractory to cleavage. Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trettin KD,Sinha NK,Eckert DM,Apple SE,Bass BL

更新日期：2017-09-19 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha L,Ichikawa T,Anver M,Dickins R,Lowe S,Sharpless NE,Krimpenfort P,Depinho RA,Bennett DC,Sviderskaya EV,Merlino G

更新日期：2007-06-26 00:00:00

abstract：:Transabdominal (Tab) is a dominant gain-of-function mutation that results in islands of sexually dimorphic abdominal cuticle in the dorsal thorax of the adult fly. This phenotype has complete penetrance and constant expressivity, and we show that it results from ectopic expression of ABD-BII, one of two proteins deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Celniker SE,Lewis EB

更新日期：1993-02-15 00:00:00

abstract：:The x-ray crystal structure of the tetrameric T-antigen-binding lectin from peanut, M(r) 110,000, has been determined by using the multiple isomorphous replacement method and refined to an R value of 0.218 for 22,155 reflections within the 10- to 2.95-A resolution range. Each subunit has essentially the same character...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee R,Mande SC,Ganesh V,Das K,Dhanaraj V,Mahanta SK,Suguna K,Surolia A,Vijayan M

更新日期：1994-01-04 00:00:00

abstract：:Despite a growing number of ion channel genes implicated in hereditary ataxia, it remains unclear how ion channel mutations lead to loss-of-function or death of cerebellar neurons. Mutations in the gene KCNMA1, encoding the α-subunit of the BK channel have emerged as responsible for a variety of neurological phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du X,Carvalho-de-Souza JL,Wei C,Carrasquel-Ursulaez W,Lorenzo Y,Gonzalez N,Kubota T,Staisch J,Hain T,Petrossian N,Xu M,Latorre R,Bezanilla F,Gomez CM

更新日期：2020-03-17 00:00:00

abstract：:A clone for the iron-responsive element (IRE)-binding protein (IRE-BP) has been transfected and expressed in mouse fibroblasts. The IRE-BP gene product binds IREs with high affinity and specificity. Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase. The 18 active site residues of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaptain S,Downey WE,Tang C,Philpott C,Haile D,Orloff DG,Harford JB,Rouault TA,Klausner RD

更新日期：1991-11-15 00:00:00

abstract：:Endosomal cargo travels through a dynamic vesicle network en route to degradation by lysosomes or recycling through the Golgi apparatus back to the cell surface. Rab5 is a key determinant of the early endosomes by organizing effector proteins in specific subdomains and mediating early endosome fusion. We find that ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antignani A,Youle RJ

更新日期：2008-06-10 00:00:00

abstract：:In the mammalian central nervous system, the excitatory amino acid transmitter L-glutamate activates three pharmacologically distinguishable receptors, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate receptors. The present paper addresses the issue of whether these three receptors operate independent channel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerma J,Kushner L,Zukin RS,Bennett MV

更新日期：1989-03-01 00:00:00

abstract：:We report on the design and characterization of a class of biomolecular interfaces based on derivatized poly(l-lysine)-grafted poly(ethylene glycol) copolymers adsorbed on negatively charged surfaces. As a model system, we synthesized biotin-derivatized poly(l-lysine)-grafted poly(ethylene glycol) copolymers, PLL-g-[(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Taylor LA,Martin TL,Zaugg FG,Witte K,Indermuhle P,Nock S,Wagner P

更新日期：2001-01-30 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Mishra S,Sakthivel R,Rojas M,Ranjan R,Sullivan WJ Jr,Fontoura BM,Ménard R,Dever TE,Nussenzweig V

更新日期：2012-03-06 00:00:00

abstract：:The reported isolation of nanobacteria from human kidney stones raises the intriguing possibility that these microorganisms are etiological agents of pathological extraskeletal calcification [Kajander, E. O. & Ciftçioglu, N. (1998) Proc. Natl. Acad. Sci. USA 95, 8274-8279]. Nanobacteria were previously isolated from F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cisar JO,Xu DQ,Thompson J,Swaim W,Hu L,Kopecko DJ

更新日期：2000-10-10 00:00:00

abstract：:Chromosomal locations of members of the xenotropic-related env gene family in the mouse genome have been determined. Endonuclease restriction site polymorphisms detected by molecular hybridization were used to study the inheritance of mink cell-focus inducing and xenotropic env gene-related sequences in recombinant in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatt C,Mileham K,Haas M,Nesbitt MN,Harper ME,Simon MI

更新日期：1983-10-01 00:00:00

abstract：:Vision loss affects >3 million Americans and many more people worldwide. Although predisposing genes have been identified their link to known environmental factors is unclear. In wild-type animals DNA alkylating agents induce photoreceptor apoptosis and severe retinal degeneration. Alkylation-induced retinal degenerat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meira LB,Moroski-Erkul CA,Green SL,Calvo JA,Bronson RT,Shah D,Samson LD

更新日期：2009-01-20 00:00:00

abstract：:Nitric oxide (NO) plays diverse and significant roles in biological processes despite its cytotoxicity, raising the question of how biological systems control the action of NO to minimize its cytotoxicity in cells. As a great example of such a system, we found a possibility that NO-generating nitrite reductase (NiR) f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasaka E,Yamada K,Wang PH,Hosokawa K,Yamagiwa R,Matsumoto K,Ishii S,Mori T,Yagi K,Sawai H,Arai H,Sugimoto H,Sugita Y,Shiro Y,Tosha T

更新日期：2017-09-12 00:00:00

abstract：:Reptiles and fish have robust regenerative powers for tooth renewal. However, extant mammals can either renew their teeth one time (diphyodont dentition) or not at all (monophyodont dentition). Humans replace their milk teeth with permanent teeth and then lose their ability for tooth renewal. Here, we study tooth rene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu P,Wu X,Jiang TX,Elsey RM,Temple BL,Divers SJ,Glenn TC,Yuan K,Chen MH,Widelitz RB,Chuong CM

更新日期：2013-05-28 00:00:00

abstract：:Here, using further optimized 3D culture that allows highly selective induction and long-term growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique aspects of self-organization in human neocorticogenesis. Self-organized cortical tissue spontaneously forms a polarity along the dorsocaud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadoshima T,Sakaguchi H,Nakano T,Soen M,Ando S,Eiraku M,Sasai Y

更新日期：2013-12-10 00:00:00

abstract：:We present here a brief review of direct force measurements between hydrophobic surfaces in aqueous solutions. For almost 70 years, researchers have attempted to understand the hydrophobic effect (the low solubility of hydrophobic solutes in water) and the hydrophobic interaction or force (the unusually strong attract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer EE,Rosenberg KJ,Israelachvili J

更新日期：2006-10-24 00:00:00

abstract：:We isolated erythroleukemic cell lines arrested at different levels of the erythroid differentiation pathway. One cell line (CB5), established from mice infected with the helper-independent Friend murine leukemia virus (F-MuLV), exhibited properties similar to those of the normal erythroid progenitor burst-forming cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibuya T,Mak TW

更新日期：1983-06-01 00:00:00

abstract：:Huntington's disease (HD) is classically characterized as a movement disorder, however cognitive impairments precede the motor symptoms by ∼15 y. Based on proteomic and bioinformatic data linking the Huntingtin protein (Htt) and KCC2, which is required for hyperpolarizing GABAergic inhibition, and the important role o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dargaei Z,Bang JY,Mahadevan V,Khademullah CS,Bedard S,Parfitt GM,Kim JC,Woodin MA

更新日期：2018-02-13 00:00:00

abstract：:Children with reading impairments have deficits in phonological awareness, phonemic categorization, speech-in-noise perception, and psychophysical tasks such as frequency and temporal discrimination. Many of these children also exhibit abnormal encoding of speech stimuli in the auditory brainstem, even though response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hornickel J,Skoe E,Nicol T,Zecker S,Kraus N

更新日期：2009-08-04 00:00:00

abstract：:Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

更新日期：2017-11-21 00:00:00