ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.

abstract：:The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen PP,Kabat EA,Wu TT,Fong S,Carson DA

更新日期：1985-04-01 00:00:00

abstract：:Through use of a synthetic oligonucleotide probe, human insulin-like growth factor I (IGF-I) cDNA clones were isolated from a liver library. Two types of cDNAs were defined by restriction enzyme analysis and DNA sequencing. Both encode IGF-I precursors of either 195 or 153 amino acids. The two predicted protein precur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotwein P

更新日期：1986-01-01 00:00:00

abstract：:RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an intracellular RNase T2 from Arabidopsis thaliana, is essential for n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hillwig MS,Contento AL,Meyer A,Ebany D,Bassham DC,Macintosh GC

更新日期：2011-01-18 00:00:00

abstract：:Past research found that the ingestion of glucose can enhance self-control. It has been widely assumed that basic physiological processes underlie this effect. We hypothesized that the effect of glucose also depends on people's theories about willpower. Three experiments, both measuring (experiment 1) and manipulating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Job V,Walton GM,Bernecker K,Dweck CS

更新日期：2013-09-10 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:The N-terminal arginine-rich motif of phage HK022 Nun protein binds to NUT sequences in phage lambda nascent transcripts and induces transcription termination. Interactions between the Nun C terminus and RNA polymerase as well as the DNA template are required for termination. We have isolated Nun C-terminal point and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HC,Zhou JG,Wilson HR,Mogilnitskiy G,Court DL,Gottesman ME

更新日期：2003-04-29 00:00:00

abstract：:Rat skeletal muscle selenoprotein W cDNA was isolated and sequenced. The isolation strategy involved design of degenerate PCR primers from reverse translation of a partial peptide sequence. A reverse transcription-coupled PCR product from rat muscle mRNA was used to screen a muscle cDNA library prepared from selenium-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vendeland SC,Beilstein MA,Yeh JY,Ream W,Whanger PD

更新日期：1995-09-12 00:00:00

abstract：:Stochasticity alters the nonlinear dynamics of inherently cycling populations. The power spectrum can describe and explain the impacts of stochasticity. We fitted models to short observed time series of flour beetle populations in the frequency domain, then used a well fitting stochastic mechanistic model to generate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reuman DC,Desharnais RA,Costantino RF,Ahmad OS,Cohen JE

更新日期：2006-12-05 00:00:00

abstract：:Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma membrane. GFP-labeled versions of both proteins cluster at sites where secretory granules have docked. Single-particle tracking shows that minority populations of both ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles MK,Barg S,Wan L,Midorikawa M,Chen X,Almers W

更新日期：2010-11-30 00:00:00

abstract：:Streptococcus pneumoniae can cause disease in various human tissues and organs, including the ear, the brain, the blood, and the lung, and thus in highly diverse and dynamic environments. It is challenging to study how pneumococci control virulence factor expression, because cues of natural environments and the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorg RA,Gallay C,Van Maele L,Sirard JC,Veening JW

更新日期：2020-11-03 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK-3) is implicated in multiple biological processes including metabolism, gene expression, cell fate determination, proliferation, and survival. GSK-3 activity is inhibited through phosphorylation of serine 21 in GSK-3 alpha and serine 9 in GSK-3 beta. These serine residues of GSK-3 have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang X,Yu SX,Lu Y,Bast RC Jr,Woodgett JR,Mills GB

更新日期：2000-10-24 00:00:00

abstract：:When an algorithm in dimension one is extended to dimension d, in nearly every case its computational cost is taken to the power d. This fundamental difficulty is the single greatest impediment to solving many important problems and has been dubbed the curse of dimensionality. For numerical analysis in dimension d, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beylkin G,Mohlenkamp MJ

更新日期：2002-08-06 00:00:00

abstract：:Two photochromic activators of the electrogenic membrane of the electroplax of Electrophorus electricus are described. Trans-3,3'-bis[alpha-(trimethylammonium)methyl]azobenzene dibromide (Bis-Q), one of the most potent ever reported, is active at concentrations of less than 10(-7) M. Its cis isomer, which is obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartels E,Wassermann NH,Erlanger BF

更新日期：1971-08-01 00:00:00

abstract：:The present work shows that arachidonic acid and some other long chain polyunsaturated fatty acids such as docosahexaenoic acid, which is abundant in fish oil, produce a direct open channel block of the major voltage-dependent K+ channel (Kv1.5) cloned in cardiac cells. The inhibitory action of these selected fatty ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honoré E,Barhanin J,Attali B,Lesage F,Lazdunski M

更新日期：1994-03-01 00:00:00

abstract：:Pathways and enzymes of fatty acid synthase-mediated, long-even-chain (generally C16-C20) fatty acid synthesis are well studied, and general metabolism involved in short-chain (C4-C7) fatty acid biosynthesis is also understood. In contrast, mechanisms of medium-chain (C8-C14) fatty acid synthesis are unclear. Recent w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroumova AB,Xie Z,Wagner GJ

更新日期：1994-11-22 00:00:00

abstract：:We resolve the 3D trajectory and the orientation of individual cells for extended times, using a digital tracking technique combined with 3D reconstructions. We have used this technique to study the motility of the uniflagellated bacterium Caulobacter crescentus and have found that each cell displays two distinct mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu B,Gulino M,Morse M,Tang JX,Powers TR,Breuer KS

更新日期：2014-08-05 00:00:00

abstract：:The explosive growth in our knowledge of genomes, proteomes, and metabolomes is driving ever-increasing fundamental understanding of the biochemistry of life, enabling qualitatively new studies of complex biological systems and their evolution. This knowledge also drives modern biotechnologies, such as molecular engin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agresti JJ,Antipov E,Abate AR,Ahn K,Rowat AC,Baret JC,Marquez M,Klibanov AM,Griffiths AD,Weitz DA

更新日期：2010-03-02 00:00:00

abstract：:Neurological dysfunction caused by traumatic brain injury results in profound changes in net synaptic efficacy, leading to impaired cognition. Because excitability is directly controlled by the balance of excitatory and inhibitory activity, underlying mechanisms causing these changes were investigated using lateral fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole JT,Mitala CM,Kundu S,Verma A,Elkind JA,Nissim I,Cohen AS

更新日期：2010-01-05 00:00:00

abstract：:Cyanobacterial clock proteins KaiA and KaiC are proposed as positive and negative regulators in the autoregulatory circadian kaiBC expression, respectively. Here, we show that activation of kaiBC expression by kaiA requires KaiC, suggesting a positive feedback control in the cyanobacterial clockwork. We found that rob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwasaki H,Nishiwaki T,Kitayama Y,Nakajima M,Kondo T

更新日期：2002-11-26 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:l-tryptophan (Trp), an essential amino acid for mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine and serotonin pathways. The kynurenine pathway is a paramount source of several immunoregulatory metabolites, including l-kynurenine (Kyn), the main product of indoleamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondanelli G,Coletti A,Greco FA,Pallotta MT,Orabona C,Iacono A,Belladonna ML,Albini E,Panfili E,Fallarino F,Gargaro M,Manni G,Matino D,Carvalho A,Cunha C,Maciel P,Di Filippo M,Gaetani L,Bianchi R,Vacca C,Iamandii

更新日期：2020-02-18 00:00:00

abstract：:Conventional markets can underprovide ecosystem services. Deliberate creation of a market for ecosystem services [e.g., a payments for ecosystem services (PES) scheme] can close the gap. The new ecosystem service market alters behaviors and quantities of ecosystem service provided and reveals prices for the ecosystems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamowicz W,Calderon-Etter L,Entem A,Fenichel EP,Hall JS,Lloyd-Smith P,Ogden FL,Regina JA,Rouhi Rad M,Stallard RF

更新日期：2019-03-19 00:00:00

abstract：:Muscle plasminogen activators (PAs), such as urokinase-like PA and, to a lesser extent, tissue PA, increase dramatically after denervation induced by axotomy. The PA/plasmin system has also been implicated in degradation of specific components of the muscle fiber basement membrane after local activation of plasminogen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hantaï D,Rao JS,Festoff BW

更新日期：1990-04-01 00:00:00

abstract：:The his4 region of yeast contains the information necessary for the catalysis of three steps in the histidine biosynthetic pathway. The three activities specified by this region remain physically associated during gel filtration and ultracentrifugation and after extensive purification. Nonsense mutations in the "opera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer B,Rytka J,Fink GR

更新日期：1969-08-01 00:00:00

abstract：:The p6 domain of HIV-1 Gag contains highly conserved peptide motifs that recruit host machinery to sites of virus assembly, thereby promoting particle release from the infected cell. We previously reported that mutations in the YPXnL motif of p6, which binds the host protein Alix, severely impair HIV-1 replication. Pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Duyne R,Kuo LS,Pham P,Fujii K,Freed EO

更新日期：2019-04-30 00:00:00

abstract：:Integrating sulfanyl substituents into copper-bonded phenoxyls significantly alters their optical and redox properties and provides insight into the influence of cysteine modification of the tyrosine cofactor in the enzyme galactose oxidase. The model complexes [1(SR2)](+) are class II mixed-valent Cu(II)-phenoxyl-phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma P,Pratt RC,Storr T,Wasinger EC,Stack TD

更新日期：2011-11-15 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:The fractionation of cells of a parsley suspension culture [Petroselinum crispum (Mill.) A. Hill] by protoplasting and subsequent removal of the vacuoles led to physiologically intact evacuolated protoplasts retaining light inducibility of chalcone synthase expression. Lysis of the evacuolated protoplasts permitted th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harter K,Frohnmeyer H,Kircher S,Kunkel T,Mühlbauer S,Schäfer E

更新日期：1994-05-24 00:00:00

abstract：:Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Hillmer A,Holmes SE,Pietrzak RH,DellaGioia N,Nabulsi N,Matuskey D,Angarita GA,Carson RE,Krystal JH,Esterlis I

更新日期：2019-06-04 00:00:00

abstract：:A landmark study published in PNAS [Côté S, House J, Willer R (2015) Proc Natl Acad Sci USA 112:15838-15843] showed that higher income individuals are less generous than poorer individuals only if they reside in a US state with comparatively large economic inequality. This finding might serve to reconcile inconsistent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmukle SC,Korndörfer M,Egloff B

更新日期：2019-05-14 00:00:00