Abstract:
:Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) to compare with that of healthy comparison controls (HC; n = 29). Volume of distribution was computed using a venous input function in the five key frontal and limbic brain regions. We observed significantly higher mGluR5 availability in PTSD compared with HC individuals in all regions of interest (P's = 0.001-0.01) and compared with MDD individuals in three regions (P's = 0.007). mGluR5 availability was not significantly different between MDD and HC individuals (P = 0.17). Importantly, we observed an up-regulation in mGluR5 availability in the PTSD-SI group (P's = 0.001-0.007) compared with PTSD individuals without SI. Findings point to the potential role for mGluR5 as a target for intervention and, potentially, suicide risk management in PTSD.
journal_name
Proc Natl Acad Sci U S Aauthors
Davis MT,Hillmer A,Holmes SE,Pietrzak RH,DellaGioia N,Nabulsi N,Matuskey D,Angarita GA,Carson RE,Krystal JH,Esterlis Idoi
10.1073/pnas.1818871116subject
Has Abstractpub_date
2019-06-04 00:00:00pages
11490-11495issue
23eissn
0027-8424issn
1091-6490pii
1818871116journal_volume
116pub_type
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