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Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation.

Abstract：

:The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the structure of the cerebellar cortex, which can be progressively rescued by newly generated cells, leading to a delayed myelination. Nevertheless, the temporal shift of the OL proliferation and myelinating program cannot completely compensate for developmental defects, resulting in impaired motor functions in the adult. Strikingly, we show that, despite these abnormalities, epigenetic factors, such as motor training, are able to fully rescue cerebellar-directed motor skills.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Collin L,Usiello A,Erbs E,Mathis C,Borrelli E

doi

10.1073/pnas.0305994101

keywords:

subject

Has Abstract

pub_date

2004-01-06 00:00:00

pages

325-30

issue

1

eissn

0027-8424

issn

1091-6490

pii

0305994101

journal_volume

101

pub_type

杂志文章

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