cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.

abstract：:Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving the chemokine receptor 4/stromal-derived cell factor 1 (CXCR4/SDF-1) axis are the major cause of ectopic overexpression of VEGF in tumors. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Nigris F,Crudele V,Giovane A,Casamassimi A,Giordano A,Garban HJ,Cacciatore F,Pentimalli F,Marquez-Garban DC,Petrillo A,Cito L,Sommese L,Fiore A,Petrillo M,Siani A,Barbieri A,Arra C,Rengo F,Hayashi T,Al-Omran M,

更新日期：2010-08-10 00:00:00

abstract：:The S(N)2 displacement of Cl(-) from 1,2-dichloroethane by acetate (CH(3)CO(2)(-)) in water and by the carboxylate of the active site aspartate in the haloalkane dehalogenase of Xanthobacter autothropicus have been compared by using molecular dynamics simulations. In aqueous solution, six families of contact-pair stru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hur S,Kahn K,Bruice TC

更新日期：2003-03-04 00:00:00

abstract：:A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JY,Clegg DO,Koshland DE Jr

更新日期：1981-08-01 00:00:00

abstract：:The use of profiling by ethnicity or nationality to trigger secondary security screening is a controversial social and political issue. Overlooked is the question of whether such actuarial methods are in fact mathematically justified, even under the most idealized assumptions of completely accurate prior probabilities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Press WH

更新日期：2009-02-10 00:00:00

abstract：:We studied visual perception using an annular random-dot motion stimulus called the racetrack. We recorded neural activity using magnetoencephalography while subjects viewed variants of this stimulus that contained no inherent motion or various degrees of embedded motion. Subjects reported seeing rotary motion during ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe DA,Leuthold AC,Georgopoulos AP

更新日期：2010-12-28 00:00:00

abstract：:The tails of newborn rats, consisting of slender continuous cones of avascular cartilage, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal carbon was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Anderson KP

更新日期：1976-09-01 00:00:00

abstract：:The complement system is highly efficient in targeting pathogens, but lack of its apposite regulation results in host-cell damage, which is linked to diseases. Thus, complement activation is tightly regulated by a series of proteins, which primarily belong to the regulators of complement activation (RCA) family. Struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panwar HS,Ojha H,Ghosh P,Barage SH,Raut S,Sahu A

更新日期：2019-05-14 00:00:00

abstract：:Tropomyosin is a key component of the contractile systems found in muscle and nonmuscle cells of higher eukaryotes. Based on properties common to all tropomyosins, we have purified a protein from Saccharomyces cerevisiae that resembles tropomyosins from higher cells. The yeast protein remains soluble after heat treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu HP,Bretscher A

更新日期：1989-01-01 00:00:00

abstract：:Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal vaccine with broadly protective activity against multiple influenza st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao HY,Wang SC,Ko YA,Lin KI,Ma C,Cheng TR,Wong CH

更新日期：2020-07-28 00:00:00

abstract：:Rhinoviruses (RVs) are the major causes of common colds in humans. They have a nonenveloped, icosahedral capsid surrounding a positive-strand RNA genome. Here we report that the antigen-binding (Fab) fragment of a neutralizing antibody (C5) can trigger genome release from RV-B14 to form emptied particles and neutraliz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong Y,Liu Y,Jiang W,Smith TJ,Xu Z,Rossmann MG

更新日期：2017-07-25 00:00:00

abstract：:Hox genes encode transcription factors that control spatial patterning during embryogenesis. To date, downstream targets of Hox genes have proven difficult to identify. Here, we describe studies designed to identify target genes under the control of the murine transcription factor Hoxc8. We used a mouse 16,463 gene ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei H,Wang H,Juan AH,Ruddle FH

更新日期：2005-02-15 00:00:00

abstract：:Peptide-protein interactions are important mediators of cellular-signaling events. Consensus binding motifs (also known as short linear motifs) within these contacts underpin molecular recognition, yet have poor pharmacological properties as discrete species. Here, we present methods to transform intact peptides into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson KV,Rose TE,Harran PG

更新日期：2013-10-01 00:00:00

abstract：:The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su SS,Modrich P

更新日期：1986-07-01 00:00:00

abstract：:Disruption of Rauscher leukemia virus (RLV) with low levels of Nonidet P-40 yielded "immature" cores. These cores have a diameter of about 920 A, as opposed to the 1300-A diameter of RLV, possess knob-like protuberances, and contain a concentrically coiled internal strand apposed to the core shell. The two major polyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshinaka Y,Luftig RB

更新日期：1977-08-01 00:00:00

abstract：:Agrobacterium tumefaciens is the causal agent of crown gall disease. The bacterium is capable of transferring a segment of single-stranded DNA (ssDNA) into recipient cells during the transformation process, and it has been widely used as a genetic modification tool for plants and nonplant organisms. Transferred DNA (T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Yang Q,Peng L,Tu H,Lee LY,Gelvin SB,Pan SQ

更新日期：2020-10-20 00:00:00

abstract：:The carbon budget and dynamics of the Earth's interior, including the core, are currently very poorly understood. Diamond-bearing, mantle-derived rocks show a very well defined peak at δ(13)C ≈ -5 ± 3‰ with a very broad distribution to lower values (∼-40‰). The processes that have produced the wide δ(13)C distribution...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horita J,Polyakov VB

更新日期：2015-01-06 00:00:00

abstract：:Cells of the human embryonic stem (hES) cell line H9, when cultured in the form of embryoid bodies, give rise to cells with markers of the keratinocyte of stratified squamous epithelia. Keratinocytes also form in nodules produced in scid mice by injected H9 cells; the hES-derived keratinocytes could be recovered in cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iuchi S,Dabelsteen S,Easley K,Rheinwald JG,Green H

更新日期：2006-02-07 00:00:00

abstract：:The explosive growth in our knowledge of genomes, proteomes, and metabolomes is driving ever-increasing fundamental understanding of the biochemistry of life, enabling qualitatively new studies of complex biological systems and their evolution. This knowledge also drives modern biotechnologies, such as molecular engin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agresti JJ,Antipov E,Abate AR,Ahn K,Rowat AC,Baret JC,Marquez M,Klibanov AM,Griffiths AD,Weitz DA

更新日期：2010-03-02 00:00:00

abstract：:Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse. Heterozygotes carry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge C,Stanley P

更新日期：2008-02-05 00:00:00

abstract：:During exercise, increased energy demands are met by increased glucose production that occurs simultaneously with the increased glucose uptake. We had previously observed that, during exercise, metabolic clearance rate of glucose (MCR) increases markedly in normal, but only marginally in poorly controlled diabetic dog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles PD,Yamatani K,Lickley HL,Vranic M

更新日期：1991-02-15 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two mediators synthesized by immune cells, specially under inflammatory and antigen stimulation conditions. Reports have shown that neuropeptides attenuate the deleterious consequences of septic shock both by down-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez C,Abad C,Delgado M,Arranz A,Juarranz MG,Rodriguez-Henche N,Brabet P,Leceta J,Gomariz RP

更新日期：2002-01-22 00:00:00

abstract：:The inositol 1,4,5-trisphosphate receptor (IP3R) in the endoplasmic reticulum mediates calcium signaling that impinges on intracellular processes. IP3Rs are allosteric proteins comprising four subunits that form an ion channel activated by binding of IP3 at a distance. Defective allostery in IP3R is considered crucial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamada K,Terauchi A,Nakamura K,Higo T,Nukina N,Matsumoto N,Hisatsune C,Nakamura T,Mikoshiba K

更新日期：2014-09-23 00:00:00

abstract：:The tips of the digits of some mammals, including human infants and mice, are capable of complete regeneration after injury. This process is reliant on the presence of the overlaying nail organ and is mediated by a proliferative blastema. Epithelial Wnt/β-catenin signaling has been shown to be necessary for mouse digi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehoczky JA,Tabin CJ

更新日期：2015-10-27 00:00:00

abstract：:Tropical birds are relatively long-lived and produce few offspring, which develop slowly and mature relatively late in life, the slow end of the life-history axis, whereas temperate birds lie at the opposite end of this continuum. We tested the hypothesis that tropical birds have evolved a reduced basal metabolic rate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiersma P,Muñoz-Garcia A,Walker A,Williams JB

更新日期：2007-05-29 00:00:00

abstract：:The state-to-state transfer of rotational and vibrational energy has been studied for S1 glyoxal (CHOCHO) in collisions with D2, N2, CO and C2H4 using crossed molecular beams. A laser is used to pump glyoxal seeded in He to its S1 zero point level with zero angular momentum about its top axis (K' = 0). The inelastic s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parmenter CS,Clegg SM,Krajnovich DJ,Lu S

更新日期：1997-08-05 00:00:00

abstract：:After the emergence of pandemic influenza viruses in 1957, 1968, and 2009, existing seasonal viruses were observed to be replaced in the human population by the novel pandemic strains. We have previously hypothesized that the replacement of seasonal strains was mediated, in part, by a population-scale boost in antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pica N,Hai R,Krammer F,Wang TT,Maamary J,Eggink D,Tan GS,Krause JC,Moran T,Stein CR,Banach D,Wrammert J,Belshe RB,García-Sastre A,Palese P

更新日期：2012-02-14 00:00:00

abstract：:Xanthophyll pigments have critical structural and functional roles in the photosynthetic light-harvesting complexes of algae and vascular plants. Genetic dissection of xanthophyll metabolism in the green alga Chlamydomonas reinhardtii revealed functions for specific xanthophylls in the nonradiative dissipation of exce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niyogi KK,Björkman O,Grossman AR

更新日期：1997-12-09 00:00:00

abstract：:The H2O2-requiring ligninase of the basidiomycete Phanerochaete chrysosporium oxidatively cleaves both lignin and lignin model compounds between C alpha and C beta (C-1 and C-2) of their aliphatic side chains. Previous work has demonstrated a reaction mechanism by which ligninase oxidizes aromatic substrates to their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammel KE,Kalyanaraman B,Kirk TK

更新日期：1986-06-01 00:00:00

abstract：:L-Fucose and D-galactose in low concentrations (0.27 or 2.7 mM) inhibited the induction of active Na+ channels in mouse and human neuroblastoma cells when the monosaccharides were added to the culture medium for 4 days with the inducing agent dimethyl sulfoxide. Active Na+ ionophores were determined by measurement of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giovanni MY,Kessel D,Glick MC

更新日期：1981-02-01 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00