Abstract:
:Antigen receptors on the T-cell surface are noncovalently associated with at least four invariant polypeptide chains, CD3-gamma, -delta, -epsilon, and -zeta. The mouse CD3-gamma gene, consisting of seven exons, was found to be highly homologous to the CD3-delta gene described earlier. Both the high level of sequence homology and the exon/intron organization indicate that the CD3-gamma and -delta genes arose by gene duplication. Surprisingly, murine and human genomic DNA clones could be isolated that contained elements of both the CD3-gamma and CD3-delta genes. In fact, the putative transcription start site of the mouse CD3-gamma gene is less than 1.4 kilobases from the transcription initiation site of the mouse CD3-delta gene. Common elements that regulate the divergent transcription of the two genes are therefore proposed to be located in the intervening 1.4-kilobase DNA segment. This might contribute to the coordinate expression of the CD3-gamma and -delta genes during intrathymic maturation of T lymphocytes.
journal_name
Proc Natl Acad Sci U S Aauthors
Saito H,Koyama T,Georgopoulos K,Clevers H,Haser WG,LeBien T,Tonegawa S,Terhorst Cdoi
10.1073/pnas.84.24.9131subject
Has Abstractpub_date
1987-12-01 00:00:00pages
9131-4issue
24eissn
0027-8424issn
1091-6490journal_volume
84pub_type
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