The gene for an inherited form of deafness maps to chromosome 5q31.

abstract：:Because it is able to produce desalinated water directly using solar energy with minimum carbon footprint, solar steam generation and desalination is considered one of the most important technologies to address the increasingly pressing global water scarcity. Despite tremendous progress in the past few years, efficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Xu W,Tang M,Zhou L,Zhu B,Zhu S,Zhu J

更新日期：2016-12-06 00:00:00

abstract：:Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debenham PG,Pongs O,Travers AA

更新日期：1980-02-01 00:00:00

abstract：:Obesity is a major health problem worldwide, given its growing incidence and its association with a variety of comorbidities. Weight gain results from an increase in energy intake without a concomitant increase in energy expenditure. To combat the obesity epidemic, many studies have focused on the pathways underlying ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaspari RR,Reyna-Neyra A,Jung L,Torres-Manzo AP,Hirabara SM,Carrasco N

更新日期：2020-09-08 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:Retroviruses evolved from long terminal repeat (LTR) retrotransposons by acquisition of envelope functions, and subsequently reinvaded host genomes. Together, endogenous retroviruses and LTR retrotransposons represent major components of animal, plant, and fungal genomes. Sequences from these elements have been exapte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodonova SO,Prinz S,Bilanchone V,Sandmeyer S,Briggs JAG

更新日期：2019-05-14 00:00:00

abstract：:We report the development of a practical ultrafast allelic profiling assay for the analysis of short tandem repeats (STRs) by using a highly optimized microfluidic electrophoresis device. We have achieved baseline-resolved electrophoretic separations of single-locus STR samples in 30 sec. Analyses of PCR samples conta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmalzing D,Koutny L,Adourian A,Belgrader P,Matsudaira P,Ehrlich D

更新日期：1997-09-16 00:00:00

abstract：:Transcription initiation in eukaryotes is controlled by nucleoprotein complexes formed through cooperative interactions among multiple transcription regulatory proteins. These complexes may be assembled via stochastic collisions or defined pathways. We investigated the dynamics of Fos-Jun-NFAT1 complexes by using a mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramirez-Carrozzi VR,Kerppola TK

更新日期：2001-04-24 00:00:00

abstract：:More than a thousand proteins are thought to contribute to mammalian chromatin and its regulation, but our understanding of the genomic occupancy and function of most of these proteins is limited. Here we describe an approach, which we call "chromatin proteomic profiling," to identify proteins associated with genomic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji X,Dadon DB,Abraham BJ,Lee TI,Jaenisch R,Bradner JE,Young RA

更新日期：2015-03-24 00:00:00

abstract：:Fumarase C was strongly induced by paraquat in a parental strain of Escherichia coli but was not induced in a strain lacking the soxRS response. Moreover, a strain that constitutively expresses the soxRS regulon contained more fumarase C than did the parental strain. The Mn-containing superoxide dismutase and glucose-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liochev SI,Fridovich I

更新日期：1992-07-01 00:00:00

abstract：:DsRed, a brilliantly red fluorescent protein, was recently cloned from Discosoma coral by homology to the green fluorescent protein (GFP) from the jellyfish Aequorea. A core question in the biochemistry of DsRed is the mechanism by which the GFP-like 475-nm excitation and 500-nm emission maxima of immature DsRed are r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross LA,Baird GS,Hoffman RC,Baldridge KK,Tsien RY

更新日期：2000-10-24 00:00:00

abstract：:Lipid interactions with the integral membrane protein Na,K-ATPase (ATP phosphohydrolase, EC 3.6.1.3) purified from the electric organ of Electrophorus electricus were studied by spin labeling. A protein-associated component (boundary layer) in equilibrium with the fluid bilayer is clearly evident in the electron spin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brotherus JR,Jost PC,Griffith OH,Keana JF,Hokin LE

更新日期：1980-01-01 00:00:00

abstract：:A recently described experimental system for analyzing the mode of action of a morphogen gradient involves the in situ hybridization of sectioned tissue constructs. In these constructs, a source of activin signaling induces the transcription of several mesodermal genes in blastula animal caps, according to the positio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gurdon JB,Mitchell A,Ryan K

更新日期：1996-09-03 00:00:00

abstract：:The objective of this study was to determine whether the vascular smooth muscle contractile effect of NG-methyl-L-arginine (NMA) is endothelium dependent and attributed to a decline in smooth muscle levels of cyclic GMP. Vascular smooth muscle levels of cyclic GMP are severalfold greater in endothelium-intact than in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gold ME,Wood KS,Byrns RE,Fukuto J,Ignarro LJ

更新日期：1990-06-01 00:00:00

abstract：:Whether Golgi enzymes remain localized within the Golgi or constitutively cycle through the endoplasmic reticulum (ER) is unclear, yet is important for understanding Golgi dependence on the ER. Here, we demonstrate that the previously reported inefficient ER trapping of Golgi enzymes in a rapamycin-based assay results...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sengupta P,Satpute-Krishnan P,Seo AY,Burnette DT,Patterson GH,Lippincott-Schwartz J

更新日期：2015-12-08 00:00:00

abstract：:Low phosphate (Pi) availability is one of the major constraints for plant productivity in natural and agricultural ecosystems. Plants have evolved a myriad of developmental and biochemical mechanisms to increase internal Pi uptake and utilization efficiency. One important biochemical pathway leading to an increase in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cruz-Ramírez A,Oropeza-Aburto A,Razo-Hernández F,Ramírez-Chávez E,Herrera-Estrella L

更新日期：2006-04-25 00:00:00

abstract：:Noonan syndrome (NS) is a relatively common genetic disorder, characterized by typical facies, short stature, developmental delay, and cardiac abnormalities. Known causative genes account for 70-80% of clinically diagnosed NS patients, but the genetic basis for the remaining 20-30% of cases is unknown. We performed ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen PC,Yin J,Yu HW,Yuan T,Fernandez M,Yung CK,Trinh QM,Peltekova VD,Reid JG,Tworog-Dube E,Morgan MB,Muzny DM,Stein L,McPherson JD,Roberts AE,Gibbs RA,Neel BG,Kucherlapati R

更新日期：2014-08-05 00:00:00

abstract：:When a mutant of Saccharomyces cerevisiae (spe2 delta) that cannot make spermidine or spermine was incubated in a polyamine-deficient medium in oxygen, there was a rapid cessation of cell growth and associated cell death. In contrast, when the mutant cells were incubated in the polyamine-deficient medium in air or ana...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasundaram D,Tabor CW,Tabor H

更新日期：1993-05-15 00:00:00

abstract：:In healthy adults, activation of γ-aminobutyric acid (GABA)(A) and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl(-)](i)), which is maintained by the potassium-chloride cotransporter KCC2. A reduction of KCC2 expression or function is implicated in the pathogenesis of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bos R,Sadlaoud K,Boulenguez P,Buttigieg D,Liabeuf S,Brocard C,Haase G,Bras H,Vinay L

更新日期：2013-01-02 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (SOD). In this article, we report that amyotrophic lateral sclerosis-associated SOD mutations with distinctly different disease progression can be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindberg MJ,Byström R,Boknäs N,Andersen PM,Oliveberg M

更新日期：2005-07-12 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These compounds are taken up by cells in a saturable, size-dependent manner compatible with receptor-mediated endocytosis. Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke SL,Stein CA,Zhang XH,Mori K,Nakanishi M,Subasinghe C,Cohen JS,Neckers LM

更新日期：1989-05-01 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:Stereotypical patterns of vascular and neuronal networks suggest that specific genetic programs tightly control path determination and, consequently, angiogenesis and axon-guidance mechanisms. Our study focuses on one member of the roundabout family of receptors, which traditionally mediate repulsion from the midline....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedell VM,Yeo SY,Park KW,Chung J,Seth P,Shivalingappa V,Zhao J,Obara T,Sukhatme VP,Drummond IA,Li DY,Ramchandran R

更新日期：2005-05-03 00:00:00

abstract：:The ribosome is one of the major targets for therapeutic antibiotics; however, the rise in multidrug resistance is a growing threat to the utility of our current arsenal. The orthosomycin antibiotics evernimicin (EVN) and avilamycin (AVI) target the ribosome and do not display cross-resistance with any other classes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arenz S,Juette MF,Graf M,Nguyen F,Huter P,Polikanov YS,Blanchard SC,Wilson DN

更新日期：2016-07-05 00:00:00

abstract：:Thymic epithelial cells (TECs), the major component of the thymic microenvironment, can be modulated by pituitary hormones. We have shown previously that prolactin (PRL) can influence the endocrine activity of TECs and stimulate TEC proliferation as well as cytokeratin expression, suggesting the existence of PRL recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Kelly PA,Bach JF,Savino W

更新日期：1991-11-01 00:00:00

abstract：:Addition of Na+ to Na+-depleted Swiss 3T3 cells causes a rapid and dramatic increase in intracellular pH, as monitored by uptake of the weak acid 5,5-dimethyloxazolidine-2,4-dione. The effect of Na+ is concentration dependent (half-maximal effect at 38 mM); this cation can be replaced by Li+ but not by K+ or the choli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuldiner S,Rozengurt E

更新日期：1982-12-01 00:00:00

abstract：:In yeast, the mRNA encoded by the MAT alpha 1 gene is unstable (t1/2 = 5 min) and the mRNAs encoded by the ACT1 gene (t1/2 = 30 min) and the PGK1 gene (t1/2 = 45 min) are stable. To understand the RNA structural features that dictate mRNA decay rates in yeast, we have constructed PGK1/MAT alpha 1 and ACT1/MAT alpha 1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker R,Jacobson A

更新日期：1990-04-01 00:00:00

abstract：:Quantifying the uncertainty for the present climate and the predictions of climate change in the suite of imperfect Atmosphere Ocean Science (AOS) computer models is a central issue in climate change science. Here, a systematic approach to these issues with firm mathematical underpinning is developed through empirical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majda AJ,Gershgorin B

更新日期：2010-08-24 00:00:00

abstract：:Newly emerging plants provide the best forage for herbivores. To exploit this fleeting resource, migrating herbivores align their movements to surf the wave of spring green-up. With new technology to track migrating animals, the Green Wave Hypothesis has steadily gained empirical support across a diversity of migrator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geremia C,Merkle JA,Eacker DR,Wallen RL,White PJ,Hebblewhite M,Kauffman MJ

更新日期：2019-12-17 00:00:00

abstract：:The nerve growth factor (NGF)-mediated increase in c-fos gene expression in the rat pheochromocytoma PC12 cell line has been investigated. NGF treatment of PC12 cells results in an increased level of c-fos mRNA within 15 min. An approximately 100-fold increase in the level of c-fos mRNA occurs 30-45 min after exposure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milbrandt J

更新日期：1986-07-01 00:00:00