A colchicine-sensitive uptake system in Morris hepatomas.

abstract：:Newly emerging plants provide the best forage for herbivores. To exploit this fleeting resource, migrating herbivores align their movements to surf the wave of spring green-up. With new technology to track migrating animals, the Green Wave Hypothesis has steadily gained empirical support across a diversity of migrator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geremia C,Merkle JA,Eacker DR,Wallen RL,White PJ,Hebblewhite M,Kauffman MJ

更新日期：2019-12-17 00:00:00

abstract：:Cofilin-actin rods are inclusion-like structures that are induced by certain chemical or physical stresses in cultured cells, and the rods formed in neurons are thought to be associated with neurodegeneration. Here, we cloned an Aplysia cofilin homolog and overexpressed it in cultured neurons. Overexpressed cofilin fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang DH,Han JH,Lee SH,Lee YS,Park H,Lee SH,Kim H,Kaang BK

更新日期：2005-11-01 00:00:00

abstract：:The mitochondrial DNA polymerase from Drosophila embryos lacks dNTP turnover activity. However, a potent 3'----5' exonuclease activity can be detected by a specific assay in which the exonuclease excises mispaired nucleotides at the 3' termini of primed synthetic and natural DNA templates. The excision of a mispaired ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaguni LS,Olson MW

更新日期：1989-09-01 00:00:00

abstract：:In yeasts and mammals, PEX10 encodes an integral membrane protein with a C3HC4 RING finger motif in its C-terminal domain and is required for peroxisome biogenesis and matrix protein import. In humans, its dysfunction in peroxisome biogenesis leads to severe Zellweger Syndrome and infantile Refsum disease. Here we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schumann U,Wanner G,Veenhuis M,Schmid M,Gietl C

更新日期：2003-08-05 00:00:00

abstract：:Formation of male-specific structures and regression of female primordia are regulated in early male embryogenesis by SRY, a single-copy gene on the Y chromosome. Assignment of SRY as the testis-determining factor in eutherian mammals is supported by molecular analysis of cytogenetic sex reversal (i.e., XX males and X...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haqq CM,King CY,Donahoe PK,Weiss MA

更新日期：1993-02-01 00:00:00

abstract：:BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bahn G,Park JS,Yun UJ,Lee YJ,Choi Y,Park JS,Baek SH,Choi BY,Cho YS,Kim HK,Han J,Sul JH,Baik SH,Lim J,Wakabayashi N,Bae SH,Han JW,Arumugam TV,Mattson MP,Jo DG

更新日期：2019-06-18 00:00:00

abstract：:The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation domain (TAD) of p53,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon JC,Lee CW,Arai M,Martinez-Yamout MA,Dyson HJ,Wright PE

更新日期：2009-04-21 00:00:00

abstract：:In this note the Weierstrass integral J is taken as L, the Riemann integral of length. Here M(n), n > 1, is a compact, connected manifold of class C(infinity) with a positive definite Riemann structure. Presentations (phi, U(phi)) in M(n) and geodesics (with the aid of the Euler-Riemann equations) are defined in Morse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morse M

更新日期：1977-06-01 00:00:00

abstract：:Evidence for hydrogen bonding between 5'-ribonucleotides in water has been obtained from a 220-MHz proton magnetic resonance study of nitrogenous protons. The amino groups of GMP, AMP, and CMP exhibit proton resonance lines which are somewhat broadened by proton exchange with the solvent at 0 degrees ; their downfield...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raszka M,Kaplan NO

更新日期：1972-08-01 00:00:00

abstract：:Several domains of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been identified that are involved in HIV-1-mediated membrane fusion. One domain that is involved in membrane fusion is the hydrophobic amino terminus of the HIV-1 transmembrane glycoprotein gp41. Here we show that a polar sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freed EO,Delwart EL,Buchschacher GL Jr,Panganiban AT

更新日期：1992-01-01 00:00:00

abstract：:Recent studies have shown that the genes of the gibberellin (GA) biosynthesis pathway in the fungus Gibberella fujikuroi are organized in a cluster of at least seven genes. P450-1 is one of four cytochrome P450 monooxygenase genes in this cluster. Disruption of the P450-1 gene in the GA-producing wild-type strain IMI ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojas MC,Hedden P,Gaskin P,Tudzynski B

更新日期：2001-05-08 00:00:00

abstract：:Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an increased risk for Alzheimer's disease (AD). While the primary function of ABCA7 is to regulate the transport of phospholipids and cholesterol, ABCA7 is also involved in maintaining homeostasis of the immune system. Since inflamm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aikawa T,Ren Y,Yamazaki Y,Tachibana M,Johnson MR,Anderson CT,Martens YA,Holm ML,Asmann YW,Saito T,Saido TC,Fitzgerald ML,Bu G,Kanekiyo T

更新日期：2019-11-19 00:00:00

abstract：:Pinus taeda L. (loblolly pine) and Arabidopsis thaliana differ greatly in form, ecological niche, evolutionary history, and genome size. Arabidopsis is a small, herbaceous, annual dicotyledon, whereas pines are large, long-lived, coniferous forest trees. Such diverse plants might be expected to differ in a large numbe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirst M,Johnson AF,Baucom C,Ulrich E,Hubbard K,Staggs R,Paule C,Retzel E,Whetten R,Sederoff R

更新日期：2003-06-10 00:00:00

abstract：:The candidate phylum TM7 is globally distributed and often associated with human inflammatory mucosal diseases. Despite its prevalence, the TM7 phylum remains recalcitrant to cultivation, making it one of the most enigmatic phyla known. In this study, we cultivated a TM7 phylotype (TM7x) from the human oral cavity. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He X,McLean JS,Edlund A,Yooseph S,Hall AP,Liu SY,Dorrestein PC,Esquenazi E,Hunter RC,Cheng G,Nelson KE,Lux R,Shi W

更新日期：2015-01-06 00:00:00

abstract：:The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apcher S,Daskalogianni C,Lejeune F,Manoury B,Imhoos G,Heslop L,Fåhraeus R

更新日期：2011-07-12 00:00:00

abstract：:An endonucleolytic activity is associated with purified PM(2) bacteriophages. It converts the double-stranded supercoiled PM(2) DNA mostly into the linear form that sediments as a homogenous peak in alkaline sucrose gradients. The same activity is found in intact or detergent-lysed phages. Optimal activity is observed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laval F

更新日期：1974-12-01 00:00:00

abstract：:We have cloned a mutS homolog from Drosophila melanogaster called spellchecker1 (spel1) and have constructed spel1 mutant flies. MutS proteins promote the correction of DNA mismatches and serve important roles in DNA replication, recombination, and repair. The spel1 gene belongs to a subfamily of mutS first characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores C,Engels W

更新日期：1999-03-16 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity as judged by gel electrophoresis, using an in vitro complementation assay. It is a dimer of identical 110,000-dalton subunits. A polypeptide of this molecular weight is uniquely induced by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugino A,Peebles CL,Kreuzer KN,Cozzarelli NR

更新日期：1977-11-01 00:00:00

abstract：:The gal operon of Escherichia coli is negatively regulated by repressor binding to bipartite operators separated by 11 helical turns of DNA. Synergistic binding of repressor to separate sites on DNA results in looping, with the intervening DNA as a topologically closed domain containing the two promoters. A closed DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choy HE,Park SW,Parrack P,Adhya S

更新日期：1995-08-01 00:00:00

abstract：:A deficit in early clearance of Pseudomonas aeruginosa (P. aeruginosa) is crucial in nosocomial pneumonia and in chronic lung infections. Few studies have addressed the role of Toll-like receptors (TLRs), which are early pathogen associated molecular pattern receptors, in pathogen uptake and clearance by alveolar macr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM

更新日期：2012-01-31 00:00:00

abstract：:Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan P,Ripoll JJ,Wang R,Vuong L,Bailey-Steinitz LJ,Ye D,Crawford NM

更新日期：2017-02-28 00:00:00

abstract：:The primary structure and phosphorylation pattern of the tandem Y(1)S(2)P(3)T(4)S(5)P(6)S(7) repeats of the RNA polymerase II carboxyl-terminal domain (CTD) convey information about the transcription apparatus--a CTD code--to a large ensemble of CTD-binding receptor proteins. Four of the seven coding "letters" of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwer B,Sanchez AM,Shuman S

更新日期：2012-10-30 00:00:00

abstract：:Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA) (EC 3.5.1.15). ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madhavarao CN,Arun P,Moffett JR,Szucs S,Surendran S,Matalon R,Garbern J,Hristova D,Johnson A,Jiang W,Namboodiri MA

更新日期：2005-04-05 00:00:00

abstract：:Chemical labeling of proteins inside of living cells can enable studies of the location, movement, and function of proteins in vivo. Here we demonstrate an approach for chemical labeling of proteins that uses the high-affinity interaction between an FKBP12 mutant (F36V) and a synthetic, engineered ligand (SLF'). A flu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marks KM,Braun PD,Nolan GP

更新日期：2004-07-06 00:00:00

abstract：:The steroid cholesterol is an essential component of eukaryotic membranes, and it functionally modulates membrane proteins, including G protein-coupled receptors. To reveal insight into how cholesterol modulates G protein-coupled receptors, we have used dynamic single-molecule force spectroscopy to quantify the mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zocher M,Zhang C,Rasmussen SG,Kobilka BK,Müller DJ

更新日期：2012-12-11 00:00:00

abstract：:Genetic manipulation of nitrogenase and key glutamate-forming enzymes can provide mutants that excrete fixed N2 as NH4+. A derepressed N2 fxation mutant (SK-24) has been isolated , which excretes up to 20.2 mumol of fixed N2 as NH4+ per mg of cell protein in 24 hr at room temperature. Biochemical analysis shows that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanmugam KT,Valentine RC

更新日期：1975-01-01 00:00:00

abstract：:High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected in crosses between inbred strains are often caused by numerous linked QTLs, each of small effect. In a study of fearfulness in mice, we have shown it is possible to fine map small-effe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mott R,Talbot CJ,Turri MG,Collins AC,Flint J

更新日期：2000-11-07 00:00:00

abstract：:An investigation by paramagnetic resonance spectroscopy of the photoreduction of ferredoxin, oxygenically by water and anoxygenically by a direct electron donor to photosystem I, led to the unexpected findings that different reductive mechanisms may be involved. Ferredoxin photoreduced by water was not reoxidized in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnon DI,Tsujimoto HY,Tang GM

更新日期：1980-05-01 00:00:00

abstract：:Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groll M,Larionov OV,Huber R,de Meijere A

更新日期：2006-03-21 00:00:00