ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.

abstract：:Creatine kinase from rabbit muscle has been specifically labeled with a derivative of a nitroxide free radical on the two essential sulfhydryl groups, one per active site. The conformation in the environment of the enzyme-bound free radical and the change in conformation induced upon binding of the substrate, metal ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor JS,Leigh JS Jr,Cohn M

更新日期：1969-09-01 00:00:00

abstract：:Due to intrinsic aggressiveness and lack of effective therapies, prognosis of pancreatic cancer remains dismal. Because the only molecular targeted drug approved for pancreatic ductal adenocarcinoma is a kinase inhibitor specific to the epidermal growth factor receptor (EGFR), and this receptor collaborates with anoth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maron R,Schechter B,Mancini M,Mahlknecht G,Yarden Y,Sela M

更新日期：2013-09-17 00:00:00

abstract：:Antigenic markers associated with the major internal protein of RNA tumor viruses of the C-type have proven extremely useful in natural history studies of these viruses. This protein possesses species-specific antigenic determinants, and, in the case of mammalian C-type viruses, the protein possesses crossreactive det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilden RV,Oroszlan S

更新日期：1972-04-01 00:00:00

abstract：:This paper reviews food (especially cereal) production trends and prospects for the world and its main regions. Despite fears to the contrary, in recent years we have seen continued progress toward better methods of feeding humanity. Sub-Saharan Africa is the sole major exception. Looking to the future, this paper arg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dyson T

更新日期：1999-05-25 00:00:00

abstract：:Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of the organosulfur in nature, where it is degraded by bacteria. A first degradation pathway for SQ has been demonstrated recently, a "sulfoglycolytic" pathway, in addition...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felux AK,Spiteller D,Klebensberger J,Schleheck D

更新日期：2015-08-04 00:00:00

abstract：:Antibody raised against the human erythrocyte glucose transporter identified a recombinant lambda gt11 bacteriophage in a cDNA library prepared from immunoselected polysomal RNA from adult rat brain. The cDNA predicts a 492-amino acid protein that demonstrates 97.6% identity to the human hepatoma hexose carrier. The t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birnbaum MJ,Haspel HC,Rosen OM

更新日期：1986-08-01 00:00:00

abstract：:Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins, including plasma proteins, hormones, neuropeptides, and growth factors. Most frequently, propeptide cleavage occurs after paired basic amino acid residues. To date, no mammalian propeptide processing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise RJ,Barr PJ,Wong PA,Kiefer MC,Brake AJ,Kaufman RJ

更新日期：1990-12-01 00:00:00

abstract：:Climate change is increasing fire activity in the western United States, which has the potential to accelerate climate-induced shifts in vegetation communities. Wildfire can catalyze vegetation change by killing adult trees that could otherwise persist in climate conditions no longer suitable for seedling establishmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis KT,Dobrowski SZ,Higuera PE,Holden ZA,Veblen TT,Rother MT,Parks SA,Sala A,Maneta MP

更新日期：2019-03-26 00:00:00

abstract：:We analyzed the distribution of the cauliflower mosaic virus (CaMV) aphid transmission factor (ATF), produced via a baculovirus recombinant, within Sf9 insect cells. Immunogold labeling revealed that the ATF colocalizes with an atypical cytoskeletal network. Detailed observation by electron microscopy demonstrated tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanc S,Schmidt I,Vantard M,Scholthof HB,Kuhl G,Esperandieu P,Cerutti M,Louis C

更新日期：1996-12-24 00:00:00

abstract：:Bacterial outer membrane porins have a robust beta-barrel structure and therefore show potential for use as stochastic sensors based on single-molecule detection. The monomeric porin OmpG is especially attractive compared with multisubunit proteins because appropriate modifications of the pore can be easily achieved b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Khalid S,Sansom MS,Bayley H

更新日期：2008-04-29 00:00:00

abstract：:Nucleotide excision repair (NER) prevents skin cancer by eliminating highly genotoxic cyclobutane pyrimidine dimers (CPDs) induced in DNA by the UVB component of sunlight. NER consists of two distinct but overlapping subpathways, i.e., global NER, which removes CPD from the genome overall, and transcription-coupled NE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathonnet G,Leger C,Desnoyers J,Drouin R,Therrien JP,Drobetsky EA

更新日期：2003-06-10 00:00:00

abstract：:A 2.9-kilobase Acc I fragment of the DNA of the pneumococcal bacteriophage Cp-1, containing the cpl gene, hybridizes with the lytA gene encoding the pneumococcal amidase. The nucleotide sequence of the cpl gene of Cp-1, encoding a muramidase (CPL), has been determined. The 3' regions of the cpl and lytA coding sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García E,García JL,García P,Arrarás A,Sánchez-Puelles JM,López R

更新日期：1988-02-01 00:00:00

abstract：:Myosin X (MyoX), encoded by Myo10, is a representative member of the MyTH4-FERM domain-containing myosins, and this family of unconventional myosins shares common functions in promoting formation of filopodia/stereocilia structures in many cell types with unknown mechanisms. Here, we present the structure of the MyoX ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Z,Yan J,Lu Q,Pan L,Zhang M

更新日期：2011-03-01 00:00:00

abstract：:A discussion of the expected mechanism of radical reduction of carbonyl compounds by dihydroflavin as it relates to the structure of the carbonyl compound is provided. Factors which must be taken into account are the free energies of formation of the radical anions (CR2O), THE ACIDITY OF THE CONJUGATE ACID OF THE CARB...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RF,Shinkai S,Bruice TC

更新日期：1975-05-01 00:00:00

abstract：:A definitive assay for microbiological and biochemical research on the biodegradation of lignin was developed using radioactive synthetic lignins specifically labeled in the side chains, aromatic rings or in the methoxyl groups. The [14C]lignins were prepared by oxidative polymerization with peroxidase and H2O2 Of spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirk TK,Connors WJ,Bleam RD,Hackett WF,Zeikus JG

更新日期：1975-07-01 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00

abstract：:The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware implementations of CS-based acquisition devices--especially in optics--have only start...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studer V,Bobin J,Chahid M,Mousavi HS,Candes E,Dahan M

更新日期：2012-06-26 00:00:00

abstract：:Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarute N,Ross SR

更新日期：2020-08-11 00:00:00

abstract：:The existence of immunoregulatory genes conferring dominant resistance to autoimmunity is well documented. In an effort to better understand the nature and mechanisms of action of these genes, we utilized the murine model of autoimmune orchitis as a prototype. When the orchitis-resistant strain DBA/2J is crossed with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meeker ND,Hickey WF,Korngold R,Hansen WK,Sudweeks JD,Wardell BB,Griffith JS,Teuscher C

更新日期：1995-06-06 00:00:00

abstract：:Oncogene-induced senescence (OIS) is an initial barrier to tumor development. Reactive oxygen species (ROS) is critical for oncogenic Ras OIS, but the downstream effectors to mediate ROS signaling are still relatively elusive. Senescent cells develop a senescence-associated secretory phenotype (SASP). However, the mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang P,Han L,Shen H,Wang P,Lv C,Zhao G,Niu J,Xue L,Wang QJ,Tong T,Chen J

更新日期：2014-05-27 00:00:00

abstract：:RNA was synthesized in vitro from a T3 DNA template by T3 RNA polymerase and subsequently separated into seven discrete size classes (molecular weights ranging between 0.21 x 10(6) and 6.2 x 10(6)) by electrophoresis in polyacrylamide slab gels. RNase T1-generated 3'-terminal oligonucleotide fragments were then select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majumder HK,Maitra U,Rosenberg M

更新日期：1979-10-01 00:00:00

abstract：:In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbertson LA,Stahl FW

更新日期：1994-12-06 00:00:00

abstract：:Atherosclerosis is a complex disease resulting from the interaction of multiple genes. We have used the Ldlr knockout mouse model in an interspecific genetic cross to map atherosclerosis susceptibility loci. A total of 174 (MOLF/Ei x B6.129S7-Ldlr(tm1Her)) x C57BL/6J-Ldlr(tm1Her) backcross mice, homozygous for the Ldl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welch CL,Bretschger S,Latib N,Bezouevski M,Guo Y,Pleskac N,Liang CP,Barlow C,Dansky H,Breslow JL,Tall AR

更新日期：2001-07-03 00:00:00

abstract：:Eosinophils have been associated with fibrosis. To investigate their direct role in fibrosis, human peripheral blood eosinophil sonicate was added to human lung or dermal fibroblasts, and proliferation ([(3)H]thymidine) and collagen synthesis ([(3)H]proline) were evaluated. Proliferation was enhanced significantly in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi-Schaffer F,Garbuzenko E,Rubin A,Reich R,Pickholz D,Gillery P,Emonard H,Nagler A,Maquart FA

更新日期：1999-08-17 00:00:00

abstract：:Because most human squamous carcinoma cell lines of the aerodigestive and genital tracts are refractory to the antiproliferative action of transforming growth factor beta 1 (TGF beta 1) in vitro, we have begun to identify the causes for resistance of squamous carcinoma cell lines to TGF beta 1 by using somatic cell ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiss M,Muñoz-Antonia T,Cowan JM,Wilkins PC,Zhou ZL,Vellucci VF

更新日期：1993-07-01 00:00:00

abstract：:The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing neurons, suggesting its possible role in vesicular zinc transport. We show here that histochemically reactive zinc, corresponding to the zinc found within synaptic vesicles, was undetectable in the brains of mice with targeted disrupti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole TB,Wenzel HJ,Kafer KE,Schwartzkroin PA,Palmiter RD

更新日期：1999-02-16 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main barriers of tumori...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hydbring P,Bahram F,Su Y,Tronnersjö S,Högstrand K,von der Lehr N,Sharifi HR,Lilischkis R,Hein N,Wu S,Vervoorts J,Henriksson M,Grandien A,Lüscher B,Larsson LG

更新日期：2010-01-05 00:00:00

abstract：:The Taq DNA polymerase is the most commonly used enzyme in DNA sequencing. However, all versions of Taq polymerase are deficient in two respects: (i) these enzymes incorporate each of the four dideoxynucleoside 5' triphosphates (ddNTPs) at widely different rates during sequencing (ddGTP, for example, is incorporated 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Mitaxov V,Waksman G

更新日期：1999-08-17 00:00:00