CACNA1S haploinsufficiency confers resistance to New World arenavirus infection.

abstract：:The effect of human papillomavirus (HPV) and activated oncogenes on the growth and morphology of primary baby mouse kidney (BMK) cells has been studied. Early region DNA from HPV types 16, 18, 31, and 33, but not type 6, under the transcriptional control of a heterologous, retroviral promoter cooperated with EJ-ras to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crook T,Storey A,Almond N,Osborn K,Crawford L

更新日期：1988-12-01 00:00:00

abstract：:Two functional human dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) cDNAs were isolated from a cDNA expression library by genetic complementation in Escherichia coli. These cDNAs differed in size but exhibited a common overlapping DNA sequence. Contained within this sequence was a single long open reading frame sufficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McIntosh EM,Ager DD,Gadsden MH,Haynes RH

更新日期：1992-09-01 00:00:00

abstract：:Four mouse POU domain genomic DNA clones--Brain-1, Brain-2, Brain-4, and Scip--and Brain-2 cDNA, which are expressed in adult brain, were cloned and the coding and noncoding regions of the genes were sequenced. The amino acid sequences of the four POU domains are highly conserved; sequences in other regions of the pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hara Y,Rovescalli AC,Kim Y,Nirenberg M

更新日期：1992-04-15 00:00:00

abstract：:An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in vivo stem cell-driven ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N

更新日期：2021-01-26 00:00:00

abstract：:We have measured the quantities of naturally occurring autoantibodies in the serum of normal, unmanipulated individuals. These changes over time following broad-band complex dynamical patterns that are similar in mouse and man. The patterns more likely reflect the network architecture of the natural antibody repertoir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varela F,Andersson A,Dietrich G,Sundblad A,Holmberg D,Kazatchkine M,Coutinho A

更新日期：1991-07-01 00:00:00

abstract：:Recombinant (r) Mycobacterium bovis strains were constructed that secrete biologically active listeriolysin (Hly) fusion protein of Listeria monocytogenes. The r-BCG strains pAT261:Hly or pMV306:Hly expressed plasmid multicopies or chromosomal single copies of the hly gene, respectively. Human and murine macrophage-li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess J,Miko D,Catic A,Lehmensiek V,Russell DG,Kaufmann SH

更新日期：1998-04-28 00:00:00

abstract：:Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of changes in the highly heterogeneous mixtures of lipids found in eukaryotic cells is central to understanding the complex functions in which lipids participate. P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova PT,Cerda BA,Horn DM,Cohen JS,McLafferty FW,Brown HA

更新日期：2001-06-19 00:00:00

abstract：:An established line of mouse fibroblasts, C3H/10T1/2 cells, was used for the assessment in vitro of oncogenic transformations caused by single and split doses of x-rays. The shape of the dose-response relationship was determined over the range from 0.1 to 10 Gy. It was found that splitting the x-ray dose into two equa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RC,Hall EJ,Rossi HH

更新日期：1979-11-01 00:00:00

abstract：:High-affinity nuclear binding sites for 17 beta-estradiol (17 beta E2) were recently found in bone cells; however, the mechanism by which estrogen exerts its effect on bone in vivo is still unknown. To study if estrogen acts on bone directly, we used an experimental model in which test substances are infused locally i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takano-Yamamoto T,Rodan GA

更新日期：1990-03-01 00:00:00

abstract：:It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226-232; Riggs AD (1975) Cytogenet Cell Ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bestor TH,Edwards JR,Boulard M

更新日期：2015-06-02 00:00:00

abstract：:Lateral organ distribution at the shoot apical meristem defines specific and robust phyllotaxis patterns that have intrigued biologists and mathematicians for centuries. In silico studies have revealed that this self-organizing process can be recapitulated by modeling the polar transport of the phytohormone auxin. Phy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinon V,Prasad K,Grigg SP,Sanchez-Perez GF,Scheres B

更新日期：2013-01-15 00:00:00

abstract：:Gecko and many insects have adopted nanoscale fibrillar structures on their feet as adhesion devices. Here, we consider adhesion between a single fiber and a substrate by van der Waals or electrostatic interactions. For a given contact area A, the theoretical pull-off force of the fiber is sigma(th)A where sigma(th) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Yao H

更新日期：2004-05-25 00:00:00

abstract：:Scholander and his coworkers have described in These Proceedings several experiments in which the osmotic pressure exerted by colloidal particles appears to be altered when the particles are subject to an external force; they interpret the experiments as showing that the traditional explanation of osmotic pressure is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie RK

更新日期：1974-08-01 00:00:00

abstract：:Climate change and resource exploitation have been shown to modify the importance of bottom-up and top-down forces in ecosystems. However, the resulting pattern of trophic control in complex food webs is an emergent property of the system and thus unintuitive. We develop a statistical nondeterministic model, capable o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynam CP,Llope M,Möllmann C,Helaouët P,Bayliss-Brown GA,Stenseth NC

更新日期：2017-02-21 00:00:00

abstract：:The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain containing the EH catalytic activity has been well studied. In contrast, a function for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman JW,Morisseau C,Harris TR,Hammock BD

更新日期：2003-02-18 00:00:00

abstract：:The spleen is the lymphoid organ that induces immune responses toward blood-borne pathogens. Specialized macrophages in the splenic marginal zone are strategically positioned to phagocytose pathogens and cell debris, but are not known to play a role in the activation of T-cell responses. Here we demonstrate that splen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backer R,Schwandt T,Greuter M,Oosting M,Jüngerkes F,Tüting T,Boon L,O'Toole T,Kraal G,Limmer A,den Haan JM

更新日期：2010-01-05 00:00:00

abstract：:Three fluorescein-labeled lectins have been shown to exhibit specificity for the surface of cells in different layers of the epidermis in the newborn rat. An isolectin from seeds of Bandeiraea simplicifolia with specificity for alpha-D-galactosyl end groups labeled the basal and lower spinous cells; a lectin from Ulex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brabec RK,Peters BP,Bernstein IA,Gray RH,Goldstein IJ

更新日期：1980-01-01 00:00:00

abstract：:Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality. Accumulation of these "compatible" organic osmolytes is believed to help the cells osmoregulate in response to the high extracellular osmolality that occurs as par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi T,Turner RJ,Burg MB

更新日期：1989-08-01 00:00:00

abstract：:3-Hydroxyanthranilic acid (HAA), a compound generated during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell death, but its molecular target is not known. Here we report that HAA inhibits NF-kappaB activation upon T cell antigen receptor engagement by specifically targeting PD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayashi T,Mo JH,Gong X,Rossetto C,Jang A,Beck L,Elliott GI,Kufareva I,Abagyan R,Broide DH,Lee J,Raz E

更新日期：2007-11-20 00:00:00

abstract：:With high-dimensional data, variable-by-variable statistical testing is often used to select variables whose behavior differs across conditions. Such an approach requires adjustment for multiple testing, which can result in low statistical power. A two-stage approach that first filters variables by a criterion indepen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bourgon R,Gentleman R,Huber W

更新日期：2010-05-25 00:00:00

abstract：:X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1 This unique insertion coincides with six additional noncoding sequence changes in TAF1, the gene that encodes TATA-binding protein-associated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bragg DC,Mangkalaphiban K,Vaine CA,Kulkarni NJ,Shin D,Yadav R,Dhakal J,Ton ML,Cheng A,Russo CT,Ang M,Acuña P,Go C,Franceour TN,Multhaupt-Buell T,Ito N,Müller U,Hendriks WT,Breakefield XO,Sharma N,Ozelius LJ

更新日期：2017-12-19 00:00:00

abstract：:Old noninbred fly mortality decreases according to the inverse linear law and reduces to a single suborder-specific age. Relative child mortality (the mortality at a given age related to the mortality at 10 years) from 1 mo to 11 years is the same with 8% mean accuracy for all humans, independent of race, country, sex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azbel' MY

更新日期：1998-07-21 00:00:00

abstract：:Eye-opening represents a turning point in the function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically. After eye-opening, the cortex starts to integrate visual information. Here we used in vivo two-photon calcium imagi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochefort NL,Garaschuk O,Milos RI,Narushima M,Marandi N,Pichler B,Kovalchuk Y,Konnerth A

更新日期：2009-09-01 00:00:00

abstract：:A series of spontaneous suppressors to the temperature-sensitive phenotype of the single-stranded DNA-binding protein mutation ssb-1 were isolated. A genomic library of EcoRI fragments from one of these suppressor strains was prepared by using pBR325 as the cloning vector. A 10.0-kilobase class of inserts was identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruben SM,VanDenBrink-Webb SE,Rein DC,Meyer RR

更新日期：1988-06-01 00:00:00

abstract：:The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim EJ,Horovitz O,Pellman BA,Tan LM,Li Q,Richter-Levin G,Kim JJ

更新日期：2013-09-03 00:00:00

abstract：:The effect of combining hormonal treatment consisting of long-acting microcapsules of the agonist [D-Trp6]LH-RH (the D-tryptophan-6 analog of luteinizing hormone-releasing hormone) with the chemotherapeutic agent cyclophosphamide was investigated in the Dunning R-3327H rat prostate cancer model. Microcapsules of [D-Tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schally AV,Redding TW

更新日期：1985-04-01 00:00:00

abstract：:The turnover rates of junctional acetylcholine receptors were measured in innervated and denervated mouse sternomastoid neuromuscular junctions by 125I-labeled alpha-bungarotoxin binding. First, we determined that the density of labeled toxin initially bound to the neuromuscular junction was essentially unchanged up t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loring RH,Salpeter MM

更新日期：1980-04-01 00:00:00

abstract：:The type I collagenopathies are a group of heterogeneous connective tissue disorders, that are caused by mutations in the genes encoding type I collagen and include specific forms of osteogenesis imperfecta (OI) and the Ehlers-Danlos syndrome (EDS). These disorders present with a broad disease spectrum and large clini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gistelinck C,Kwon RY,Malfait F,Symoens S,Harris MP,Henke K,Hawkins MB,Fisher S,Sips P,Guillemyn B,Bek JW,Vermassen P,De Saffel H,Witten PE,Weis M,De Paepe A,Eyre DR,Willaert A,Coucke PJ

更新日期：2018-08-21 00:00:00

abstract：:Signal transduction pathways activated by chemoattractants have been extensively studied, but little is known about the events mediating responses to mechanical stimuli. We discovered that acute mechanical perturbation of cells triggered transient activation of all tested components of the chemotactic signal transduct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Artemenko Y,Axiotakis L Jr,Borleis J,Iglesias PA,Devreotes PN

更新日期：2016-11-22 00:00:00

abstract：:Binding of carbon monoxide and oxygen to sterically protected heme model compounds (basket-handle porphyrins) was investigated in liquid toluene at temperatures from 180 to 300 K by laser flash photolysis. Only a single exponential rebinding process from the solvent could be seen in the time range of 20 nsec to millis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tetreau C,Lavalette D,Momenteau M,Lhoste JM

更新日期：1987-04-01 00:00:00