Structure and evolution of four POU domain genes expressed in mouse brain.

abstract：:Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of molecules that might be thera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khatri A,Kraft BD,Tata PR,Randell SH,Piantadosi CA,Pendergast AM

更新日期：2019-01-29 00:00:00

abstract：:High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan MK,McDonald RD,Ramshaw BJ,Betts JB,Shekhter A,Bauer ED,Harrison N

更新日期：2020-05-05 00:00:00

abstract：:A number of genes associated with sexual traits and reproduction evolve at the sequence level faster than the majority of genes coding for non-sex-related traits. Whole genome analyses allow this observation to be extended beyond the limited set of genes that have been studied thus far. We use cDNA microarrays to demo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meiklejohn CD,Parsch J,Ranz JM,Hartl DL

更新日期：2003-08-19 00:00:00

abstract：:RNA interference, mediated by small interfering RNAs (siRNAs), is a conserved regulatory process that has evolved as an antiviral defense mechanism in plants and animals. It is not known whether host cells also use siRNAs as an antibacterial defense mechanism in eukaryotes. Here, we report the discovery of an endogeno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katiyar-Agarwal S,Morgan R,Dahlbeck D,Borsani O,Villegas A Jr,Zhu JK,Staskawicz BJ,Jin H

更新日期：2006-11-21 00:00:00

abstract：:Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes. To study the importance of cardiolipin synthesis for mitochondrial integrity, membrane protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serricchio M,Bütikofer P

更新日期：2012-04-17 00:00:00

abstract：:The Amazon rainforest is the Earth's largest reservoir of plant and animal diversity, and it has been subjected to especially high rates of land use change, primarily to cattle pasture. This conversion has had a strongly negative effect on biological diversity, reducing the number of plant and animal species and homog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues JL,Pellizari VH,Mueller R,Baek K,Jesus Eda C,Paula FS,Mirza B,Hamaoui GS Jr,Tsai SM,Feigl B,Tiedje JM,Bohannan BJ,Nüsslein K

更新日期：2013-01-15 00:00:00

abstract：:The mouse p19Arf (human p14ARF) tumor suppressor protein, encoded in part from an alternative reading frame of the Ink4a (Cdkn2a) gene, inhibits the Mdm2 E3 ubiquitin ligase to activate p53. Arf is not expressed in most normal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Oosterwijk JG,Li C,Yang X,Opferman JT,Sherr CJ

更新日期：2017-07-11 00:00:00

abstract：:We have determined the nucleotide sequence of the dihydrofolate reductase-thymidylate synthetase (DHFR-TS) gene of the protozoan parasite Leishmania major (dihydrofolate reductase, EC 1.5.1.3 and thymidylate synthase, EC 2.1.1.45). The DHFR-TS protein is encoded by a single 1560-base-pair open reading frame within gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beverley SM,Ellenberger TE,Cordingley JS

更新日期：1986-04-01 00:00:00

abstract：:In early phases of human T-cell lymphotrophic virus I-induced adult T-cell leukemia (ATL), the malignant cell proliferation is associated with an autocrine process involving coordinate expression of interleukin (IL) 2 and its receptor. However, during late-phase ATL, leukemic cells no longer produce IL-2 yet continue ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton JD,Bamford RN,Peters C,Grant AJ,Kurys G,Goldman CK,Brennan J,Roessler E,Waldmann TA

更新日期：1994-05-24 00:00:00

abstract：:The semidwarf phenotype has been extensively selected during modern crop breeding as an agronomically important trait. Introduction of the semidwarf gene, semi-dwarf1 (sd1), which encodes a gibberellin biosynthesis enzyme, made significant contributions to the "green revolution" in rice (Oryza sativa L.). Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asano K,Yamasaki M,Takuno S,Miura K,Katagiri S,Ito T,Doi K,Wu J,Ebana K,Matsumoto T,Innan H,Kitano H,Ashikari M,Matsuoka M

更新日期：2011-07-05 00:00:00

abstract：:The ability to analyze and isolate cells based on the expression of specific surface markers has increased our understanding of cell biology and produced numerous applications for biomedicine. However, established cell-sorting platforms rely on labels that are limited in number due to biophysical constraints, such as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahotre SN,Chang YM,Wieland A,Stammen SR,Kwong GA

更新日期：2018-04-24 00:00:00

abstract：:A cloned segment of yeast DNA containing the structural gene for imidazoleglycerolphosphate dehydratase (D-erythro-imidazoleglycerolphosphate hydro-lase, EC 4.2.1.19) is transcribed and translated in Escherichia coli with sufficient fidelity to produce functional enzyme. This segment of yeast DNA was isolated as a via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Struhl K,Davis RW

更新日期：1977-12-01 00:00:00

abstract：:The generation of high-titer, helper-free retroviruses by transient transfection has been achieved by using the highly transfectable 293T cell line into which are stably introduced constructs that express retroviral packaging functions. The resulting ecotropic virus packaging cell line BOSC 23 produces infectious retr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pear WS,Nolan GP,Scott ML,Baltimore D

更新日期：1993-09-15 00:00:00

abstract：:Graphene superlattices were shown to exhibit high-temperature quantum oscillations due to periodic emergence of delocalized Bloch states in high magnetic fields such that unit fractions of the flux quantum pierce a superlattice unit cell. Under these conditions, semiclassical electron trajectories become straight agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishna Kumar R,Mishchenko A,Chen X,Pezzini S,Auton GH,Ponomarenko LA,Zeitler U,Eaves L,Fal'ko VI,Geim AK

更新日期：2018-05-15 00:00:00

abstract：:The conservation of developmental functions exerted by Antp-class homeoproteins in protostomes and deuterostomes suggested that homologs with related functions are present in diploblastic animals. Our phylogenetic analyses showed that Antp-class homeodomains belong either to non-Hox or to Hox/paraHox families. Among t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gauchat D,Mazet F,Berney C,Schummer M,Kreger S,Pawlowski J,Galliot B

更新日期：2000-04-25 00:00:00

abstract：:Glutamate transport by the excitatory amino acid carrier EAAC1 is known to be reversible. Thus, glutamate can either be taken up into cells, or it can be released from cells through reverse transport, depending on the electrochemical gradient of the co- and countertransported ions. However, it is unknown how fast and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Z,Tao Z,Gameiro A,Barcelona S,Braams S,Rauen T,Grewer C

更新日期：2007-11-13 00:00:00

abstract：:Interleukin 1 (IL-1) is a two-member family of proteins (IL-1 alpha and IL-1 beta) that mediates a diverse series of immune and inflammatory responses. These two proteins have only 26% amino acid homology yet bind to the same receptor. It is of importance to define the active sites of these molecules in order to under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosley B,Dower SK,Gillis S,Cosman D

更新日期：1987-07-01 00:00:00

abstract：:Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa-Pereira AP,Tininini S,Strobl B,Alonzi T,Schlaak JF,Is'harc H,Gesualdo I,Newman SJ,Kerr IM,Poli V

更新日期：2002-06-11 00:00:00

abstract：:Impaired regulatory T-cell function results in a severe chronic autoimmune disease affecting multiple organs in Scurfy mice and humans with the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Previous studies have shown that T helper cells but not cytotoxic T cells are critical for the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aschermann S,Lehmann CH,Mihai S,Schett G,Dudziak D,Nimmerjahn F

更新日期：2013-11-19 00:00:00

abstract：:Although soft devices (grippers, actuators, and elementary robots) are rapidly becoming an integral part of the broad field of robotics, autonomy for completely soft devices has only begun to be developed. Adaptation of conventional systems of control to soft devices requires hard valves and electronic controls. This ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preston DJ,Rothemund P,Jiang HJ,Nemitz MP,Rawson J,Suo Z,Whitesides GM

更新日期：2019-04-16 00:00:00

abstract：:Both plants and animals require the activity of proteins containing nucleotide binding (NB) domain and leucine-rich repeat (LRR) domains for proper immune system function. NB-LRR proteins in plants (NLR proteins in animals) also require conserved regulation via the proteins SGT1 and cytosolic HSP90. RAR1, a protein sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hubert DA,He Y,McNulty BC,Tornero P,Dangl JL

更新日期：2009-06-16 00:00:00

abstract：:The synthesis of the covalently-closed, circular DNA form of colicinogenic factor E(1) (ColE(1)) continues in Escherichia coli cells after the addition of chloramphenicol. A large portion of the purified supercoiled ColE(1) DNA molecules made in the presence of chloramphenicol are converted to the open circular DNA fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blair DG,Sherratt DJ,Clewell DB,Helinski DR

更新日期：1972-09-01 00:00:00

abstract：:Males of the androdioecious species Caenorhabditis elegans are more likely to attempt to mate with and successfully inseminate C. elegans hermaphrodites that do not concurrently harbor sperm. Although a small number of genes have been implicated in this effect, the mechanism by which it arises remains unknown. In the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leighton DH,Choe A,Wu SY,Sternberg PW

更新日期：2014-12-16 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:The problem of the propagation of conformational changes over long distances or through a closely packed protein is shown to fit a model of a ligand-induced conformational change between two protein states selected by evolution. Moreover, the kinetics of the pathway between these states is also selected so that the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu EW,Koshland DE Jr

更新日期：2001-08-14 00:00:00

abstract：:Gene knockout is the most powerful tool for determining gene function or permanently modifying the phenotypic characteristics of a cell. Existing methods for gene disruption are limited by their efficiency, time to completion, and/or the potential for confounding off-target effects. Here, we demonstrate a rapid single...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santiago Y,Chan E,Liu PQ,Orlando S,Zhang L,Urnov FD,Holmes MC,Guschin D,Waite A,Miller JC,Rebar EJ,Gregory PD,Klug A,Collingwood TN

更新日期：2008-04-15 00:00:00

abstract：:IL-17-producing CD27(-) γδ cells (γδ(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ-producing γδ(27+) cells are poorly elucidated. Moreover, although human IL-17-producing γδ cells are commonly imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michel ML,Pang DJ,Haque SF,Potocnik AJ,Pennington DJ,Hayday AC

更新日期：2012-10-23 00:00:00

abstract：:Vaccination is the most effective medical intervention ever introduced and, together with clean water and sanitation, it has eliminated a large part of the infectious diseases that once killed millions of people. A recent study concluded that since 1924 in the United States alone, vaccines have prevented 40 million ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rappuoli R,Pizza M,Del Giudice G,De Gregorio E

更新日期：2014-08-26 00:00:00

abstract：:The tails of newborn rats, consisting of slender continuous cones of avascular cartilage, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal carbon was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Anderson KP

更新日期：1976-09-01 00:00:00

abstract：:The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be involved in sickle disease pathobiology. We have examined rates of heme transfer to hemopexin from hemoglobin in dilute aqueous solution (0.5 mg of Hb per ml) at 37 degrees C. HbO2 S loses ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hebbel RP,Morgan WT,Eaton JW,Hedlund BE

更新日期：1988-01-01 00:00:00